ELAINE CHAN WAN LING



Salutation
Associate Professor Dr

School/Centre
Institute of Research, Development and Innovation (IRDI)

Department
-

Appointment
Head, Centre for Environmental and Population Health

Position
Associate Professor

Email
elainechan@imu.edu.my

Professional Network


Education

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Doctor of Philosophy (Pharmacognosy), 2014 Monash University Malaysia
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Bachelor of Science (Biotechnology, Hons) (Biotechnology), 2010 Monash University Malaysia

Memberships

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American Society of Pharmacognosy | International | Member
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Golden Key International Honour Society | International | Member

Research Funding
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Development of an automated decision support tool in diagnosing kidney allograft pathology based on the Banff criteria using a deep convolutional neural network IMU Internal Research Grant | 01 Jun 2024 - 31 May 2026
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Clinical Prediction of Oral Potentially Malignant Disorders (OPMDs) through Convolutional Neural Network (CNN)-Based Deep Learning IMU Internal Research Grant | 23 May 2024 - 31 Mar 2025
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Food and built environment and its correlates in type 2 diabetes patients of the Seremban Diabetes Cohort (SeDia) IMU Internal Research Grant | 01 Jan 2024 - 31 Dec 2025
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Development of an automated decision support tool for diagnosis of Thyroid lesions through fine needle aspirates using machine learning algorithms (Artificial Intelligence). IMU Internal Research Grant | 01 Jan 2024 - 30 Jun 2024
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Development of a machine learning model for image-based analysis of cervical cytology in Papanicolaou smear (Pap Smear) IMU Internal Research Grant | 12 Jun 2023 - 16 Sep 2023
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Transcriptomic landscape and identification of biomarkers and pathways for colorectal cancer- A pilot study IMU Internal Research Grant | 01 Jun 2023 - 31 Oct 2023
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A long term longitudinal big data approach for developing precision health for Type 2 Diabetes (T2DM) in Malaysia IMU, MOH | 01 Jan 2023 - 31 Dec 2033
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Development of a bleeding risk score from predictive bleeding risk factors for multi-racial Malaysian patients requiring oral anticoagulants IMU | 01 Sep 2021 - 31 Aug 2022
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Personalising Diabetes Care through Community-empowered Digital Healthcare Engaged Faculty Scholar Research grant | 01 Jul 2021 - 31 May 2023
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The neuro-protective effects of TGF-βR1 inhibitors against beta-amyloid-induced neurotoxicity and microglia-mediated neurotoxicity Internal IMU | 01 Jul 2021 - 15 Nov 2021
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Predictive factors for the risk of proliferative lupus nephritis in Malaysian children with paediatric Systemic Lupus Erythematosus (pSLE) Internal Grant | 01 May 2021 - 31 Jul 2022
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Predictive factors for the risk of proliferative lupus nephritis in Malaysian children with paediatric Systemic Lupus Erythematosus (pSLE) Bachelor in Medical Sciences (Hons) | 01 Apr 2021 - 30 Jun 2022
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Development of an Artificial Intelligence System for Image Based Analysis of cervical cytology in Papanicolaou Smear Industrial Collaboration | 13 Jan 2021 - 31 Dec 2021
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Development of an Artificial Intelligence System for Image Based Analysis of Peripheral Blood Smears Industrial Collaboration | 13 Jan 2021 - 31 Dec 2021
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MMU-UKM-IMU Artificial Intelligence for Digital Pathology (AI4DP): Development of an artificial intelligence system to aid cell block analysis of fine needle aspirates for pancreatic cancer diagnosis. MoHE RESEARCH EXCELLENCE CONSORTIUM (REC) | 01 Jan 2021 - 31 Dec 2022
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Development of a model to predict disease activity patterns in paediatric Systemic Lupus Erythematosus (pSLE) among Malaysian children: A retrospective study Asia Pacific University of Technology and Innovations Research Development Internal Grant | 01 Jan 2021 - 31 Dec 2022
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Mechanistic studies on the neuroprotective effect of beta-sitosterol during beta amyloid-induced microglia-mediated neuro-inflammation Internal -IMU | 07 Dec 2020 - 30 Jun 2021
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Functional role of MIRO1 in NLRP1 inflammasome-mediated neuronal cell death Fundamental Research Grant Scheme | 01 Nov 2020 - 31 Oct 2022
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Perceived Stress and Quality Of Life among End Stage Kidney Disease Patients In Private Dialysis Centers, Malaysia. IMU | 22 Oct 2020 - 30 Apr 2021
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Five-year experience of using sodium-glucose cotransporter-2 (SGLT2) inhibitors among patients with type 2 diabetes mellitus in Tuanku Mizan Armed Forces Hospital IMU | 01 Aug 2020 - 01 Dec 2020
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Identification of the relationships between autopsy-based neuropathology and the mode (abrupt/stepwise), time of onset (early/late onset) and type (normal/impaired) of cognitive impairments in patients with Alzheimer’s disease Internal IMU | 15 Jul 2020 - 15 Nov 2020
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Determination of the predictive factors for clinically relevant worsening of daily living, and baseline decline in cognitive functions of patients with Alzheimer’s disease using support vector machine (SVM) Internal IMU | 15 Jul 2020 - 15 Nov 2020
