THIAGARAJAN MADHESWARAN



Salutation
Dr

School/Centre
School of Pharmacy

Department
Pharmaceutical Technology

Appointment
Head of Department, Pharmaceutical Technology

Position
Senior Lecturer

Email
thiagarajan@imu.edu.my

Professional Network


Education

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PhD (Pharmaceutical Sciences), 2014 Yeungnam University, South Korea
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Master of Pharmacy (Pharmaceutical Analysis), 2008 The Tamil Nadu Dr MGR Medical University, Chennai, India
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Bachelor of Pharmacy (Pharmaceutical Sciences), 2005 The Tamil Nadu Dr MGR Medical University, Chennai, India

Memberships

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International Pharmaceutical Federation (FIP) FIP member 2023 - 2024
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The British Society for Nanomedicine Nanomembership- Scientific 2020 - Present
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Association of Pharmaceutical Teachers of India Member 2008 - Present
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Tamil Nadu Pharmacy Council, Chennai, India Registered Pharmacist 2006 - Present

Research Funding
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Assessing the Anti-inflammatory Potential of Nobiletin-loaded Nanostructured Lipid Carrier in Human Airway Epithelium-derived Basal Cells IMU Internal Research Grant | 01 Sep 2024 - 28 Feb 2025
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A quality-by-design approach to develop and optimise budesonide-loaded lipid nanoparticles for therapeutic intervention in chronic obstructive pulmonary disease (COPD) IMU Internal Research Grant | 03 Jun 2024 - 30 Sep 2024
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Microencapsulated mefenamic acid into starch-alginate beads for sustained drug delivery IMU Internal Research Grant | 18 Mar 2024 - 25 May 2024
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Membrane-targeting peptides enhancing uptake of antibacterial and anticancer ruthenium-based photosensitisers: feasibility and synergistic mechanism studies IMU Internal Research Grant | 04 Dec 2023 - 31 Oct 2024
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Investigating the Potential of Microfluidic Technology to Formulate Dasatinib-Loaded Lyotropic Liquid Crystalline Nanoparticles: A One-Step Process to Prepare Nanoparticles with Controllable Size and High Drug Encapsulation FRGS 2023-1 | 01 Oct 2023 - 30 Sep 2025
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Development, characterization, and in vitro evaluation of topical cream containing essential oil of Vernonia amygdalina leaves to enhance its anti-inflammatory property IMU Internal Research Grant | 21 Sep 2023 - 31 Jan 2024
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Comparative study on the effects of two cooking processes on selected toxic heavy metal concentrations in selected varieties of commercially available fish and prawns consumed in Malaysia. IMU Internal Research Grant | 01 Jun 2023 - 31 Dec 2023
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Assessing the Potential of Nano-delivery Systems Containing Asarone in Targeting Inflammation IMU Internal Research Grant | 01 Mar 2023 - 29 Feb 2024
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Quality by Design approach to optimise spray drying process in the development of nano-tocotrienol dry powder IMU Internal Research Grant | 29 Nov 2022 - 30 Jul 2023
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Assessing the Potential of Nano-delivery Systems Containing 18β-Glycyrrhetinic acid in Targeting Inflammation IMU Internal Research Grant | 01 Sep 2022 - 28 Feb 2023
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Assessing the Potential of Nano-delivery Systems Containing Zerumbone in Targeting Inflammation MSc in Molecular Medicine | 05 Apr 2021 - 28 Feb 2022
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Development of a physiological-based pharmacokinetic model to predict bendamustine exposure in paediatric population. Master in Pharmacy Practice | 14 Jan 2021 - 31 Oct 2021
