Chew Shu Yih



Salutation
Dr

School/Centre
School of Medicine

Department
Microbiology and Immunology

Position
Senior Lecturer


Professional Network


Education

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Doctor of Philosophy (Molecular Biology and Genetic Engineering (Medical Microbiology)), 2020 Universiti Putra Malaysia
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Master of Science (Molecular Biology (Medical Microbiology)), 2015 Universiti Putra Malaysia
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Bachelor of Science (Hons) (Biochemistry), 2010 Universiti Putra Malaysia

Memberships

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Malaysian Society of Infectious Diseases and Chemotherapy (MSIDC) - Mycology Interest Group (MMIG) Subcommittee Member 2024 - Present
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The International Society for Human and Animal Mycology (ISHAM) Member 2023 - 2025
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Malaysian Society for Lactic Acid Bacteria (MSLAB) Executive Committee Member (2024/2025) 2021 - Present

Research Funding
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Deciphering extracellular vesicles of Candida glabrata: Impact on intercellular communication, fungal pathogenicity and host-pathogen interplay Fundamental Research Grant Scheme (FRGS) | 01 Aug 2024 - 31 Jul 2027
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Encapsulation and Packaging of Probiotic L29B towards the Doorstep of Commercialisation Ministry of Economy - Promotion of Research, Development, Commercialisation and Innovation Grant | 04 Dec 2023 - 03 Jun 2024
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Elucidating the gastroprotective mechanisms of Tualang honey against paraquat-induced dysbiosis in rats Fundamental Research Grant Scheme (FRGS) | 01 Oct 2023 - 30 Sep 2026
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Evaluation of culture and non-culture methods and their economic aspect for early diagnosis of invasive candidiasis in diagnostic laboratories in Malaysia Pfizer Global Medical Grant | 01 Dec 2022 - 30 Nov 2024
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Effect of physiologically relevant alternative carbon sources on cell wall properties and host-pathogen interactions in Candida glabrata Fundamental Research Grant Scheme (FRGS) | 07 Sep 2021 - 06 Sep 2024
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Host immune response towards fungal cell wall of pathogenic Candida glabrata grown in various alternative carbon sources Geran Putra Berimpak (GP-GPB) | 15 Jul 2021 - 14 Feb 2024
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Knowledge, attitude and practices level of COVID-19 among refugees who seek COVID-19 test in HPUPM Malaysia One Health University Network (MyOHUN) COVID-19 Supplementary Fund | 01 Nov 2020 - 31 May 2021
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Development of prototype of palm oil-based probiotics pessary for vaginal health Prototype Development Research Grant (PRGS) | 01 Aug 2019 - 30 Apr 2022
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Probiotic interference of lactobacilli strains against vaginal fungal pathogen Candida glabrata Research University Grant Scheme (RUGS) | 26 Jan 2012 - 25 Jan 2014

Publications

Research Articles

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Comparative genomic and phenotypic analyses of pathogenic fungi Neoscytalidium dimidiatum and Bipolaris papendorfii isolated from human skin scraping BRAZILIAN JOURNAL OF MICROBIOLOGY 2023
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Probiotic Strain Limosilactobacillus reuteri 29B is Proven Safe and Exhibits Potential Probiotic Traits in a Murine Vaginal Model PROBIOTICS AND ANTIMICROBIAL PROTEINS 2023
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Limosilactobacillus reuteri 29A Cell-Free Supernatant Antibiofilm and Antagonistic Effects in Murine Model of Vulvovaginal Candidiasis PROBIOTICS AND ANTIMICROBIAL PROTEINS 2023
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The Antibiofilm Role of Biotics Family in Vaginal Fungal Infections FRONTIERS IN MICROBIOLOGY 2022
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Assessment of Inflammation in Animal Models (Quantification of TNF-α, IFN-γ, IL-4, and IL-10 Proteins by ELISA) BIOSAFETY ASSESSMENT OF PROBIOTIC POTENTIAL 2022
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Role of Vaginal Mucosa, Host Immunity and Microbiota in Vulvovaginal Candidiasis PATHOGENS 2022
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Revisiting Trigonella foenum-graecum L.: Pharmacology and Therapeutic Potentialities PLANTS 2022
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Transcriptomic and proteomic profiling revealed reprogramming of carbon metabolism in acetate-grown human pathogen Candida glabrata JOURNAL OF BIOMEDICAL SCIENCE 2021
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Candida glabrata: Pathogenicity and resistance mechanisms for adaptation and survival JOURNAL OF FUNGI 2021
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Vaginal microbiota and the potential of Lactobacillus derivatives in maintaining vaginal health MICROBIAL CELL FACTORIES 2020
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Isolation and safety characterisation of lactobacilli strains with antimicrobial properties as potential probiotics for human use LWT 2020
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Glyoxylate cycle gene ICL1 is essential for the metabolic flexibility and virulence of Candida glabrata SCIENTIFIC REPORTS 2019
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Characterisation of the probiotic qualities exhibited by Lactobacilli strains isolated from the anogenital tract MALAYSIAN J. MED. HEALTH SCI 2019
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Physiologically relevant alternative carbon sources modulate biofilm formation, cell wall architecture, and the stress and antifungal resistance of Candida glabrata INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2019
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The glyoxylate cycle and alternative carbon metabolism as metabolic adaptation strategies of Candida glabrata: perspectives from Candida albicans and Saccharomyces cerevisiae JOURNAL OF BIOMEDICAL SCIENCE 2019
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Vulvovaginal candidosis: contemporary challenges and the future of prophylactic and therapeutic approaches MYCOSES 2016
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SNF3 as high affinity glucose sensor and its function in supporting the viability of Candida glabrata under glucose-limited environment FRONTIERS IN MICROBIOLOGY 2015
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Inávitro modulation of probiotic bacteria on the biofilm of Candida glabrata ANAEROBE 2015
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Probiotic Lactobacillus rhamnosus GR‐1 and Lactobacillus reuteri RC‐14 exhibit strong antifungal effects against vulvovaginal candidiasis‐causing Candida glabrata isolates JOURNAL OF APPLIED MICROBIOLOGY 2015
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Candida glabrata: Niche adaptation and mechanisms of survival UPDATES IN MEDICAL MICROBIOLOGY; UNIVERSITI PUTRA MALAYSIA PRESS: SELANGOR, MALAYSIA 2012

