CHEONG SIEW LEE



Salutation
Dr

School/Centre
School of Pharmacy

Department
Pharmaceutical Chemistry

Position
Senior Lecturer

Email
cheongsiewlee@imu.edu.my



Education

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Doctor of Philosophy (Medicinal Chemistry), 2011 National University of Singapore
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Bachelor of Science (Pharmacy) (Honours) (Pharmacy), 2005 National University of Singapore

Memberships

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Malaysian Pharmacists Society Member 2017 - Present
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Royal Society of Chemistry Member 2015 - 2022
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Pharmaceutical Society of Singapore Member 2006 - Present

Research Funding
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Biological evaluation of selected in silico repositioned FDA-approved drugs as potential inhibitors of Porphyromonas gingivalis peptidylarginine deiminase IMU Internal Research Grant | 01 Oct 2024 - 31 Mar 2025
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Biological evaluation of in silico repositioned FDA-approved drugs as potential inhibitors of Porphyromonas gingivalis gingipain K, a causative agent for Alzheimer’s disease IMU Internal Research Grant | 20 May 2024 - 30 Sep 2024
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2D ligand-based similarity searching and structure-based virtual screening for identification of potential Porphyromonas gingivalis peptidylarginine deiminase inhibitors as rheumatoid arthritis pharmacotherapy IMU Internal Research Grant | 08 Apr 2024 - 07 Feb 2025
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Evaluation of effectiveness of 3-D virtual molecules for teaching and learning of chemistry in foundation in science and pharmaceutical chemistry programmes IMU Internal Research Grant | 18 Mar 2024 - 31 Dec 2024
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Computational drug repurposing study of Porphyromonas gingivalis peptidylarginine deiminase inhibitors with FDA-approved drugs as potential pharmacotherapy for rheumatoid arthritis: an extended investigation IMU Internal Research Grant | 04 Sep 2023 - 29 Jun 2024
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In silico repurposing of FDA-approved drugs as inhibitors of Porphyromonas gingivalis gingipain K, a causative agent for Alzheimer’s disease IMU Internal Research Grant | 01 Jun 2023 - 31 Aug 2023
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In silico pharmacokinetic and molecular docking studies of labdane diterpenes of Alpinia genus against butyrylcholinesterase, a therapeutic target for Alzheimer’s disease IMU Internal Research Grant | 01 Jul 2022 - 02 May 2023
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In silico repositioning of FDA-approved drugs as inhibitors of Porphyromonas gingivalis peptidylarginine deiminase and gingipain R, the putative causal agents of rheumatoid arthritis IMU Internal Research Grant | 01 Jul 2022 - 30 Sep 2022
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In silico repurposing of FDA-approved drugs as inhibitors of Porphyromonas gingivalis peptidylarginine deiminase and gingipain R, the putative causal agents of rheumatoid arthritis IMU Internal Research Grant | 21 Mar 2022 - 23 May 2022
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Bacterial photoinactivation potency of ruthenium photosensitizers IMU Internal Research Grant | 01 Dec 2021 - 31 Jul 2022
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Repositioning of FDA-approved drugs as inhibitors of Porphyromonas gingivalis gingipain K, a a causative agent for Alzheimer’s disease: in silico and biological evaluation IMU Internal Research Grant | 03 May 2021 - 30 Nov 2021
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Repositioning of FDA-approved drugs as inhibitors of Porphyromonas gingivalis gingipain R, a putative causal agent of rheumatoid arthritis: in silico and biological evaluation IMU Internal Research Grant | 02 Nov 2020 - 30 Jun 2021
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In silico repositioning of FDA-approved drugs as inhibitors of Porphyromonas gingivalis peptidylarginine deiminase, a putative causal agent of rheumatoid arthritis External Grant from Tunku Abdul Rahman University College | 01 Sep 2019 - 01 Mar 2021
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Literature review: Multi-target approaches in malaria drug discovery IMU Internal Research Grant | 03 Dec 2018 - 28 Feb 2019
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In silico and in vitro antibacterial evaluation of Schiff base ligands and their metal complexes IMU Internal Research Grant | 05 Sep 2018 - 12 May 2021
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Synthesis of Novel Bis (Indolymethyl) Carbazoles IMU Internal Research Grant | 01 Jul 2018 - 01 Nov 2018
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Synthesis, Characterisation and Antimicrobial (In vitro and In Silico) Evaluation of Schiff Base Ligands and their Metal Complexes IMU Internal Research Grant | 01 Jun 2018 - 01 Dec 2018
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Instructional Briefing Video: An Approach to Enhance Students Self-Directed Learning for Laboratory Practical Sessions IMU Internal Research Grant | 01 Sep 2016 - 01 Dec 2017
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Effect of some organic and inorganic proteasome inhibitors on the growth of selected bacteria IMU Internal Research Grant | 01 Dec 2015 - 29 Feb 2016
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Bicyclic scaffold as versatile template for the design of human adenosine receptor antagonists: Comparison of pharmacophore elucidation at the A2A and A3 adenosine receptor. IMU Internal Research Grant | 01 May 2015 - 31 Oct 2015

