Hoh Boon Peng



Salutation
Professor

School/Centre
School of Health Sciences

Department
Applied Biomedical Science and Biotechnology

Position
Professor

Email
boonpenghoh@imu.edu.my



Education

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PhD (Genetics), 2005 Universiti Putra Malaysia
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BSc (H) (Biology), 2000 Universiti Putra Malaysia

Memberships

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Malaysian Biosafety and Biosecurity Association Member 2020 - Present
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AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE Member 2007 - Present
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Genetic Society Malaysia Member 2005 - Present

Research Funding
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Assessing the Performance of a Polygenic Risk Scores (PRS) Model for Diabetes Mellitus in Asian Population IMU Internal Research Grant | 01 Sep 2024 - 31 Aug 2025
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Association of plasma exosomal caveolin-1 with diabetes and its complication in Seremban diabetes (SeDia) population: a potential biomarker IMU Internal Research Grant | 09 Aug 2024 - 30 Sep 2026
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Tracing the Signatures of Natural Selection and Local Adaptation of Blood Pressure Regulation among the Negrito from Peninsular Malaysia IMU Internal Research Grant | 01 Jun 2024 - 31 Dec 2024
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Inference of Putative Positive Natural Selections Signatures among the Indigenous Populations from Peninsular Malaysia IMU Internal Research Grant | 01 Jun 2023 - 01 Jun 2024
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Inference of Population Genetic Structure of the Natives from Peninsular Malaysia IMU Internal Research Grant | 20 Apr 2023 - 19 Oct 2023
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MAPPING EXPRESSION QUANTITATIVE TRAIT LOCI (eQTL) OF THE NATIVE POPULATIONS FROM PENINSULAR MALAYSIA: BRIDGING THE GENOMICS TO PHENOMICS FOR THE IMPLICATION OF EVOLUTIONARY AND PRECISION MEDICINE FRGS | 07 Sep 2021 - 06 Sep 2024

