WONG SHEW FUNG



Salutation
Professor

School/Centre
School of MedicineInstitute of Research, Development and Innovation (IRDI)

Department
Microbiology and Immunology

Appointment
Deputy Director, Research

Position
Professor

Email
shewfung_wong@imu.edu.my



Education

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PhD (by research) (Medical Sciences), 2008 International Medical University
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Master of Science (by research) (Chemical Pathology), 2002 University Putra Malaysia
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Bachelor of Science (Biomedical Sciences) (Biomedical Sciences), 1999 University Putra Malaysia

Memberships

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European Society of Digital and Integrative Pathology | International | Member
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Malaysian Society of Parasitology and Tropical Medicine (MSPTM) | National | Member

Research Funding
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Development of an automated decision support tool in diagnosing kidney allograft pathology based on the Banff criteria using a deep convolutional neural network IMU Internal Research Grant | 01 Jun 2024 - 31 May 2026
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Food and built environment and its correlates in type 2 diabetes patients of the Seremban Diabetes Cohort (SeDia) IMU Internal Research Grant | 01 Jan 2024 - 31 Dec 2025
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Development of a machine learning model for image-based analysis of cervical cytology in Papanicolaou smear (Pap Smear) IMU Internal Research Grant | 12 Jun 2023 - 16 Sep 2023
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Transcriptomic landscape and identification of biomarkers and pathways for colorectal cancer- A pilot study IMU Internal Research Grant | 01 Jun 2023 - 31 Oct 2023
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A long term longitudinal big data approach for developing precision health for Type 2 Diabetes (T2DM) in Malaysia IMU, MOH | 01 Jan 2023 - 31 Dec 2033
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Transcriptome-wide prediction of nasopharyngeal carcinoma (NPC) metastasis IMU Internal Research Grant | 01 Sep 2022 - 31 Mar 2023
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Molecular mechanisms of toxicity induced by polyfluoroalkyl substances in human bronchial and alveolar epithelial cells FRGS | 07 Sep 2021 - 06 Sep 2023
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Single nucleotide polymorphisms (SNPs) of SLC2A2 (GLUT2) gene and risk of prediabetes and type-2 diabetes mellitus among Malaysian Indians in Seremban District: a pilot study IMU | 01 Feb 2020 - 01 Jul 2020
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D-MOSS (Dengue MOsquito Simulation from Satellites): extending the approach from Vietnam to Malaysia UK Space Agency | 01 Jan 2020 - 01 Jan 2021
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Indoor air quality (IAQ) of two type 1 community clinics at Selangor IMU | 19 Mar 2019 - 01 Feb 2020
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Effects of Interferon-l (IFN-l) on Human Pancreatic Cancer Cells IMU | 01 Jul 2018 - 01 Dec 2018
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Influence of Wolbachia on Susceptibility to Insecticide in Aedes albopictus and its Underlying Mechanism of Action FRGS | 01 May 2018 - 01 Apr 2019
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1. Elucidation of the mechanism on how Cladosporium sphaerospermum establish respiratory allergies FRGS | 01 Jul 2013 - 30 Jun 2015

