ONG CHIN ENG



Salutation
Professor

School/Centre
School of Pharmacy

Appointment
Dean, School of Pharmacy

Position
Professor

Email
chinengong@imu.edu.my

Professional Network


Education

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PhD (Pharmacology), 1998 Flinders University
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BPharm (Hons) (Pharmacy), 1992 Universiti Sains Malaysia

Memberships

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International Society for the Study of Xenobiotics Member 2013 - Present
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Malaysian Pharmacists Society Member 1999 - Present

Research Funding
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Evaluation of cytochrome P450 inhibition potential of Ag8, a silver-N-heterocyclic carbene compound with promising anti-cancer action: in vitro and in silico studies IMU Internal Research Grant | 10 Jul 2023 - 30 Nov 2023
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The inhibitory effects of osmanthus flower extracts on human cytochrome P450 3A4 (CYP3A4) IMU Internal Research Grant | 01 Jun 2023 - 31 Dec 2023
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Size- and shape- dependent modulatory mechanisms of zinc oxide (ZnO) nanoparticles (NPs) towards cytochrome P450 enzymes and ZnO-bio-interactions in Caenorhabditis elegans FRGS | 01 Sep 2019 - 31 May 2023
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Deciphering the Inhibitory Mechanism of Bile Pigments on Tobacco Carcinogenesis FRGS | 15 Aug 2018 - 30 Jun 2022
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Cytochrome P450 3A4 (CYP3A4) – probing mechanisms of genetic polymorphism by assessing enzyme kinetics, ligand binding and computational modeling for three common genetic variants CYP3A4*2, CYP3A4*3 and CYP3A4*17 FRGS | 01 Jul 2014 - 31 Dec 2016
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Functional pharmacogenetics of human cytochromes P450 - multipronged approaches to elucidate their mechanism in drug therapy and development eScienceFund | 01 Apr 2012 - 30 Sep 2014
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Cytochrome P450 2A6 (CYP2A6): in vitro studies on genetic polymorphism and drug-flavonoid interactions Malaysia Toray Science Foundation Grant | 01 Jan 2008 - 31 Dec 2009
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Development of in vitro specific assays for screening of drug-herb pharmacokinetic interactions for commonly used Malaysian herbs eScienceFund | 01 Aug 2007 - 31 Oct 2009