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The crosstalk between pancreatic ductal adenocarcinoma (PDA) and macrophages in tumour microenvironments, and its effects on inflammasome activations and release of pro-inflammatory cytokines IMU Internal | 06 May 2020 - 30 Jun 2021
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Development of pooling strategy for COVID 19 RT-PCR testing IMU | 17 Apr 2020 - 30 Apr 2020
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Validation of a brief, reliable diet assessment to rapidly assess diets among people at risk of diabetes in Kuala Lumpur. IMU | 01 Feb 2020 - 01 Jul 2020
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Elucidating the genotypic clustering and transmission pattern of pediatric tuberculosis cases in Malaysia using epidemiological and molecular approaches Internal IMU- TB Challenge Grant | 11 Jul 2019 - 09 Feb 2021
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Investigating the differences in somatic mutation landscape of stomach, lung, liver, and head and neck cancer in Asian and non-Asian populations Internal IMU | 01 Jul 2019 - 15 Nov 2019
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Identification of gene signature associated with metastasis in pancreatic ductal adenocarcinoma (PDAC) using machine learning Internal IMU | 01 Jul 2019 - 15 Nov 2019
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Identification of predictive markers for gemcitabine response in pancreatic cancers BPhar | 01 Jul 2019 - 31 Oct 2019
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The effect of β-sitosterol against beta amyloid (Aβ)-induced neuro-inflammation in BV-2 microglia cells Internal IMU | 01 Jun 2019 - 30 Sep 2020
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Prevalence and risk factors of pre-diabetes and the efficacy of community-based behavioural interventions at Desa Petaling KOSPEN site Internal IMU- IMU Cares | 31 May 2019 - 31 Dec 2020
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Risk factors and outcomes associated with falls among community-dwelling elderly in Malaysia IMU | 19 Mar 2019 - 19 Sep 2019
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Role of NLRP3 inflammasome in lipopolysaccharides-induced pancreatic cancer cell proliferation and development Internal IMU | 25 Feb 2019 - 30 Sep 2020
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Development of an automated decision support tool for pancreatic diagnosis through fine needle aspirates using deep convolution neural network Internal IMU-Pancreatic Cancer Challenge Grant | 25 Feb 2019 - 31 May 2020
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Combinational Antibacterial Effect of 1,4-Naphthoquinone and β-Lactams against Selected Gram Positive and Gram Negative Pathogenic Bacteria Internal IMU | 01 Nov 2018 - 31 Jan 2019
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Identification of Genetic Drivers of Cancer Dependency in Pancreatic Cancers through Integrated Analysis of Dataset Derived from Large-Scale, Deep RNAi Screening IMU | 18 Jul 2018 - 18 Dec 2018
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Effects of interferon-l (IFN-l) on human pancreatic cancer cells Internal IMU | 01 Jul 2018 - 15 Nov 2018
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Extraction and Characterization of Antimicrobial Compounds from Escherichia coli Clones Containing Genomic Fragments of DNA Obtained from the Fluid of Nepenthes gracillis IMU | 01 Jul 2018 - 01 Nov 2018
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Extraction and Characterisation of Antimicrobial Compounds from Escherichia coli ClonesContainig Genomic Fragments of DNA Obtained from the fluuid of Nepenthes gracillis Internal IMU | 01 Jul 2018 - 15 Nov 2018
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Long Term Outcome in Malaysian Children with Paediatric Systemic Lupus Erythematosus (pSLE) Internal IMU | 10 Apr 2017 - 31 Dec 2018
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Neuroprotective effect of neuronal stem cells (NSCs) on SHSY5Y cells via the regulation of inflammasome-mediated inflammation in BV2 microglia cells. Internal IMU | 14 Feb 2017 - 12 Apr 2018
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Bioassay-Guided Isolation of Antimicrobial Molecules from Escherichia Coli Clones Containing Genomic Fragments of DNA Obtained from the Fluid of Nepenthes Gracilis Internal IMU | 01 Nov 2016 - 31 Jan 2017
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The regulation of inflammasome activation in BV-2 microglia cells by neuronal stem cells (NSCs) Internal IMU | 01 Sep 2016 - 20 Feb 2017
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A microarray-coupled gene trap mutagenesis approach for the identification of NLRP1 inflammasome activation targets mediating beta amyloid (Aβ)-induced neuronal pyroptosis Fundamental Research Grant Scheme | 01 Aug 2016 - 31 Jul 2020
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The neuroprotective effect of Piper sarmentosum in neuronal and microglia cells for the prevention of tau and amyloidosis development and neuroinflammation. Internal IMU | 01 Jul 2016 - 15 Nov 2016
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Designer Food: Preparation and evaluation of their antioxidant & α-glucosidase inhibitory activity. Internal IMU | 01 Jul 2016 - 15 Nov 2016
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Fucosterol inhibited the cholinesterase activities and reduced the release of pro-inflammatory mediators in lipopolysaccharide and amyloid-induced microglial cells Internal IMU | 01 Jul 2016 - 15 Nov 2016
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Assessing the factors contributing to the strains of caregivers for Alzheimer’s disease (AD) patients at the Alzheimer’s Disease Foundation Malaysia (ADFM) center in Malaysia. Internal IMU (IMU Cares) | 01 Feb 2016 - 31 Dec 2016
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Synergistic antibacterial activity of nonsteroidal anti-inflammatory drugs (NSAIDs) and antibiotics against Staphylococcus aureus strains Internal IMU | 01 Nov 2015 - 31 Jan 2016
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Metagenomic characterisation of antimicrobials in the fluids of Nepenthes (Nepenthaceae) pitcher plant Internal IMU | 02 Jan 2015 - 31 Dec 2016