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Quality-by-design approach on the development of dasatinib-loaded liquid crystalline nanoparticles using novel lipids to enhance the solubility and its anticancer activity in human PC3 prostate cancer cell line IMU | 01 Jul 2020 - 01 Jun 2021
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In vitro and in vivo evaluation of acitretin-loaded lipid nanoparticles developed by quality-by-design approach IMU | 01 Jun 2020 - 01 Oct 2020
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Formulation of Berberine hydrochloride loaded lipid crystaline nanoparticles for the therapeutic intervention in asthma. A quality-by- design approach. IMU | 01 Jun 2020 - 01 Oct 2020
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In vitro skin permeation evaluation of acitretin-loaded lipid nanoparticles using Strat-M® Membrane for topical application IMU | 01 Apr 2020 - 01 Jun 2020
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Development of abemaciclib-loaded solid lipid nanoparticles using quality-by-design approach and evaluation of its anticancer activity in MCF7 breast cancer cells IMU | 01 Mar 2020 - 01 Dec 2020
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Novel isoniazid and Schiff base derivatives loaded liquid crystalline nanoparticles for tuberculosis therapeutics IMU | 01 Dec 2019 - 01 Jan 2021
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A quality-by-design approach to develop and optimise acitretin-loaded lipid nanoparticles with enhanced solubility and stability for topical application IMU | 19 Jun 2019 - 19 Oct 2019
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Development of a novel HPLC Method to Quantify Acitretin in Nanoformulation IMU | 01 Jun 2019 - 01 Oct 2019
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Assessing the anti-inflammatory potential of Rhamnetin nanoparticles using immortalised bronchial epithelial cells as a therapeutic intervention for asthma IMU | 01 Jun 2019 - 01 Sep 2019
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Re(1) Tricarbonyl Complexes Combinations, Conjugates and Formulations with Liquid Crystalline Nanoparticles for Pancreatic Cancer Photodunamic Theraphy and Bioimaging IMU (TB Challenge Grant) | 01 Apr 2019 - 01 Sep 2020
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Novel gemcitabine – Re(I) tricarbonyl complexes combinations, conjugates and formulations with liquid crystalline nanoparticles for pancreatic cancer photodynamic therapy and bioimaging (IMU Pancreatic Cancer Challenge Grant) IMU | 01 Mar 2019 - 01 Feb 2020
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Development of potential marketable bioadhesive oral gel formulation IMU | 01 Jan 2019 - 01 Dec 2019
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Novel gemcitabine and copper(II) complex loaded liquid crystalline nanoparticles for pancreatic Cancer therapeutics - unlocking the black box IMU | 18 Aug 2018 - 01 Mar 2019
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Formulation of Rutin Loaded Liquid Crystalline Nanoparticles for Therapeutic Intervention in Asthma IMU | 18 Jul 2018 - 18 Dec 2018
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Assessing the Anti-Inflammatory and Cytotoxic Potential of a Chinese Traditional Herb Artemisia vulgaris in a Nano-Formulation IMU | 18 Jul 2018 - 18 Dec 2018
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Development and characterisation of long-acting intraocular implants based on biodegradable poly (lactic-co-glycolic) polymer IMU | 01 Jun 2018 - 01 Oct 2018
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Development and Optimization of analytical for the quantitative analysis of heavy metals (ICH-Class1) in semisolid dosage forms, herbal products and food products using Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) IMU | 01 Jun 2018 - 01 Nov 2018
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Formulation of Celastrol Loaded Liquid Crystalline Nanoparticles as a Therapeutic Intervention in Asthma IMU | 07 Jan 1900 - 18 Dec 2018

