GAN SOOK YEE



Salutation
Associate Professor Dr

School/Centre
School of Pharmacy

Department
Life Sciences

Appointment
Associate Dean, Academic

Position
Associate Professor

Email
sookyee_gan@imu.edu.my



Education

a
PhD (Molecular Biology), 2005 University of Malaya
a
Master (Master of Philosophy), 2001 University of Malaya
a
Bachelor (Bachelor of Science (Biotechnology)), 1995 University Pertanian Malaysia

Research Funding
a
Non-ionic surfactant Niosomes Membrane Rigidity and Stability IMU Internal Research Grant | 18 Jun 2024 - 25 Sep 2024
a
DIFFERENTIAL GENE EXPRESSION IN DIFFERENT STAGES OF ALZHEIMER DISEASE IMU Internal Research Grant | 01 Jun 2024 - 31 Oct 2024
a
In Vitro Antioxidative, Anti-cholinesterase, and Anti-α-amylase Effects of Gelatin-phenolic acid Conjugates Bachelor in Medical Sciences (Hons) | 10 Jan 2022 - 07 May 2021
a
The neuro-protective effects of TGF-βR1 inhibitors against beta-amyloid-induced neurotoxicity and microglia-mediated neurotoxicity BPharm | 01 Jul 2021 - 30 Sep 2021
a
Mechanistic studies on the neuroprotective effect of beta-sitosterol during beta amyloid-induced microglia-mediated neuro-inflammation. MMM | 01 Mar 2021 - 31 Aug 2021
a
Functional role of MIRO1 in NLRP1 inflammasome-mediated neuronal cell death MoHE Fundamental Research Grant Scheme (FRGS) | 01 Nov 2020 - 31 Oct 2022
a
Roles of salivary microRNAs as potential noninvasive biomarkers in assessing effectiveness of combined therapy with gliclazide and metformin regimen among obese Type 2 diabetes mellitus (TD2M) patients Fundamental Research Grant Scheme (FRGS) | 01 Nov 2020 - 30 Nov 2023
a
The effect of astaxanthin on the biological functions of NPC cells IMU | 01 Jul 2020 - 01 Nov 2020
a
Alterations of Inflammatory Markers by Madecassoside/Catalpol in Pancreatic Beta-Cell Line Under High Glucose Condition IMU Internal Research Grant | 01 Jul 2019 - 30 Sep 2019
a
Involuntary smoking and the risk of head and neck cancers: A meta-analysis of observational studies IMU | 01 Jun 2019 - 01 Dec 2019
a
The Effect of β-Sitosterol Against Beta Amloid (Aβ)-Induced Neuro-Inflammation in BV2 Microglia Cells IMU | 01 May 2019 - 01 Jun 2020
a
Systematic Review on the Association of SNP rs 1800630 of Tumour Necrosis Factor-Alpha (TNF-α) with the Development of Overweight and Obesity IMU | 18 Jul 2018 - 18 Dec 2018
a
Investigating the Insulin Signaling Protein and Neuroinflammatory Markers in the Brain Regions of High Fat Diet and Streptozotocin Induced Type 2 Diabetes Mice IMU Internal Research Grant | 01 Jul 2018 - 30 Sep 2018
a
Investigating the Alteration of PGC-1α, PPAR-γ and Oxidative Stress in the Brain Regions of High Fat Diet/STZ Induced Type-2 Diabetes Mice IMU Internal Research Grant | 01 Jul 2018 - 30 Sep 2018
a
Evaluating the research progress of undergraduate pharmacy students in the final year projects IMU | 01 Jan 2017 - 01 Aug 2018
a
A microarray-coupled gene trap mutagenesis approach for the identification of NLRP1 inflammasome activation targets mediating beta amyloid (Aβ)-induced neuronal pyroptosis Fundamental Research Grant Scheme | 01 Aug 2016 - 31 Jul 2020
a
Potential anti-Alzheimer’s activity of brown algae metabolites. E-Science MOSTI | 01 Jan 2012 - 01 Jan 2014
a
Expression profiling of microRNA in nasopharyngeal carcinoma in response to interleukins and transforming growth factor: Towards unraveling the roles of microRNA in invasion and metastasis. Fundamental Research Grant Scheme | 01 Jan 2010 - 01 Jan 2012