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Publications

Research Articles

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Lipopolysaccharide (LPS) stimulation of Pancreatic Ductal Adenocarcinoma (PDAC) and macrophages activates the NLRP3 inflammasome that influences the levels of pro-inflammatory cytokines in a co-culture model CANCER BIOLOGY & THERAPY | 2023
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Multi-configuration analysis of DenseNet architecture for whole slide image scoring of ER-IHC IEEE ACCESS | 2023
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A Preliminary Predictive Model for Proliferative Lupus Nephritis in Juvenile Systemic Lupus Erythematosus RHEUMATO | 2023
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PancreaSys: An Automated Cloud-Based Pancreatic Cancer Grading System FRONTIERS IN SIGNAL PROCESSING | 2022
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Pancreatic cancer grading in pathological images usin g deep learning convolutional neural networks [version 2; peer N/A | 2022
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AI in healthcare: Applications and challenges INTERNATIONAL E-JOURNAL OF SCIENCE, MEDICINE AND EDUCATION | 2021
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Pancreatic cancer grading in pathological images using deep learning convolutional neural networks F1000RESEARCH | 2021
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COVID-19 Sample Pooling: From RNA Extraction to Quantitative Real-time RT-PCR BIO-PROTOCOL | 2021
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Genes Associated with Amyloid-beta-induced Inflammasome-mediated Neuronal Death Identified Using Functional Gene Trap Mutagenesis Approach International journal of biochemistry & cell biology | 2021
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Is Misdiagnosis of Type 1 Diabetes Mellitus in Malaysian Children a Common Phenomenon? Frontiers in Endocrinology | 2021
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Piper sarmentosum Roxb. Attenuates Beta Amyloid (Aβ)-Induced Neurotoxicity Via the Inhibition of Amyloidogenesis and Tau Hyperphosphorylation in SH-SY5Y Cells. Current Alzheimer Research | 2021
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Synergistic antibacterial activity between 1, 4-naphthoquinone and β-lactam antibiotics against methicillin-resistant Staphylococcus aureus Microbial Drug Resistance | 2021
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Functional Gene Trap Mutagenesis Screen for Genes and Molecular Mechanisms Underlying Amyloid-β-induced Inflammasome-mediated Neuronal Death N/A | 2020
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The Antibacterial Agent Identified from Acidocella spp. in the Fluid of Nepenthes gracilis Against Multidrug-Resistant Klebsiella pneumoniae: A Functional Metagenomic Approach Microbial Drug Resistance | 2020
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A novel strategy for community screening of SARS-CoV-2 (COVID-19): Sample pooling method PloS one | 2020
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The influence of climate factors on COVID-19 transmission in Malaysia: An autoregressive integrated moving average (ARIMA) model MEDRXIV | 2020
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Clinical features, disease activity and outcomes of Malaysian children with paediatric systemic lupus erythematosus: A cohort from a tertiary centre Lupus | 2020
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The effects of NLRP3 inflammasome inhibition by MCC950 on LPS-induced pancreatic adenocarcinoma inflammation Journal of cancer research and clinical oncology | 2020
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Association between long-term exposure to ambient air pollution and prevalence of diabetes mellitus among Malaysian adults Environmental Health | 2020
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Factors associated with high strain in caregivers of Alzheimer's disease (AD) in Malaysia Geriatric Nursing | 2019
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Piper sarmentosum roxb. Root extracts confer neuroprotection by attenuating beta amyloid-induced pro-inflammatory cytokines released from microglial cells Current Alzheimer Research | 2019
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The NLRP3 inflammasome is involved in the neuroprotective mechanism of neural stem cells against microglia-mediated toxicity in SH-SY5Y cells via the attenuation of tau hyperphosphorylation and amyloidogenesis Neurotoxicology | 2019
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The roles of circular RNAs in human development and diseases BIOMEDICINE & PHARMACOTHERAPY | 2019
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The role of neuronal NLRP1 inflammasome in Alzheimer’s disease: bringing neurons into the neuroinflammation game MOLECULAR NEUROBIOLOGY | 2019
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Autophagy and GLUT4: The missing pieces DIABETES & METABOLIC SYNDROME: CLINICAL RESEARCH & REVIEWS | 2018
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Edible foxtail millet flour stabilises and retain the in vitro activity of blueberry bioactive components INTERNATIONAL JOURNAL OF FOOD SCIENCE & TECHNOLOGY | 2018
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Fucosterol inhibits the cholinesterase activities and reduces the release of pro-inflammatory mediators in lipopolysaccharide and amyloid-induced microglial cells Journal of applied phycology | 2018
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Piper sarmentosum Roxb. confers neuroprotection on beta-amyloid (Aβ)-induced microglia-mediated neuroinflammation and attenuates tau hyperphosphorylation in SH-SY5Y cells Journal of ethnopharmacology | 2018
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Synergistic effect of non-steroidal anti-inflammatory drugs (NSAIDs) on antibacterial activity of cefuroxime and chloramphenicol against methicillin-resistant Staphylococcus aureus Journal of global antimicrobial resistance | 2017
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Galloylated flavonol rhamnosides from the leaves of Calliandra tergemina with antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) Phytochemistry | 2014
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Assessment of phytochemical content, polyphenolic composition, antioxidant and antibacterial activities of Leguminosae medicinal plants in Peninsular Malaysia BMC complementary and alternative medicine | 2011

