KOK YIH YIH



Salutation
Associate Professor Dr

School/Centre
School of Health Sciences

Department
Applied Biomedical Science and Biotechnology

Appointment
Associate Dean, SOHS (Academic & Quality)

Position
Associate Professor

Email
yihyih_kok@imu.edu.my

Professional Network


Education

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Master (Health Professions Education), 2021 International Medical University
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phD (Algal Biotechnology), 2009 International Medical University
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Master (Animal Biotechnology), 2002 Universiti Putra Malaysia
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Bachelor of Science (Hons) Biotechnology (Biotechnology), 1999 University Putra Malaysia

Memberships

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Malaysian Society for Biochemistry and Molecular Biology Exco member 2024 - Present
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Malaysian Society for Biochemistry and Molecular Biology Co-Opt 2017 - 2023

Research Funding
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Exogenous Administration of Carbon Monoxide as A Putative Molecule To Modify Heavy Metal Toxicity In Microalgae IMU Internal Research Grant | 01 Dec 2024 - 30 Nov 2025
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Assessing the Effects of Heavy Metals on Antarctic Microalgae Using in vitro and in silico Approaches IMU Internal Research Grant | 05 Aug 2024 - 08 Nov 2024
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Utilising Tropical Microalgae for the Phycoremediation of Diesel Hydrocarbon IMU Internal Research Grant | 01 Jul 2024 - 31 Jan 2025
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Joint toxicity of per- and polyfluorinated substances (PFAS) in microalgae NUW alliance: Research Internship Program: Malaysia | 01 Dec 2023 - 10 Feb 2024
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Building Resilience Among Undergraduate Health Professional Students in an Asian University: Unveiling the Strategies for Success IMU Internal Research Grant | 01 Jun 2023 - 31 Jul 2024
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Effects of Temperature on Bioremediation of Diesel Hydrocarbon by Antarctic Microalgae IMU Internal Research Grant | 01 Jun 2023 - 31 Dec 2023
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Influence of micro- and nanoplastic (polystyrene micro- and nanosphere) on the combined toxicity of chromium (Cr) and cadmium (Cd) in microalgae IMU Internal Research Grant | 01 Jun 2023 - 31 Dec 2023
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Photoprotective Potential of Mycosporine-Like Amino Acids (MAAs) and Bioactive Compounds from Antarctic Microalgae on Human Keratinocytes IMU Internal Research Grant | 01 Mar 2023 - 28 Feb 2026
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Influence of polyethylene micro- and nano plastic on the combined toxicity of copper and lead in Antarctic microalgae based on a suite of biomarkers and transcriptomic profiles IMU Internal Research Grant | 02 Jan 2023 - 31 Dec 2025
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Immunomodulatory effects of tiger milk mushroom extract Lignosus rhinocerus TM02® Cultivar (Agaricomycetes) in sensitized human keratinocyte cell line NCTC2544 BMedSc | 02 Jan 2023 - 30 Jul 2023
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Influence of polyethylene micro- and nano plastic on the combined toxicity of copper and lead in Antarctic microalgae based on a suite of biomarkers and transcriptomic profiles YPASM | 01 Nov 2022 - 31 Oct 2025
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Immunomodulatory effects of Chinese Caterpillar Mushroom, Ophiocordyceps sinensis Cultivar OCS02 (Ascomycetes) in sensitized human keratinocyte cell line NCTC2544 Master in Molecular Medicine | 01 Sep 2022 - 31 Jul 2023
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Influence of micro- and nanoplastic (polystyrene micro- and nanosphere) on the combined toxicity of copper (Cu) and manganese (Mn) in microalgae Chlorella sp. TJ6-5 MB | 08 Aug 2022 - 25 Nov 2022
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Influence of micro- and nanoplastic (polystyrene micro- and nanosphere) on the combined toxicity of copper (Cu) and manganese (Mn) in microalgae Chlorella sp. TJ6-5 MB | 08 Aug 2022 - 25 Nov 2022