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Publications

Research Articles

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Review of Lipid Nanoparticles for Breast Cancer Management: Targeting Strategies and Clinical Perspective CURRENT NANOMEDICINE 2024
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18-β-Glycyrrhetinic acid encapsulated PLGA nanoparticles attenuate lung cancer proliferation and migration JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY 2024
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Strategies to improve the stability of amorphous solid dispersions in view of the hot melt extrusion (HME) method INTERNATIONAL JOURNAL OF PHARMACEUTICS 2023
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Zerumbone-incorporated liquid crystalline nanoparticles inhibit proliferation and migration of non-small-cell lung cancer in vitro NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY 2023
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Acknowledgment to the Reviewers of Pharmaceutics in 2022 PHARMACEUTICS 2023
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Recent Advances in the Development of Liquid Crystalline Nanoparticles as Drug Delivery Systems PHARMACEUTICS 2023
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Coencapsulation of Gemcitabine and Thymoquinone in Citrem–Phosphatidylcholine Hexosome Nanocarriers Improves In Vitro Cellular Uptake in Breast Cancer Cells MOLECULAR PHARMACEUTICS 2023
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Exploring the role of antibiotics and steroids in managing respiratory diseases JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY 2022
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Acknowledgment to Reviewers of Polymers in 2021 POLYMERS 2022
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Announcing the Winner of the Inaugural Nano Letters Seed Grant Program, Central America, South Asia, Africa Region NANO LETTERS 2022
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Bacterial cancer therapy: A turning point for new paradigms FEATURE DRUG DISCOVERY TODAY 2022
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A Perspective on Therapeutic Applications and Strategies to Mitigate Toxicity of Metallic Nanoparticles CURRENT PHARMACEUTICAL DESIGN 2022
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Phytantriol-Based Berberine-Loaded Liquid Crystalline Nanoparticles Attenuate Inflammation and Oxidative Stress in Lipopolysaccharide-Induced RAW264. 7 Macrophages NANOMATERIALS 2022
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Acknowledgment to Reviewers of Pharmaceutics in 2021 PHARMACEUTICS 2022
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Novel Gemcitabine-Re (I) Bisquinolinyl Complex Combinations and Formulations with Liquid Crystalline Nanoparticles for Pancreatic Cancer Photodynamic Therapy FRONTIERS IN PHARMACOLOGY 2022
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Berberine-loaded liquid crystalline nanoparticles inhibit non-small cell lung cancer proliferation and migration in vitro ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH 2022
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Recent advances in the development of multifunctional lipid-based nanoparticles for Co-Delivery, combination treatment strategies, and theranostics in breast and lung cancer JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY 2022
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Unravelling the Therapeutic Potential of Nano-Delivered Functional Foods in Chronic Respiratory Diseases NUTRIENTS 2022
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Acknowledgment to Reviewers of Materials in 2021 MATERIALS 2022
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Autoantibodies and autoimmune disorders in SARS-CoV-2 infection: pathogenicity and immune regulation ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH 2022
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Evaluation of the Cytotoxic Activity and Anti-Migratory Effect of Berberine–Phytantriol Liquid Crystalline Nanoparticle Formulation on Non-Small-Cell Lung Cancer In Vitro PHARMACEUTICS 2022
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Unravelling the molecular mechanisms underlying chronic respiratory diseases for the development of novel therapeutics via in vitro experimental models EUROPEAN JOURNAL OF PHARMACOLOGY 2022
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Human serum albumin as multifunctional nanocarrier for cancer therapy Journal of Pharmaceutical Sciences 2021
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Acknowledgment to Reviewers of Pharmaceutics in 2020 PHARMACEUTICS 2021
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Acknowledgment to Reviewers of Pharmaceuticals in 2020 Pharmaceuticals 2021
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Effect of Propolis Nanoparticles against Enterococcus faecalis Biofilm in the Root Canal Molecules 2021
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Biomimetic bacterial and viral-based nanovesicles for drug delivery, theranostics, and vaccine applications Drug Discovery Today 2021
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Anti‐inflammatory and anticancer activities of Naringenin‐loaded liquid crystalline nanoparticles in vitro Journal of food biochemistry 2021
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Versatility of liquid crystalline nanoparticles in inflammatory lung diseases Nanomedicine 2021
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Rutin loaded liquid crystalline nanoparticles inhibit non-small cell lung cancer proliferation and migration in vitro Life sciences 2021
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Middle East Respiratory Syndrome (MERS) Virus—Pathophysiological Axis and the Current Treatment Strategies AAPS PharmSciTech 2021
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Celastrol-loaded liquid crystalline nanoparticles as an anti-inflammatory intervention for the treatment of asthma International Journal of Polymeric Materials and Polymeric Biomaterials 2021
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Molecular and immunological mechanisms underlying the various pharmacological properties of the potent bioflavonoid, rutin ENDOCRINE, METABOLIC & IMMUNE DISORDERS-DRUG TARGETS (FORMERLY CURRENT DRUG TARGETS-IMMUNE, ENDOCRINE & METABOLIC DISORDERS) 2020
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Applications of nanocarriers as drug delivery vehicles for active phytoconstituents Current pharmaceutical design 2020
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Labeling and tracking cells with gold nanoparticles Drug discovery today 2020
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Encapsulation of berberine into liquid crystalline nanoparticles to enhance its solubility and anticancer activity in MCF7 human breast cancer cells Journal of Drug Delivery Science and Technology 2020
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Molecular mechanisms of action of naringenin in chronic airway diseases European journal of pharmacology 2020