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Publications

Research Articles

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Mechanism-based Inactivation of Cytochromes P450: Implications in Drug Interactions and Pharmacotherapy XENOBIOTICA 2024
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Effects of Zinc Oxide Particles of Different Sizes, Concentrations, and Exposure Durations on Behavioral Changes of Caenorhabditis elegans and Expressions of cep-1 and pmk-1 NANO LIFE 2024
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Interactions of coumarin and amine ligands with six cytochrome P450 2D6 allelic variants: molecular docking COMPUTATIONAL TOXICOLOGY 2023
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Heterologous Expression of Recombinant Human Cytochrome P450 (CYP) in Escherichia coli: N-Terminal Modification, Expression, Isolation, Purification, and Reconstitution BIOTECH 2023
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In vitro and in silico studies of interactions of cathinone with human recombinant cytochrome P450 CYP (1A2), CYP2A6, CYP2B6, CYP2C8, CYP2C19, CYP2E1, CYP2J2, and CYP3A5 TOXICOLOGY REPORTS 2022
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In vitro effects of 95% khat ethanol extract (KEE) on human recombinant cytochrome P450 (CYP) 1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C19, CYP2E1, CYP2J2 and CYP3A5 DRUG METABOLISM AND PERSONALIZED THERAPY 2022
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Cytochromes P450: Role in Carcinogenesis and Relevance to Cancers. CURRENT DRUG METABOLISM 2022
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Protein-Ligand Identification and In Vitro Inhibitory Effects of Cathine on 11 Major Human Drug Metabolizing Cytochrome P450s INTERNATIONAL JOURNAL OF TOXICOLOGY 2022
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Role of P34S, G169R, R296C, and S486T Substitutions in Ligand Access and Catalysis for Cytochrome P450 2D6 Allelic Variants CYP2D6* 14A and CYP2D6* 14B. DRUG METABOLISM LETTERS 2022
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In Vitro Inhibitory Effects of Agarwood Tea (Aquilaria malaccensis Lamk) Aqueous Extract on Human Cytochrome P450 (CYP) Enzyme Activities DRUG METABOLISM AND BIOANALYSIS LETTERS FORMERLY: DRUG METABOLISM LETTERS 2022
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Unveiling the Role of Cytochrome P450 (2E1) in Human Brain Specifically in Parkinson's Disease-Literature Review. Current Drug Metabolism 2021
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Current updates on the in vivo assessment of zinc oxide nanoparticles toxicity using animal models BioNanoScience 2021
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In vitro inhibitory effects of glucosamine, chondroitin and diacerein on human hepatic CYP2D6 Drug Metabolism and Personalized Therapy 2021
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The CYP2R1 Enzyme: Structure, Function, Enzymatic Properties and Genetic Polymorphism JOURNAL OF PHARMACY & PHARMACEUTICAL SCIENCES 2021
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The Molecular and Enzyme Kinetic Basis for Altered Activity of Three Cytochrome P450 2C19 Variants Found in the Chinese Population Current molecular pharmacology 2020
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Cytochrome P450 4B1 (CYP4B1) as a target in cancer treatment Human & experimental toxicology 2020
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The current understanding of the interactions between nanoparticles and cytochrome P450 enzymes–a literature-based review Xenobiotica 2019
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Expression of cytochrome P450 2C9 (CYP2C9) in Escherichia coli and its functional characterization ASIA PACIFIC JOURNAL OF MOLECULAR BIOLOGY AND BIOTECHNOLOGY 2019
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Effect of 95% ethanol khat extract and cathinone on in vitro human recombinant cytochrome P450 (CYP) 2C9, CYP2D6, and CYP3A4 activity European journal of drug metabolism and pharmacokinetics 2019
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Functional and structural characterisation of common cytochrome P450 2D6 allelic variants—roles of Pro34 and Thr107 in catalysis and inhibition NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY 2019
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Current high-throughput approaches of screening modulatory effects of xenobiotics on cytochrome P450 (CYP) enzymes High-throughput 2018
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Cytochrome P450 genotype‐guided drug therapies: an update on current states Clinical and Experimental Pharmacology and Physiology 2018
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A review on the expression and metabolic features of orphan human cytochrome P450 2S1 (CYP2S1) CURRENT DRUG METABOLISM 2018
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Cytochrome P450 2C9‐natural antiarthritic interactions: Evaluation of inhibition magnitude and prediction from in vitro data Biopharmaceutics & drug disposition 2018
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Site-directed mutagenesis of cytochrome P450 2D6 and 2C19 enzymes: expression and spectral characterization of naturally occurring allelic variants Applied biochemistry and biotechnology 2018
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In vitro study of modulatory effects of extracts of Strobilanthes crispus on human cDNA-expressed cytochrome P450 2A6 (CYP2A6) Drug Metabolism and Pharmacokinetics 2017
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The roles of cytochromes P450 in vascular biology and cardiovascular homeostasis INT J CLIN EXP MED 2017
