Mai Chun Wai



Salutation
Professor

School/Centre
Institute of Research, Development and Innovation (IRDI)

Position
Professor

Email
chunwai_mai@imu.edu.my

Professional Network


Education

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Postdoctoral Certificate (Clinical Medicine), 2023 Shanghai Jiao Tong University
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Doctor of Philosophy in Medical and Health Sciences (Medicinal Chemistry, Cancer Drug Discovery), 2014 International Medical University
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Bachelor of Pharmacy (Hons) (Pharmacy), 2009 International Medical University

Publications

Research Articles

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Phytochemical Analysis and Biological Activities of Flavonoids and Anthraquinones from Cassia alata (Linnaeus) Roxburgh and Their Implications for Atopic Dermatitis Management PLANTS 2025
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Revolutionizing the treatment for nasopharyngeal cancer: the impact, challenges and strategies of stem cell and genetically engineered cell therapies FRONTIERS IN IMMUNOLOGY 2024
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Yunnanensine type indole and secostemmadenine-yunnanensine type bisindole alkaloids from the bark of Alstonia scholaris PHYTOCHEMISTRY LETTERS 2024
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Revolutionizing the treatment for nasopharyngeal cancer: the impact, challenges and strategies of stem cell and genetically engineered cell therapies FRONTIERS IN IMMUNOLOGY 2024
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OPEN ACCESS EDITED AND REVIEWED BY FRONTIERS IN IMMUNOLOGY 2024
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Novel preclinical model, biomarker, treatment and drug delivery to address immune evasion in cancer FRONTIERS IN IMMUNOLOGY 2024
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The immunological regulation of extracellular vesicles on chronic diseases FRONTIERS IN IMMUNOLOGY 2024
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Scoping review of enablers and challenges of implementing pharmacogenomics testing in the primary care settings BMJ OPEN 2024
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Cassia alata and Its Phytochemicals: A Promising Natural Strategy in Wound Recovery SCI 2024
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Polyethylene glycol-phospholipid functionalized single-walled carbon nanotubes for enhanced siRNA systemic delivery SCIENTIFIC REPORTS 2024
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Recent Developments in Luteolin-Loaded Nanoformulations for Enhanced Anti-Carcinogenic Activities: Insights from In Vitro and In Vivo Studies SCI 2024
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Epigenetic Drug Interventions in Breast Cancer: A Narrative Review of Current Research and Future Directions PROGRESS IN MICROBES & MOLECULAR BIOLOGY 2024
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Novel preclinical model, biomarker, treatment and drug delivery to address immune evasion in cancer FRONTIERS IN IMMUNOLOGY 2024
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OPEN ACCESS EDITED AND REVIEWED BY THE IMMUNOLOGICAL REGULATION OF EXTRACELLULAR VESICLES ON CHRONIC DISEASES 2024
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Tetrazolopyrimidine Tethered Phenothiazine Molecular Hybrids: Synthesis, Biological and Molecular Docking Studies NEW JOURNAL OF CHEMISTRY 2024
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Cassia alata and Its Phytochemicals: A Promising Natural Strategy in Wound Recovery SCI 2024
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The immunological regulation of extracellular vesicles on chronic diseases FRONTIERS IN IMMUNOLOGY 2024
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Tetrazolopyrimidine-tethered phenothiazine molecular hybrids: synthesis, biological and molecular docking studies NEW JOURNAL OF CHEMISTRY 2024
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Major dietary patterns in the United Kingdom Women's Cohort Study showed no evidence of prospective association with pancreatic cancer risk NUTRITION RESEARCH 2023
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Comparison of vegetable oils on the uptake of lutein and zeaxanthin by ARPE-19 cells INTERNATIONAL JOURNAL OF OPHTHALMOLOGY 2023
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Targeting the crosstalk of epigenetic modifications and immune evasion in nasopharyngeal cancer CELL BIOLOGY AND TOXICOLOGY 2023
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Blood compatible and noncytotoxic superhydrophobic graphene/titanium dioxide coating with antibacterial and antibiofilm properties JOURNAL OF APPLIED POLYMER SCIENCE 2023
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Vitamin E in the management of pancreatic cancer: A scoping review WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY 2023
