Renu Agarwal



Salutation
Professor

School/Centre
School of Medicine

Department
Pharmacology and Therapeutics

Appointment
Associate Dean, Research & Innovation and Postgraduate Studies (School of Medicine)

Position
Professor

Email
renuagarwal@imu.edu.my

Professional Network


Education

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PhD (Pharmacology), 2009 University of Delhi, India
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MSc (Pharmacology), 2005 Universiti Sains Malaysia
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Research Officer (Pharmacology), 2005 Universiti Sains Malaysia
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MBBS (Medicine), 1988 Dr SN Medical College, Jodhpur, Rajasthan, India

Memberships

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Malaysian Society of Pharmacology & Physiology Life Member (MSPP/LM/0073/2013) 2021 - Present
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British Pharmacological Society member 2020 - Present
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Indian Pharmacology Society Life Member 2006 - Present

Research Funding
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Immersive technology for Faculty Development: Exploring usefulness for improving lecture delivery skills among early career academicians IMU Internal Research Grant | 10 Oct 2024 - 31 Dec 2025
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Studies to investigate mechanisms of protective effect of Atorvastatin against NMDA-induced Excitotoxic Retinal Injury in Rats: Role of Autophagy IMU Internal Research Grant | 05 Sep 2024 - 30 Jun 2027
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Neuroprotective Effect of Atorvastatin: Understanding Lipid Raft-Mediated Modulation of NMDA Excitotoxicity in Glaucoma IMU Internal Research Grant | 01 Sep 2024 - 31 Aug 2027
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Mechanisms of the protective effects of atorvastatin against NMDA-induced retinal injury in rats: focus on PPAR-α/CREB pathway and glial activation IMU Internal Research Grant | 01 Oct 2023 - 30 Sep 2027
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Mechanisms of Trans-Resveratrol on Renin-Angiotensin System (RAS) in Dexamethasone-Induced Human Trabecular Meshwork Cells. FRGS | 01 Oct 2023 - 30 Sep 2025
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Mechanisms underlying the neuroprotective effect of trans-resveratrol: Focus on crosstalk between adenosine receptors and renin-angiotensin system. FRGS | 01 Oct 2023 - 30 Sep 2026
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Role of sphingolipid rheostat in the neuroprotective effect of atorvastatin against NMDA-induced excitotoxic retinal injury IMU Internal Research Grant | 01 Apr 2023 - 31 Mar 2026
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Efficacy and safety of molecular-targeted therapies in nasopharyngeal carcinoma: A network meta-analysis IMU Internal Research Grant | 06 Mar 2023 - 30 Jun 2025
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Efficacy and safety of immunotherapies for Alzheimer’s disease: a network meta-analysis IMU Internal Research Grant | 02 Jan 2023 - 31 Dec 2024
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Development and Validation of a Questionnaire for Pattern of Social Media Usage and Comparison of Social Media Usage Pattern Among Health care students IMU Internal Research Grant | 01 Jan 2023 - 31 Mar 2024
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A systematic review and meta-analysis of adverse events of WHO approved COVID-19 treatment regimens IMU Internal Research Grant | 01 Aug 2022 - 30 Jun 2024
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Role of renin-angiotensin-aldosterone system (RAAS) in excitotoxic retinal damage in rats Bachelor in Medical Sciences (Hons) | 03 Jan 2022 - 01 Jul 2021
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Role of renin-angiotensin-aldosterone system (RAAS) in ischemic retinal damage in rats Bachelor in Medical Sciences (Hons) | 01 Dec 2021 - 31 Jul 2021
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Effect of trans-resveratrol on glutamate clearance and visual behavior due to excitotoxic retinal injury in rats IMU | 01 Jun 2021 - 01 Jun 2021
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Effect of trans-resveratrol on glutamate clearance and visual behavior due to excitotoxic retinal injury in rats. BMedSc | 01 Jan 2021 - 31 Jul 2021
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Dual Mechanisms Underlying the Neuroprotective Effect of Trans-Resverakterol against Excitotoxic Etinal Ganglion Cell Loss: Involvement of Adenosine A1Receptors and Glutamate Transporters MoHE Fundamental Research Grant Scheme (FRGS) | 01 Nov 2020 - 31 Oct 2023
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Mechanisms of corneal abrasion healing properties of tocotrienol rich fraction (TRF) in rats: Focus on suppression of proinflammatory and oxidative stress markers MoHE Fundamental Research Grant Scheme (FRGS) | 01 Nov 2020 - 31 Oct 2023
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Effect of Tocotrienol-Rich Fraction (TRF) on Visual behavior and Retinal Cell Apoptosis in Rats with Streptozotocin-induced Diabetic Retinopathy IMU | 01 Feb 2020 - 01 Jul 2021
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Development and evaluation of an innovative mobile application on antibiotics for pharmacology teaching and learning IMU | 01 Jan 2020 - 01 Oct 2021
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Mechanisms underlying the effect of resveratrol on extracellular matrix secretion by dexamethasone-treated human trabecular meshwork cells: Focus on non-canonical TGF-β2- signaling. FRGS | 01 Sep 2019 - 31 May 2022
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Unravelling mechanisms of neuroprotection by resveratrol in rats with intracerebral haemorrhage: new insight into the role of adenosine A1 receptor FRGS Racer | 01 Jan 2019 - 30 Nov 2021
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Mechanisms of protective effect of tocotrienol-rich fraction against diabetic retinopathy in rats FRGS | 01 Jan 2019 - 31 Mar 2022
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Mechanisms of action of resveratrol against dexamethasone-induced extracellular matrix remodeling by human trabecular meshwork cells. FRGS | 01 Jan 2019 - 30 Jun 2023
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Mechanism of Neuroprotection by Philanthotoxin against NMDA-Induced Excitotoxicity in the Retina of Glaucoma Rat Model. FRGS | 15 Aug 2017 - 14 Aug 2020