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Publications

Research Articles

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Neurotoxicity of nanoplastics: A review F1000RESEARCH | 2024
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Human cytokeratin 1 plays a role in the interaction of Pteropine orthoreovirus with Hek293 cells but not HeLa cells MICROBES AND INFECTION | 2023
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Physicochemical Properties of Raw Cleaned Edible Bird’s Nest after Different Primary Processing Including a New Cleaning Method SAINS MALAYSIANA | 2023
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Optimization of Process Conditions for the Production of High-yield and High-quality Edible Bird’s Nest (EBN) Hydrolysate PERTANIKA JOURNAL OF TROPICAL AGRICULTURAL SCIENCE | 2023
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STRUCTURAL AND CHEMICAL ANALYSIS OF DIFFERENT TYPES OF RAW CLEANED (RC) EDIBLE BIRD’S NEST (EBN) MALAYSIAN JOURNAL OF MICROSCOPY | 2023
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Skin allergenicity of airborne and soil algae isolated from Malaysia AEROBIOLOGIA | 2023
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Structural and Chemical Analysis of Edible Bird's Nest Hydrolysates N/A | 2022
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The Effects of Meteorological Factors on Dengue Cases in Malaysia INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH | 2022
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Impact of microplastics and nanoplastics on human health Nanomaterials | 2021
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Gene expression profiling of giant fibroadenomas of the breast Surgical Oncology | 2021
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Impact of microplastics and nanoplastics on human health. Nanomaterials 11, 496 N/A | 2021
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Potential Residual Contaminants in Edible Bird's Nest Frontiers in pharmacology | 2021
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COVID-19 Sample Pooling: From RNA Extraction to Quantitative Real-time RT-PCR BIO-PROTOCOL | 2021
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Dengue fever and insecticide resistance in Aedes mosquitoes in Southeast Asia: A review PARASITES & VECTORS | 2021
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Impact of microplastics and Nanoplastics on human health. Nanomaterials 11 (2): 496 N/A | 2021
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COVID-19–A Malaysian private university’s immediate response to provide testing services EDITORIAL BOARD | 2020
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A novel strategy for community screening of SARS-CoV-2 (COVID-19): Sample pooling method PloS one | 2020
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Production of Biodegradable Palm Oil-Based Polyurethane as Potential Biomaterial for Biomedical Applications Polymers | 2020
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Gene expression changes in human bronchial epithelial cells (BEAS-2B) and human pulmonary alveolar epithelial cells (HPAEpiC) after interaction with Cladosporium sphaerospermum Medical mycology | 2020
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Molecular mechanisms and potential therapeutic reversal of pancreatic cancer-induced immune evasion Cancers | 2020
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Association between long-term exposure to ambient air pollution and prevalence of diabetes mellitus among Malaysian adults Environmental Health | 2020
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In vitro adhesion and invasion by Cladosporium sphaerospermum in human bronchial epithelial cells (BEAS-2B) and human pulmonary alveolar epithelial cells (HPAEpiC) Tropical Biomedicine | 2019
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Morphology of Glycycometus malaysiensis, a domestic mite in Malaysia Tropical Biomedicine | 2019
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PROTOCOL: The effects of flipped classrooms to improve learning outcomes in undergraduate health professional education: A systematic review CAMPBELL SYSTEMATIC REVIEWS | 2019
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NAING et al. CAMPBELL SYSTEMATIC REVIEWS | 2019
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Therapeutic challenges and current immunomodulatory strategies in targeting the immunosuppressive pancreatic tumor microenvironment Journal of Experimental & Clinical Cancer Research | 2019
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Biocompatible palm stearin‐based polyesteramide as polymer carrier for solid dispersion Journal of Applied Polymer Science | 2018
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Parasites in soil samples from Signy island, Antarctica Tropical biomedicine | 2018
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Molecular characterization of culturable bacteria in raw and commercial edible bird nests (EBNs) International Food Research Journal | 2018
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Biocompatible Polyurethane Scaffolds Prepared from Glycerol Monostearate-Derived Polyester Polyol Journal of Polymers and the Environment | 2018
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One‐pot synthesis of palm oil‐based polyester polyol for production of biodegradable and biocompatible polyurethane Journal of Applied Polymer Science | 2018
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Clinical significance of SLC 2A9/GLUT 9 rs11722228 polymorphisms in gout International journal of rheumatic diseases | 2018
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Correction: Correlation of serum cartilage oligometric matrix protein (COMP) and interleukin-16 (IL-16) levels with disease severity in primary knee osteoarthritis: A pilot study in a Malaysian population Plos one | 2017
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Preparation and optimization of palm-based lipid nanoparticles loaded with griseofulvin IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH: IJPR | 2017
