SREENIVASA RAO SAGINEEDU



Salutation
Associate Professor Dr

School/Centre
School of Pharmacy

Department
Pharmaceutical Chemistry

Appointment
Head of Department, Pharmaceutical Chemistry

Position
Associate Professor

Email
sreenivasarao@imu.edu.my



Education

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PhD (Medicinal Chemistry), 2011 Universiti Putra Malaysia
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MPharm (Pharmacognosy), 1998 Andhra Univerisity
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BPharm (Pharmacy), 1996 Andhra Univerisity

Memberships

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Royal Society of Chemistry, UK Chartered Chemist and MRSC 2013 - Present

Research Funding
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Comparative analysis of commercial ω-3 fish-oils in correlation with their composition and biological activity: A chemometric study using chromatographic and spectroscopic methods. IMU Internal Research Grant | 01 Jul 2024 - 28 Feb 2025
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Phytochemical Composition and Antioxidant Activity of Commercial Green Tea Leaves: A Comparative Study using 2D-Thin Layer Chromatography IMU Internal Research Grant | 01 Mar 2024 - 30 Jun 2024
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Development, characterization, and in vitro evaluation of topical cream containing essential oil of Vernonia amygdalina leaves to enhance its anti-inflammatory property IMU Internal Research Grant | 21 Sep 2023 - 31 Jan 2024
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Evaluation of the potential of chemometrics-assisted FTIR spectroscopy for authentication analysis of selected commercial medicinal essential oils IMU | 01 Apr 2021 - 01 Jun 2021
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Anti-proliferative activity of labdane diterpenoid lactones and selected derivatives on psoriatic and lung cancer cell lines IMU | 01 Jun 2020 - 01 Sep 2020
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Molecular insights into the action of new andrographolide derivatives as anti-psoriatic agents. FRGS | 01 Sep 2019 - 01 Jun 2023
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Development of a novel HPLC Method to Quantify Acitretin in Nanoformulation IMU | 01 Jun 2019 - 01 Oct 2019
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Investigation of Molecular Mechanisms of Antiatherosclerotic Effect of Labdane Diterpenoid Lactones of Andrographis Paniculata IMU | 01 Jul 2018 - 01 Dec 2018
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Deciphering the Interplay between Autophagy and Apoptosis in Cancer Models Treated with RAS-Inhibitors FRGS | 15 Aug 2017 - 01 Nov 2020
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Elucidation of antiinflammatory mechanisms of action of SRS143 as an antiasthma agent FRGS | 01 Nov 2015 - 31 Oct 2017
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Hit to Lead Optimisation: Synthesis and Biological Evaluation of New Thienopyrimidine Derivatives as Potential Antagonists eSciencefund | 01 May 2015 - 01 Oct 2017
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Efficacy of Andrographis paniculata in preventing the atherosclerosis induced by high-cholesterol diet in vivo NRGS | 01 Jan 2015 - 17 Jun 2016
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Prophylaxis of asthma and COPD via inhibition of inflammatory mediators in the lungs by A. paniculata NRGS | 01 Jan 2015 - 30 Jun 2017
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Swietenine potentiates the antidiabetic activity of metformin: Identification of molecular mechanisms involved. FRGS | 01 Jul 2014 - 30 Jun 2016
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Blocking Signalling in Cancer Stem Cells to Eradicate Relapse in Cancer Chemotherapy FRGS | 01 Dec 2013 - 31 Dec 2015
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Synthesis of Drug-like ent-Labdane Diterpenoids as Neuroprotective Agents Targeting Amyloid-ß-Induced Neurotoxicity by Suppressing NF-kB and ROS eSciencefund | 01 Jul 2013 - 30 Jun 2016
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Chemical Pharmacophores for the Development of New Generation Broad Spectrum Antibiotics Effective Against Multi-Drug Resistant Bacteria FRGS | 01 Jul 2013 - 31 Jul 2015
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Structure-based optimisation of the novel compound tetrahydrothiazolopyridine for the treatment of obesity ERGS | 01 Apr 2013 - 31 Mar 2015
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Identification Of Chemical Pharmacophores For Development of New Generation Broad Spectrum Antibiotics FRGS | 01 Apr 2013 - 31 Mar 2015
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SRJ23 and its Derivatives as New Anticancer agents Targeting RAS-MAP Kinase and NF-kB Pathways: In Vitro & In Vivo RUGS | 01 Jul 2012 - 31 Dec 2014