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Ecotoxicological Joint Effects of Nanoplastic and Herbicide Atrazine on Microalgae: Physiological and Molecular Responses FRGS | 01 Apr 2021 - 31 Oct 2025
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Influence of micro- and nanoplastic (polyethylene micro- and nanosphere) on the combined toxicity of copper and cadmium in microalgae FRGs | 01 Jan 2020 - 31 Mar 2023
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Joint toxicity of copper (Cu) and manganese (Mn) on Chlorella strains isolated from a farmland and an eutrophic lake: Concentration addition (CA) versus independent action (IA) models MB | 01 Jan 2020 - 30 Apr 2020
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Toxicity of tetracycline on freshwater microalgae: effects of chronic and repeated pulse exposure BMedSc | 01 Jun 2019 - 27 May 2020
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Assessment of the toxicity of binary mixture and sequential exposure of Cu and Cd in microalgae MB | 02 Jan 2019 - 28 Apr 2019
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Toxicity of nano- and micrometer size copper oxide (CuO)particles in Chlorella sp. after 96 h and prolonged (10 days) exposure BMedSc | 01 Feb 2018 - 31 Jan 2019
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Toxicity of Heavy Metals in a Tropical and an Antarctic isolate of Chlorella after Short- and Long-Term Exposure Medical Biotechnology | 02 Jan 2018 - 29 Apr 2018
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Effects of Warming on Toxicity due to Repeated Exposure to Pesticides in Microalgae Isolated from Farming Areas in Cameron Highlands FRGS | 01 Jul 2016 - 30 Sep 2020
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Comparing the toxicity of copper oxide nanoparticles and soluble copper sulfate in the tropical microalga Chlorella sp.. BMedSc | 01 Dec 2015 - 28 Oct 2016
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Biomarkers of polar and lower latitudes microbes in relation to heavy metal stress. Flagship Program FP1213E036 diversity and adaptation of microbes: a cross latitudinal study MOSTI Flagship | 01 Aug 2014 - 31 Jul 2017
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Effects of airborne algae on contractility of tracheal smooth muscle BMedSc | 01 Feb 2014 - 31 Jan 2015
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Nanoparticle toxicity in marine microalgae: characterisation of particle size and zeta potential Medical Biotechnology | 02 Jan 2014 - 30 Apr 2014
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Influence of salinity on the toxicity of single-walled carbon nanotubes in marine microalgae Medical Biotechnology | 02 Jan 2014 - 30 Apr 2014
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Assessment of the Combined Effects of Nutrient Enrichment and Pesticide Toxicity on Various Biomarkers in Microalgae FRGS | 01 Jan 2014 - 01 Jan 2017
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Allergenic potential of airborne microalgae isolated from Malaysia FRGs | 15 Feb 2013 - 25 Feb 2021
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Assessment of the toxicity of nanomaterials in marine microalgae Medical Biotechnology | 03 Jan 2013 - 29 Apr 2013
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ASSESSMENT OF THE TOXICITY OF FUNCTIONALISED SINGLE-WALLED CARBON NANOTUBES IN TWO MARINE MICROALGAE BMedSc | 01 Jan 2013 - 26 Oct 2013
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Effect of aqueous extract and phycocyanin from Spirulina platensis on expression of Epstein-Barr virus (EBV) latent and lytic genes in lymphoblastoid cell lines BMedSc | 01 Feb 2012 - 29 Dec 2012
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Inhibitory activity of algal compounds against Epstein-Barr virus lytic cycle and proteins expression BMedSc | 02 Mar 2011 - 25 Nov 2011
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Inhibition of Spirulina platensis aqueous extract and phycocyanin against the expression of Epstein - Barr virus lytic proteins Medical Biotechnology | 03 Jan 2011 - 29 Apr 2011
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Induction of Programmed Cell Death (PCD) in Algae by Environmental Toxicants FRGS | 19 Sep 2010 - 01 Feb 2014

