Purushotham Krishnappa



Salutation
Professor

School/Centre
School of Medicine

Department
Pathology

Appointment
Associate Dean, Student Affairs (School of Medicine)

Position
Professor

Email
purushotham_krishnappa@imu.edu.my

Professional Network


Education

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Postgraduate Diploma in Medical Education (Medical Education), 2024 University of Dundee
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Postgraduate Certificate in Medical Education (Medical Education), 2023 University of Dundee
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Doctor of Medicine (MD) (Pathology), 2006 Rajiv Gandhi University of Health Sciences
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Bachelor of Medicine and Bachelor of Surgery (Medicine), 2001 Bangalore University

Memberships

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College of American Pathology Ordinary Member 2018 - Present
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Royal College of Pathology - UK Diplomate 2015 - Present
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Malaysian Medical Association Ordinary Member 2013 - Present

Research Funding
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Study to elucidate the involvement of Dynamin-related protein 1 (Drp1) signalling pathways in oestrogen-regulated mitochondrial dynamic and biogenesis in breast cancer cell line IMU Internal Research Grant | 06 Feb 2025 - 31 Dec 2026
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Evaluation of the role of inflammatory protein biomarkers LAMA2, MLL4 and PLXDC2 as a predictor for diabetes IMU Internal Research Grant | 07 Jan 2025 - 04 Jul 2025
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Immersive technology for Faculty Development: Exploring usefulness for improving lecture delivery skills among early career academicians IMU Internal Research Grant | 10 Oct 2024 - 31 Dec 2025
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Overcoming Educational Barriers: Tailored Science Teaching for Grade 8 Refugee Students (IMU University & British Pharmacological Society initiative) IMU Internal Research Grant | 20 Sep 2024 - 19 Sep 2025
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Studies to investigate mechanisms of protective effect of Atorvastatin against NMDA-induced Excitotoxic Retinal Injury in Rats: Role of Autophagy IMU Internal Research Grant | 05 Sep 2024 - 30 Jun 2027
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Neuroprotective Effect of Atorvastatin: Understanding Lipid Raft-Mediated Modulation of NMDA Excitotoxicity in Glaucoma IMU Internal Research Grant | 01 Sep 2024 - 31 Aug 2027
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Anti-hypercholesterolemia and anti-obesity effects of polyherbal formulations (PHFs) in high-fat diet -induced rats IMU Internal Research Grant | 01 Mar 2024 - 31 Jul 2024
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Development of an automated decision support tool for diagnosis of Thyroid lesions through fine needle aspirates using machine learning algorithms (Artificial Intelligence). IMU Internal Research Grant | 01 Jan 2024 - 30 Jun 2024
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Study to elucidate the involvement of Drp1 signaling pathways in oestrogen-regulated mitochondrial dynamics in ER-postive breast cancer cell lines FRGS | 01 Nov 2023 - 31 Dec 2027
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Mechanisms of the protective effects of atorvastatin against NMDA-induced retinal injury in rats: focus on PPAR-α/CREB pathway and glial activation IMU Internal Research Grant | 01 Oct 2023 - 30 Sep 2027
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Role of sphingolipid rheostat in the neuroprotective effect of atorvastatin against NMDA-induced excitotoxic retinal injury IMU Internal Research Grant | 01 Apr 2023 - 31 Mar 2026
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Determination of the role of Dynamin-related protein 1 post-translational modification (phosphoDrp1) in ER-positive human breast cancer samples IMU Internal Research Grant | 10 Mar 2023 - 31 Dec 2024
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Combination of hormonal therapy and mitochondrial-targeted therapy as a novel strategy for breast cancer treatment Bachelor in Medical Sciences (Hons) | 01 Jan 2022 - 30 Jun 2021
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Comparative study of connective tissue and carbohydrate preservation in formalin-fixed and alternative fixatives-fixed tissues in mouse tissue sections Bachelor of Science (Hons) in Biomedical Science | 14 Jun 2021 - 18 Sep 2021
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Comparative study of Methyl Green Pyronin Y (MGPY) staining in formalin-fixed and alternative fixatives-fixed tissues in histological visualization of nucleic acid in mouse tissue sections IMU | 01 Jul 2020 - 01 Oct 2020
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Comparative Study of Xylene-free Hematoxylin and Eosin (H & E) Staining Procedure with Conventional H & E Staining on Morphological Quality of Tissue Sections IMU | 01 Jul 2020 - 01 Oct 2022
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Analysis of students’ satisfaction and effectiveness on light microscopy and virtual microscopy in teaching learning sessions of undergraduate medical course: A randomized cross-over trial study IMU | 01 Mar 2020 - 01 Feb 2021
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Association of Clinicopathological Parameters of Colorectal Cancer and Diabetes Mellitus: A Hospital Based Descriptive study IMU | 01 Feb 2020 - 01 Jul 2021
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Comparative Study of Microwave Oven Assisted Tissue Processing with Xylene and Xylene Substitutes on Morphological Quality of Tissue Sections IMU | 01 Jul 2019 - 01 Oct 2019
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Development of an automated decision support tool for pancreatic diagnosis through fine needle aspirates using deep convolution neural network Internal IMU-Pancreatic Cancer Challenge Grant | 25 Feb 2019 - 31 May 2020
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Development of an automated decision support tool for pancreatic diagnosis through fine needle aspirates using deep convolution neural network Internal IMU-Pancreatic Cancer Challenge Grant | 25 Feb 2019 - 31 May 2020
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Effect of two different meal compositions on plasmaghrelin levels in young adultmale Asians with BMI in the normal and overweight range IMU | 01 Feb 2019 - 01 Jun 2019
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Comparative Study of Microwave Oven Assisted Tissue Processing and Conventional Method of Tissue Processing on Turnaround Laboratory Time and Morphological Quality of Tissue Sections IMU | 01 Jan 2018 - 01 Nov 2018
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Diagnostic role of micro vascular density in the evaluation of neoplastic cervical lesions in Hospital Tuanku Ja’afar, Seremban. Study was carried out at IMU, Kuala Lumpur, Malaysia BMedScience | 01 Jan 2015 - 31 Dec 2015
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Effect of madecassoside in reducing oxidative stress and blood glucose and in protecting the β-cells in streptozotocin-nicotinamide induced diabetes in rats FRGS | 01 Jan 2014 - 01 Dec 2017
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Estimating CD40 polymorphism as a risk factor for cervical cancer in a subset of Malaysian population” BMedScience | 01 Jan 2013 - 31 Dec 2013
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Role of p16 Immunohistochemistry investigation in high risk Human papilloma virus (HR-HPV) related lesions of uterine cervix in Hospital Tuanku Ja’afar, Seremban BMedScience | 01 Jan 2012 - 31 Dec 2012
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“Histomorphology and Immunohistochemistry characteristics of Gastrointestinal Stromal Tumors (GISTs) in Malaysia” BMedScience | 01 Jan 2011 - 31 Dec 2011