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Fibroblast growth factor receptor 4 (FGFR4) and fibroblast growth factor 19 (FGF19) autocrine enhance breast cancer cells survival Oncotarget | 2016
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In-vitro evaluation of griseofulvin loaded lipid nanoparticles for topical delivery JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY | 2016
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Mutant p53-R273H mediates cancer cell survival and anoikis resistance through AKT-dependent suppression of BCL2-modifying factor (BMF) Cell death & disease | 2015
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Field evaluation of a rapid diagnostic test to detect antibodies in human toxocariasis Acta tropica | 2015
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Culture and molecular identification of fungal contaminants in edible bird nests FOOD ADDITIVES & CONTAMINANTS: PART A | 2015
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Mutant p53-R273H mediates cancer cell survival and anoikis resistance through AKT-dependent suppression of BCL2-modifying factor (BMF). Cell Death Dis. 2015; 6: e1826 N/A | 2015
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Isolation and identification of mites associated with raw and commercial farm edible bird nests TROP. BIOMED | 2015
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Sero-prevalence study of IgE responses to allergens from Malaysian house dust (HDM) and storage mites (SM) Tropical biomedicine | 2015
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Characterization of Cyst and Trophozoite Proteins of Environmental Isolates of Acanthamoeba Castellanii by Two-Dimensional Gel Electrophoresis Southeast Asian Journal of Tropical Medicine and Public Health | 2014
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Determination of the presence and levels of heavy metals and other elements in raw and commercial edible bird nests Malaysian Journal of Nutrition | 2014
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Structural analysis of raw and commercial farm edible bird nests Tropical biomedicine | 2014
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Identification and characterization of allergens from malaysian house dust (HDM) and storage mites (SM) with sera from a local urban population: O3-268 Allergy: European Journal of Allergy and Clinical Immunology | 2013
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Meta-analysis: the association between HIV infection and extrapulmonary tuberculosis Lung | 2013
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Malaria and soil-transmitted intestinal helminth co-infection and its effect on anemia: a meta-analysis Transactions of the royal society of tropical medicine and hygiene | 2013
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Association of Methylentetraydrofolate Reductase (MTHFR) 677 C> T gene polymorphism and homocysteine levels in psoriasis vulgaris patients from Malaysia: a case-control study Nutrition journal | 2012
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Differential expression of the angiogenesis growth factors in psoriasis vulgaris BMC research notes | 2012
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Molecular identification of house dust mites and storage mites Experimental and applied acarology | 2011
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A histopathological study of cardiac candidiasis and its behaviour under immunosuppressive effect of disseminated breast carcinoma Cardiology | 2011
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Antigenic profile of Blomia tropicalis, Aleuroglyphus ovatus and Glycycometus malaysiensis Tropical biomedicine | 2011
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Candida parapsilosis-specific monoclonal antibodies and their use for detection of Candida antigens in experimental systemic candidiasis HYBRIDOMA | 2010
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Immunosuppressive effect of disseminated breast carcinoma on severity of hepatic candidiasis. RESEARCH JOURNAL OF IMMUNOLOGY | 2010
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A histopathological study of severity of cerebral candidiasis as a result of immunosuppression caused by breast carcinoma INT. J. MOL. MED. ADV. SCI | 2010
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Determination of the Presence and Levels of Heavy Metals and N/A | 2010
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Monoclonal Antibody Against Candida parapsilosis HYBRIDOMA | 2010
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A comparative histopathological study of systemic candidiasis in association with experimentally induced breast cancer oncology letters | 2010
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Potential use of a monoclonal antibody for the detection of Candida antigens in an experimental systemic candidiasis model HYBRIDOMA | 2008
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Environmental health and building related illnesses JOURNAL OF SCIENCE, MEDICINE AND EDUCATION | 2008
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New mechanical disruption method for extraction of whole cell protein from Candida albicans Southeast Asian journal of tropical medicine and public health | 2007
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Monoclonal Antibody Production Against Candida Albicans And C. Parapsilosis And Immunopathological Changes In Experimental Infections In Rodents N/A | 2007
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Effect of cathepsin D and prostate specific antigen on latent transforming growth factor-beta in breast cancer cell lines. The Malaysian journal of pathology | 2003
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Roles of transforming growth factor-beta, insulin-like growth factors and proteases in human breast cancer N/A | 2002
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Effect of transforming growth factor-β 1, insulin-like growth factor-I and insulin-like growth factor-II on cell growth and oestrogen metabolism in human breast cancer cell lines Pathology | 2001
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The role of TGFβ in human cancers Pathology | 2001