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Molecular Mechanism of Tocotrienol-Mediated Anticancer Properties: A Systematic Review of the Involvement of Endoplasmic Reticulum Stress and Unfolded Protein Response NUTRIENTS 2023
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Comparison of vegetable oils on the uptake of lutein and zeaxanthin by ARPE-19 cells INTERNATIONAL JOURNAL OF OPHTHALMOLOGY 2023
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TP53 loss‐of‐function causes vulnerability to autophagy inhibition in aggressive prostate cancer INTERNATIONAL JOURNAL OF UROLOGY 2022
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N, N’‐Disubstituted Benzimidazolium Salts: Synthesis, Characterization, Micromolar Detection of Fe (III) ions in Aqueous system, Biological Evaluation and Molecular Docking Studies CHEMISTRYSELECT 2022
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Effect of Carotenes against Oxidative Stress Induced Age-Related Macular Degeneration in Human Retinal Pigment Cells ACS FOOD SCIENCE & TECHNOLOGY 2022
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Histone Deacetylase Inhibitors Restore Cancer Cell Sensitivity towards T Lymphocytes Mediated Cytotoxicity in Pancreatic Cancer CANCERS 2022
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Modeling prostate cancer: What does it take to build an ideal tumor model? CANCER LETTERS 2022
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Novel Gemcitabine-Re (I) Bisquinolinyl Complex Combinations and Formulations With Liquid Crystalline Nanoparticles for Pancreatic Cancer Photodynamic Therapy FRONTIERS IN PHARMACOLOGY 2022
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Functional roles of JNK and p38 MAPK signaling in nasopharyngeal carcinoma INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2022
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Pentacyclic and hexacyclic cucurbitacins from Elaeocarpus petiolatus PHYTOCHEMISTRY 2022
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Targeting pancreatic cancer immune evasion by inhibiting histone deacetylases WORLD JOURNAL OF GASTROENTEROLOGY 2022
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Inhibition of Janus Kinase 1 synergizes docetaxel sensitivity in prostate cancer cells JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 2021
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Novel Phenothiazinyl Acrylonitrile Hybrids: Synthesis, Biological, and Density Functional Theory Studies INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 2021
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Sphingosine Kinase 1 Signaling in Breast Cancer: A Potential Target to Tackle Breast Cancer Stem Cells FRONTIERS IN MOLECULAR BIOSCIENCES 2021
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Novel Phenothiazinyl Acrylonitrile Hybrids: Synthesis, Biological, and Density Functional Theory Studies INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 2021
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Unusual diarylheptanoid-phenylpropanoid adducts and diarylheptanoid alkaloids from Pellacalyx saccardianus PHYTOCHEMISTRY LETTERS 2021
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Prostate organoid technology-the new POT of gold in prostate stem cell and cancer research ACTA PHYSIOLOGICA SINICA 2021
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Monomeric, Dimeric, and Trimeric Tropane Alkaloids from Pellacalyx saccardianus JOURNAL OF NATURAL PRODUCTS 2021
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Co-encapsulation of gemcitabine and tocotrienols in nanovesicles enhanced efficacy in pancreatic cancer Nanomedicine 2021
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Potential of Superhydrophobic Surface for Blood-Contacting Medical Devices INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2021
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Roles of Inflammasomes in Epstein–Barr Virus-Associated Nasopharyngeal Cancer CANCERS 2021
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Parallel genome-wide RNAi screens identify lymphocyte-specific protein tyrosine kinase (LCK) as a targetable vulnerability of cell proliferation and chemoresistance in nasopharyngeal carcinoma Cancer letters 2021
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Gene expression profiling of giant fibroadenomas of the breast Surgical Oncology 2021
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Protein expression patterns in hek-Blue™-Cells treated with Clinacanthus nutans extracts PHARMACOGNOSY MAGAZINE 2020
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Phosphoinositide-dependent Kinase-1 (PDPK1) regulates serum/glucocorticoid-regulated Kinase 3 (SGK3) for prostate cancer cell survival (vol 24, pg 12188, 2020) JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 2020
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Phosphoinositide-dependent Kinase-1 (PDPK1) regulates serum/glucocorticoid-regulated Kinase 3 (SGK3) for prostate cancer cell survival (vol 24, pg 12188, 2020) JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 2020
