MOHD ZULKEFELI BIN MAT JUSOH



Salutation
Professor

School/Centre
School of Pharmacy

Department
Pharmaceutical Chemistry

Appointment
Director, Quality

Position
Professor

Email
mohdzulkefeli@imu.edu.my

Professional Network


Education

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Post-Doctoral Fellow (Supramolecular Chemistry), 2010 Tokyo University of Science
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Doctor of Philosophy (PhD) (Pharmaceutical Science), 2005 Hiroshima University
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Master of Pharmaceutical Science (Molecular Science Pharmacy (Medicinal Chemistry)), 2002 Hiroshima University
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Non-Diploma Research Fellow (Molecular Science Pharmacy (Medicinal Chemistry)), 2000 Hiroshima University
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Bachelor of Pharmaceutical Science (Pharmacy), 1998 Hiroshima University

Memberships

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International Pharmaceutical Federation Member 2019 - Present
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The Malaysian Academy of Pharmacy Council Member and Principal 2018 - Present
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The American Chemical Society Regular Member (31576003) 2018 - Present
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Malaysian Pharmacists Society Ordinary Member 2005 - Present

Research Funding
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Novel ruthenium polypyridyl complexes as antibacterial photosensitizers and biofunctionalization of Au-TFBG for SARS-CoV-2 virus and bacterial detection IMU Internal Research Grant | 15 Feb 2024 - 28 Feb 2025
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Membrane-targeting peptides enhancing uptake of antibacterial and anticancer ruthenium-based photosensitisers: feasibility and synergistic mechanism studies IMU Internal Research Grant | 04 Dec 2023 - 31 Oct 2024
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Product Development of Mikto-Arm Star Polymer for Novel Oral/Transdermal Drug Delivery System Applications REVOLUIoNT - iNanovation | 01 Jul 2023 - 31 Dec 2024
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In Silico Binding Role of Naturally Occurring Bioactive Chalcones as Anti-COVID-19 agents: A Molecular Docking Simulation-Based Virtual Screening IMU Internal Research Grant | 01 Jul 2021 - 30 Nov 2021
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Bacterial membrane targeting agent – ruthenium based photosensitizer conjugates as novel effective therapeutics against multi-drug resistant bacteria: feasibility and synergistic mechanism studies (FRGS funded) MSc in Medical & Health Sciences (by Research) | 03 May 2021 - 30 Apr 2023
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Bacterial membrane targeting agent - ruthenium/rhenium based photosensitizer conjugates as novel effective therapeutics against multi-drug resistant bacteria: feasibility and synergistic mechanism studies MoHE Fundamental Research Grant Scheme (FRGS) | 01 Nov 2020 - 31 Oct 2022
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In vitro anti-inflammatory activity of 4,4'-(alk-1,5-diylbis(oxy))dibenzimidamides and their zinc complexes analogue IMU | 01 Jul 2020 - 01 Dec 2020
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Development of Convenient Methods for Detection and Capture of Circulating Tumor Cells IMU | 01 Aug 2019 - 01 Dec 2019
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Analysis on the role of atypical protein kinase (aPKC) in cancer stem cells IMU | 01 Aug 2019 - 01 Dec 2019
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Re(1) Tricarbonyl Complexes Combinations, Conjugates and Formulations with Liquid Crystalline Nanoparticles for Pancreatic Cancer Photodunamic Theraphy and Bioimaging IMU (TB Challenge Grant) | 01 Apr 2019 - 01 Sep 2020
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Novel gemcitabine – Re(I) tricarbonyl complexes combinations, conjugates and formulations with liquid crystalline nanoparticles for pancreatic cancer photodynamic therapy and bioimaging (IMU Pancreatic Cancer Challenge Grant) IMU | 01 Mar 2019 - 01 Feb 2020
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Preparation, Characterization and Anticancer Effects of Gemcitabine-Tocotrienols Entrapped Niosomes in Pancreatic Cancer MPOB | 01 Feb 2018 - 01 Jun 2018
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Evaluating the research progress of undergraduate pharmacy students in the final year projects IMU | 01 Jan 2017 - 01 Aug 2018