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Publications

Research Articles

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More than just a KRAS inhibitor: DCAI abrogates the self-renewal of pancreatic cancer stem cells in vitro ONCOLOGIE 2023
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The impact of cycleanine in cancer research: a computational study JOURNAL OF MOLECULAR MODELING 2022
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Melanoma metastasis: What role does melanin play? ONCOLOGY REPORTS 2022
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Pancreatic cancer treatment with targeted therapies: are we there yet? EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES 2022
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Interplay Between Autophagy And Apoptosis In A Pancreatic Cancer Cell Line Treated With SRJ23, Gemcitabine Or Combination Of Both Agents. MALAYSIAN JOURNAL OF MEDICINE & HEALTH SCIENCES 2022
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Pharmacological Modulation of Apoptosis and Autophagy in the Treatment of Pancreatic Cancer MINI REVIEWS IN MEDICINAL CHEMISTRY 2022
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Toxicological and pharmacokinetic analysis at therapeutic dose of SRS27, an investigational anti-asthma agent NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY 2021
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Microarray-based identification of differentially expressed genes associated with andrographolide derivatives-induced resistance in colon and prostate cancer cell lines TOXICOLOGY AND APPLIED PHARMACOLOGY 2021
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In silico and saturation transfer difference NMR approaches to unravel the binding mode of an andrographolide derivative to K-Ras oncoprotein FUTURE MEDICINAL CHEMISTRY 2020
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In silico and saturation transfer difference NMR approaches to unravel the binding mode of an andrographolide derivative to K-Ras oncoprotein (vol 12, pg 1611, 2020) FUTURE MEDICINAL CHEMISTRY 2020
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AK‐RAS Inhibitor Abrogates Self‐Renewal of Pancreatic Cancer Stem Cells via K‐RAS–NF‐κB–SOX2 Axis THE FASEB JOURNAL 2020
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Advances and challenges in developing andrographolide and its analogues as cancer therapeutic agents DRUG DISCOVERY TODAY 2019
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Edible foxtail millet flour stabilises and retain the in vitro activity of blueberry bioactive components INTERNATIONAL JOURNAL OF FOOD SCIENCE & TECHNOLOGY 2018
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A semisynthetic diterpenoid lactone inhibits NF-κB signalling to ameliorate inflammation and airway hyperresponsiveness in a mouse asthma model TOXICOLOGY AND APPLIED PHARMACOLOGY 2016
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SRJ09, a promising anticancer drug lead: Elucidation of mechanisms of antiproliferative and apoptogenic effects and assessment of in vivo antitumor efficacy PHARMACOLOGICAL RESEARCH 2016
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SRS06, a new semisynthetic andrographolide derivative with improved anticancer potency and selectivity, inhibits nuclear factor-κB nuclear binding in the A549 non-small cell lung cancer cell line PHARMACOLOGY 2015
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Acute oral toxicity studies of Swietenia macrophylla seeds in Sprague Dawley rats PHARMACOGNOSY RESEARCH 2015
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靶向 K-ras 的半合成穿心莲内酯衍生物: 发现潜在抗癌药物先导物的有效方法 (英文) >**'**,-- 2015
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Salt stress-induced protein pattern associated with photosynthetic parameters and andrographolide content in Andrographis paniculata Nees BIOSCIENCE, BIOTECHNOLOGY, AND BIOCHEMISTRY 2015
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Stress degradation studies and development of a validated RP-HPLC method for determination of tiagabine in presence of its degradation products INTERNATIONAL JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES 2015
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Targeting the undruggable KRAS: In vitro anticancer property of andrographolide and its semisynthetic analogues in pancreatic adenocarcinoma cell lines harbouring oncogenic mutant K-ras >**'**,-- 2015
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SRS27, a semisynthetic diterpenoid lactone, inhibits airway inflammation and hyper-responsiveness via NF-κB pathway in an allergic mouse asthma model >**'**,-- 2015
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In vitro 3D colon tumor penetrability of SRJ09, a new anti-cancer andrographolide analog INVESTIGATIONAL NEW DRUGS 2014
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SRJ09, a semisynthetic anticancer agent, targets Ras-MAPK signaling pathway: assessment in breast and colon cancer cell lines CANCER RESEARCH 2014
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A stability-indicating RP-HPLC method for simultaneous determination of simvastatin and niacin in a combined dosage form INTERNATIONAL JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES 2014
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NCI in vitro and in silico anticancer screen, cell cycle pertubation and apoptosis-inducing potential of new acylated, benzylidene and isopropylidene derivatives of andrographolide ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 2014
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SRJ23, a new semisynthetic andrographolide derivative: in vitro growth inhibition and mechanisms of cell cycle arrest and apoptosis in prostate cancer cells CELL BIOLOGY AND TOXICOLOGY 2014
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In vitro 3D evaluation of penetrability of SRJ09, a semisynthetic anticancer agent (1048.4) THE FASEB JOURNAL 2014
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A classical genetic solution to enhance the biosynthesis of anticancer phytochemicals in Andrographis paniculata Nees PLOS ONE 2014
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Andrographolide derivatives inhibit guanine nucleotide exchange and abrogate oncogenic Ras function PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES 2013
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Prevalence of macrolide resistance and in vitro activities of six antimicrobial agents against clinical isolates of Streptococcus pneumoniae from a multi-center surveillance in Malaysia MED J MALAYSIA 2013
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Analysis of the anticancer phytochemicals in Andrographis paniculata Nees. under salinity stress BIOMED RESEARCH INTERNATIONAL 2013
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Abstract C147: Mechanism of resistance to a semisynthetic anticancer andrographolide derivative: Possible involvement of Ras-MAPK signaling pathway. MOLECULAR CANCER THERAPEUTICS 2013
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SRJ23, a potent inducer of cell cycle arrest and apoptosis in prostate cancer cells THE FASEB JOURNAL 2012
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Andrographolide and its analogues: versatile bioactive molecules for combating inflammation and cancer CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY 2012
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Andrographolide induces cell cycle arrest and apoptosis in PC-3 prostate cancer cells AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY 2011
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Andrographolide as a template in the synthesis of new anticancer agents with potentially novel molecular targets THE FASEB JOURNAL 2010
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132 POSTER SRJ09, a lead compound in anticancer drug design: in vitro, in vivo and mechanistic studies EUROPEAN JOURNAL OF CANCER SUPPLEMENTS 2008
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14-Deoxy-11, 12-didehydro-3, 19-isopropylideneandrographolide ACTA CRYSTALLOGRAPHICA SECTION E: STRUCTURE REPORTS ONLINE 2006
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3, 19-(2-Bromobenzylidene) andrographolide ACTA CRYSTALLOGRAPHICA SECTION E: STRUCTURE REPORTS ONLINE 2006
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3, 19-(2, 6-Dimethoxybenzylidene) andrographolide ACTA CRYSTALLOGRAPHICA SECTION E: STRUCTURE REPORTS ONLINE 2006
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Phytochemicals from Phyllanthus niruri Linn. and their pharmacological properties: a review JOURNAL OF PHARMACY AND PHARMACOLOGY 2006
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SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF GATIFLOXACIN ORIENTAL JOURNAL OF CHEMISTRY 2003