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Publications

Research Articles

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Building resilience among undergraduate health professions students: identifying influencing factors BMC MEDICAL EDUCATION 2024
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Focus: Chronic Disease: Natural Bioactive Compounds from Macroalgae and Microalgae for the Treatment of Alzheimer’s Disease: A Review THE YALE JOURNAL OF BIOLOGY AND MEDICINE 2024
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Prospecting bioactivity in Antarctic algae: A review of extracts, isolated compounds and their effects FITOTERAPIA 2024
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Supplementation of Spirulina (= Arthrospira) Platensis Induces Immunosuppression through Increasing T-regulatory Cells in a Syngeneic Mouse Model of Breast Cancer ACTA SCIENTIFIC CANCER BIOLOGY 2023
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Comparison of Cell-based and Nanoparticle-based Therapeutics in Treating Atherosclerosis CURRENT PHARMACEUTICAL DESIGN 2023
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Harnessing Diesel-Degrading Potential of an Antarctic Microalga from Greenwich Island and Its Physiological Adaptation BIOLOGY 2023
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Skin allergenicity of airborne and soil algae isolated from Malaysia AEROBIOLOGIA 2023
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Utilisation of Oil Palm’s Empty Fruit Bunch Spikelets for Oil-Spill Removal AGRONOMY 2022
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Influence of heavy metals on the occurrence of Antarctic soil microalgae ANTARCTIC SCIENCE 2021
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An analysis of health science students’ preparedness and perception of interactive virtual laboratory simulation MEDICAL SCIENCE EDUCATOR 2021
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Potential application of algae in biodegradation of phenol: A review and bibliometric study PLANTS 2021
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Impact of microplastics and nanoplastics on human health Nanomaterials 2021
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Influence of polystyrene microplastic and nanoplastic on copper toxicity in two freshwater microalgae Environmental Science and Pollution Research 2021
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Evaluating Anticancer and Immunomodulatory Effects of Spirulina (Arthrospira) platensis and Gamma-Tocotrienol Supplementation in a Syngeneic Mouse Model of Breast Cancer Nutrients 2021
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Heavy metal pollution in Antarctica and its potential impacts on algae Polar Science 2019
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Sensitivity of selected tropical microalgae isolated from a farmland and a eutrophic lake to atrazine and endosulfan Journal of Applied Phycology 2019
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Combined effects of glufosinate ammonium and temperature on the growth, photosynthetic pigment content and oxidative stress response of Chlorella sp. and Pseudokirchneriella subcapitata Journal of Applied Phycology 2018
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Assessing the toxicity of copper oxide nanoparticles and copper sulfate in a tropical Chlorella Journal of Applied Phycology 2018
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Distribution of microplastics and nanoplastics in aquatic ecosystems and their impacts on aquatic organisms, with emphasis on microalgae REVIEWS OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY VOLUME 246 2018
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Enhanced marine antifouling performance of silver-titania nanotube composites from hydrothermal processing Colloids and Surfaces A: Physicochemical and Engineering Aspects 2017
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Green synthesis of graphene-silver nanocomposites and its application as a potent marine antifouling agent Colloids and Surfaces B: Biointerfaces 2016
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Assessment of Paracetamol (Acetaminophen) Toxicity in Microalgae. Polish Journal of Environmental Studies 2015
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Low temperature, rapid solution growth of antifouling silver-zeolite nanocomposite clusters Microporous and Mesoporous Materials 2015
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Inhibitory activities of microalgal extracts against Epstein-Barr virus (EBV) antigen expression in lymphoblastoid cells Archives of Biological Sciences 2014
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Potent antifouling silver-polymer nanocomposite microspheres using ion-exchange resin as templating matrix Colloids and Surfaces A: Physicochemical and Engineering Aspects 2014
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Anti-tumour promoting activity and antioxidant properties of girinimbine isolated from the stem bark of Murraya koenigii S. Molecules 2012
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Inhibitory activities of microalgal extracts against Epstein-Barr virus DNA release from lymphoblastoid cells JOURNAL OF ZHEJIANG UNIVERSITY SCIENCE B 2011
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Antiproliferative activity of microalgal extracts on nasopharyngeal carcinoma (NPC) cells Malaysian Journal of Science 2008
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Anti-tumor promoting activity of some malaysian traditional vegetable (ulam) extracts by immunoblotting analysis of Raji cells Natural Product Sciences 2000