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Publications

Research Articles

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Mapping key trends, relationships, and molecular pathways for neuroprotection in glaucoma: a bibliometric approach INTERNATIONAL JOURNAL OF OPHTHALMOLOGY 2025
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The Anti-inflammatory Effects of Curcuma longa and Berbem’s aristata in Endotoxin—Induced Journal: lnvestigative Ophthalmology and Visual Science 2025
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Efficacy and safety of molecular targeted therapies in nasopharyngeal carcinoma: a network meta-analysis BMC CANCER 2025
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Trans-Resveratrol Attenuates Fibronectin Deposition via Downregulation of TGFβ1-SMAD Pathway in Dexamethasonetreated Human Trabecular Meshwork Cells. MALAYSIAN JOURNAL OF MEDICINE & HEALTH SCIENCES 2024
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Identifying the stability of housekeeping genes to be used for the quantitative real-time PCR normalization in retinal tissue of streptozotocin-induced diabetic rats INTERNATIONAL JOURNAL OF OPHTHALMOLOGY 2024
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Unveiling enigmatic essence of Sphingolipids: A promising avenue for glaucoma treatment VISION RESEARCH 2024
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N-Methyl-d-Aspartate-Induced Excitotoxicity and Its Impact on the Renin–Angiotensin System in Retinal Tissue JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS 2024
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Tocotrienol-rich fraction (TRF) protects against retinal cell apoptosis and preserves visual behavior in rats with streptozotocin-induced diabetic retinopathy BMC COMPLEMENTARY MEDICINE AND THERAPIES 2024
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Adverse Events Associated with Monoclonal Antibodies Used for Treatment of COVID-19: A systematic review and meta-analysis AUTHOREA PREPRINTS 2024
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Role of TGF-β1/SMADs signalling pathway in resveratrol-induced reduction of extracellular matrix deposition by dexamethasone-treated human trabecular meshwork cells THE KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY 2024
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Advances in targeting the extracellular matrix for glaucoma therapy: current updates EXPERT OPINION ON THERAPEUTIC TARGETS 2023
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Genetic rodent models of glaucoma in representing disease phenotype and insights into the pathogenesis MOLECULAR ASPECTS OF MEDICINE 2023
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Diabetic retinopathy: a comprehensive update on in vivo, in vitro and ex vivo experimental models BMC OPHTHALMOLOGY 2023
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Connective tissue growth factor: Role in trabecular meshwork remodeling and intraocular pressure lowering EXPERIMENTAL BIOLOGY AND MEDICINE 2023
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Exploring the current use of animal models in glaucoma drug discovery: where are we in 2023? EXPERT OPINION ON DRUG DISCOVERY 2023
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外源性脑源性神经营养因子对淀粉样 β 蛋白 1-40 致视网膜变性的神经保护 >**"Y" (<-***O/OO^) 2023
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Tocotrienol-rich fraction reduces retinal inflammation and angiogenesis in rats with streptozotocin-induced diabetes BMC COMPLEMENTARY MEDICINE AND THERAPIES 2023
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Neuroprotective effects of exogenous brain-derived neurotrophic factor on amyloid-beta 1–40-induced retinal degeneration NEURAL REGENERATION RESEARCH 2023
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The effect of palm oil-derived tocotrienol-rich fraction in preserving normal retinal vascular diameter in streptozotocin-induced diabetic rats GRAEFE'S ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY 2023
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Neuroprotection by trans-resveratrol in rats with N-methyl-D-aspartate (NMDA)–induced retinal injury: Insights into the role of adenosine A1 receptors NEUROSCIENCE RESEARCH 2023
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Neuroprotection by Trans-Resveratrol in Rats With Intracerebral Hemorrhage: Insights into the Role of Adenosine A1 Receptors JOURNAL OF NEUROPATHOLOGY & EXPERIMENTAL NEUROLOGY 2022
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The ameliorative effects of exogenous L-glutathione on testicular cell apoptosis in STZ-induced diabetic C57BL/6 mice INTERNATIONAL CONGRESS OF DIABETES AND METABOLISM 2022
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Mechanisms of the protective effect of philanthotoxin against NMDA-induced retinal oxidative and nitrosative stress INTERNATIONAL CONGRESS OF DIABETES AND METABOLISM 2022
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Involvement of calcium regulated proteins in the antiapoptotic effect of philanthotoxin-343 against NMDA-induced retinal ganglion cell apoptosis in sprague dawley rats INTERNATIONAL CONGRESS OF DIABETES AND METABOLISM 2022
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Effect of tocotrienol-rich fraction on retinal vessel diameter and angiogenesis-related markers in rats with streptozotocininduced diabetic retinopathy INTERNATIONAL CONGRESS OF DIABETES AND METABOLISM 2022
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Antioxidant and anti-apoptotic effects of tocotrienol-rich fraction against streptozotocin-induced diabetic retinopathy in rats BIOMEDICINE & PHARMACOTHERAPY 2022
