CHIN BEEK YOKE
Salutation
Professor
School/Centre
School of Health Sciences
Department
Applied Biomedical Science and Biotechnology
Appointment
Dean, Industrial Partnership ; Head, Centre for Cancer and Stem Cell Research
Position
Professor
Email
Education
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PhD (Toxicological Sciences), 2001
Johns Hopkins University
a
ScM (Physiology), 1995
Johns Hopkins University
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B.A. (Biological Sciences), 1987
Mount Holyoke College
Research Funding
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Exogenous Administration of Carbon Monoxide as A Putative Molecule To Modify Heavy Metal Toxicity In Microalgae
IMU Internal Research Grant | 01 Dec 2024 - 30 Nov 2025
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A systematic review on the toxicity of salsolinol and its metabolites
IMU Internal Research Grant | 01 Jun 2023 - 31 Dec 2023
a
Functional roles of IKK alpha in pancreatic ductal adenocarcinoma
FUNDAMENTAL RESEARCH GRANT SCHEME (FRGS) | 02 Nov 2020 - 10 Feb 2023
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Carbon monoxide is a bactericidal molecule
Sunway University Internal Grant | 10 Sep 2012 - 16 Sep 2013
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Carbon monoxide promotes cardiac tolerance: Role of the Dendritic Cell
American Society of Transplantation | 06 Jul 2009 - 11 Jul 2011
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Carbon monoxide attenuates chronic aortic rejection and development of arteriosclerotic lesions
American Heart Association Scientific Development Grant | 09 Jul 2007 - 11 Jul 2011
Publications
Research Articles
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Carbon Monoxide Suppresses Neointima Formation in Transplant Arteriosclerosis by Inhibiting Vascular Progenitor Cell Differentiation
ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY 2021
a
Stimulation of pro-alpha (1)(I) collagen by TGF-beta (1) in mesangial cells: role of the p38 MAPK pathway (vol 280, pg F495, 2001)
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 2020
a
Macrophages sense and kill bacteria through carbon monoxide–dependent inflammasome activation
THE JOURNAL OF CLINICAL INVESTIGATION 2014
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Carbon monoxide induced PPARγ SUMOylation and UCP2 block inflammatory gene expression in macrophages
PLOS ONE 2011
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Carbon monoxide enhances early liver regeneration in mice after hepatectomy
HEPATOLOGY 2011
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Intraoperative administration of inhaled carbon monoxide reduces delayed graft function in kidney allografts in Swine
AMERICAN JOURNAL OF TRANSPLANTATION 2010
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Nitric oxide–dependent bone marrow progenitor mobilization by carbon monoxide enhances endothelial repair after vascular injury
CIRCULATION 2010
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Carbon monoxide is a poison… to microbes! CO as a bactericidal molecule
CURRENT OPINION IN PHARMACOLOGY 2009
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Cell surface biliverdin reductase mediates biliverdin-induced anti-inflammatory effects via phosphatidylinositol 3-kinase and Akt
JOURNAL OF BIOLOGICAL CHEMISTRY 2009
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Inhale to survive, cycle or die? Carbon monoxide and cellular proliferation
CELL CYCLE 2008
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Heme oxygenase and carbon monoxide initiate homeostatic signaling
JOURNAL OF MOLECULAR MEDICINE 2008
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CARBON MONOXIDE PREVENTS REJECTION OF CARDIAC ALLOGRAFTS VIA ACTIVATION OF HIF1A;: 1455
TRANSPLANTATION 2008
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Toll‐like receptor 4 suppression leads to islet allograft survival
THE FASEB JOURNAL 2007
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Restoring HOmeostasis: is heme oxygenase-1 ready for the clinic?
TRENDS IN PHARMACOLOGICAL SCIENCES 2007
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Inhaled carbon monoxide prevents graft-induced intimal hyperplasia in swine
JOURNAL OF SURGICAL RESEARCH 2007
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INCLUDING TOXICOLOGICAL SCIENCES
SCIENCES 2007
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Hypoxia-inducible factor 1α stabilization by carbon monoxide results in cytoprotective preconditioning
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES 2007
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Carbon monoxide signals via inhibition of cytochrome c oxidase and generation of mitochondrial reactive oxygen species
THE FASEB JOURNAL 2007
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Carbon monoxide orchestrates a protective response through PPARγ
IMMUNITY 2006
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Carbon monoxide reverses established pulmonary hypertension
THE JOURNAL OF EXPERIMENTAL MEDICINE 2006
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Bilirubin can induce tolerance to islet allografts
ENDOCRINOLOGY 2006
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CARBON MONOXIDE SUPPRESSES NEOINTIMA FORMATION IN TRANSPLANT ARTERIOSCLEROSIS BY INHIBITING DIFFERENTIATION OF VASCULAR PROGENITOR CELLS.