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Publications

Research Articles

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Daily Supplementation of High Doses of Tocotrienol‐Rich Fraction From Palm Oil Produced No Toxic Effects in Healthy Mice JOURNAL OF TOXICOLOGY 2025
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Limitation of cane sugar solution as a tissue fixative for glycogen preservation in mouse liver THE MEDICAL JOURNAL OF MALAYSIA 2025
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A Study of the Association between Colorectal Cancer and Diabetes Mellitus in a Tertiary Hospital in Malaysia AVAILABLE AT SSRN 4973394 2025
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Recent advances in breast cancer metastasis with special emphasis on metastasis to the brain PATHOLOGY-RESEARCH AND PRACTICE 2024
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Protective effects of madecassoside, a triterpenoid from Centella asiatica, against oxidative stress in INS-1E cells NATURAL PRODUCT RESEARCH 2024
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N-Methyl-d-Aspartate-Induced Excitotoxicity and Its Impact on the Renin–Angiotensin System in Retinal Tissue JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS 2024
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ANALYSIS OF STUDENTS'SATISFACTION AND EFFECTIVENESS OF VIRTUAL MICROSCOPY IN UNDERGRADUATE PATHOLOGY TEACHING: A RANDOMISED CROSS-OVER TRIAL STUDY. INTERNATIONAL E-JOURNAL OF SCIENCE, MEDICINE & EDUCATION 2024
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A comparative study of microwave oven-assisted tissue processing and conventional method of tissue processing on turnaround laboratory time and morphological quality of tissue … MED J MALAYSIA 2023
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Natural fixatives alternative to formalin in histopathology: A systematic review MEDICAL JOURNAL OF MALAYSIA 2023
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Effect of madecassoside in reducing oxidative stress and blood glucose in streptozotocin–nicotinamide-induced diabetes in rats JOURNAL OF PHARMACY AND PHARMACOLOGY 2023
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THE DIABETIC WOUND HEALING ABILITIES OF THE AQUEOUS ETHANOLIC EXTRACT OF TINOSPORA CORDIFOLIA STEM IN STREPTOZOTOCIN--NICOTINAMIDE INDUCED DIABETIC RATS AUTHOREA PREPRINTS 2023
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Effect of Two Different Meal Compositions on 1-hour Plasma Ghrelin Levels in Young Men MALAYSIAN JOURNAL OF MEDICINE AND HEALTH SCIENCES 2023
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The Diabetic Wound Healing Abilities of the Aqueous Ethanolic Extract of Tinospora Cordifolia STEM in Streptozotocin-Induced Diabetic Rats ESS OPEN ARCHIVE EPRINTS 2023
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Non-Hodgkin lymphoma research (excluding all B cell lymphoma) in Malaysia: A review INTERNATIONAL E-JOURNAL OF SCIENCE, MEDICINE AND EDUCATION 2023
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Quercetin and metformin synergistically reverse endothelial dysfunction in the isolated aorta of streptozotocin-nicotinamide-induced diabetic rats SCIENTIFIC REPORTS 2022
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Comparative Study of Microwave Oven-Assisted Tissue Processing with Isopropanol and Mineral Oil Mixture and Propylene Glycol Methyl Ether on Morphological Quality of Tissue Sections IIUM MEDICAL JOURNAL MALAYSIA 2021
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Comparative Study of Microwave Oven-Assisted Tissue-Processing with Xylene and Xylene Substitutes on Morphological Quality of Tissue Sections INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH 2021
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Comparative Study of Microwave Oven-Assisted Tissue-Processing with Xylene and Xylene Substitutes on Morphological Quality of Tissue Sections. INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH (09752366) 2021
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Gastro Intestinal Stromal Tumors – A review of literature. WORLD JOURNAL OF PHARMACEUTICAL AND MEDICAL RESEARCH 2020
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Current Trend in Diagnosis of Tuberculosis Infection INTERNATIONAL JOURNAL OF COLLABORATIVE RESEARCH ON INTERNAL MEDICINE AND PUBLIC HEALTH 2019
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Student preparedness characteristics important for clinical learning: perspectives of supervisors from medicine, pharmacy and nursing BMC MEDICAL EDUCATION 2017