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Intravitreal Trans-Resveratrol Ameliorates NMDA-Induced Optic Nerve and Retinal Injury CURRENT EYE RESEARCH 2022
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Effect of trans-resveratrol on glutamate clearance and visual behaviour in rats with glutamate induced retinal injury EXPERIMENTAL EYE RESEARCH 2022
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Relationship between serum and tear levels of tissue plasminogen activator and plasminogen activator inhibitor-1 in diabetic retinopathy BMC OPHTHALMOLOGY 2022
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Brain-Derived Neurotrophic Factor-Mediated Neuroprotection in Glaucoma: A Review of Current State of the Art FRONTIERS IN PHARMACOLOGY 2022
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Utilizing computer assisted laboratory procedures in pharmacology remotely: teaching & learning at times of uncertainty background Computer Assisted Learning (CAL) SOUTH-EAST ASIAN JOURNAL OF MEDICAL EDUCATION 2021
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Medical Management of Open-Angle Glaucoma: Focus on Mechanisms of Action and Adverse Drug Reactions JOURNAL OF CLINICAL AND HEALTH SCIENCES 2021
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Modulation of NFκB signalling pathway by tocotrienol: A systematic review ASIA PACIFIC JOURNAL OF CLINICAL NUTRITION 2021
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The Use of Fiji Image J as an Image Analysis Tool for Measuring Retinal Vessel Diameter in Rodent Model of Diabetic Retinopathy ASIAN JOURNAL OF MEDICINE AND BIOMEDICINE 2021
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Open field mirror test as a tool for the assessment of visual functions in rats with streptozotocin-induced diabetes NEUROSCIENCE RESEARCH NOTES 2021
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Knowledge, attitudes, and practices related to adverse drug reaction reporting by healthcare professionals in a tertiary hospital in Malaysia JOURNAL OF APPLIED PHARMACEUTICAL SCIENCE 2021
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Utility of online clinical teaching: an analysis of feedback from students SOUTH-EAST ASIAN JOURNAL OF MEDICAL EDUCATION 2021
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New solutions for old challenges in glaucoma treatment: is taurine an option to consider? Neural Regeneration Research 2021
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青光眼治疗的新解决方案: 是否可以考虑使用牛磺酸? >**"Y" (<-***O/OO^) 2021
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EFFECT OF TOCOTRIENOL-RICH FRACTION ON THE VISUAL-BEHAVIOUR RESPONSE OF RATS WITH STREPTOZOTOCIN-INDUCED DIABETIC RETINOPATHY INTERNATIONAL JOURNAL OF ALLIED HEALTH SCIENCES 2021
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Tackling retinal ganglion cell apoptosis in glaucoma: role of adenosine receptors EXPERT OPINION ON THERAPEUTIC TARGETS 2021
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Neuroprotection Against NMDA-Induced Retinal Damage by Philanthotoxin-343 Involves Reduced Nitrosative Stress FRONTIERS IN PHARMACOLOGY 2021
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Glutathione (GSH) improves sperm quality and testicular morphology in streptozotocin-induced diabetic mice Asian Journal of Andrology 2021
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Magnesium acetyltaurate prevents retinal damage and visual impairment in rats through suppression of NMDA-induced upregulation of NF-κB, p53 and AP-1 (c-Jun/c-Fos) >**"Y" (<-***O/OO^) 2021
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Changes in the Urinary Metabolites in Losartan-Treated Spontaneously Hypertensive Rats JOURNAL OF CLINICAL AND HEALTH SCIENCES 2021
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Protective effect of magnesium acetyltaurate against NMDA-induced retinal ganglion cell loss in rats involves calcium-regulated proteins MOLECULAR VISION 2020
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Oral Administration of Palm Oil-derived Tocotrienol-Rich Fraction Reduces Retinal Oxidative Stress in Rat Model of Streptozotocin-Induced Diabetic Retinopathy INTERNATIONAL CONGRESS OF DIABETES AND METABOLISM 2020
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L-glutathione alleviates testicular oxidative stress in streptozotocin-induced diabetic mice INTERNATIONAL CONGRESS OF DIABETES AND METABOLISM 2020
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Philanthotoxin-343 attenuates retinal and optic nerve injury, and protects visual function in rats with N-methyl-D-aspartate-induced excitotoxicity PloS one 2020
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Effect of L-glutathione on antioxidant enzyme and Bax/Bcl2 ratio in the testes of diabetes-induced C57BL/6NTac mice INTERNATIONAL CONGRESS OF DIABETES AND METABOLISM 2020
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Palm Oil-Derived Tocotrienol-Rich Fraction Preserves Normal Retinal Vascular Structures in Streptozotocin-Induced Diabetic Rats INTERNATIONAL CONGRESS OF DIABETES AND METABOLISM 2020
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Targeting the BDNF/TrkB pathway for the treatment of amyloid beta 1‐40‒induced neurodegeneration: Focus on ocular manifestations of Alzheimer’s disease: Nonhuman/Target identification and validation studies: Amyloid ALZHEIMER'S & DEMENTIA 2020
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Neuroprotective effects of brain‐derived neurotrophic factor against amyloid beta 1‐40‐induced retinal and optic nerve damage European Journal of Neuroscience 2020