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Other Publications

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Expression of Interferon Regulatory Factor-5 (IRF5) in asthmatic and non-asthmatic patients EUROPEAN JOURNAL OF IMMUNOLOGY | 01 Jan 2016
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Production of monoclonal antibodies against Candida albicans 14th National Biotechnology Seminar, Penang, Malaysia | 03 Dec 2003
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2. Effect of Cathepsin D and Prostate Specific Antigen on latent Transforming Growth Factor-beta in breast cancer cell lines 194th Meeting of Society for Endocrinology and Society for Endocrinology UK | 03 Nov 2003
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Effect of proteases on activation of Transforming Growth Factor-beta 2 in breast cancer cell lines The 22nd World Congress of Pathology & Laboratory Medicine | 28 Sep 2003

Books

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Springer, Tokyo (2015). Institute for Research, Development and Innovation (IRDI) of the International Medical University (IMU), Malaysia


Supervisions
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Ms Cindy Yeoh Shin Ly | Master (Research) | 20 Dec 2022 - 30 Nov 2024 Thesis: Molecular mechanisms of toxicity induced by polyfluoroalkyl substances in human bronchial and alveolar epithelial cells
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Ms Habibatul Saaadiah Binti Isa | Master (Mixed Mode) | 01 Nov 2022 - 30 Sep 2023 Thesis: Transcriptome-wide prediction of nasopharyngeal carcinoma (NPC) metastasis
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Ms Dorea Soong Shi Hui | Doctorate | 01 Jan 2022 - 31 Dec 2024 Thesis: Molecular mechanisms of toxicity induced by nanoplastics in human cells
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Ms Sandya Menon | Doctorate | 01 Jul 2021 - 30 Jun 2024 Thesis: Indoor air quality (IAQ) of five community clinics at Selangor
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Ms Yeo Bee Hui (GS55447) | Doctorate | 23 Jul 2020 - 29 Jun 2024 Thesis: Optimization of edible bird nest’s cleaning and processing parameters
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Mr Jua Harn Li | Master (Research) | 01 Sep 2019 - 30 Nov 2021 Thesis: Skin allergenicity of airborne and soil algae isolated from Malaysia
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Ms Gan Li Lian | Master (Research) | 01 Sep 2018 - 31 Dec 2020 Thesis: Identification of tumor cell-intrinsic immune modulators in pancreatic cancer cells
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Mr Low Aik Zuan | Undergraduate | 01 Aug 2018 - 31 Jul 2019 Thesis: The role of biomarker Cytokeratin-18 (CK-18) in severity assessment and stratification of patients with non-alcoholic fatty liver disease
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Ms Looi Chin King | Master (Research) | 01 Jun 2018 - 31 Dec 2020 Thesis: Mechanistic basis of tumour evasion from cytotoxic T cells (CTL) surveillance in pancreatic cancers
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Ms Lo Sing Gee | Master (Research) | 01 Jan 2018 - 31 Dec 2020 Thesis: In vitro elucidation of the mechanism on how Cladosporium sphaerospermum establish respiratory allergies
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Tan Yuen Fen | Doctorate | 01 Aug 2015 - 31 Dec 2018 Thesis: Systemic delivery of siRNA-based therapeutics using functionalized single-walled carbon nanotubes (SWNTs)
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Ms June Kew Pei Ern | Undergraduate | 01 Aug 2013 - 31 Jul 2014 Thesis: Isolation and identification of mites associated with raw and commercial edible bird nest (EBN)
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Ms Loh Heng She | Undergraduate | 01 Aug 2013 - 31 Jul 2014 Thesis: Correlation between serum and salivary house dust mite specific immunoglobulins in allergic rhinitis (AR) patients and non-allergic rhinitis matched controls
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Mr Terry Sua Shiang Cheng | Undergraduate | 01 Aug 2012 - 31 Jul 2013 Thesis: Enhancing thermostability of Mycobacterium bovis (BCG vaccine) in ambient environment via formulation approaches
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Ms Jennifer Chen XiaoJing | Undergraduate | 01 Aug 2012 - 31 Jul 2013 Thesis: Determination of heavy metals and fungi associated with raw and commercial edible bird nests (EBN)
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Mr Jeffrey Chong Kam Thim | Undergraduate | 01 Aug 2012 - 31 Jul 2013 Thesis: Identification and characterization of allergens from Malaysian house dust mites (HDM) and storage mites (SM) with sera from a Malaysian patients attending a clinic in Penang
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Ms Ling Suk Jiun | Master (Research) | 01 Jan 2012 - 31 Dec 2014 Thesis: Production and use of polyclonal and monoclonal antibodies against Austroglycyphagus malaysiensis for immunological studies in an animal model sensitized against this mite
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Ms Amy Chong Ai Ling | Undergraduate | 01 Aug 2011 - 31 Jul 2012 Thesis: Isolation and characterization of mites from dust collected from International Medical University animal holding facility
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Ms Tang Jia Chorng | Undergraduate | 01 Aug 2010 - 31 Jul 2011 Thesis: Dust mites sensitization study in rodents at IMU animal holding facility
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Mr Lee Shing Long | Undergraduate | 01 Aug 2009 - 01 Jul 2010 Thesis: SLC2A9/GLUT9 rs11722228 polymorphism in gout among Malaysian population
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Mr Chester Choo Chee Wei | Undergraduate | 01 Aug 2009 - 31 Jul 2010 Thesis: A comparative histopathological study of systemic candidiasis in mice with and without experimentally induced breast cancer
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Mr Low Yoon Tong | Undergraduate | 01 Aug 2008 - 31 Jul 2009 Thesis: Cell mediated immunity to Candida albicans and Candida parapsilosis in experimental systemic candidiasis rat model

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