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Other Publications

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INFLUENCE OF MICRO AND NANOPASTICS ON THE TOXICITY OF POLLUTANTS IN MICROALGAE 47 Annual Conference of the MSBMB | 23 Aug 2023
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Influence of polyethylene micro- and nano-plastic on the combined toxicity of copper and lead in Antarctic microalgae based on a suite of biomarkers and transcriptomic profiles Polar research symposium | 18 Oct 2022
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Toxicity of triclosan in Antarctic isolate of Chlorella: non-monotonic response 9th Malaysian International Seminar on Antarctica | 25 Oct 2021
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AN ANALYSIS OF HEALTH SCIENCE STUDENTS’ PREPAREDNESS AND PERCEPTION OF INTERACTIVE VIRTUAL LABORATORY SIMULATION International Medical Education Conference | 12 Mar 2021
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Effect of long-term exposure to copper on the growth, pigmentation and oxidative response in a tropical and an Antarctic isolate of Chlorella 30th Regional Conference on Solid State Science & Technology | 06 Nov 2019
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Toxicity of Copper and Lead in a Tropical and an Antarctic isolate of Chlorella after Short- and Long-Term Exposure 8th Malaysian International Seminar on Antarctica | 18 Jun 2019
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Response of Tracheal Smooth Muscle to Airborne Algae The 8th Asian Pacific Phycological Forum (APPF2017) | 08 Oct 2017
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Response of Dunaliella tertiolecta and Isochrysis sp. to Titanium Dioxide Nanoparticles International meeting and 42nd Annual Conference of MSBMB | 16 Aug 2017
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Antiviral activity of microalgae extracts against Epstein-Barr virus in lymphoblastoid cell lines 6. Asia-Pacific Conference on Algal Biotechnology,, Makati City (Philippines), 12-15 Oct 2006 | 01 Jan 2006
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Antineoplastic activity of microalgae extracts against nasopharyngeal carcinoma (NPC) cells lines 6. Asia-Pacific Conference on Algal Biotechnology,, Makati City (Philippines), 12-15 Oct 2006 | 01 Jan 2006