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Pyrazolylphenanthroimidazole heterocycles: synthesis, biological and molecular docking studies New Journal of Chemistry 2020
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Protein expression patterns in hek-Blue™-Cells treated with Clinacanthus nutans extracts Pharmacognosy Magazine 2020
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Prevalence of Nocturia Among Community-dwelling Adults: A Population-based Study in Malaysia BMC UROLOGY 2020
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The Role of Ras-Associated Protein 1 (Rap1) in Cancer: Bad Actor or Good Player? BIOMEDICINES 2020
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Phenothiazine and amide-ornamented novel nitrogen heterocyclic hybrids: synthesis, biological and molecular docking studies New Journal of Chemistry 2020
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Antibacterial Activity of Clinacanthus nutans Polar and Non-Polar Leaves and Stem Extracts. Biomedical and Pharmacology Journal 2020
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Integrative Nutrition CARE in the Community—Starting with Pharmacists PHARMACY 2020
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The synthesis of trifluoromethylated N-nitroaryl-2-amino-1, 3-dichloropropane derivatives and their evaluation as potential anti-cancer agents Bioorganic & medicinal chemistry letters 2020
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Development and evaluation of curcumin liquid crystal systems for cervical cancer Scientia Pharmaceutica 2020
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Phosphoinositide‐dependent Kinase‐1 (PDPK1) regulates serum/glucocorticoid‐regulated Kinase 3 (SGK3) for prostate cancer cell survival Journal of cellular and molecular medicine 2020
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Histone deacetylase (HDAC) inhibitors and doxorubicin combinations target both breast cancer stem cells and non-stem breast cancer cells simultaneously Breast Cancer Research and Treatment 2020
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Sphingosine kinase 1 regulates the survival of breast cancer stem cells and non-stem breast cancer cells by suppression of STAT1 Cells 2020
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Novel cyanoacetamide integrated phenothiazines: Synthesis, characterization, computational studies and in vitro antioxidant and anticancer evaluations Journal of Molecular Structure 2020
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Recent Emergence of Rhenium (I) Tricarbonyl Complexes as Photosensitisers for Cancer Therapy MOLECULES 2020
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The effects of NLRP3 inflammasome inhibition by MCC950 on LPS-induced pancreatic adenocarcinoma inflammation Journal of cancer research and clinical oncology 2020
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Molecular mechanisms and potential therapeutic reversal of pancreatic cancer-induced immune evasion CANCERS 2020
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Molecular Hybrids Integrated with Benzimidazole and Pyrazole Structural Motifs: Design, Synthesis, Biological Evaluation, and Molecular Docking Studies ACS omega 2020
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Separation of prescribing and dispensing in Malaysia: public perception of pharmacists’ roles and agreement towards a separation policy Journal of Pharmacy Practice and Research 2020
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Hydrazide-integrated carbazoles: synthesis, computational, anticancer and molecular docking studies New Journal of Chemistry 2019
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Development and evaluation of liquid crystal systems of combination of 5-fluorouracil and curcumin for cervical cancer cell line JOURNAL OF PHARMACY & PHARMACOGNOSY RESEARCH 2019
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Cytotoxic activity of phytochemicals from the stem bark of Calophyllum castaneum. Pakistan journal of pharmaceutical sciences 2019
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Evaluation of Computer-based Simulation Learning on Knowledge, Learning Approaches and Motivation among Pharmacy Students INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH 2019
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Identification of Novel Sesamol Dimers with Unusual Methylenedioxy Ring-Opening Skeleton and Evaluation of Their Antioxidant and Cytotoxic Activities Current organic synthesis 2019
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Phenothiazine and amide-ornamented dihydropyridines via a molecular hybridization approach: design, synthesis, biological evaluation and molecular docking studies New Journal of Chemistry 2019