Show More


Publications

Research Articles

a
Pharmacy students’ and supervisors’ perceptions of the effectiveness of assessment rubrics for undergraduate research performance review PHARMACY EDUCATION 2023
a
Lipopolysaccharide (LPS) stimulation of Pancreatic Ductal Adenocarcinoma (PDAC) and macrophages activates the NLRP3 inflammasome that influences the levels of pro-inflammatory cytokines in a co-culture model CANCER BIOLOGY & THERAPY 2023
a
Recent progress in genetically modified microalgae for enhanced carbon dioxide sequestration Biomass and Bioenergy 2021
a
Genes associated with amyloid-beta-induced inflammasome-mediated neuronal death identified using functional gene trap mutagenesis approach The international journal of biochemistry & cell biology 2021
a
Piper sarmentosum Roxb. Attenuates Beta Amyloid (Aβ)-Induced Neurotoxicity Via the Inhibition of Amyloidogenesis and Tau Hyperphosphorylation in SH-SY5Y Cells Current Alzheimer Research 2021
a
Self-reported perception of a Dedicated research semester in Pharmacy curriculum in enhancing research competencies The Asia Pacific Scholar 2020
a
Catalpol ameliorates insulin sensitivity and mitochondrial respiration in skeletal muscle of type-2 diabetic mice through insulin signaling pathway and AMPK/SIRT1/PGC-1α/PPAR-γ activation Biomolecules 2020
a
The role of neuronal NLRP1 inflammasome in Alzheimer’s disease: bringing neurons into the neuroinflammation game Molecular neurobiology 2019
a
The NLRP3 inflammasome is involved in the neuroprotective mechanism of neural stem cells against microglia-mediated toxicity in SH-SY5Y cells via the attenuation of tau hyperphosphorylation and amyloidogenesis Neurotoxicology 2019
a
Fucosterol exerts protection against amyloid β-induced neurotoxicity, reduces intracellular levels of amyloid β and enhances the mRNA expression of neuroglobin in amyloid β-induced SH-SY5Y cells International journal of biological macromolecules 2019
a
Green algal molecular responses to temperature stress Acta physiologiae plantarum 2019
a
Piper sarmentosum Roxb. root extracts confer neuroprotection by attenuating beta amyloid-induced pro-inflammatory cytokines released from microglial cells Current Alzheimer Research 2019
a
Piper sarmentosum Roxb. confers neuroprotection on beta-amyloid (Aβ)-induced microglia-mediated neuroinflammation and attenuates tau hyperphosphorylation in SH-SY5Y cells Journal of ethnopharmacology 2018
a
Gene expression profile of marine Chlorella strains from different latitudes: stress and recovery under elevated temperatures Journal of Applied Phycology 2018
a
Fucosterol inhibits the cholinesterase activities and reduces the release of pro-inflammatory mediators in lipopolysaccharide and amyloid-induced microglial cells Journal of applied phycology 2018
a
Agrobacterium-mediated gene delivery and transient expression in the red macroalga Chondrus crispus Botanica Marina 2018
a
In vitro neuroprotective effects of naringenin nanoemulsion against β-amyloid toxicity through the regulation of amyloidogenesis and tau phosphorylation International journal of biological macromolecules 2018
a
Effect of elevated temperature on the physiological responses of marine Chlorella strains from different latitudes Journal of Applied Phycology 2018
a
Random mutagenesis and precise gene editing technologies: applications in algal crop improvement and functional genomics European Journal of Phycology 2017
a
MicroRNAs serving as potential biomarkers and therapeutic targets in nasopharyngeal carcinoma: A critical review Critical reviews in oncology/hematology 2016
a
Comparison of visual observation and emission intensity of resazurin for antimicrobial properties of hexane, dichloromethane, methanol and water extracts from a brown alga, Turbinaria ornata COGENT BIOLOGY 2016
a
Antioxidative, anticholinesterase and anti-neuroinflammatory properties of Malaysian brown and green seaweeds INTERNATIONAL JOURNAL OF INDUSTRIAL AND MANUFACTURING ENGINEERING 2015
a
Elucidating the roles of miR-372 in cell proliferation and apoptosis of nasopharyngeal carcinoma TW01 cells Experimental oncology 2014
a
The effect of cytokines on microRNA expression in TW01 nasopharyngeal carcinoma cells JOURNAL OF ADVANCES IN MEDICINE AND MEDICAL RESEARCH 2013
a
Effects of IL-6, IL-10 and TGF-β on the expression of survivin and apoptosis in nasopharyngeal carcinoma TW01 cells Experimental oncology 2012
a
Interleukins, laminin and Epstein-Barr virus latent membrane protein 1 (EBV LMP1) promote metastatic phenotype in nasopharyngeal carcinoma BMC cancer 2010
a
PHYLOGENY OFCHLORELLASTRAINS ISOLATED FROM DIFFERENT LATITUDES FROM THE NORTH TO THE SOUTH POLE: 304 Phycologia 2009
a
GENETIC TRANSFORMATION OFCHLORELLA VULGARIS: 95 Phycologia 2009
a
Seaweed diversity in Malaysia STATUS OF BIOLOGICAL DIVERSITY IN MALAYSIA AND THREAT ASSESSMENT OF PLANT SPECIES IN MALAYSIA. FOREST RESEARCH INSTITUTE MALAYSIA 2007
a
Identification of random amplified polymorphic DNA (RAPD) marker for differentiating male from female and sporophytic thalli of Gracilaria changii (Rhodophyta) Journal of Applied Phycology 2007
a
Crop improvement in seaweed cultivation ADVANCES IN SEAWEED CULTIVATION AND UTILISATION IN ASIA. UNIVERSITY OF MALAYA MARITIME RESEARCH CENTER PUBLICATION 2006
a
Morphological and molecular characterisation and differentiation of Sargassum baccularia and S. polycystum (Phaeophyta) Journal of applied phycology 2004
a
Development of a transformation system for Gracilaria changii (Gracilariales, Rhodophyta), a Malaysian red alga via microparticle bombardment The 4 th Annual Seminar of National Science Fellowship 2004
a
Transient expression of lacZ in particle bombarded Gracilaria changii (Gracilariales, Rhodophyta) Journal of Applied Phycology 2003