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Supervisions
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Aw Yong Poi Yi | Doctorate | 01 Mar 2023 Thesis: Influence of polyethylene micro- and nano plastic on the combined toxicity of copper and lead in Antarctic microalgae based on a suite of biomarkers and transcriptomic profiles
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Lam Chuo Zi | Undergraduate | 01 Feb 2023 - 26 Jul 2023 Thesis: Immunomodulatory effects of tiger milk mushroom extract Lignosus rhinocerus TM02® Cultivar (Agaricomycetes) in sensitized human keratinocyte cell line NCTC2544
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Nur Imannina | Undergraduate | 21 Sep 2022 - 25 Nov 2022 Thesis: Influence of micro- and nanoplastic (polystyrene micro- and nanosphere) on the combined toxicity of copper (Cu) and manganese (Mn) in microalgae Chlorella sp. TJ6-5
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Darren Hue | Undergraduate | 21 Sep 2022 - 26 Nov 2022 Thesis: Influence of micro- and nanoplastic (polystyrene micro- and nanosphere) on the combined toxicity of copper (Cu) and manganese (Mn) in microalgae Chlorella sp. TJ6-5
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Bryan Chan Yi Hann | Undergraduate | 08 Sep 2022 - 25 Nov 2022 Thesis: Influence of micro- and nanoplastic (polystyrene micro- and nanosphere) on the combined toxicity of copper (Cu) and manganese (Mn) in microalgae Chlorella sp. TJ6-5
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Yong Yi Keng | Master (Coursework) | 25 Aug 2022 - 27 Jun 2023 Thesis: Immunomodulatory effects of Chinese Caterpillar Mushroom, Ophiocordyceps sinensis Cultivar OCS02 (Ascomycetes) in sensitized human keratinocyte cell line NCTC2544
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Gan Wen Cong | Doctorate | 11 Jan 2022 Thesis: Ecotoxicological Joint Effects of Nanoplastic and Herbicide Atrazine on Microalgae: Physiological and Molecular Responses
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Tae Ruo Shan, Goh Wen Xi | Undergraduate | 01 Jan 2022 - 29 Apr 2022 Thesis: Assessing the Effects of Heavy Metals on Bioremediation of Diesel Hydrocarbon by Antarctic Microalgae
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Lukman Hakim Abdullah | Master (Research) | 01 Apr 2021 Thesis: Influence of micro- and nanoplastic (polyethylene micro- and nanosphere) on the combined toxicity of copper and cadmium in microalgae
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Low Qin Hao | Undergraduate | 01 Jan 2021 - 01 Jun 2021 Thesis: Influence of micro- and nanoplastic (polystyrene micro- and nanosphere) on the combined toxicity of copper (Cu) and manganese (Mn) in microalgae Chlorella sp. TJ6-5
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Praveen Kumar | Undergraduate | 01 Jan 2021 - 01 Jun 2021 Thesis: Influence of micro- and nanoplastic (polystyrene micro- and nanosphere) on the combined toxicity of copper (Cu) and manganese (Mn) in microalgae
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Bryan Soong Chor Yue, Azraai Danial Khirzeri | Undergraduate | 01 Jan 2021 - 29 Apr 2021 Thesis: Isolation and characterisation of microalgae from selected pollution sites of rivers in Malaysia
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Ong Min Hui | Undergraduate | 01 Jan 2021 - 01 Jun 2021 Thesis: Influence of micro- and nanoplastic (polystyrene micro- and nanosphere) on the combined toxicity of copper (Cu) and manganese (Mn) in microalgae Chlorella sp. TJ6-5
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Hans Lee De En, Ooi Shu Hua, Melvin Teoh Lek Jin | Undergraduate | 01 Jan 2020 - 01 Jun 2020 Thesis: Joint toxicity of copper (Cu) and manganese (Mn) on Chlorella strains isolated from a farmland and an eutrophic lake: Concentration addition (CA) versus independent action (IA) models
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Aw Yong SIew Chan, Yeo Ee Lin | Undergraduate | 01 Jan 2019 - 01 Jun 2019 Thesis: Assessment of the toxicity of binary mixture and sequential exposure of Cu and Cd in microalgae
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Lukman Hakim Abdullah | Undergraduate | 01 Jan 2019 - 01 Jan 2020 Thesis: Toxicity of tetracycline on freshwater microalgae: effects of chronic and repeated pulse exposure
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Yang Shin Yi | Undergraduate | 01 Jan 2018 - 01 Jan 2019 Thesis: Toxicity of nano- and micrometer size copper oxide (CuO)particles in Chlorella sp. after 96 h and prolonged (10 days) exposure
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Rupini Krishna, Wan Nur Sarah Wan Mohd Zaid, Raja Mohamad Shazmin Bin Raha Muhammad, Lim Xie Thong | Undergraduate | 01 Jan 2018 - 01 Jun 2018 Thesis: Toxicity of Heavy Metals in a Tropical and an Antarctic isolate of Chlorella after Short- and Long-Term Exposure
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Wan Jun Kit | Master (Research) | 01 Jan 2017 - 01 Jan 2019 Thesis: EFFECT OF MICROPLASTIC AND NANOPLASTIC ON THE TOXICITY OF COPPER IN MICROALGAE