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Publications

Research Articles

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Ruthenium (II) polypyridyl complexes as emerging photosensitisers for antibacterial photodynamic therapy JOURNAL OF INORGANIC BIOCHEMISTRY 2023
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Students’ and Supervisors’ Perceptions of the Effectiveness of Assessment Rubrics for Undergraduate Research Performance Review PHARMACY EDUCATION 2023
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Swietenine Alleviates Nonalcoholic Fatty Liver Disease in Diabetic Mice via Lipogenesis Inhibition and Antioxidant Mechanisms ANTIOXIDANTS 2023
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Synthesis of New Shogaol Analogues as NRF2 Activators and Evaluation of Their Anti-Inflammatory Activity, Modes of Action and Metabolic Stability ANTIOXIDANTS 2023
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Synthesis and Anti‐Inflammatory Activity of 2‐Amino‐4, 5, 6, 7‐tetrahydrobenzo [b] thiophene‐Derived NRF2 Activators CHEMISTRYOPEN 2022
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Anti-Inflammatory Effects of Auranamide and Patriscabratine—Mechanisms and In Silico Studies MOLECULES 2022
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Novel Gemcitabine-Re (I) Bisquinolinyl Complex Combinations and Formulations with Liquid Crystalline Nanoparticles for Pancreatic Cancer Photodynamic Therapy FRONTIERS IN PHARMACOLOGY 2022
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Studies on the mechanism of anti-inflammatory action of swietenine, a tetranortriterpenoid isolated from Swietenia macrophylla seeds PHYTOMEDICINE PLUS 2021
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Preparation of (Substituted)-Benzyltriphenylphosphonium Bromide Salts Under Microwave Irradiation BIOMEDICAL JOURNAL OF SCIENTIFIC & TECHNICAL RESEARCH 2021
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Co-encapsulation of gemcitabine and tocotrienols in nanovesicles enhanced efficacy in pancreatic cancer Nanomedicine 2021
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Development of metallosupramolecular phosphatases based on the combinatorial self-assembly of metal complexes and organic building blocks for the catalytic hydrolysis of phosphate monoesters Results in Chemistry 2021
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Synthesis, characterization and multiple targeting with selectivity: Anticancer property of ternary metal phenanthroline-maltol complexes Journal of Inorganic Biochemistry 2021
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A Critical Outlook on the Role of Research Practices in Laboratory towards Student Skills Development in Malaysian and Japanese Public Universities INTERNATIONAL JOURNAL OF INNOVATIVE RESEARCH AND ADVANCED STUDIES 2020
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Recent Emergence of Rhenium (I) Tricarbonyl Complexes as Photosensitisers for Cancer Therapy Molecules 2020
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Pharmacy education during and beyond COVID-19 in six Asia-Pacific countries: Changes, challenges, and experiences Pharmacy Education 2020
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Polymer-wrapped single-walled carbon nanotubes: A transformation toward better applications in healthcare Drug delivery and translational research 2019
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Challenges and opportunities of nanotechnology as delivery platform for tocotrienols in cancer therapy Frontiers in Pharmacology 2018
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Relationship Dimension In University Laboratories And Its Effects On Students’ Interest THE EUROPEAN PROCEEDINGS OF SOCIAL AND BEHAVIOURAL SCIENCES 2018
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Supramolecular complexes formed by the self-assembly of hydrophobic Bis (Zn2+-cyclen) complexes, copper, and Di-or Triimide units for the hydrolysis of phosphate Mono-and diesters in two-phase solvent systems (Cyclen= 1, 4, 7, 10-Tetraazacyclododecane) Chemical and Pharmaceutical Bulletin 2016
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Synthesis of 2-(2-methoxyphenyl)-5-phenyl-1, 3, 4-oxadiazole derivatives and evaluation of their antiglycation potential Medicinal Chemistry Research 2016
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A quantum chemical and statistical study of cytotoxic activity of compounds isolated from Curcuma zedoaria International journal of molecular sciences 2015
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Synergy in Supramolecular Chemistry BY NABESHIMA T., CRC, BOCA RATON, FL 2015
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Supramolecular Phosphatases Formed by the Self‐Assembly of the Bis (Zn2+–Cyclen) Complex, Copper (II), and Barbital Derivatives in Water CHEMISTRY"AN ASIAN JOURNAL 2014
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Antioxidant activity of hispidin oligomers from medicinal fungi: A DFT study Molecules 2014
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Solute solvent interactions of polyvinyl pyrrolidone wrapped single walled carbon nanotubes (PVP-SWNTs) in water by acoustic studies Journal of Nanofluids 2013
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Design, synthesis, in vitro cytotoxicity evaluation and structure–activity relationship of Goniothalamin analogs Archives of pharmacal research 2013
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Agarwood production-a multidisciplinary field to be explored in Bangladesh INTERNATIONAL JOURNAL OF PHARMACEUTICAL AND LIFE SCIENCES 2013
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Molecular Recognition of Hydrocarbon Guests by a Supramolecular Capsule Formed by the 4: 4 Self‐Assembly of Tris (Zn2+–Cyclen) and Trithiocyanurate in Aqueous Solution CHEMISTRY"AN ASIAN JOURNAL 2012
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Selective hydrolysis of phosphate monoester by a supramolecular phosphatase formed by the self-assembly of a bis (Zn2+-cyclen) complex, cyanuric acid, and copper in an aqueous solution (cyclen= 1, 4, 7, 10-tetraazacyclododecane) Inorganic chemistry 2011
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Design and synthesis of a stable supramolecular trigonal prism formed by the self-assembly of a linear tetrakis (Zn2+− cyclen) complex and trianionic trithiocyanuric acid in aqueous solution and its complexation with DNA (cyclen= 1, 4, 7, 10-tetraazacyclododecane) Inorganic chemistry 2009
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A Luminescence Sensor of Inositol 1, 4, 5-Triphosphate and Its Model Compound by Ruthenium-Templated Assembly of a Bis (Zn2+-Cyclen) Complex Having a 2, 2 ‘-Bipyridyl Linker (Cyclen= 1, 4, 7, 10-Tetraazacyclododecane) Journal of the American Chemical Society 2005
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New supramolecular trigonal prisms from zinc (II)–1, 4, 7, 10-tetraazacyclododecane (cyclen) complexes and trithiocyanurate in aqueous solution PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES 2002