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Publications

Research Articles

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The ASEAN genome consortium: advancing equitable precision medicine through regional solidarity THE LANCET REGIONAL HEALTH"WESTERN PACIFIC 2025
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Secondary Prevention Medications in 17 Countries Grouped by Income Level (PURE) A Prospective Cohort Study JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 2025
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Dietary vitamin intake and its association with hypertension (HPT) among Malaysian adults SCIENTIFIC REPORTS 2025
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Expression quantitative trait loci (eQTL): from population genetics to precision medicine JOURNAL OF GENETICS AND GENOMICS 2025
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High-coverage whole-genome sequencing of a Jakun individual from the “Orang Asli” Proto-Malay subtribe from Peninsular Malaysia HUMAN GENOME VARIATION 2025
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AGT, CYP11B2 & ADRB2 gene polymorphism & essential hypertension (HT): A meta-analysis INDIAN JOURNAL OF MEDICAL RESEARCH 2024
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A genotype imputation reference panel specific for native Southeast Asian populations NPJ GENOMIC MEDICINE 2024
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Apolipoproteins and Its Association with Dengue Virus Serotype 2 (DENV-2) Infectivity in Human Hepatoma Cell Line (Huh7) TRENDS IN SCIENCES 2024
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Precision Medicine in Hypertension: Are We There? JOURNAL OF CLINICAL AND HEALTH SCIENCES (JCHS) 2024
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ONE HEATLH: The need for a robust framework. INTERNATIONAL E-JOURNAL OF SCIENCE, MEDICINE & EDUCATION 2024
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Focus: Cell Fate: H19: An Oncogenic Long Non-coding RNA in Colorectal Cancer THE YALE JOURNAL OF BIOLOGY AND MEDICINE 2023
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Genetic connections and convergent evolution of tropical indigenous peoples in Asia MOLECULAR BIOLOGY AND EVOLUTION 2022
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The Peopling and Migration History of the Natives in Peninsular Malaysia and Borneo: A Glimpse on the Studies Over the Past 100 years FRONTIERS IN GENETICS 2022
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Association of Socioeconomic Disparities and Predisposing Factors with Higher Prevalence of Hypertension related Left Ventricular Hypertrophy in Males: a Malaysian Community-Based Study MEDRXIV 2022
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Was Wuhan the early epicenter of the COVID-19 pandemic?–A critique NATIONAL SCIENCE REVIEW 2022
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Sequence analyses of Malaysian Indigenous communities reveal historical admixture between Hoabinhian hunter-gatherers and Neolithic farmers SCIENTIFIC REPORTS 2022
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Factors Influencing COVID-19 Vaccination Intention among University Students: A Cross-Sectional Study in Malaysia BIOSAFETY AND HEALTH 2022
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The indigenous populations as the model by nature to understand human genomic-phenomics interactions. QUANTITATIVE BIOLOGY 2022
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Natural human infections with Plasmodium cynomolgi, P. inui, and 4 other simian malaria parasites, Malaysia EMERGING INFECTIOUS DISEASES 2021
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Current status and future perspectives about molecular biomarkers of nasopharyngeal carcinoma CANCERS 2021
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Shared Signature of Recent Positive Selection on the TSBP1–BTNL2–HLA-DRA Genes in Five Native Populations from North Borneo GENOME BIOLOGY AND EVOLUTION 2020
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OPPORTUNITIES AND CHALLENGES FOR PUBLIC HEALTH IN GENOMICS PROSIDING FK UC 2020
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Metabolic syndrome and cardiometabolic risk factors among indigenous Malaysians PUBLIC HEALTH 2019
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PGG. SNV: understanding the evolutionary and medical implications of human single nucleotide variations in diverse populations GENOME BIOLOGY 2019
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Prevalence, intensity and associated risk factors of soil transmitted helminth infections: A comparison between Negritos (indigenous) in inland jungle and those in resettlement at town peripheries PLOS NEGLECTED TROPICAL DISEASES 2019
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Natural selection and local adaptation of blood pressure regulation and their perspectives on precision medicine in hypertension HEREDITAS 2019
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Analysis of five deep-sequenced trio-genomes of the Peninsular Malaysia Orang Asli and North Borneo populations BMC GENOMICS 2019
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Hepatitis B virus infection: Epidemiology and seroprevalence rate amongst Negrito tribe in Malaysia. THE MEDICAL JOURNAL OF MALAYSIA 2019
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A genome-wide characterization of copy number variations in native populations of Peninsular Malaysia EUROPEAN JOURNAL OF HUMAN GENETICS 2018
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Genetic relatedness of indigenous ethnic groups in northern Borneo to neighboring populations from Southeast Asia, as inferred from genome‐wide SNP data ANNALS OF HUMAN GENETICS 2018
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Genomic structure of the native inhabitants of Peninsular Malaysia and North Borneo suggests complex human population history in Southeast Asia HUMAN GENETICS 2018