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Novel 2-Benzoyl-6-(2, 3-Dimethoxybenzylidene)-Cyclohexenol Confers Selectivity toward Human MLH1 Defective Cancer Cells through Synthetic Lethality SLAS DISCOVERY: ADVANCING LIFE SCIENCES R&D 2019
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Design, Synthesis and Characterisation of Novel Phenothiazine‐Based Triazolopyridine Derivatives: Evaluation of Anti‐Breast Cancer Activity on Human Breast Carcinoma ChemistrySelect 2019
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Zebularine and trichostatin A sensitized human breast adenocarcinoma cells towards tumor necrosis factor-related apoptosis inducing ligand (TRAIL)-induced apoptosis Heliyon 2019
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Novel acrylamide/acrylonitrile-tethered carbazoles: synthesis, structural, biological, and density functional theory studies New Journal of Chemistry 2019
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Goniolanceolatins A–H, Cytotoxic Bis-styryllactones from Goniothalamus lanceolatus JOURNAL OF NATURAL PRODUCTS 2019
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Alstobrogaline, an unusual pentacyclic monoterpenoid indole alkaloid with aldimine and aldimine-N-oxide moieties from Alstonia scholaris Tetrahedron Letters 2019
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Tocotrienols modulate a life or death decision in cancers INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2019
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Epigenetics in metastatic breast cancer: its regulation and implications in diagnosis, prognosis and therapeutics CURRENT CANCER DRUG TARGETS 2019
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The synergism of Clinacanthus nutans Lindau extracts with gemcitabine: downregulation of anti-apoptotic markers in squamous pancreatic ductal adenocarcinoma BMC complementary and alternative medicine 2019
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Co-culture Systems for the production of secondary metabolites: Current and future prospects The Open Biotechnology Journal 2019
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Therapeutic challenges and current immunomodulatory strategies in targeting the immunosuppressive pancreatic tumor microenvironment JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH 2019
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Comparative efficacy of vanilloids in inhibiting toll-like receptor-4 (TLR-4)/myeloid differentiation factor (MD-2) homodimerisation Food & function 2018
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Combinatory Effect of Jerantinine A and Chemotherapeutic Agent in Regulating Spliceosome in Breast Cancer Stem Cells and Non-Stem Breast Cancer Cells JOURNAL OF GLOBAL ONCOLOGY 2018
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Combinatory Effect of Jerantinine A and Chemotherapeutic Agent in Regulating Spliceosome in Breast Cancer Stem Cells and Non-Stem Breast Cancer Cells JOURNAL OF GLOBAL ONCOLOGY 2018
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Combined Treatment of 5-Fluorouracil and Delta-Tocotrienol Induce of Apoptosis and Autophagy in Colorectal Cancer Cells JOURNAL OF GLOBAL ONCOLOGY 2018
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Mode of action of cinnamon bark (Cinnamomum verum) essential oil and the combinatory bactericidal activity with meropenem against KPC-producing Klebsiella pneumoniae ASIAN JOURNAL OF MEDICINE AND BIOMEDICINE 2018
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Styryl lactones from roots and barks goniothalamus lanceolatus Natural Product Communications 2018
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Advancing Pharmacy Service using Big Data–Are We Fully Utilising the Big Data’s Potential Yet? JOURNAL OF PHARMACY & PHARMACEUTICAL SCIENCES 2018
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Drug‐like dietary vanilloids induce anticancer activity through proliferation inhibition and regulation of bcl‐related apoptotic proteins Phytotherapy Research 2018
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Cytotoxic lactam and naphthoquinone alkaloids from roots of Goniothalamus lanceolatus Miq. Phytochemistry Letters 2018
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Academic dishonesty among academics in Malaysia: a comparison between healthcare and non-healthcare academics BMC medical education 2018
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Alstoscholactine and alstolaxepine, monoterpenoid indole alkaloids with γ-lactone-bridged cycloheptane and oxepane moieties from Alstonia scholaris Organic letters 2018
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Contrasting sirtuin and poly (ADP‐ribose) polymerase activities of selected 2, 4, 6‐trisubstituted benzimidazoles Chemical biology & drug design 2018
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Challenges and opportunities of nanotechnology as delivery platform for tocotrienols in cancer therapy FRONTIERS IN PHARMACOLOGY 2018