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Other Publications

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Membrane-targeting Peptides Enhancing Uptake Of Ruthenium(II) Polypyridyl Photosensitisers Into Clinically Relevant Bacteria MYCRS Young Scientist Symposium 2023 | 17 Aug 2023
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Enhancing Global Experience and International Collaboration Through Undergraduate Research Module of IMU Bpharm Programme The 11th Asian Association of Schools of Pharmacy Conference (AASP 2023) | 04 Aug 2023
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Strategies to Improve Enrolment in Schools of Pharmacy – Launch of the FIP AIM Handbook The International Pharmaceutical Federation (FIP) Academic Institutional Membership (AIM) Digital Event Webinar | 23 Jan 2023
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Pharmacy Education During and Beyond COVID-19: Changes, Challenges and Experiences in Asia-Pacific The Federation of Asian Pharmaceutical Associations (FAPA) and the Malaysian Pharmaceutical Society (MPS) Webinar | 15 Mar 2020
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Virtual Innovations via. Simulations Training and Assessment (VISTA): Adapting IR 4.0 competencies to foster new medicine development skills among IMU School of Pharmacy graduates 19th OTTAWA Conference 2020 | 29 Feb 2020
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Co-Formulation of Cholesterol Lowering Drugs and Nutraceuticals within The STAR Polymer 7th International Postgraduate Conference on Pharmaceutical Science 2020 (iPOPS2020) | 28 Feb 2020
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Advanced Experiential Education Through Collaboration with Healthcare Organisations Johor Pharmacy Conference 2019 | 06 Apr 2019
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Preparation and Characterisation of Gemcitabine and Tocotrienol-Rich-Fraction Entrapped Niosomes "Drug Delivery Seminar Series 1/2019 THE NEXT FRONTIER OF DRUG DELIVERY: WHERE ARE WE NOW?" | 14 Jan 2019
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Science & Technology Through Media in Japanese Way Academic Conference of Malaysia Japan Discourse Project 2018 | 04 Dec 2018
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Advance in Molecular Biology: Future Personalised Diagnostic Medical Devices 2017 International Conference on Future Healthcare and Economic Development in Southeast ASIA | 13 Aug 2017
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Self-Assembly of Hetero-Building Blocks Supramolecule of Dimeric (Zn2+-Cyclen) Complexes, Organic Anion and Metal Ions in Aqueous Solution 4th International Postgraduate Conference on Pharmaceutical Science 2016 (iPOPS2016) | 27 Feb 2016
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Design and Synthesis of Functional Supramolecules by Self-Assembly of Dimeric (Zn+-Cyclen) Complex, Organic Anion and Metal Ions in Aqueous Solution Drug Discovery & Therapy World Congress 2015 | 22 Jul 2015
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Design and Synthesis of Ortho-, Meta- and Para-xylylguanidinium-Zn2+-Cyclen Complex and Its Interaction Towards Deoxyribonucleic Acid (Cyclen = 1,4,7,10-Tetraazacyclododecane) 18th Malaysian International Chemical Congress (MICC) | 03 Nov 2014
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Postgraduate Study in Pharmacy as a Specialization Studies for Career in Pharmacy and Pharmaceuticals; for Bachelor of Pharmacy Graduates or any Sciences Graduates? 4th Asia Pacific Pharmacy Education Workshop | 25 Nov 2013