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Genetic polymorphism and natural selection in the C-terminal 42 kDa region of merozoite surface protein-1 (MSP-1) among Plasmodium knowlesi samples from Malaysia PARASITES & VECTORS 2018
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A4617 GENETIC VARIATIONS AMONG PATIENTS WITH DILATED CARDIOMYOPATHY IN MALAYSIA JOURNAL OF HYPERTENSION 2018
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Evaluation of CXCL10 as potential biomarker for early detection of severe dengue INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES 2018
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A4422 ANALYSIS OF GENETIC ASSOCIATION REVEALED NO SIGNIFICANT ASSOCIATION BETWEEN AGT-rs699 AND HYPERTENSION AMONG THE MALAYS FROM PENINSULAR MALAYSIA JOURNAL OF HYPERTENSION 2018
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A4530 Prevalence of dilated cardiomyopathy in Malaysia population by echocardiographic screening JOURNAL OF HYPERTENSION 2018
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A4406 CORRELATION BETWEEN MINOR ALLELE FREQUENCIES, MAF (RS699 AND RS10087214) AND GEOGRAPHICAL COORDINATES WITHIN POPULATIONS JOURNAL OF HYPERTENSION 2018
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The epidemiological spectrum of Hepatitis B virus infection amongst aborigines in Malaysia INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES 2018
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Observational study of the status of coronary risk biomarkers among Negritos with metabolic syndrome in the east coast of Malaysia BMJ OPEN 2018
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A5637 TGF-β-BMP signalling provides an insight into hypertension-related left ventricular hypertrophy JOURNAL OF HYPERTENSION 2018
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Characterising private and shared signatures of positive selection in 37 Asian populations EUROPEAN JOURNAL OF HUMAN GENETICS 2017
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Genetic and Historical Migration Relationships of Three Northern Sabah Native Ethnic Groups with Their Southern China and Southeast Asia Neighbours SHORT COMMUNICATIONS IN BIOTECHNOLOGY 2017
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The identification of copy number variation of CD209 (DCSIGN) gene among dengue patients from peninsular Malaysia META GENE 2016
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Status of inflammation, endothelial activation and prothrombogenesis among Negritos and Malays with metabolic syndrome ATHEROSCLEROSIS 2016
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Translational research for improving the care of familial hypercholesterolemia: the “Ten Countries Study” and beyond JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 2016
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Genetic study of low-density lipoprotein receptor gene and apolipoprotein B-100 gene among Malaysian patients with familial hypercholesterolaemia INTERNATIONAL ARCHIVES OF MEDICINE 2016
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Generation of Epstein-Barr Virus immortalized-B lymphocytes cell line of Orang Asli JOURNAL OF GENETICS AND GENOME RESEARCH 2016
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Rare copy number variants identified suggest the regulating pathways in hypertension-related left ventricular hypertrophy PLOS ONE 2016
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The high-affinity human IgG receptor Fc gamma receptor I (FcγRI) is not associated with vascular leakage of dengue J NEGAT RESULTS BIOMED. 2015
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Effect of DNase treatment on RNA extraction from preimplantation murine embryos GENETICS AND MOLECULAR RESEARCH 2015
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Dissecting the genetic structure and admixture of four geographical Malay populations SCIENTIFIC REPORTS 2015
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A 3.4-kb copy-number deletion near EPAS1 is significantly enriched in high-altitude Tibetans but absent from the Denisovan sequence THE AMERICAN JOURNAL OF HUMAN GENETICS 2015
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Fine-scale population structure of Malays in Peninsular Malaysia and Singapore and implications for association studies HUMAN GENOMICS 2015
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Cardio-metabolic health risks in indigenous populations of Southeast Asia and the influence of urbanization BMC PUBLIC HEALTH 2015
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Common variants of chemokine receptor gene CXCR3 and its ligands CXCL10 and CXCL11 associated with vascular permeability of dengue infection in peninsular Malaysia HUMAN IMMUNOLOGY 2015
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Genetic association of single nucleotide polymorphisms of ABCA1, APOA1 and LCAT genes in subjects with low concentration of high density lipoprotein-cholesterol ATHEROSCLEROSIS 2015
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A comparison of assays for accurate copy number measurement of the low-affinity Fc gamma receptor genes FCGR3A and FCGR3B PLOS ONE 2015
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Differential positive selection of malaria resistance genes in three indigenous populations of Peninsular Malaysia HUMAN GENETICS 2015
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Illegitimacy and sibship assignments in oil palm (Elaeis guineensis Jacq.) half-sib families using single locus DNA microsatellite markers MOLECULAR BIOLOGY REPORTS 2015
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Unravelling the genetic history of Negritos and indigenous populations of Southeast Asia GENOME BIOLOGY AND EVOLUTION 2015
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A novel rare copy number variant of the ABCF1 gene identified among dengue fever patients from Peninsular Malaysia GENET MOL RES 2014
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Homozygous familial hypercholesterolemia. MALAYSIAN JOURNAL OF PATHOLOGY 2014