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Identification of inhibitors synergizing gemcitabine sensitivity in the squamous subtype of pancreatic ductal adenocarcinoma (PDAC) Apoptosis 2018
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Plant-derived antimicrobials: insights into mitigation of antimicrobial resistance RECORDS OF NATURAL PRODUCTS 2018
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Lutein improves cell viability and reduces Alu RNA accumulation in hydrogen peroxide challenged retinal pigment epithelial cells Cutaneous and ocular toxicology 2018
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Cudraflavone C induces tumor-specific apoptosis in colorectal cancer cells through inhibition of the phosphoinositide 3-kinase (PI3K)-AKT pathway PLoS One 2017
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Jerantinine A induces tumor-specific cell death through modulation of splicing factor 3b subunit 1 (SF3B1) Scientific reports 2017
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A Bis-benzopyrroloisoquinoline alkaloid incorporating a Cyclobutane Core and a Chlorophenanthroindolizidine alkaloid with cytotoxic activity from Ficus fistulosa var. tengerensis JOURNAL OF NATURAL PRODUCTS 2017
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Targeting legumain as a novel therapeutic strategy in cancers CURRENT DRUG TARGETS 2017
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Additivity vs synergism: investigation of the additive interaction of cinnamon bark oil and meropenem in combinatory therapy Molecules 2017
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Separation of prescribing and dispensing in Malaysia: the history and challenges International Journal of Pharmacy Practice 2016
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In vitro cytotoxic activity of isolated compounds from Malaysian Calophyllum species Medicinal Chemistry Research 2016
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Mechanisms underlying the anti-inflammatory effects of Clinacanthus nutans Lindau extracts: inhibition of cytokine production and toll-like receptor-4 activation Frontiers in pharmacology 2016
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Cytochrome P450 2W1 (CYP2W1) in colorectal cancers CURRENT CANCER DRUG TARGETS 2016
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Global antimicrobial stewardship: a closer look at the formidable implementation challenges Frontiers in microbiology 2016
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Chemistry content in the pharmacy curriculum: relevance to develop pharmacists fit-to-work in diverse pharmacy profession sectors Indian Journal of Pharmaceutical Education and Research 2015
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Academic integrity of health care educators: requisite for nurturing professionalism MED EDU 2015
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Chalcones with electron-withdrawing and electron-donating substituents: anticancer activity against TRAIL resistant cancer cells, structure–activity relationship analysis and regulation of apoptotic proteins European Journal of Medicinal Chemistry 2014
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Should a Toll-like receptor 4 (TLR-4) agonist or antagonist be designed to treat cancer? TLR-4: its expression and effects in the ten most common cancers ONCOTARGETS AND THERAPY 2013
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6-Shogaol inhibits breast and colon cancer cell proliferation through activation of peroxisomal proliferator activated receptor γ (PPARγ) Cancer letters 2013
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Perceived impact of clinical placements on students' preparedness to provide patient-centered care in Malaysia Currents in Pharmacy Teaching and Learning 2013
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Antibacterial and antifungal testing of the different extract of Dillenia obovata (Blume) Hoogl WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES 2013
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Antiproliferative and apoptotic studies of the standardised extracts of Etlingera elatior on human colorectal carcinoma cells Malaysian Journal of Chemistry 2009
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Nasopharyngeal Carcinoma cell proliferation and apoptosis induced by the standardised ethanolic extracts of Mucuna bracteata MAL. J. CHEM 2009

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Other Publications

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Conception, Synthesis and Evaluation of Tricarbonylrhenium Complexes as Potent Antibacterial and/or Anticancer Agents. Malaysia-France Convention on Higher Education, Research and Innovation | 01 Jan 2023
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Discovery of naturally occurring toll-like receptor-4 signalling inhibitors: Their anticancer effects and mechanisms of action EUROPEAN JOURNAL OF CANCER | 01 Jan 2013