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In vitro functional characterisation of cytochrome P450 (CYP) 2C19 allelic variants CYP2C19* 23 and CYP2C19* 24 Biochemical genetics 2017
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In vitro and in silico approaches to study cytochrome P450-mediated interactions JOURNAL OF PHARMACY & PHARMACEUTICAL SCIENCES 2017
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Cytochrome P450 2W1 (CYP2W1)–ready for use as the biomarker and drug target for cancer? Xenobiotica 2017
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Inhibition of human cytochrome p450 2c8-catalyzed amodiaquine n-desethylation: Effect of five traditionally and commonly used herbs PHARMACOGNOSY RESEARCH 2016
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In vitro study of modulatory effects of extracts of Strobilanthes Crispus on human cDNA-expressed cytochrome P450 2A6 (CYP2A6) and CYP3A4 THE ALL RESULTS JOURNALS: BIOL 2016
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The use of natural remedies to treat osteoarthritis CELLMED 2016
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In vitro effect of important herbal active constituents on human cytochrome P450 1A2 (CYP1A2) activity Phytomedicine 2014
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Effect of eurycomanone on cytochrome P450 isoforms CYP1A2, CYP2A6, CYP2C8, CYP2C9, CYP2C19, CYP2E1 and CYP3A4 in vitro Journal of natural medicines 2014
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Drug-herb interactions: Mechanisms involved and clinical implications of five commonly and traditionally used herbs CELLMED 2014
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Inhibitory potency of 8-methoxypsoralen on cytochrome P450 2A6 (CYP2A6) allelic variants CYP2A6* 15, CYP2A6* 16, CYP2A6* 21 and CYP2A6* 22: differential susceptibility due to different sequence locations of the mutations PloS one 2014
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In vitro approaches to investigate cytochrome P450 activities: update on current status and their applicability Expert opinion on drug metabolism & toxicology 2013
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Cellulose and its application in biomolecules purification INTERNATIONAL RESEARCH JOURNAL OF APPLIED AND BASIC SCIENCES 2013
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Heterologous expression of human cytochrome P450 (CYP) 2C19 in Escherichia coli and establishment of RP‐HPLC method to serve as activity marker Biomedical Chromatography 2013
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In vitro modulatory effects of flavonoids on human cytochrome P450 2C8 (CYP2C8) NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY 2012
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In-vitro inhibitory effect of Tualang honey on cytochrome P450 2C8 activity Journal of Pharmacy and Pharmacology 2012
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Inhibitory effects of cytochrome P450 enzymes CYP2C8, CYP2C9, CYP2C19 and CYP3A4 by Labisia pumila extracts Journal of ethnopharmacology 2012
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In vitro determination of the effect of Andrographis paniculata extracts and andrographolide on human hepatic cytochrome P450 activities Journal of natural medicines 2011
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Heterologous expression of human cytochromes P450 2D6 and CYP3A4 in Escherichia coli and their functional characterization The protein journal 2011
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In vitro modulatory effects of Andrographis paniculata, Centella asiatica and Orthosiphon stamineus on cytochrome P450 2C19 (CYP2C19) Journal of ethnopharmacology 2011
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In vitro effects of active constituents and extracts of Orthosiphon stamineus on the activities of three major human cDNA-expressed cytochrome P450 enzymes Chemico-biological interactions 2011
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In vitro modulation of naturally occurring flavonoids on cytochrome P450 2A6 (CYP2A6) activity Xenobiotica 2010
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In vitro modulatory effects on three major human cytochrome P450 enzymes by multiple active constituents and extracts of Centella asiatica Journal of ethnopharmacology 2010
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Functional characterization of cytochrome P450 2A6 allelic variants CYP2A6* 15, CYP2A6* 16, CYP2A6* 21, and CYP2A6* 22 Drug metabolism and disposition 2010
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Pharmacogenomics in drug therapy and interaction: the role of cytochrome P450 INT E-JOURNAL SCI MED EDUC 2008
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Functional role of Ile264 in CYP2C8: mutations affect haem incorporation and catalytic activity Drug metabolism and pharmacokinetics 2008
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Genetic polymorphism of CYP2C8 in three Malaysian ethnics: CYP2C8* 2 and CYP2C8* 3 are found in Malaysian Indians Journal of clinical pharmacy and therapeutics 2005
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A simple multiplex PCR method for the concurrent detection of three CYP2C8 variants Clinica chimica acta 2004
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Involvement of cytochromes p450 in drug-drug interactions: an overview. The Medical journal of Malaysia 2002
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The xenobiotic inhibitor profile of cytochrome P4502C8 British journal of clinical pharmacology 2000
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Baculovirus-mediated expression of cytochrome P4502C8 and human NADPH-cytochrome P450 reductase: optimization of protein expression Xenobiotica 1998