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Effect of probiotic microbial cell preparation (MCP) on fasting blood glucose, body weight, waist circumference, and faecal short chain fatty acids among overweight Malaysian adults: a pilot randomised controlled trial of 4 weeks MALAYSIAN JOURNAL OF NUTRITION 2017
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CD40 polymorphism in cervical carcinoma in a subset of Malaysian population JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH 2017
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Histomorphology and immunohistochemistry of gastrointestinal stromal tumors in a Malaysian population ASIAN PAC J CANCER PREV 2016
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A Histomorphological and Immunohistochemical study of Gastrointestinal stromal tumors in Hospital Tuanku Ja’afar Seremban, Malaysia ASIAN PACIFIC JOURNAL OF CANCER PREVENTION 2016
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Multi centre study from Malaysia on student preparedness for clinical learning-Perspectives of lecturers and students from medicine, pharmacy and allied health sciences PROCEEDINGS OF ANNUAL SCIENTIFIC SESSIONS OF FACULTY OF MEDICAL SCIENCES 2015
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The protective action of the aqueous extract of auricularia polytricha in paracetamol induced hepatotoxicity in rats. MALAYSIAN JOURNAL OF PHARMACY 2015
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GENE POLYMORPHISM IN CERVICAL CANCER INTERNATIONAL JOURNAL OF CURRENT MEDICAL AND PHARMACEUTICAL RESEARCH 2015
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The protective action of the aqueous extract of Auricularia polytricha in paracetamol induced hepatotoxicity in rats RECENT PATENTS ON DRUG DELIVERY & FORMULATION 2015
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Usefulness of Fine needle aspiration cytology in the evaluation of the Nodular Goiter with histopathological correlation SCIENCES JOURNAL 2014
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CYTOLOGICAL EVALUATION OF THYROID LESIONS BY FINE NEEDLE ASPIRATION VERSUS NON-ASPIRATION CYTOLOGY TECHNIQUES-A COMPARATIVE STUDY INTERNATIONAL JOURNAL OF CURRENT RESEARCH AND REVIEW 2014
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NEOPLASTIC LESIONS OF THYROID–KEY CYTODIAGNOSTIC CHARACTERISTICS INT J MED PHARM SCI 2014
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Expression of P16 in high-risk human papillomavirus related lesions of the uterine cervix in a government hospital, Malaysia DIAGNOSTIC PATHOLOGY 2014
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Journal of Molecular Pathophysiology JOURNAL OF MOLECULAR PATHOPHYSIOLOGY 2013
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CYTOLOGICAL FEATURES OF NON-NEOPLASTIC LESIONS OF THYROID: An overview V CARE FOR LIFE SCIENCE JOURNAL 2013
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“ROLE OF P16 IMMUNOHISTOCHEMISTRY INVESTIGATION IN HIGH-RISK HUMAN PAPILLOMAVIRUS RELATED LESIONS OF THE UTERINE CERIX IN HOSPITAL TUANKU JA'AFAR, MALAYSIA”. THE INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER 2013
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Paediatric Lymphadenopathy–A clinicopathological review. JOURNAL OF MOLECULAR PATHOPHYSIOLOGY 2013
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Comparison of free hand versus ultrasound-guided fine needle aspiration of thyroid with histopathological correlation JOURNAL OF ENVIRONMENTAL PATHOLOGY, TOXICOLOGY AND ONCOLOGY 2013
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Follicular Carcinoma Of The Thyroid Presenting As Distant Metastases: A Case Report And Review Of The Literature. JOURNAL OF LABORATORY MEDICINE 2012
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Convocation IMU 2012
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Follicular carcinoma of the thyroid presenting as distant metastasis: A case report and review of literature THE INTERNET JOURNAL OF LABORATORY MEDICINE. 2012
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Telepathology–an update INTERNATIONAL JOURNAL OF COLLABORATIVE RESEARCH ON INTERNAL MEDICINE & PUBLIC HEALTH 2012
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Occult Papillary Carcinoma Thyroid presenting as Lateral Cystic Neck Mass.–A Case Report & Review of Literature THE INTERNET JOURNAL OF PATHOLOGY 2009