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Other Publications

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Virtual Educational Field Trips: Making meaningful engagement possible for remote learning environments Variety in Chemistry Education and the Physics Higher Education Conference (ViCEPhEC2020) | 17 Aug 2020
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Assessment of Competence in Medicine and Health Professions OTTAWA 2020 | 28 Feb 2020
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Synthesis and biological evaluation of new benzylidene derivatives of 12,13-dihydroandrographolide analogues as neuroprotective agents 47th IUPAC World Chemistry Congress (IUPAC 2019) | 05 Jul 2019
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Leveraging the Versatility of Cloud-based Apps to Foster 4C's of Learning: A Case of Facilitating Hands-on Workshop on Structure Determination 47th IUPAC World Chemistry Congress (IUPAC 2019) | 05 Jul 2019
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Leveraging reliability and versatility of cloud-based apps to foster critical thinking and collaborative skills in synchronous learning environments 10th Asian Medical Education Association Symposium (AMEA 2019) | 12 Apr 2019
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Quantitative analysis of andrographolide, a biomarker of Andrographis paniculata, using qNMR spectroscopy International Conference on Drug Discovery and Translational Medicine 2018 (ICDDTM'18) | 03 Dec 2018
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Determination of the Binding Mode of An Andrographolide Derivative to K-Ras Oncoprotein via Molecular Modelling and STD-NMR Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018 (The 18th World Congress of Basic and Clinical Pharmacology) | 01 Jan 2018
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DRUGGING THE ELUSIVE RAS ONCOPROTEIN WITH SEMISYNTHETIC ANDROGRAPHOLIDE DERIVATIVES Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018 (The 18th World Congress of Basic and Clinical Pharmacology) | 01 Jan 2018
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Protection and Deprotection of 1,2- and 1,3-Diols as Acetonides using PVP/Iodine, a mild, efficient and reusable catalyst International Conference | 21 Aug 2016
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A stability-indicating RP-HPLC method for simultaneous determination of simvastatin and niacin in a combined dosage form Drug Analysis 2014 | 22 Jun 2014
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SRJ23, A NEW INVESTIGATIONAL ANTI‐PROSTATE CANCER AGENT FASEB Journal | 01 Jan 2010
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H-bonds in andrographolide and related molecules: Neutron diffraction, database and modeling studies Acta Crystallographica A - Foundation and Advances | 01 Jan 2008