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Recent Emergence of Rhenium (I) Tricarbonyl Complexes as Photosensitisers for Cancer Therapy Molecules 2020
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Immunological axis of berberine in managing inflammation underlying chronic respiratory inflammatory diseases Chemico-biological interactions 2020
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Curcumin-loaded niosomes downregulate mRNA expression of pro-inflammatory markers involved in asthma: an in vitro study Nanomedicine 2020
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Acknowledgement to Reviewers of Pharmaceutics in 2019 PHARMACEUTICS 2020
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Acknowledgement to Reviewers of Pharmaceutics in 2019 Pharmaceutics 2020
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Perspectives and advancements in the design of nanomaterials for targeted cancer theranostics Chemico-biological interactions 2020
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Hand sanitizers: a review on formulation aspects, adverse effects, and regulations International journal of environmental research and public health 2020
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Green synthesis and antibacterial potential of Artemisia vulgaris extract in silver nanoparticles against wound bacteria JURNAL ILMIAH FARMASI 2020
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Combating Intracellular Pathogens with Nanohybrid-Facilitated Antibiotic Delivery International Journal of Nanomedicine 2020
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Preparation, characterization and in-vitro efficacy of quercetin loaded liquid crystalline nanoparticles for the treatment of asthma Journal of Drug Delivery Science and Technology 2019
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Therapeutic potential of Artemisia vulgaris: An insight into underlying immunological mechanisms Journal of Environmental Pathology, Toxicology and Oncology 2019
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Formulation and characterization of glibenclamide and quercetin-loaded chitosan nanogels targeting skin permeation Therapeutic delivery 2019
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Current potential and challenges in the advances of liquid crystalline nanoparticles as drug delivery systems Drug discovery today 2019
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Molecular modulators of celastrol as the keystones for its diverse pharmacological activities Biomedicine & Pharmacotherapy 2019
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Preparation, characterisation and biological applications of Rutin loaded liquid crystalline nanoparticles in targeting airway diseases SYDNEY NEW HORIZONS-2019 2019
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Immunological axis of curcumin-loaded vesicular drug delivery systems Future medicinal chemistry 2018
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Assessing the potential of liposomes loaded with curcumin as a therapeutic intervention in asthma COLLOIDS AND SURFACE B: BIOINTERFACES 2018
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Nanogels linked with chitosan: a perspective Minerva medica 2018
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Three-dimensional (3-D) printing technology exploited for the fabrication of drug delivery systems Current pharmaceutical design 2018
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Lipid based nanocarriers system for topical delivery of photosensitizers Drug discovery today 2017
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In vitro and in vivo skin distribution of 5α-reductase inhibitors loaded into liquid crystalline nanoparticles Journal of pharmaceutical sciences 2017
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Emerging potential of stimulus-responsive nanosized anticancer drug delivery systems for systemic applications Archives of Pharmacal Research 2017
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Protective and curative effects of polyphenolic extracts from Ichnocarpus frutescense leaves on experimental hepatotoxicity by carbon tretrachloride and tamoxifen Annals of hepatology 2016
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Enhanced skin permeation of 5α-reductase inhibitors entrapped into surface-modified liquid crystalline nanoparticles Archives of pharmacal research 2015
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Enhanced Topical Delivery of Finasteride Using Glycerjl Monooleate-Based Liquid Crystalline Nanoparticles Stailized by Cremophor Surfactants -'^OEOE--**OE ----...' 2014
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Enhanced topical delivery of finasteride using glyceryl monooleate-based liquid crystalline nanoparticles stabilized by cremophor surfactants Aaps Pharmscitech 2014
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Entrapment of curcumin into monoolein-based liquid crystalline nanoparticle dispersion for enhancement of stability and anticancer activity International journal of nanomedicine 2014
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Design and in vitro evaluation of finasteride-loaded liquid crystalline nanoparticles for topical delivery Aaps Pharmscitech 2013
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3-Caffeoyl, 4-dihydrocaffeoylquinic acid from Salicornia herbacea attenuates high glucose-induced hepatic lipogenesis in human HepG2 cells through activation of the liver kinase B1 and silent information regulator T1/AMPK-dependent path -'^OEOE--**OE ----...' 2013
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Preparation, characterization, and release study of tacrolimus-loaded liquid crystalline nanoparticles Journal of dispersion science and technology 2013
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Effect of saturated fatty acids on tacrolimus-loaded liquid crystalline nanoparticles Journal of Drug Delivery Science and Technology 2013
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In vitro release and skin permeation of tacrolimus from monoolein-based liquid crystalline nanoparticles Journal of drug delivery science and technology 2012
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High-performance liquid chromatography method for the quantification of pantoprazole in rat plasma INTERNATIONAL JOURNAL OF CHEMTECH RESEARCH 2010
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Pharmacognostical Studies of Zanthoxylum tetraspermum Wignt and Arn Research Journal of Pharmacy and Technology 2010
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Bioequivalence study and bioanalytical method development of Levofloxacin tablets in albino rat plasma using RP-HPLC method ARCHIVES OF APPLIED SCIENCE RESEARCH 2010
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RP-HPLC method development and validation for the simultaneous estimation of ofloxacin and tinidazole in tablets INT. J. PHARMTECH RES 2009
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Anti-carcinoma Activity of Polyphenolic Extract of Ichnocarpus frutescens Planta Medica 2009