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Neuroprotection by trans-resveratrol against collagenase-induced neurological and neurobehavioural deficits in rats involves adenosine A1 receptors Neurological research 2020
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Effect of dexamethasone on the expression of MMPs, adenosine A1 receptors and NFKB by human trabecular meshwork cells Journal of Basic and Clinical Physiology and Pharmacology 2020
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Effect of trans-resveratrol on dexamethasone-induced changes in the expression of MMPs by human trabecular meshwork cells: Involvement of adenosine A1 receptors and NFkB European journal of pharmacology 2020
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Protective effect of palm oil-derived tocotrienol-rich fraction against retinal neurodegenerative changes in rats with streptozotocin-induced diabetic retinopathy Biomolecules 2020
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Magnesium acetyltaurate protects against endothelin-1 induced RGC loss by reducing neuroinflammation in Sprague dawley rats Experimental eye research 2020
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Exogenous L-glutathione administration enhances the level of antioxidants enzymes and testicular morphology in the testes of STZ-induced diabetic C57BL/6NTac mice INTERNATIONAL CONGRESS OF DIABETES AND METABOLISM 2019
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IOP Lowering Effects of Ocimum basilicum Seed Extract in Two Rabbit Models of Ocular Hypertension JOURNAL OF CLINICAL AND HEALTH SCIENCES 2019
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Tocotrienol-Rich Fraction Supplementation Reduces Retinal Cell Apoptosis and Angiogenic Protein Expression in Rats with Streptozotocin-Induced Diabetic Retinopathy INTERNATIONAL CONGRESS OF DIABETES AND METABOLISM 2019
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Neuroprotective Approach for the Intervention of Glaucoma Associated Diabetes Mellitus using Philanthotoxin (PhTX-343) INTERNATIONAL CONGRESS OF DIABETES AND METABOLISM 2019
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EFFECT OF TOCOTRIENOL-RICH FRACTION TOWARDS RETINAL LAYER THICKNESS AND CELL COUNTS IN RATS WITH STREPTOZOTOCIN-INDUCED DIABETIC RETINOPATHY IN: COMPARISON BETWEEN ORAL AND TOPICAL ROUTE OF ADMINISTRATION INTERNATIONAL CONGRESS OF DIABETES AND METABOLISM 2019
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Neuroprotective effect of Philanthotoxin-343 (PhTX-343) on NMDA-induced Retinal Damage and Visual Impairments in Sprague Dawley Rats INTERNATIONAL CONGRESS OF DIABETES AND METABOLISM 2019
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Dose-Dependent Effects of Endothelin-1 on Retinal and Optic Nerve Morphology in Sprague Dawley Rats Neurochemical Journal 2019
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Blood pressure lowering effect of Ficus deltoidea var kunstleri in spontaneously hypertensive rats: possible involvement of renin–angiotensin–aldosterone system, endothelial function and anti-oxidant system Molecular biology reports 2019
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Dose-dependent effects of NMDA on retinal and optic nerve morphology in rats International journal of ophthalmology 2019
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Taurine protects against NMDA-induced retinal damage by reducing retinal oxidative stress Amino acids 2019
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Antiapoptotic effect of taurine against NMDA-induced retinal excitotoxicity in rats Neurotoxicology 2019
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Intraocular pressure-lowering effects of imidazo [1, 2-a]-and pyrimido [1, 2-a] benzimidazole compounds in rats with dexamethasone-induced ocular hypertension European journal of pharmacology 2019
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Magnesium acethyltaurate as a potential agent for retinal and optic nerve protection in glaucoma Neural regeneration research 2018
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牛磺酸通过抗氧化作用保护内皮素-1 诱导的视网膜和视神经损伤 >**"Y" (<-***O/OO^) 2018
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Ocular permeation of topical tazocin and its effectiveness in the treatment of Pseudomonas aeruginosa induced keratitis in rabbits JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS 2018
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Data on the effects of imidazo [1, 2-a] benzimidazole and pyrimido [1, 2-a] benzimidazole compounds on intraocular pressure of ocular normotensive rats Data in brief 2018
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Relationship between intraocular pressure lowering effect and chemical structure of imidazo [1, 2-a] benzimidazole and pyrimido [1, 2-a] benzimidazole derivatives Data in brief 2018
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Topical losartan reduces IOP by altering TM morphology in rats with steroid-induced ocular hypertension INDIAN J PHYSIOL PHARMACOL 2018
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乙酰水杨酸镁作为青光眼视网膜和视神经保护的潜在药物 >**"Y" (<-***O/OO^) 2018
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Time-and dose-related effects of amyloid beta1-40 on retina and optic nerve morphology in rats International Journal of Neuroscience 2018
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Trabecular meshwork ECM remodeling in glaucoma: could RAS be a target? Expert opinion on therapeutic targets 2018
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Effect of magnesium acetyltaurate and taurine on endothelin1-induced retinal nitrosative stress in rats Current eye research 2018