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Other Publications

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In vitro and in silico analysis of genetic variants of CYP2D6: structural and functional impact on drug metabolism 4th International Conference of Pharmacy & Health Sciences 2023 | 25 Oct 2023
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In vitro and in silico studies of interactions of cathine on 11 major human drug metabolising cytochrome P450 (CYP) enzyme activities BRITISH JOURNAL OF PHARMACOLOGY | 01 Jan 2023
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Problem-based learning: sharing of experience from the IMU School of Pharmacy Asia-Pacific Association on PBL in Health Sciences Webinar | 20 Aug 2022
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Structure-function analysis of cytochrome P450 2C19 (CYP2C19) alleles: kinetic and computational modeling studies 9th International Postgraduate Conference on Pharmaceutical Sciences (iPoPS) 2022 | 21 Jun 2022
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Structure-function analysis of cytochrome P450 enzymes: kinetic and computational modelling for drug clearance prediction 34th Malaysian Society of Pharmacology and Physiology Scientific Meeting | 15 Jul 2021
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Role of cytochromes P450 in drug metabolism and interaction Drug Metabolism & Pharmacokinetics and Population PK/PD Modelling Workshop | 08 Oct 2019
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In vitro approaches for drug metabolism studies – focus on cytochromes P450 13th Asia Pacific Federation of Pharmacologist Meeting | 01 Mar 2016
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Functional Characterization of Cytochrome P450 2D6 (CYP2D6) Allelic Variant CYP2D6* 10 PUBLIC HEALTH GENOMICS | 01 Jan 2015
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STUDIES OF IN VITRO MODULATORY EFFECT OF LABISIA PUMILA ON CYP1A2, CYP2A6 AND CYP3A4 Drug Metabolism Reviews | 01 Jan 2014
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Recent advances in studying cytochrome P450 polymorphism: updates on in vitro and in vivo approaches 21st Malaysian Society of Pharmacology and Physiology Scientific Meeting | 24 Apr 2006

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Books

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Springer, Cham (2022). Naturally Occurring Cathinone From Khat, Synthetic Cathinones and Cytochrome P450.
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Jenny Stanford Publishing (2019). Cytochromes P450, Cardiovascular Homeostasis and Disease


Supervisions
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Gan Su Ee | Undergraduate | 01 Jul 2023 Thesis: Evaluation of cytochrome P450 inhibition potential of Ag8, a silver-N-heterocyclic carbene compound with promising anti-cancer action: in vitro and in silico studies
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Amelia Dong | Doctorate | 01 Feb 2012 - 01 Apr 2017 Thesis: Determining the functional consequences of CYP2D6 and CYP2C19 genetic mutations in major alleles
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Tan Boon Hooi | Doctorate | 01 Sep 2010 - 31 Jul 2015 Thesis: Evaluation of the modulatory effects of glucosamine, chondroitin and diacerein on human hepatic cytochrome P450 enzymes
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Tiong Kai Hung | Master (Research) | 01 Jun 2006 - 30 Sep 2009 Thesis: Cytochrome P450 2A6 (CYP2A6): in vitro studies on genetic polymorphism and drug-flavonoid interactions
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Pan Yan | Doctorate | 01 Aug 2005 - 31 Aug 2009 Thesis: Effects of Andropgraphis paniculata (Hempedu Bumi), Centella asiatica (Pegaga) and Orthosiphon stamineus (Misai Kucing) on four important human hepatic cytochrome P450 isoforms