Show More


Other Publications

a
Effect of catalpol on liver glucose homeostasis in high fat diet/low dose streptozotocin-induced type 2 diabetes mellitus BRITISH JOURNAL OF PHARMACOLOGY | 01 Jan 2019

Books

a
Springer, Cham (2016). Genetic and metabolic engineering of microalgae


Supervisions
a
MR SAKTI JAIGANEISH A/L E. VENNARAJAN | Master (Research) | 29 Mar 2022 Thesis: Roles of salivary microRNAs as potential non-invasive biomarkers in assessing effectiveness of combined therapy with gliclazide and metformin regimen among obese Type 2 diabetes mellitus (T2DM) patients
a
Mr Ng Jia Hao | Master (Research) | 30 Nov 2021 Thesis: The functional role of MIRO1 in NLRP1 inflammasome-mediated neuronal cell death
a
MS NUR NAJIHAH BINTI SALAHUDDIN | Master (Coursework) | 25 Nov 2021 Thesis: “Synthesis, characterisation, antioxidant and alpha-glucosidase inhibitory activities of pectin-phenolic acid conjugate”
a
Yap Kah Heng | Doctorate | 01 Aug 2021 Thesis: Antidiabetic activities of catalpol on high-fat-diet/streptozotocin induced Type-2 diabetes mice by improving insulin sensitivity and mitochondrial function
a
Ng Kar Wei | Undergraduate | 06 Jun 2021 - 06 Jun 2022 Thesis: In vitro antioxidative, anti-cholinesterase, and anti-α-amylase effects of gelatinphenolic acid conjugates
a
Ms Agnes Gwenhure | Master (Coursework) | 26 Mar 2021 - 30 Sep 2021 Thesis: Mechanistic studies on the neuroprotective effect of beta-sitosterol during beta amyloid-induced microglia-mediated neuro-inflammation
a
Bahram Barati | Doctorate | 01 Jan 2019 - 30 Jul 2021 Thesis: The Effect of Elevated Temperature on Growth, Photosynthetic Performance, Biochemical Composition and Expression Pattern of Heat Induced Genes
a
Cindy Wong | Master (Coursework) | 01 Mar 2017 - 01 Mar 2018 Thesis: Neuroprotective effect of neuronal stem cells (NSCs) on SHSY5Y cells via the regulation of inflammasome-mediated inflammation in BV2 microglia cells.
a
Ms Sangeetha Krishnansamy | Master (Coursework) | 24 Aug 2016 - 28 Feb 2017 Thesis: The regulation of inflammasome activation in BV 2 microglia cells by neuronal stem cells (NSCs)
a
Jeremy Yap Kean Yi | Master (Research) | 01 Aug 2016 - 31 Jul 2020 Thesis: A microarray-coupled gene trap mutagenesis approach for the identification of NLRP1 inflammasome activation targets mediating beta amyloid (Aβ)-induced neuronal pyroptosis
a
Siti Aisya Bt Saud Gany | Master (Research) | 01 Jan 2012 - 01 Jan 2014 Thesis: Antioxidant and anti-neuroinflammatory properties of Padina, a genus of brown algae in the order of Dictyotales
a
Tan Swee Ching | Master (Research) | 01 Jan 2012 - 01 Jan 2015 Thesis: Cholinesterase Inhibitory andneuroprotective properties of Sargassum, a genus of brownalgae in the order of Fucales.
a
Anusha Ramessur | Doctorate | 06 Jul 2010 - 29 Jun 2013 Thesis: Genetic Transformation of Chondrus
a
Lee Ting Wei | Master (Research) | 01 Jan 2010 - 01 Jan 2012 Thesis: Expression profiling of microRNA in nasopharyngeal carcinoma in response to interleukins and transforming growth factor: Towards unraveling the roles of microRNA in invasion and metastasis.

Show More