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IOP lowering effect of topical trans-resveratrol involves adenosine receptors and TGF-β2 signaling pathways European journal of pharmacology 2018
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Protective effect of magnesium acetyltaurate and taurine against NMDA-induced retinal damage involves reduced nitrosative stress Molecular vision 2018
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Taurine protects against retinal and optic nerve damage induced by endothelin-1 in rats via antioxidant effects Neural regeneration research 2018
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Intraocular pressure lowering effect and structure-activity relationship of imidazo [1, 2-a] benzimidazole and pyrimido [1, 2-a] benzimidazole compounds in ocular normotensive rats: insight on possible link with hypotensive activity European Journal of Pharmaceutical Sciences 2018
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Reduction of oxidative-nitrosative stress underlies anticataract effect of topically applied tocotrienol in streptozotocin-induced diabetic rats PloS one 2017
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Possible involvement of RAAS in the mechanism of anti-hypertensive effect of standardized aqueous ethanolic extract of Ficus deltoidea Kunstleri in spontaneously hypertensive rats International Journal of Cardiology 2017
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The effect of trans-resveratrol on the viability of human trabecular meshwork cells RESEARCH JOURNAL OF PHARMACEUTICAL BIOLOGICAL AND CHEMICAL SCIENCES 2017
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Protective effect of magnesium acetyltaurate against NMDA-induced retinal damage involves restoration of minerals and trace elements homeostasis Journal of Trace Elements in Medicine and Biology 2017
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Targeting extracellular matrix remodeling in disease: Could resveratrol be a potential candidate? Experimental Biology and Medicine 2017
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Rodent models of glaucoma and their applicability for drug discovery Expert opinion on drug discovery 2017
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Neuroprotective effect of magnesium acetyltaurate against NMDA-induced excitotoxicity in rat retina Neurotoxicity research 2017
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Students’ perception of teaching methods in pharmacology in a Malaysian medical school JOURNAL OF CLINICAL AND HEALTH SCIENCES 2016
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Liposomes in topical ophthalmic drug delivery: an update Drug delivery 2016
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Zingiber officinale attenuates retinal microvascular changes in diabetic rats via anti-inflammatory and antiangiogenic mechanisms Molecular vision 2016
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Protective effect of magnesium acetyltaurate against endothelin-induced retinal and optic nerve injury Neuroscience 2016
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Topical trans-resveratrol ameliorates steroid-induced anterior and posterior segment changes in rats Experimental eye research 2016
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Mechanism of the anticataract effect of liposomal magnesium taurate in galactose-fed rats Molecular vision 2016
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Intraocular distribution of topically applied hydrophilic and lipophilic substances in rat eyes Drug delivery 2016
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The effect of dexamethasone on synthesis of collagen, fibronectin and α-smooth muscle actin in cultured human trabecular meshwork cells IND J PHYSIOL PHARMACOL 2016
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Time-and dose-dependent effects of Amyloid Beta 1-40 (Aß1-40) peptide on retinal ganglion cell survival: TUNEL assay FRONT. CELL. NEUROSCI. CONFERENCE ABSTRACT: 14TH MEETING OF THE ASIAN-PACIFIC SOCIETY FOR NEUROCHEMISTRY 2016
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Magnesium acetyltaurate prevents retinal ganglion cells apoptosis induced by N-methyl-D-aspartate FRONT. CELL. NEUROSCI. CONFERENCE ABSTRACT: 14TH MEETING OF THE ASIAN-PACIFIC SOCIETY FOR NEUROCHEMISTRY 2016
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Cáceres-del-Carpio J 828 Cagini C 494 Cameron AD 596 Campbell WG 508 CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY 2015
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Regenerative medicine: a promising approach in overcoming diabetes as an increasing economic health burden JOURNAL OF EMERGING ECONOMIES AND ISLAMIC RESEARCH (JEEIR) 2015
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Aqueous humor TGF-β2 levels in patients with open-angle glaucoma: A meta-analysis Molecular vision 2015
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Early effect of hydroxychloroquine therapy: relationship between cumulative dose and retinal thickness Cutaneous and ocular toxicology 2015
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Role of adenosine receptors in resveratrol‐induced intraocular pressure lowering in rats with steroid‐induced ocular hypertension CLINICAL & EXPERIMENTAL OPHTHALMOLOGY 2015
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Anterior and posterior segment changes in rat eyes with chronic steroid administration and their responsiveness to antiglaucoma drugs European journal of pharmacology 2015
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Pathogenetic role of magnesium deficiency in ophthalmic diseases Biometals 2014