TRANSPLANTATION 2006
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Bilirubin can induce tolerance to islet allografts (vol 147, pg 762, 2006)
ENDOCRINOLOGY 2006
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Carbon monoxide increases macrophage bacterial clearance through Toll-like receptor (TLR) 4 expression.
CELLULAR AND MOLECULAR BIOLOGY (NOISY-LE-GRAND, FRANCE) 2005
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Transcriptional regulation of the HO-1 gene in cultured macrophages exposed to model airborne particulate matter
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 2003
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Transcriptional regulation of the heme oxygenase 1 gene in cultured macrophages exposed to model airborne particulate matter
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 2002
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Achieving molecular selectivity in imaging using multiphoton Raman spectroscopy techniques
TRAFFIC 2001
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Stimulation of pro-α1 (I) collagen by TGF-β1 in mesangial cells: role of the p38 MAPK pathway
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 2001
a
AP-1 and STAT mediate hyperoxia-induced gene transcription of heme oxygenase-1
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 2000
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Transforming growth factor β1 rescues serum deprivation-induced apoptosis via the mitogen-activated protein kinase (MAPK) pathway in macrophages
JOURNAL OF BIOLOGICAL CHEMISTRY 1999
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Protective effects of heme oxygenase-1 in acute lung injury
CHEST 1999
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CELL BIOLOGY AND METABOLISM-Transforming growth factor b1 rescues serum deprivation-induced apoptosis via the mitogen-activated protein kinase (MAPK) pathway in macrophages
JOURNAL OF BIOLOGICAL CHEMISTRY 1999
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Mitogen-activated protein kinase pathway mediates hyperoxia-induced apoptosis in cultured macrophage cells
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 1999
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Mitogen Activating Protein Kinase (MAPK) mediates carbon particle-induced tumor necrosis factor-α expression
FASEB JOURNAL 1998
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Transcriptional activation of the HO-1 gene by lipopolysaccharide is mediated by 5′ distal enhancers: role of reactive oxygen intermediates and AP-1
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY 1998
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Induction of apoptosis by particulate matter: role of TNF-α and MAPK
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 1998
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Pulmonary apoptosis in aged and oxygen-tolerant rats exposed to hyperoxia
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 1998
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Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia
JOURNAL OF BIOLOGICAL CHEMISTRY 1997
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Differential gene expression of antioxidant enzymes in macrophages exposed to carbon particles adsorbed with benzo-[a]-pyrene
ACS DIVISION OF FUEL CHEMISTRY, PREPRINTS 1997
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Mechanism of hemoglobin-induced protection against endotoxemia in rats: a ferritin-independent pathway
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 1997
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Hyaluronan fragments induce nitric-oxide synthase in murine macrophages through a nuclear factor κB-dependent mechanism
JOURNAL OF BIOLOGICAL CHEMISTRY 1997
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Culture of arterial chemoreceptor cells from adult cats in defined medium
BRAIN RESEARCH 1994
Other Publications
a
Toll-like receptor 4 suppression leads to islet allograft survival following transplantation.
AMERICAN JOURNAL OF TRANSPLANTATION | 01 Jan 2007
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Induction of tumor necrosis factor alpha (TNF alpha) signaling genes in alveolar macrophages (M phi) after exposure to ultrafine particles (UFP).
TOXICOLOGICAL SCIENCES | 01 Jan 2003
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Microarray evaluation of global gene regulation by tumor necrosis factor alpha
MOLECULAR BIOLOGY OF THE CELL | 01 Jan 2001
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The application of nonlinear Raman spectroscopy to provide molecular specificity in 3-D biological imaging
Technical Digest. Summaries of papers presented at the Conference on Lasers and Electro-Optics. Postconference Technical Digest (IEEE Cat. No. 01CH37170) | 01 Jan 2001
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Application of coherent antistokes Raman scattering (CARS) to imaging mammalian cells: a means for gaining molecular selectivity in multiphoton imaging
Multiphoton Microscopy in the Biomedical Sciences | 01 Jan 2001
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Macrophages generate H202 after exposure to carbon particles plus benzo [a] pyrene.
FASEB JOURNAL | 01 Jan 2000
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Regulation of particulate matter (PM)-induced secretion of chemokines in macrophages by the mitogen activated protein kinase (MAPK) pathway.
American Journal of Respiratory and Critical Care Medicine | 01 Jan 1999
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Differential activation of Bcl-2 related proteins and Fas ligand death pathways in hyperoxia-induced apoptosis in macrophages.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | 01 Jan 1999
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Induction of caspases and bcl-2 related proteins in particulate matter (PM)-induced apoptosis matter cultured macrophages.