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Supervisions
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Dineshwar Sugumaran | Doctorate | 15 Sep 2022 Thesis: Molecular insights into the action of new andrographolide derivatives as anti-psoriatic agents PhD Co- supervisor In progress
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Lee Jie Ying | Undergraduate | 15 Aug 2022 - 15 Oct 2022 Thesis: Phytochemical profiling and evaluation of antioxidant and antibacterial potential of polyphenolic-rich fractions of selected medicinal plants of Malaysia
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Kiberly Tan Hwee | Undergraduate | 15 Aug 2022 - 15 Oct 2022 Thesis: Phytochemical profiling and evaluation of antioxidant and antibacterial potential of polyphenolic-rich fractions of selected medicinal plants of Malaysia
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Raden Seri Shazrina | Undergraduate | 15 Aug 2022 - 15 Oct 2022 Thesis: Phytochemical profiling and evaluation of antioxidant and antibacterial potential of polyphenolic-rich fractions of selected medicinal plants of Malaysia
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Reginia Ho Qin Qing | Undergraduate | 15 Apr 2022 - 15 Jun 2022 Thesis: Composition and variability of selected medicinal essential oils in correlation with their antioxidant properties in vitro: A chemometrics approach using ATR-FTIR and NMR spectroscopies (Apr- Jun 2022)
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Yew Siu Hui | Undergraduate | 15 Apr 2022 - 15 Jun 2022 Thesis: Composition and variability of selected medicinal essential oils in correlation with their antioxidant properties in vitro: A chemometrics approach using ATR-FTIR and NMR spectroscopies (Apr- Jun 2022)
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Lee Zin Chee | Undergraduate | 15 Apr 2022 - 15 Jun 2022 Thesis: Composition and variability of selected medicinal essential oils in correlation with their antioxidant properties in vitro: A chemometrics approach using ATR-FTIR and NMR spectroscopies (Apr- Jun 2022)
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Shawnice Lim Xiao Shian | Undergraduate | 15 Apr 2021 - 15 Jun 2021 Thesis: Evaluation of the potential of chemometrics-assisted FTIR spectroscopy for authentication analysis of selected commercial medicinal essential oils
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Dorea Soong Shi Hui | Undergraduate | 15 Apr 2021 - 15 Jun 2021 Thesis: Evaluation of the potential of chemometrics-assisted FTIR spectroscopy for authentication analysis of selected commercial medicinal essential oils
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Tuang Ling Kai | Undergraduate | 15 Apr 2021 - 15 Jun 2021 Thesis: Evaluation of the potential of chemometrics-assisted FTIR spectroscopy for authentication analysis of selected commercial medicinal essential oils
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Kiranjeet Kaur Bajwa | Undergraduate | 15 Apr 2021 - 15 Jun 2021 Thesis: Evaluation of the potential of chemometrics-assisted FTIR spectroscopy for authentication analysis of selected commercial medicinal essential oils
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Ramesh Ranggasamy | Doctorate | 15 Nov 2018 Thesis: Immunomodulatory Activity of Standardised Aqueous Ethanolic Extract of Moringa oleifera Lam. Leaves In vivo
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Nityaa Selvarajoo | Master (Research) | 15 Feb 2018 - 15 Jun 2022 Thesis: Interplay between autophagy and apoptosis in gemcitabine resistant pancreatic cancer
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Sopna Devi Ravindran | Master (Research) | 15 Feb 2018 - 15 Jun 2022 Thesis: Deciphering the interplay between autophagy and apoptosis in gemcitabine resistant pancreatic cancer MSc Co- supervisor 2022
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Ogochukwu Ngozi | Doctorate | 03 Nov 2017 - 30 Dec 2022 Thesis: An Ethnobotanical Study of Anticancer Plants and Bioactivity-guided isolation of Cytotoxic agents from Synchlisia scabrida
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Zhi Sam Tai | Master (Mixed Mode) | 15 Sep 2017 - 15 Mar 2018 Thesis: Efficacy and molecular mechanism studies of 14-deoxy-11,12-didehydroandrographolide in regression of poloxamer 407-induced atherosclerosis in mouse model