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Other Publications

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Alzheimer’s Disease: Is Inflammasome a missing link? CNS disease Conference 2019 | 16 Sep 2019
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Treating methicillin-resistant Staphylococcus aureus (MRSA) with synergistic drug combinations Clinical Pharmacology Conference 2017 | 14 Dec 2017
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Piper sarmentosum Roxb. confers neuroprotection by inhibiting microglia-mediated neuroinflammation Natural Products & Bioactive Compounds Gordon Research Conference 2017 | 29 Jul 2017
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Galloylated Flavonol Glycosides from Leaves of Calliandra tergemina with Antibacterial Activities against Methicillin-Resistant Staphylococcus aureus (MRSA) The American Society of Pharmacognosy's annual meeting 2013 | 14 Jul 2013


Supervisions
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Ng Jia Hao | Master (Research) | 01 Apr 2021 Thesis: Functional role of MIRO1 in NLRP1 inflammasome-mediated neuronal cell death
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AGNES GWENHURE | Master (Coursework) | 01 Mar 2021 Thesis: Mechanistic studies on the neuroprotective effect of beta-sitosterol during beta amyloid-induced microglia-mediated neuro-inflammation
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Tan Wai Keat | Master (Mixed Mode) | 01 Dec 2019 - 23 May 2020 Thesis: Risk Factors And Interventions Outcomes Associated With Falls Among Community-Dwelling Elderly In Malaysia
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Agilandiswari Arumuga Jothi | Undergraduate | 01 Jun 2019 - 30 Sep 2020 Thesis: The Effects Of β-Sitosterol On Aβ-Induced Microglia-Mediated Neuroinflammation
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Alan Yaw Cheuk Keong | Master (Mixed Mode) | 25 Feb 2019 - 30 Sep 2020 Thesis: Role of NLRP3 Inflammasome In Lipopolysaccharides-Induced Pancreatic Cancer Cell Proliferation And Development
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JEREMY YAP KEAN YI | Master (Research) | 01 Aug 2016 - 31 Jul 2020 Thesis: A GENE TRAP MUTAGENESIS APPROACH FOR THE IDENTIFICATION OF NLRP1 INFLAMMASOME ACTIVATION TARGETS MEDIATING AMYLOID-β-INDUCED NEURONAL PYROPTOSIS

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