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Newer targets for modulation of intraocular pressure: focus on adenosine receptor signaling pathways Expert opinion on therapeutic targets 2014
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Effects of topically applied tocotrienol on cataractogenesis and lens redox status in galactosemic rats Molecular vision 2014
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Mechanisms of angiotensin converting enzyme inhibitor-induced IOP reduction in normotensive rats European journal of pharmacology 2014
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Транспорт лекарственных средств через роговицу глаза: перспективы применения липосомальных лекарственных форм ', ",OE 2014
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Evaluation of the anticataract effects of magnesium taurate in vitro ACTA PHARMACOLOGICA SINICA 2013
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Tocotrienol delays onset and progression of galactose-induced cataract in rat ACTA PHARMACOLOGICA SINICA 2013
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Calcium and magnesium level in cataractous lenses of galactosemic rats topically treated with liposomal formulation of magnesium taurate ACTA PHARMACOLOGICA SINICA 2013
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Effects of magnesium taurate on the onset and progression of galactose-induced experimental cataract: in vivo and in vitro evaluation Experimental eye research 2013
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Effect of difference in the dietary galactose on the rate of onset and progression of cataract in Rats RESEARCH JOURNAL OF PHARMACEUTICAL, BIOLOGICAL AND CHEMICAL SCIENCES 2013
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Topically applied standardized aqueous extract of Curcuma longa Linn. suppresses endotoxin-induced uveal inflammation in rats Indian J. Exp. Biol 2013
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Anticholinesterase, antioxidant and nitric oxide scavenging activity of the aqueous extract of some medicinal plants BRITISH JOURNAL OF PHARMACEUTICAL RESEARCH 2013
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Mechanisms of cataractogenesis in the presence of magnesium deficiency Magnesium research 2013
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Effects of magnesium taurate in liposomal formulation on the onset and progression of cataract in galactose-fed rats ACTA PHARMACOLOGICA SINICA 2013
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Glaucomatous neurodegeneration: an eye on tumor necrosis factor-alpha Indian journal of ophthalmology 2012
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Magnesium deficiency: Does it have a role to play in cataractogenesis? Experimental eye research 2012
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Curcumin prevents experimental diabetic retinopathy in rats through its hypoglycemic, antioxidant, and anti-inflammatory mechanisms Journal of Ocular Pharmacology and Therapeutics 2011
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Future target molecules in antiglaucoma therapy: TGF-β may have a role to play Ophthalmic research 2010
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Current concepts in the pathophysiology of glaucoma Indian journal of ophthalmology 2009
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Intraocular pressure-lowering activity of topical application of Aegle marmelos fruit extract in experimental animal models Ophthalmic research 2009
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Therapeutic potential of Curcuma longa, the golden spice of India, in drug discovery for ophthalmic diseases Expert opinion on drug discovery 2009
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The anti-inflammatory effects of Curcuma longa and Berberis aristata in endotoxin-induced uveitis in rabbits Investigative ophthalmology & visual science 2008
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Oculohypotensive effects of Foeniculum vulgare in experimental models of glaucoma INDIAN J PHYSIOL PHARMACOL 2008
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Lowering of intraocular pressure by topical application of Daucus carota seed extract in rabbits Indian journal of experimental biology 2008
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Oculohypotensive Activity of Aegle Marmelos Fruit Extract in Rabbits: Poster No.: GC-D3-144 Panel No.: 144 CLINICAL & EXPERIMENTAL OPHTHALMOLOGY 2008
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Comparative efficacy of pilocarpine, timolol and latanoprost in experimental models of glaucoma. METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY 2007
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A multicentric case-control study on the impact of air pollution on eyes in a metropolitan city of India Indian Journal of Occupational and Environmental Medicine 2007
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Estimation of intraocular pressure in rabbits using noncontact tonometer: a comparative evaluation with Schiotz tonometer. METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY 2007
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Basic principles of clinical research and methodology (NO TITLE) 2007
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Therapeutic potential of green tea: a new horizon in drug discovery EXPERT OPINION ON DRUG DISCOVERY 2007
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Open label clinical trial to study adverse effects and tolerance to dry powder of the aerial part of Andrographis paniculata in patients type 2 with diabetes mellitus THE MALAYSIAN JOURNAL OF MEDICAL SCIENCES: MJMS 2005