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Quah Shun Ying | Doctorate | 15 Nov 2016 - 10 Jul 2021 Thesis: SRJ23 and its Derivatives as New Anticancer Agents Targeting Ras-Map Kinase and NF-Kb Pathways: In Silico and In Vivo approaches
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Yamen Al Khateeb | Master (Mixed Mode) | 15 Sep 2016 - 15 Mar 2017 Thesis: In-Vivo Pharmacokinetics and Oral Bioavailability of Andrographolide in SMEDDS, Formulation using HPLC
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Toh Boon Ling | Undergraduate | 15 Jun 2016 - 15 Sep 2016 Thesis: Comparative quantitative analysis of andrographolide, a biomarker of Andrographis paniculata by chromatography, ATR-FTIR and qNMR spectroscopy
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Chu Vun San | Undergraduate | 15 Jun 2016 - 15 Sep 2016 Thesis: Comparative quantitative analysis of andrographolide, a biomarker of Andrographis paniculata by chromatography, ATR-FTIR and qNMR spectroscopy
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Phang Sze Ying | Undergraduate | 15 Jun 2016 - 15 Sep 2016 Thesis: Comparative quantitative analysis of andrographolide, a biomarker of Andrographis paniculata by chromatography, ATR-FTIR and qNMR spectroscopy
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Kong La Ling | Undergraduate | 15 Jun 2016 - 15 Sep 2016 Thesis: Comparative quantitative analysis of andrographolide, a biomarker of Andrographis paniculata by chromatography, ATR-FTIR and qNMR spectroscopy
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Tan Khai Shin | Master (Mixed Mode) | 15 Dec 2015 - 15 Dec 2016 Thesis: Drug-like labdane diterpenes as neuroprotective agents: Synthesis and evaluation of NF-Kb inhibitory property and in vitro metabolic stability
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Rajakumari Rajasingam | Master (Mixed Mode) | 15 Dec 2014 - 15 Sep 2015 Thesis: Stress Degradation Studies on Tiagabine and Development of a Validated RP-HPLC Method for its Determination in Bulk and Dosage Forms
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Teh Yuan Han | Doctorate | 30 Nov 2014 - 12 Jun 2020 Thesis: Blocking Signalling through CD44 in Pancreatic Cancer Stem Cells. PhD Co- supervisor 2020
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Tan Yee Hon | Master (Mixed Mode) | 15 Sep 2014 - 15 Mar 2015 Thesis: Identification and quantification of various synthetic adulterants in registered herbal supplements in Malaysia: a preliminary study using LCMS
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Yogeshini Batumalai | Undergraduate | 15 Aug 2014 - 15 Dec 2014 Thesis: Neuroprotective Activity of Andrographolide Analogues in Neuronal Cell lines
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Hema A/P Balakrishnan | Undergraduate | 15 Aug 2014 - 15 Dec 2014 Thesis: Neuroprotective Activity of Andrographolide Analogues in Neuronal Cell lines
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Tong Tze Hau | Undergraduate | 15 Jul 2014 - 15 Dec 2014 Thesis: Neuroprotective Activity of Andrographolide Analogues in Neuronal Cell lines
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Albert Tan Bean Yao | Undergraduate | 15 Jul 2014 - 15 Dec 2014 Thesis: Neuroprotective Activity of Andrographolide Analogues in Neuronal Cell lines
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Augustine Foong Hua Yi | Undergraduate | 15 Jul 2014 - 15 Dec 2014 Thesis: Neuroprotective Activity of Andrographolide Analogues in Neuronal Cell lines
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Michelle Siying | Master (Research) | 15 Nov 2013 - 15 Jun 2019 Thesis: SRJ23 and its Derivatives as New Anticancer Agents Targeting Ras-Oncoprotein: In Vitro and Protein Crystallography Approaches MSc Co- supervisor 2019
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Jeyashantini Nalaiya | Master (Mixed Mode) | 15 Sep 2013 - 15 Mar 2014 Thesis: Development and validation of a stability-indicating RP-HPLC method for simultaneous determination of simvastatin and niacin in a combined product
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Kulasekar Kulasingam | Master (Mixed Mode) | 15 Sep 2013 - 15 Mar 2014 Thesis: Phytochemical and Antimicrobial Studies on Alternanthera sessilis Linn Leaves

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