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Publications

Research Articles

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Inhibitory activity of mangiferin against Porphyromonas gingivalis gingipain K, a causal agent of Alzheimer's disease: An integrated in vitro and in silico study SCIENCEASIA 2024
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Novel Cu (II) Schiff Base Complex Combination with Polymyxin B/Phenylalanine-Arginine β-Naphthylamide Against Various Bacterial Strains INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS 2022
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Current Pharmacotherapy and Multi-Target Approaches for Alzheimer’s Disease PHARMACEUTICALS 2022
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Inhibition of Porphyromonas gingivalis peptidyl arginine deiminase, a virulence factor, by antioxidant-rich Cratoxylum cochinchinense: In vitro and in silico evaluation SAUDI JOURNAL OF BIOLOGICAL SCIENCES 2022
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Implications of Porphyromonas gingivalis peptidyl arginine deiminase and gingipain R in human health and diseases FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY 2022
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Current progress in antimalarial pharmacotherapy and multi-target drug discovery EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2020
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Design, synthesis and evaluation of new indolylpyrimidylpiperazines for gastrointestinal cancer therapy MOLECULES 2019
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Design, Synthesis and Characterisation of Novel Phenothiazine‐Based Triazolopyridine Derivatives: Evaluation of Anti‐Breast Cancer Activity on Human Breast Carcinoma CHEMISTRYSELECT 2019
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The current status of pharmacotherapy for the treatment of Parkinson’s disease: transition from single-target to multitarget therapy DRUG DISCOVERY TODAY 2019
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Discovery of indolylpiperazinylpyrimidines with dual-target profiles at adenosine A2A and dopamine D2 receptors for Parkinson's disease treatment PLOS ONE 2018
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Pharmacological relationships and ligand discovery of G protein-coupled receptors revealed by simultaneous ligand and receptor clustering JOURNAL OF MOLECULAR GRAPHICS AND MODELLING 2017
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A3 adenosine receptor ligands in the treatment of inflammation and cancer PHARMACOLOGY-RESEARCH, SAFETY TESTING AND REGULATION 2016
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A facile and novel synthesis of N2-, C6-substituted pyrazolo [3, 4-d] pyrimidine-4 carboxylate derivatives as adenosine receptor antagonists EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2015
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Discovery of simplified N2-substituted pyrazolo [3, 4-d] pyrimidine derivatives as novel adenosine receptor antagonists: Efficient synthetic approaches, biological evaluations and molecular docking studies BIOORGANIC & MEDICINAL CHEMISTRY 2014
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Organoruthenium antagonists of human A3 adenosine receptors CHEMISTRY"A EUROPEAN JOURNAL 2013
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The A3 adenosine receptor as multifaceted therapeutic target: pharmacology, medicinal chemistry, and in silico approaches MEDICINAL RESEARCH REVIEWS 2013
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Does the combination of optimal substitutions at the C2-, N5-and N8-positions of the pyrazolo-triazolo-pyrimidine scaffold guarantee selective modulation of the human A3 adenosine receptors? BIOORGANIC & MEDICINAL CHEMISTRY 2011
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Pharmacophore elucidation for a new series of 2-aryl-pyrazolo-triazolo-pyrimidines as potent human A3 adenosine receptor antagonists BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 2011
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Pyrazolo derivatives as potent adenosine receptor antagonists: an overview on the structure-activity relationships INTERNATIONAL JOURNAL OF MEDICINAL CHEMISTRY 2011
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Synthesis and biological evaluation of a new series of 1, 2, 4-triazolo [1, 5-a]-1, 3, 5-triazines as human A2A adenosine receptor antagonists with improved water solubility JOURNAL OF MEDICINAL CHEMISTRY 2011
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The Significance of 2-Furyl Ring Substitution with a 2-(para-substituted) Aryl Group in a New Series of Pyrazolo-triazolo-pyrimidines as Potent and Highly Selective hA3 Adenosine Receptors Antagonists: New Insights into Structure− Affinity Relationship and Receptor− Antagonist Recognition JOURNAL OF MEDICINAL CHEMISTRY 2010