Other Publications

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Impact of adaptive microevolution under hypoxia condition on pathogenicity of Candida glabrata Emerging Fungal Infections Symposium | 07 Oct 2024
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Exploring molecular targets of Limosilactobacillus reuteri 29A culture supernatants against hyphal maintenance of Candida albicans The 14th Asian Conference on Lactic Acid Bacteria | 29 May 2024
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Optimization of medium components for Limosilactobacillus reuteri 29B production via statistical approach for probiotic pessary The 14th Asian Conference on Lactic Acid Bacteria | 29 May 2024
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Palm oil-based probiotic suppository to address vaginal infections and for overall vaginal health The 8th Microbiome R&D and Business Collaboration Congress: Asia | 07 May 2024
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Potent antibiofilm activity of postbiotic by Limosilactobacillus sp. 29A in a murine model of vulvovaginal candidiasis The 12th Asian Conference on Lactic Acid Bacteria | 10 Oct 2022
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Postbiotic Limosilactobacillus reuteri 29A reduces biofilms and hyphal formation of vulvovaginal candidiasis-causing Candida albicans The 11th Asian Conference on Lactic Acid Bacteria | 05 Nov 2021
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Alternative carbon metabolism induces multitude of physiological changes associated with pathogenicity of Candida glabrata 3rd International Conference on Molecular Biology and Biotechnology | 24 Apr 2019
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Effects of serial passaging and glucose on growth and biofilm formation ability of Candida glabrata INFECTIONS 2017 | 24 Oct 2017
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Growth in different glucose concentrations and biofilm formation abilities among Candida glabrata clinical strains isolated from different anatomical sites 33rd Symposium of the Malaysian Society for Microbiology | 14 Dec 2016
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Development and characterisation of hybridoma- producing monoclonal antibody directed against human pathogen Candida glabrata INFECTIONS 2015 | 07 Apr 2015
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Cross-kingdom interactions of probiotic bacteria with planktonic and biofilm forms of vaginal fungal pathogen Candida glabrata The 10th International Mycological Congress | 03 Aug 2014
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Antagonistic activities of probiotic Lactobacillus spp. against vaginal fungal pathogen Candida glabrata. 8th National Infectious Diseases Seminar and Workshop (NIDSAW 2013) | 27 Aug 2013

Books

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Springer US (2022). Assessment of Bacterial Translocation Through Blood Cultures

Patents

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Identification, Characterisation of Probiotics Strain and Its Formulation | 15 Nov 2022

Medias

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Biotics battle vaginal fungal biofilms Contemporary OB/GYN | 09 Jul 2022


Supervisions
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Wan Sarah Zainina Binti Wan Mohd Zahiruddin | Master (Research) | 30 May 2024 Thesis: Effects on Tualang honey on gut function, microbial composition, oxidative and inflammatory markers following three months low-dose exposure to paraquat in rats
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Siti Nordiana Binti Mohd Nasir Shah Ngui | Doctorate | 09 Oct 2023 Thesis: Development of a recombinase polymerase amplification lateral flow assay (RPA-LFA) for rapid detection and differentiation of invasive fungal infections
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Haizat Bin Yamang | Doctorate | 01 Mar 2022 Thesis: Impact of adaptive microevolution under hypoxia condition on the fitness and virulence of Candida glabrata
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Subatrra Nair Balakrishnan | Master (Research) | 01 Oct 2021 Thesis: In vitro evaluation on effect of innate immunity on Candida glabrata cell wall properties on host-pathogen interactions
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Ang Li Hui | Master (Research) | 01 Oct 2020 Thesis: Prototype development and characterisation of palm oil-based probiotic pessary for vaginal Health