American Journal of Respiratory and Critical Care Medicine | 01 Jan 1999
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The mitogen activated protein kinases (MAPK) pathway mediates heme oxygenase-1 (HO-1) gene transcription in macrophages exposed to particulate matter (PM).
American Journal of Respiratory and Critical Care Medicine | 01 Jan 1999
a
Activation of extracellular signal-regulated kinase 1 (ERK1) and activator protein-1 (AP-1) by transforming growth factor-beta 1 in mesangial cells is dependent on TGF-beta type II receptor.
FASEB JOURNAL | 01 Jan 1998
a
Differential gene expression of antioxidant enzymes in macrophages exposed to carbon particles adsorbed with benzo-[a]-pyrene.
Abstracts of Papers of the American Chemical Society | 01 Jan 1997
a
Transforming growth factor beta 1 (TGF-beta 1) rescues serum deprivation-induced apoptosis via the mitogen-activated protein kinases (MAPK) pathway in macrophages.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 01 Jan 1997
a
Differential gene expression of antioxidant enzymes (AOE) in a murine alveolar macrophage cell line in response to carbon black adsorbed with benzo-[a]-pyrene.
FASEB JOURNAL | 01 Jan 1997
a
OZONE EXPOSURE STIMULATES NUCLEAR FACTOR-KAPPA-BETA (NF-KAPPA-B) AND INTERLEUKIN-8 (IL-8) EXPRESSION IN 16HBE14O-CELLS
FASEB JOURNAL | 01 Jan 1995
a
IDENTIFICATION OF FUNCTIONING CULTURED CAROTID-BODY TYPE-I CELLS FROM ADULT CAT
FASEB JOURNAL | 01 Jan 1993
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IMMUNOCYTOCHEMICAL CHARACTERIZATION OF THE JUNCTION BETWEEN BOVINE PULMONARY MICROVASCULAR ENDOTHELIAL-CELLS
FASEB JOURNAL | 01 Jan 1991
Books
a
American Thoracic Society (2010). Carbon Monoxide Enhances The Bactericidal Activity Of Macrophages Infected With Enterococci Faecalis
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American Thoracic Society (2010). Carbon Monoxide Enhances The Bactericidal Activity Of Macrophages Infected With Enterococci Faecalis
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Springer, Berlin, Heidelberg (1997). Epithelial Functionas a Focus of Ozone-Allergen Interaction
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Springer, Boston, MA (1994). Culturing carotid body cells of adult cats
Supervisions
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Katie Long | Undergraduate | 01 Dec 2022 - 15 Feb 2023
Thesis: The Paradoxical use of Carbon Monoxide (CO) as a protective molecule against environmental pollutants: using a toxicant to reduce the negative effect of heavy metal toxicity.
a
Asil Asaaka | Undergraduate | 01 Dec 2022 - 15 Feb 2023
Thesis: The Paradoxical use of Carbon Monoxide (CO) as a protective molecule against environmental pollutants: using a toxicant to reduce the negative effect of heavy metal toxicity.
a
Yee Zong Yang | Doctorate | 07 Feb 2022 - 07 Feb 2025
Thesis: Functional roles of IKKα in pancreatic ductal adenocarcinoma (PDAC)
a
LEE KHAI SHIEN | Undergraduate | 06 Apr 2020 - 05 Oct 2020
Thesis: IDENTIFICATION OF POTENTIAL NOVEL COMPOUNDS THAT MAY ENHANCE ANTICANCER EFFECT OF POTENTIAL IKKα INHIBITORS
a
Laurena Wong Gui Jin | Undergraduate | 06 Apr 2020 - 05 Oct 2020
Thesis: IDENTIFICATION OF INHIBITORY KAPPA B KINASES α (IKKα) INHIBITORS THAT HAVE AN ENHANCED INHIBITION ON THE NON-CANONICAL NF-κB PATHWAY IN PROSTATE CANCER
a
VANESSA SEE VERN YEE | Undergraduate | 06 Apr 2020 - 05 Oct 2020
Thesis: DISCOVERY OF POTENTIAL IKKα INHIBITORS VIA IN VITRO CHEMICAL LIBRARY SCREENING AND ITS COMBINATION EFFECT WITH 5-FLUOROURACIL IN TREATING PANCREATIC CANCER
a
Gan Ming Yi | Undergraduate | 26 Nov 2018 - 11 May 2020
Thesis: Pentacyclic triterpenoids as antibiofilm agents against methicillin-resistant and biofilm-forming Staphylococcus aureus (MRSA).
a
Ramona Khanum | Doctorate | 04 Jan 2016 - 03 Jun 2019
Thesis: Targeting Clinically Relevant Biofilms of Staphylococcus epidermidis with lactoferrin and carbon monoxide