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Other Publications

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In silico pharmacokinetic and molecular docking studies of labdane diterpenes of Alpinia genus against butyrylcholinesterase, a therapeutic target for Alzheimer’s disease Monash INITIATE 2023, Monash International Health Science and Technology Conference | 25 Oct 2023
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Use of 3-D virtual molecules for teaching and learning of stereochemistry in undergraduate programmes 16th International Medical Education Conference 2023 | 13 Oct 2023
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Membrane-targeting peptides enhancing uptake of ruthenium(II) polypyridyl photosensitisers into clinically relevant bacteria MyCRS Young Scientist Symposium 2023 | 17 Aug 2023
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Repositioning of FDA-approved drugs as inhibitors of Porphyromonas gingivalis gingipain K, a causative agent for Alzheimer’s disease: in silico and biological evaluation Monash INITIATE 2022 | 27 Sep 2022
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Repositioning of FDA-approved drugs as inhibitors of Porphyromonas gingivalis gingipain K, a causative agent for Alzheimer’s disease: in silico and biological evaluation International Postgraduate Conference on Pharmaceutical Sciences (IPoPS) | 21 Jun 2022
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Repurposing of FDA-approved drugs as inhibitors of Porphyromonas gingivalis gingipain R, a causal agent of rheumatoid arthritis: in silico and biological studies Royal Society of Chemistry International Accreditation Celebration Event | 12 Oct 2021
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Repositioning of FDA-approved drugs as inhibitors of Porphyromonas gingivalis gingipain R, a putative causal agent of rheumatoid arthritis: in silico and biological evaluation Virtual International Research Network Initiative (IRNI) and International Postgraduate Conference on Pharmaceutical Sciences (IPoPS) | 28 Sep 2021
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Rational design of new ligands as human adenosine receptor antagonists: transition from tricyclic to bicyclic scaffold-based derivatives 8th Edition of International Conference on Chemistry Education and Research | 27 Aug 2018
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In silico pharmacophore elucidation for bicyclic antagonists of human A3 adenosine receptors and its comparison with A2A adenosine receptor bicyclic antagonists 12th Malaysian Pharmaceutical Society - Pharmacy Scientific Conference | 13 Nov 2015
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In silico pharmacophore elucidation for bicyclic antagonists of human A2A adenosine receptors and its comparison with A3 adenosine receptor bicyclic antagonists 12th Malaysian Pharmaceutical Society - Pharmacy Scientific Conference | 13 Nov 2015
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Alkylamino-pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidines. Influence of the substituent on the affinity at the adenosine receptor subtypes Congresso Nazionale della Società Chimcia Italiana XXIV | 11 Sep 2011
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1, 2, 4-Triazolo [1, 5-a]-1, 3, 5-triazine nucleus: a possible template for adenosine receptor subtypes. Nuove Prospettive in Chimica Farmaceutica V | 01 Mar 2011
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Structural investigations on a novel class of 1,2,4-triazolo[1,5-c]pyrimidines as adenosine receptor antagonists Nuove Prospettive in Chimica Farmaceutica V | 01 Mar 2011
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The pyrazolo-triazolo-pyrimidine scaffold as a versatile platform to design potent and highly selective hA3 adenosine receptor’s antagonists 8th Annual Congress of International Drug Discovery Science and Technology | 23 Oct 2010
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A new series of 2-aryl-pyrazolo-triazolo-pyrimidines as potent human A3 adenosine receptor antagonists: QSAR analysis and COMFA-guided modeling of antagonist binding site through a human A3 ‘hybrid’ homology model 18th European Symposium on Quantitative Structure-Activity Relationships | 19 Sep 2010
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The significance of 2-furyl ring substitution with a 2-(para-substituted) aryl group in a new series of pyrazolo-triazolo-pyrimidines as potent and highly selective hA3 adenosine receptor’s antagonists: New insights into structure-affinity relationship and receptor-antagonist recognition Nuove Prospettive in Chimica Farmaceutica IV | 06 May 2010
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The pyrazolo-trizolo-pyrimidine scaffold as a versatile platform to design potent and highly selective hA3 adenosine receptor antagonists: the role of 2-furyl ring substitution demystified through analysis on a novel series of 2-(para-substituted) aryl analogs Nuove Prospettive in Chimica Farmaceutica IV | 06 May 2010
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Synthesis, characterization and evaluation of new human adenosine receptors’ antagonists Bandung International Conference on Medicinal Chemistry | 06 Aug 2009
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Synthesis, characterization and evaluation of new adenosine receptors’ antagonists European School of Medicinal Chemistry | 06 Jul 2008
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Synthesis, characterization and evaluation of new adenosine receptors’ antagonists PharmSci@Asia Symposium | 01 Jun 2008
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Synthesis, characterization and evaluation of new adenosine receptors’ antagonists 19th Singapore Pharmacy Congress | 19 Oct 2007