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Other Publications

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The effect of trans-resveratrol against NMDA-induced retinal nitrosative stress involves adenosine A1 receptors BRITISH JOURNAL OF PHARMACOLOGY | 01 Jan 2023
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Virtual Medical Clinic on Rational and Safe Prescribing: An Andragogical Approach to Nurturing Safe Prescribers BRITISH JOURNAL OF PHARMACOLOGY | 01 Jan 2023
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Effect of Palm Oil-Derived Tocotrienol-Rich Fraction on the Expression of Inflammatory Biomarkers in Streptozotocin-Induced Diabetic Rodent Model BRITISH JOURNAL OF PHARMACOLOGY | 01 Jan 2023
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Protective effect of RU-615 against N-methyl-D-aspartate-induced excitotoxicity in rat retina BRITISH JOURNAL OF PHARMACOLOGY | 01 Jan 2023
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A compact ground-slitted CPW-fed polarization reconfigurable antenna for wireless LAN applications 2022 IEEE Microwaves, Antennas, and Propagation Conference (MAPCON) | 01 Jan 2022
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EFFECT OF TRANS-RESVERATROL ON RETINAL ANTIOXIDANTS LEVELS OF NMDA-INDUCED RETINAL EXCITOTOXICITY RAT MODEL 34th Scientific Meeting of Malaysian Society of Pharmacology and Physiology | 15 Jul 2021
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Brain-Derived Neurotrophic Factor Attenuates Amyloid Beta 1-40 Induced Retinal Injury and Visual Impairment in Sprague Dawley Rats. 34th Scientific Meeting of Malaysian Society of Pharmacology and Physiology | 15 Jul 2021
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Effect of Tocotrienol Rich Fraction on Retinal Cell Apoptosis in Rats with Streptozotocin-Induced Diabetic Retinopathy 34th Scientific Meeting of Malaysian Society of Pharmacology and Physiology | 15 Jul 2021
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Effect of trans-resveratrol on glutamate clearance and visual behaviour due to excitotoxic retinal injury in rats 34th Scientific Meeting of Malaysian Society of Pharmacology and Physiology | 15 Jul 2021
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Protective effects of magnesium acetyltaurate against NMDA-induced retinal damage and visual impairment in rats via suppression of NF-κB, p53 and AP-1 (c-Jun/c-Fos) 34th Scientific Meeting of Malaysian Society of Pharmacology and Physiology | 15 Jul 2021
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Effect of Palm Oil-Derived Tocotrienol-Rich Fraction on Angiogenic Gene Expression in Streptozotocin-induced Diabetic Retinopathy in Rats 34th Scientific Meeting of Malaysian Society of Pharmacology and Physiology | 15 Jul 2021
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Glaucoma and Neuroinflammation: Role of magnesium-based compounds as therapeutic instruments 34th Scientific Meeting of Malaysian Society of Pharmacology and Physiology | 15 Jul 2021
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Magnesium acetyltaurate protects against excitotoxicity-induced RGC apoptosis by modulating retinal expression of calpain, cabin-1 and CAMKII in rats. 9th World Glaucoma Congress | 30 Jun 2021
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Effect of trans-resveratrol against excitotoxic retinal and optic nerve injury in rats. 5th Asia Pacific Glaucoma Congress. | 04 Jun 2021
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Role of adenosine A1 receptors in neuroprotection by resveratrol in rats with collagenase-induced intrastriatal hemorrhage BRITISH JOURNAL OF PHARMACOLOGY | 01 Jan 2021
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Effect of tocotrienol-rich fraction on visual behaviour in rats with streptozotocin-induced diabetic retinopathy BRITISH JOURNAL OF PHARMACOLOGY | 01 Jan 2021
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Effect of trans-resveratrol on glutamate-induced changes in retinal morphology and visual behaviour in rats BRITISH JOURNAL OF PHARMACOLOGY | 01 Jan 2021
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Circular edge cut diminutive UWB antenna for wireless communications 2019 IEEE Indian Conference on Antennas and Propogation (InCAP) | 01 Jan 2019
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INTRAOCULAR PRESSURE LOWERING EFFECT OF IMIDAZO [1, 2-a] BENZIMIDAZOLE AND PYRIMIDO [1, 2-a] BENZIMIDAZOLE COMPOUNDS IN OCULAR NORMOTENSIVE AND HYPERTENSIVE RATS Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018 (The 18th World Congress of Basic and Clinical Pharmacology) | 01 Jan 2018
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Role of renin-angiotensin system inhibitors in attenuation of dexamethasone-induced ECM remodeling in human trabecular meshwork cells Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018 (The 18th World Congress of Basic and Clinical Pharmacology) | 01 Jan 2018
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Ocular tissue distribution of topically applied PEGylated and non-PEGylated liposomes Advanced Materials Research | 01 Jan 2014
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IOP lowering effect of losartan and latanoprost in oculohypertensive rats: A comparative evaluation ACTA PHARMACOLOGICA SINICA | 01 Jan 2013
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Oculohypotensive effect of topical losartan potassium in ocular normotensive and steroid-induced ocular hypertensive rat models ACTA PHARMACOLOGICA SINICA | 01 Jan 2013
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Pharmacological utility of streptozotocin induced rat model of diabetic retinopathy INDIAN JOURNAL OF PHARMACOLOGY | 01 Jan 2008

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Books

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Academic Press (2023). Neuroinflammation: Role of magnesium
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Springer Nature Singapore (2022). General Issues of Chirality in Pharmacology
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Springer Nature Singapore (2022). Separation, Asymmetric Synthesis and Analysis of Stereoisomers
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Springer Nature Singapore (2022). In Silico Search for Chiral Drug Compounds
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Springer Nature Singapore (2022). General Principles of Molecular Chirality
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CRC Press (2019). Lycopene: cataract and oxidative stress
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Adis, Cham (2016). Steroidal and Nonsteroidal Anti-inflammatory Agents for Ocular Use

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Patents

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Two Chamber mirror test | 02 Nov 2023