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Association between basal stem rot disease and simple sequence repeat markers in oil palm, Elaeis guineensis Jacq. EUPHYTICA 2014
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An evaluation of the World Health Organization’s 1997 and 2009 dengue classifications in hospitalized dengue patients in Malaysia JOURNAL OF INFECTION IN DEVELOPING COUNTRIES 2014
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The population genomic landscape of human genetic structure, admixture history and local adaptation in Peninsular Malaysia HUMAN GENETICS 2014
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Novel population specific autosomal copy number variation and its functional analysis amongst Negritos from Peninsular Malaysia PLOS ONE 2014
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Human gene copy number variation and infectious disease HUMAN GENETICS 2014
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P-135 The effect of piezo-assisted biopsy on preimplantation mouse embryo development and gene expression HUMAN REPRODUCTION 2013
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The utility of copy number variation (CNV) in studies of hypertension-related left ventricular hypertrophy (LVH): rationale, potential and challenges MOLECULAR CYTOGENETICS 2013
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An alternate method for DNA and RNA extraction from clotted blood. GENETICS AND MOLECULAR RESEARCH: GMR 2013
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Systematic pharmacogenomics analysis of a Malay whole genome: proof of concept for personalized medicine PLOS ONE 2013
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Somatic copy-neutral loss of heterozygosity and copy number abnormalities in Malaysian sporadic colorectal carcinoma patients GENET MOL RES 2013
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Segregation and genetic linkage analyses of river catfish, Mystus nemurus, based on microsatellite markers GENETICS AND MOLECULAR RESEARCH 2013
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Genetic Association Study of KCNB1 Gene with the Susceptibility of Hypertension Related LVH (Left Ventricular Hypertrophy) Patients in Malaysia JOURNAL OF LIFE SCIENCES 2013
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Evolutionary history of continental Southeast Asians:“Early train” hypothesis based on genetic analysis of mitochondrial and autosomal DNA data MOLECULAR BIOLOGY AND EVOLUTION 2012
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Genetic dating indicates that the Asian–Papuan admixture through Eastern Indonesia corresponds to the Austronesian expansion PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES 2012
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Paleolithic contingent in modern Japanese: estimation and inference using genome-wide data SCIENTIFIC REPORTS 2012
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Microsatellite instability and loss of heterozygosity in oral squamous cell carcinoma in Malaysian population ORAL ONCOLOGY 2011
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Addition of Low-Cost Additives Improves Real Time PCR Assay of GC Rich FMR1 Region Utilizing Taqman Probe. INTERNATIONAL MEDICAL JOURNAL 2011
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CHARACTERIZATION OF SEVEN (CA) n MICROSATELLITE MARKERS AMONG THREE POPULATIONS OF NEGRITOS FROM PENINSULAR MALAYSIA MALAYSIAN APPLIED BIOLOGY 2011
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How Many SNPs Should Be Used for the Human Phylogeny of Highly Related Ethnicities? A Case of Pan Asian 63 Ethnicities GENOMICS & INFORMATICS 2011
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PanSNPdb: the Pan-Asian SNP genotyping database PLOS ONE 2011
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Population genetic structure of peninsular Malaysia Malay sub-ethnic groups PLOS ONE 2011
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Identification of close relatives in the HUGO Pan-Asian SNP database PLOS ONE 2011
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Genetic evidence supports linguistic affinity of Mlabri-a hunter-gatherer group in Thailand BMC GENETICS 2010
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Mapping human genetic diversity in Asia SCIENCE 2009
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Screening of dystrophin gene deletions in Malaysian patients with Duchenne muscular dystrophy MED J MALAYSIA 2008
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Y-chromosomal STR Variation in Malays of Kelantan and Minang PERTANIKA J TROP AGRIC SCI 2008
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Isolation of trinucleotide microsatellite markers for Mystus nemurus RUSSIAN JOURNAL OF GENETICS 2008
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A novel single nucleotide polymorphism, IVS2-97A> T, in the prostaglandin F2alpha receptor gene was identified among the Malaysian patients with glaucoma KOBE J. MED. SCI 2007
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A report of a SNP EX3 1209A> G of prostaglandin F receptor gene among Malaysians INTERNATIONAL MEDICAL JOURNAL 2007
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Isolation and development of DNA microsatellite markers for the river catfish (Mystus nemurus) ASIAN FISHERIES SCIENCE 2007
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An improved rapid genotyping method for the study of beta‐2 adrenergic receptor gene polymorphisms using single tube allele specific multiplex PCR JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS 2006
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Mendelian inheritance of microsatellite markers in Southeast Asian river catfish, Mystus nemurus PERTANIKA JOURNAL OF TROPICAL AGRICULTURAL SCIENCE 2005
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A rapid method of isolating microsatellite markers from the Asian Red-tailed catfish Mystus nemurus MALAYSIA BULLETIN OF THE GENETICS SOCIETY 2004