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Books

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Società chimica Italiana (2012). Structural Investigations on a Novel Class of [1, 2, 4] Triazolo [1, 5-c] pyrimidines as Adenosine Receptor Antagonists.
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Società chimica italiana (2011). 5-Alkylamino-pyrazolo [4, 3-e] 1, 2, 4-triazolo [1, 5-c] pyrimidines. Influence of the Substituent on the Affinity at the Adenosine Receptor Subtypes


Supervisions
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Nieh Zee Ernn Ryan | Undergraduate | 18 Mar 2024 - 31 Dec 2024 Thesis: Evaluation of effectiveness of 3-D virtual molecules for teaching and learning of chemistry in foundation in science and pharmaceutical chemistry programmes
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Lee Peak Ngan | Master (Mixed Mode) | 04 Sep 2023 - 29 Jun 2024 Thesis: Computational drug repurposing study of Porphyromonas gingivalis peptidylarginine deiminase inhibitors with FDA-approved drugs as potential pharmacotherapy for rheumatoid arthritis: an extended investigation
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Ong Wei Quan, Muhamad Zakwan Hafiq bin Abdul Razak | Undergraduate | 01 Jun 2023 - 31 Aug 2023 Thesis: In silico repurposing of FDA-approved drugs as inhibitors of Porphyromonas gingivalis gingipain K, a causative agent for Alzheimer’s disease
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Leong How Wan | Master (Mixed Mode) | 01 Jul 2022 - 02 May 2023 Thesis: In silico pharmacokinetic and molecular docking studies of labdane diterpenes of Alpinia genus against butyrylcholinesterase, a therapeutic target for Alzheimer’s disease
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Lai Weng Yeen, Wo Weeng Yue | Undergraduate | 01 Jul 2022 - 30 Sep 2022 Thesis: In silico repositioning of FDA-approved drugs as inhibitors of Porphyromonas gingivalis peptidylarginine deiminase and gingipain R, the putative causal agents of rheumatoid arthritis
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Yap Soong Zhi, Ang Kin Loon | Undergraduate | 21 Mar 2022 - 23 May 2022 Thesis: In silico repurposing of FDA-approved drugs as inhibitors of Porphyromonas gingivalis peptidylarginine deiminase and gingipain R, the putative causal agents of rheumatoid arthritis
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Mohamedali Elhag Mohamed Ahmed, Bong Wan Qing | Undergraduate | 01 Dec 2021 - 31 Jul 2022 Thesis: Bacterial photoinactivation potency of ruthenium photosensitizers
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Lai Jia Hui | Master (Mixed Mode) | 03 May 2021 - 30 Nov 2021 Thesis: Repositioning of FDA-approved drugs as inhibitors of Porphyromonas gingivalis gingipain K, a a causative agent for Alzheimer’s disease: in silico and biological evaluation
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Samantha Valerie Anak Unting | Master (Mixed Mode) | 02 Nov 2020 - 30 Jun 2021 Thesis: Repositioning of FDA-approved drugs as inhibitors of Porphyromonas gingivalis gingipain R, a putative causal agent of rheumatoid arthritis: in silico and biological evaluation
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Gan Wei Khang | Master (Mixed Mode) | 01 Dec 2019 - 01 Dec 2020 Thesis: In silico and in vitro antibacterial evaluation of Schiff base ligands and their metal complexes
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Chow Yoke Chan | Master (Research) | 01 Sep 2019 - 01 Mar 2021 Thesis: In silico repositioning of FDA-approved drugs as inhibitors of Porphyromonas gingivalis peptidylarginine deiminase, a putative causal agent of rheumatoid arthritis
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Natasha Stella Tibon | Undergraduate | 03 Dec 2018 - 28 Feb 2019 Thesis: Literature review: Multi-target approaches in malaria drug discovery
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Chai Shin Yiing, Corina Sia Yao Lian, Chen Kee Zhe, Woo Yi Mun | Undergraduate | 01 Jul 2018 - 01 Nov 2018 Thesis: Synthesis of Novel Bis (Indolymethyl) Carbazoles
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Ngew Wei Yue, Chan Kuan Hui | Undergraduate | 01 Jun 2018 - 01 Dec 2018 Thesis: Synthesis, Characterisation and Antimicrobial (In vitro and In Silico) Evaluation of Schiff Base Ligands and their Metal Complexes
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Chuah Chong Ho, Tong Jin Yan, Chia Jing Wen | Undergraduate | 01 Dec 2015 - 29 Feb 2016 Thesis: Effect of some organic and inorganic proteasome inhibitors on the growth of selected bacteria
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Jong Yi Wen, Joyce Wong Xin Yi | Undergraduate | 01 May 2015 - 31 Oct 2015 Thesis: Bicyclic scaffold as versatile template for the design of human adenosine receptor antagonists: Comparison of pharmacophore elucidation at the A2A and A3 adenosine receptor.

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