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Yeo Bann Siang | Master (Research) | 01 Jan 2016 - 01 Jan 2020 Thesis: Effects of Warming on Toxicity due to Repeated Exposure to Pesticides in Microalgae Isolated from Farming Areas in Cameron Highlands
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Noel Jacques Awi, Navindi Sandalika Samaraweera | Undergraduate | 01 Jan 2015 - 29 Apr 2015 Thesis: Assessing the toxicity resulting from exposure to multiple pulses of heavy metals in tropical and Antarctic Chlorella
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Wan Jun Kit | Undergraduate | 01 Jan 2015 - 01 Jan 2016 Thesis: Comparing the toxicity of copper oxide nanoparticles and soluble copper sulfate in the tropical microalga Chlorella sp..
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Nirosha Pragash | Undergraduate | 01 Feb 2014 - 31 Jan 2015 Thesis: Effects of airborne algae on contractility of tracheal smooth muscle
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Christina Diong, Aniqah Zulfa Abdul Latif | Undergraduate | 02 Jan 2014 - 30 Apr 2014 Thesis: Nanoparticle toxicity in marine microalgae: characterisation of particle size and zeta potential
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Chin Yin Yien | Doctorate | 01 Jan 2014 - 01 Jan 2021 Thesis: Assessment of the combined effects of nutrient enrichment and pesticide toxicity on various biomarkers in microalgae
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Nicholas Kok, Kiew Kim Boon, Harrcanaa Rajah | Undergraduate | 01 Jan 2014 - 01 Jun 2014 Thesis: Influence of salinity on the toxicity of single-walled carbon nanotubes in marine microalgae
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Dang Nguk Ling | Doctorate | 01 Jan 2014 - 01 Jan 2019 Thesis: Assessing the effects of heavy metals on oxidative stress response and metabolomic profiles of microalgae isolated from Signy Island, Antarctica.
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ANDRINA NG YANN-YI | Undergraduate | 23 May 2013 - 23 May 2014 Thesis: ASSESSMENT OF THE TOXICITY OF FUNCTIONALISED SINGLE-WALLED CARBON NANOTUBES IN TWO MARINE MICROALGAE
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Ng Sheu Yun, Choong Siew Ling | Undergraduate | 03 Jan 2013 - 29 Apr 2013 Thesis: Assessment of the toxicity of nanomaterials in marine microalgae
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Choong Siew Ling | Master (Research) | 01 Jan 2013 - 01 Jan 2016 Thesis: Allergenic Potential of Airborne Algae and Cyanobacteria Isolated in Malaysia
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Janice Siew | Undergraduate | 01 Feb 2012 - 29 Dec 2012 Thesis: Effect of aqueous extract and phycocyanin from Spirulina platensis on expression of Epstein-Barr virus (EBV) latent and lytic genes in lymphoblastoid cell lines
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Lim Jun Keit | Undergraduate | 01 Jan 2012 - 01 Nov 2012 Thesis: Influence of nitrogen and phosphorus levels on heavy metal toxicity in microalgae
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Hemavathy Subramaniam | Doctorate | 01 Jan 2012 - 01 Jan 2018 Thesis: Immunomodulatory Effects of Tocotrienol and Spirulina on Tumourigenesis using A Mouse Model of Breast Cancer
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Wee Whay Chiat | Undergraduate | 02 Mar 2011 - 25 Nov 2011 Thesis: Inhibitory activity of algal compounds against Epstein-Barr virus lytic cycle and proteins expression
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Amelia Nathania Dong Hui Min, Chai Chean Nee | Undergraduate | 01 Jan 2011 - 29 Apr 2011 Thesis: Inhibition of Spirulina platensis aqueous extract and phycocyanin against the expression of Epstein - Barr virus lytic proteins
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Liew Wee Sam, Lim Jiunn Jie, Polly Yap Soo Xi | Undergraduate | 01 Jan 2011 - 29 Apr 2011 Thesis: Antioxidant and antiproliferative activities of the algal pigment fucoxanthin
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Low Sook Yee | Undergraduate | 01 Jan 2011 - 01 Nov 2011 Thesis: Acid phosphatase bioassay for the assessment of heavy metal toxicity in algae
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Tan Chee Hoong | Undergraduate | 01 Jan 2011 - 01 Jun 2011 Thesis: Influence of urea levels on the sensitivity of microalgae to triclosan
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Khor Wei Ping, Lee E Lyn, Lim Kean Ping | Undergraduate | 01 Jan 2010 - 01 Jun 2010 Thesis: Influence of nitrogen source on the sensitivity of microalgae to triclosan
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Daniel Wang Ching Ye | Undergraduate | 01 Jan 2010 - 01 Nov 2010 Thesis: Use of Microalgae as Bioassay Organisms for Toxicity Testing of Paracetamol (Acetaminophen)
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Chin Yin Yien | Master (Research) | 01 Jan 2009 - 01 Jan 2011 Thesis: Assessment of the toxicity of pharmaceuticals in microalgae based on cell viability and oxidative stress biomarkers
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Dang Nguk Ling | Master (Research) | 01 Jan 2008 - 01 Jan 2010 Thesis: Induction of Programmed Cell Death (PCD) in Algae by Environmental Toxicants

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