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Other Publications

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Malaysia Genomic-to-Phenomics (MyGen2Phen) Initiative: Challenges and Opportunities 4th International Symposium of Human Phenomics | 31 Oct 2023
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Precision Medicine of Hypertension INTERNATIONAL CONGRESS OF PATHOLOGY AND LABORATORY MEDICINE (ICPaLM 2023) | 20 Sep 2023
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Sero-prevalence of Hepatitis B amongst indigenous people in Malaysia INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 01 Jan 2017
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Archaic introgression in indigenous populations of Malaysia revealed by whole genome sequencing HUMAN GENOMICS | 01 Jan 2016
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RS12718465 SINGLE NUCLEOTIDE POLYMORPHISM IN EXON 3 OF APOA1 GENE IS ASSOCIATED WITH LOW HIGH-DENSITY LIPOPROTEIN SUBJECTS HYPERTENSION | 01 Jan 2014
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ENHANCED ENDOTHELIAL ACTIVATION IN HUMAN SUBJECTS WITH LOW CONCENTRATION OF HIGH DENSITY LIPOPROTEIN HYPERTENSION | 01 Jan 2014
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The effect of piezo-assisted biopsy on preimplantation mouse embryo development and gene expression HUMAN REPRODUCTION | 01 Jan 2013
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GENETIC POLYMORHPISM OF ANTIOXIDANT GENES: IMPLICATIONS ON OPTIC NERVE HEAD ABNORMALITY IN PRIMARY OPEN ANGLE GLAUCOMA PATIENTS CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY | 01 Jan 2012
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Genome-wide somatic uniparental disomy in sporadic colorectal carcinoma patients JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | 01 Jan 2010
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MULTIPLE PATHS TO DRUG RESISTANCE PHENOTYPE IN CHRONIC MYELOID LEUKEMIA PATIENTS UNDERGOING IMATINIB MESYLATE TREATMENT ANTICANCER RESEARCH | 01 Jan 2008
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Detection of a novel SNP of the PGF2-alpha receptor gene among glaucomatous patients by dHPLC JOURNAL OF MEDICAL GENETICS | 01 Jan 2005

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Supervisions
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Nathaniel Fong | Undergraduate | 01 Jun 2023 - 01 Jun 2024 Thesis: Inference of Putative Positive Natural Selections Signatures among the Indigenous Populations from Peninsular Malaysia
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Lee Ying Qi | Undergraduate | 01 Jun 2023 - 01 Jun 2024 Thesis: Inference of Putative Positive Natural Selections Signatures among the Indigenous Populations from Peninsular Malaysia
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Tham Pei Mei | Undergraduate | 20 Apr 2023 - 19 Oct 2023 Thesis: Inference of Population Genetic Structure of the Natives from Peninsular Malaysia
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Lee Xin | Undergraduate | 20 Apr 2023 - 19 Oct 2023 Thesis: Inference of Population Genetic Structure of the Natives from Peninsular Malaysia
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Calistan Chan | Undergraduate | 20 Apr 2023 - 19 Oct 2023 Thesis: Inference of Population Genetic Structure of the Natives from Peninsular Malaysia
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Foo Hoi Thung | Undergraduate | 20 Apr 2023 - 19 Oct 2023 Thesis: Inference of Population Genetic Structure of the Natives from Peninsular Malaysia
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Wong Zhi Qi | Doctorate | 01 May 2022 Thesis: Expression Quantitative Trait Loci (eQTL) of the Orang Asli Negrito and the Malays from Peninsular Malaysia
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Alvin Cengnata | Doctorate | 01 Sep 2021 Thesis: Demographic History and Genetic Adaptation of the Orang Asli in Peninsular Malaysia
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Yap Wai Sum | Doctorate | 01 Sep 2016 - 26 Sep 2023 Thesis: Genetic Architecture and Population History of Orang Asli in Peninsular Malaysia
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Nur Hasnah Ma'amor | Doctorate | 01 Apr 2015 - 01 Mar 2022 Thesis: Genetic Susceptibility of Hypertension: A case for AGT, ADRB2 and CYP11B2

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