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Other Publications

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Liquid Crystalline Nanoparticle Systems to Enhance the Delivery Of Anticancer Drugs National Level Seminar on "Innovation in Pharmaceuticals: Revolutionizing Global Wellness Through Public Health Advancement" | 10 Jan 2024
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Liquid Crystalline Nanoparticle Systems to Enhance the Delivery Of Anticancer Drugs The International Conference on Integration of Innovation, Research And Pharmaceutical Education, KTN-APSE CON-2023 | 21 Dec 2023
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“Development of abemaciclib-loaded solid lipid nanoparticles using quality-by-design approach and evaluation of its anticancer activity in MDA-MB-231 and T47D breast cancer cells 81st FIP World Congress of Pharmacy and Pharmaceutical Sciences | 24 Sep 2023
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Risk assessments of material attributes and process parameters 9th International Postgraduate Conference on Pharmaceutical Sciences (iPoPS) 2022 Workshop 4: Applying 'Quality by Design’ (QbD) in Pharmaceutical Dosage Form Development, IMU | 23 Jun 2022
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Cubosomes and Hexosomes: Smart lipid nanocarriers for drug delivery applications Webinar Series 1, College of Pharmaceutical Sciences, Government Medical College, Kozhikode | 07 Aug 2020
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Current application and future utility of self-assembled liquid crystalline nanoparticles as drug delivery carrier 27th International Virtual Learning Series, Arulmigu Kalasalingam College of Pharmacy, India | 30 Jun 2020
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Current Trends in Topical and Transdermal Drug Delivery International Webinar Series 4, Virtual event, Nandha College of Pharmacy, India | 15 Jun 2020
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Current Trends in Topical and Transdermal Drug Delivery Trends in Drug Delivery Systems : Post COVID 19 Scenario, Virtual event, GITAM University, Hyderabad | 29 May 2020
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Cubosomes and Hexosomes: from Production and Characterisation to Clinical Translation” WORKSHOP ON MICRO-/NANOPARTICLES FABRICATION AND CHARACTERISATION, IMU | 30 Sep 2019
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Current Application and Future Utility of Self-Assembled Liquid Crystalline Nanoparticles as Drug Delivery Carrier India-UK Second International Conference on Advanced Nanomaterials for Energy, Environment and Healthcare Applications (ANEH-2019) | 04 Feb 2019
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Granulation preparation Workshop on Granulation Technology From Bench to Market, IMU | 09 Oct 2017

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Books

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Academic Press (2023). Artificial intelligence (AI) in drug product designing, development, and manufacturing
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Academic Press (2022). Stimuli-responsive nanomaterials in infectious diseases
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Academic Press (2019). Nanoemulsions as effective carriers for the treatment of lung cancer
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Academic Press (2018). Drug–excipient interaction and incompatibilities
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Academic Press (2018). Drug Complexation: Implications in Drug Solubilization and Oral Bioavailability Enhancement

Medias

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The Current issue of “The view from here” is concerned with Cancer and Drug Delivery Drug Discovery Today, Elsevier | 27 Aug 2020
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Best Poster Award for IMU Dentistry Student at Congress in Bangkok International Medical University | 18 Aug 2020


Supervisions
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Nisanthei Gunasegaran | Master (Coursework) | 20 Dec 2022 Thesis: Quality by Design approach to optimise spray drying process in the development of nano-tocotrienol dry powder
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Ms Dvya Delilaa Clarence | Master (Coursework) | 18 May 2021 - 31 Jan 2022 Thesis: Assessing the potential of nano-delivery systems containing Zerumbone in targeting inflammation
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MS BONNIE CHIN | Master (Coursework) | 14 May 2021 - 31 Jan 2022 Thesis: Development of abemaciclib-loaded solid lipid nanoparticles using quality-by-design approach and evaluation of its anticancer activity in MCF7 breast cancer cells
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Ms Leong Hui Wen | Master (Coursework) | 26 Mar 2021 - 28 Feb 2022 Thesis: Development of a physiological-based pharmacokinetic model to predict bendamustine exposure in paediatric population
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Mr Eddy Yii Chung Ann | Master (Coursework) | 30 Jul 2020 - 30 Sep 2021 Thesis: Quality-by-design approach on the development of dasatinib-loaded liquid crystalline nanoparticles using novel lipids to enhance the solubility and its anticancer activity in human PC3 prostate cancer cell line
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Ms Liew Hui Shan | Master (Research) | 24 Oct 2019 - 30 Nov 2020 Thesis: Novel gemcitabine - Re(1) Tricarbonyl complexes combinations, conjugates and formulations with liquid crystalline nanoparticles for pancreatic cancer photodynamic therapy and bioimaging

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