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Other Publications

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Madecassoside protects pancreatic beta cells from glucotoxicity and oxidative stress British Journal of Pharmacology | 01 Jan 2019


Supervisions
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Wong Jing Yi | Master (Research) | 01 Apr 2023 - 31 Dec 2024 Thesis: Role of sphingolipid rheostat in the neuroprotective effect of atorvastatin against NMDA-induced excitotoxic retinal injury
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Leong Wen Kang | Undergraduate | 10 Mar 2023 - 31 Dec 2024 Thesis: Determination of the role of Dynamin-related protein 1 post-translational modification (phosphoDrp1) in ER-positive human breast cancer samples
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Adriana | Undergraduate | 01 Jul 2020 - 01 Oct 2020 Thesis: Comparative study of Methyl Green Pyronin Y (MGPY) staining in formalin-fixed and alternative fixatives-fixed tissues in histological visualization of nucleic acid in mouse tissue sections
a
Ong Finnee | Undergraduate | 01 Jan 2018 - 01 Nov 2018 Thesis: Comparative Study of Microwave Oven Assisted Tissue Processing and Conventional Method of Tissue Processing on Turnaround Laboratory Time and Morphological Quality of Tissue Sections
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Lim Sin Ling | Undergraduate | 01 Jan 2015 - 31 Dec 2015 Thesis: Diagnostic role of micro vascular density in the evaluation of neoplastic cervical lesions in Hospital Tuanku Ja’afar, Seremban. Study was carried out at IMU, Kuala Lumpur, Malaysia
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Kong Jeffrey Hong Mun | Undergraduate | 01 Jan 2013 - 31 Dec 2013 Thesis: Estimating CD40 polymorphism as a risk factor for cervical cancer in a subset of Malaysian population”
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Yip Jo Lin | Undergraduate | 01 Jan 2012 - 31 Dec 2012 Thesis: Role of p16 Immunohistochemistry investigation in high risk Human papilloma virus (HR-HPV) related lesions of uterine cervix in Hospital Tuanku Ja’afar, Seremban
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Lo Eu Jin | Undergraduate | 01 Jan 2011 - 31 Dec 2011 Thesis: “Histomorphology and Immunohistochemistry characteristics of Gastrointestinal Stromal Tumors (GISTs) in Malaysia”

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