Supervisions
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Heethal Jaiprakash | Doctorate | 01 Mar 2023 - 01 Dec 2026 Thesis: Mechanisms of the protective effects of atorvastatin against NMDA-induced retinal injury in rats: focus on PPAR-α/CREB pathway and glial activation
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Wong Jing Yi | Master (Research) | 01 Dec 2022 - 01 Dec 2025 Thesis: Role of sphingolipid rheostat in the neuroprotective effect of atorvastatin against NMDA-induced excitotoxic retinal injury
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Mohammed Irfan Abdul Malick Sahib | Doctorate | 01 Jul 2021 - 30 Jun 2025 Thesis: Elucidation of the mechanisms underlying the neuroprotective effect of trans-resveratrol: Role of adenosine receptors and renin-angiotensin system
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Goh You | Undergraduate | 05 Jan 2021 - 30 Jun 2021 Thesis: EFFECT OF TOCOTRIENOL-RICH FRACTION ON VISUAL BEHAVIOUR AND RETINAL CELL APOPTOSIS IN RATS WITH STREPTOZOTOCIN-INDUCED DIABETIC RETINOPATHY
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Tee Hann Yih | Undergraduate | 05 Jan 2021 - 30 Jun 2021 Thesis: THE EFFECTS OF TRANS-RESVERATROL ON RETINAL GLUTAMATE CLEARANCE AND VISUAL BEHAVIOUR DUE TO EXCITOTOXIC RETINAL INJURY IN RATS
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Amy Suzana Binti Abu Bakar | Master (Research) | 10 Nov 2020 - 09 Nov 2022 Thesis: Anti-remodeling effects of resveratrol and RU-615 on dexamethasone-treated human trabecular meshwork cells
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Mohd Daniel Shafiq Bin Hassan | Master (Research) | 10 Nov 2020 - 09 Nov 2022 Thesis: Mechanisms underlying the effect of resveratrol on extracellular matrix secretion by dexamethasone-treated human trabecular meshwork cells: Focus on non-canonical TGF-B signaling
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Mohamad Haiqal Nizar Bin Mohamad | Doctorate | 01 Nov 2020 - 31 Dec 2023 Thesis: Mechanism of Neuroprotection by Philanthotoxin against NMDA-Induced Excitotoxicity in the Retina of Glaucoma Rat Model.
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Nurbadriah Binti Jasmiad | Master (Mixed Mode) | 01 Jan 2020 - 31 Jan 2022 Thesis: THE ASSOCIATION OF SERUM AND TEAR PLASMINOGEN-ACTIVATOR INHIBITOR-1 (PAI-1) AND TISSUE PLASMINOGEN ACTIVATOR (tPA) IN PATIENTS WITH DIABETIC RETINOPATHY
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Sarah Aina Binti Azman | Master (Research) | 26 Nov 2019 - 30 Jun 2022 Thesis: Optimization of topical nanoemulsion formulation containing tocotrienol rich fraction (TRF) for ocular use
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Nurliyana Ain by Abd Ghani | Master (Mixed Mode) | 25 Nov 2019 - 30 May 2021 Thesis: Effect of tocotrienol-rich fraction (TRF) on diabetic retinopathy in streptozotocin (STZ)-induced diabetic rats
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Fathiah Abdullah | Doctorate | 01 Jan 2019 - 31 Dec 2021 Thesis: Effect Of Exogenous Glutathione On Male Reproductive Functions In Streptozotocin-Induced Diabetic C57BL6NTac Mice
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Muhammad Zulfiqah bin Sadikan | Doctorate | 01 Jan 2019 - 31 Dec 2021 Thesis: MECHANISMS UNDERLYING THE PROTECTIVE EFFECT OF TOCOTRIENOL–RICH FRACTION (TRF) AGAINST RETINAL OXIDATIVE STRESS, INFLAMMATION, APOPTOSIS AND ANGIOGENESIS IN STREPTOZOTOCIN (STZ)-INDUCED DIABETIC RATS
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Afiqq Aiman Abd Ghapor | Doctorate | 01 Sep 2018 - 31 Dec 2021 Thesis: Protective effect of trans-resveratrol and RU615 against excitotoxic retinal damage in rats: focus and NMDA receptor-mediated Ca2+ signaling and adenosine A1 receptor
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Norasikin Binti Abdul Aziz | Doctorate | 01 Mar 2016 - 30 Jun 2019 Thesis: PROTECTIVE EFFECT AND MOLECULAR MECHANISMS OF ACTION OF MAGNESIUM ACETYLTAURATE AGAINST ENDOTHELIN-1-INDUCED RETINAL AND OPTIC NERVE DAMAGE IN RATS: FOCUS ON NEUROINFLAMMATION
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Noor Azliza Wani bt Abd Aziz | Doctorate | 01 Mar 2016 - 31 Jul 2020 Thesis: MECHANISMS OF NEUROPROTECTIVE EFFECT OF RESVERATROL IN RATS WITH HAEMORRHAGIC STROKE
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Natasha Najwa Nor Arfuzir | Doctorate | 01 Sep 2014 - 31 May 2019 Thesis: PROTECTIVE EFFECT AND MOLECULAR MECHANISMS OF MAGNESIUM ACETYLTAURATE AGAINST ENDOTHELIN-1-INDUCED RETINAL AND OPTIC NERVE DAMAGE IN RATS: FOCUS ON NEUROINFLAMMATION
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Azliana Jusnida Ahmad Jafri | Doctorate | 01 Sep 2014 - 31 Jan 2020 Thesis: NEUROPROTECTIVE EFFECT AND MOLECULAR MECHANISMS OF ACTION OF MAGNESIUM ACETYLTAURATE AGAINST NMDA-INDUCED RETINAL INJURY IN RATS: FOCUS ON CALCIUM REGULATED PROTEINS
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Norhafiza Razali | Doctorate | 01 Mar 2014 - 31 Oct 2016 Thesis: CELLULAR MECHANISMS OF ACTION OF RESVERATROL IN REGULATION OF AQUEOUS HUMOUR DYNAMICS
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Nurul Alimah Binti Abdul Nasir | Doctorate | 01 Sep 2013 - 31 May 2016 Thesis: STUDIES TO ELUCIDATE MECHANISMS UNDERLYING THE ANTICATARACT EFFECT OF TOCOTRIENOL IN RATS
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Zulhilmi Bin Abdul Razak | Master (Mixed Mode) | 01 Mar 2013 - 31 Dec 2014 Thesis: A STUDY ON OCULAR PHARMACOKINETICS OF TAZOCIN
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Robin Ngu Soon Tat | Master (Mixed Mode) | 01 Jan 2013 - 31 Dec 2015 Thesis: Efficacy of Topical Piperacillin/Tazobactam (Tazocin) in the Treatment of Pseudomonas Aeruginosa Induced Keratitis in Rabbits

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