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Structural and Phosphate Monoester Hydrolysis activity of 2:2:2 Supramolecule from Dimeric Zinc Complexes, Barbital and Cu(II) 131st Annual Meeting of The Pharmaceutical Society of Japan | 28 Mar 2011
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Selective Hydrolysis of Phosphate Monoester in Aqueous Solution by Supramolecular Catalysts Formed by Self-Assembly of Bipyridyl-appended bis(Zn2+−Cyclen) Complex, Cyanurate, and Copper (Cyclen = 1,4,7,10-Tetraazacyclodecane) 2010 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010) | 15 Dec 2010
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A Novel Kind of p53 Inhibitor That Targets The Zinc Binding Site of p53 The 53rd Annual Meeting of The Japan Radiation Research Society | 20 Oct 2010
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Short and Efficient Synthesis of Goniothalamin 16th Malaysian Chemical Congress (16MCC) | 12 Oct 2010
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Supramolecular Chemistry Utilizing Self-Assembly of Zinc(II) Complexes in Aqueous Solution 16th Malaysian Chemical Congress (16MCC) | 12 Oct 2010
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Novel Route For The Synthesis of Goniothalamin And Its Derivatives/Analogues 23rd Malaysian Symposium On Analytical Sciences (SKAM-23) | 04 Oct 2010
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Artificial Phosphatase Formed by Self-Assembly of Zinc Complex, Copper Ion, and Organic Anions 60th Anniversary Conference on Coordination Chemistry | 27 Sep 2010
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Hydrolysis of Phosphate Monoesters by a Supramolecular Catalyst Formed by Self-Assembly of Metal Complexes 20th Symposium on Role of Metals in Biological Reactions, Biology and Medicine (SRM 2010) | 25 Jun 2010
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Synthesis of Styryllactone Derivatives 3rd International Conference For Young Chemists 2010 | 23 Jun 2010
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A Novel Way to Prepare Wittig Reagents under Microwave Irradiation and Synthesis of Halogenated Styryllactones 3rd International Conference For Young Chemists 2010 | 23 Jun 2010
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Short and Efficient Synthesis of Goniothalamin From (3,4-Dihydro-2H-pyran-2-yl)Methanol 3rd International Conference For Young Chemists 2010 | 23 Jun 2010
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Molecular Recognition of Water-Soluble Supramolecular Cage Formed by Self-Assembly of Trimeric Zinc(II) Complex The 6th Symposium on Host-Guest Chemistry | 11 Jun 2010
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Selective Hydrolysis of Phosphate Monoester by A Supramolecular Catalyst 5th International Symposium on Macrocyclic & Supramolecular Chemistry | 06 Jun 2010
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Simple Synthesis of Goniothalamin From (3,4-Dihydro-2H-pyran-2-yl)Methanol Regional Seminar On Science, Technology & Social Sciences (STSS 2010) | 01 Jun 2010
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A Self-Assembly and Phosphomonoester Hydrolysis of Supramolecular from Dinuclear Metal Complexes, Organic Anions and Copper Ions 8th Organic Chemistry-The Next Generation Symposium | 13 May 2010
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A Water–Soluble Supramolecular Complex Formed by 4:4:4 Self–Assembly of Bis(Zn2+–Cyclen) Having 2,2’–Bipyridyl Linker, Cyanuric Acid (CA), and Copper 130th Annual Meeting of The Pharmaceutical Society of Japan | 28 Mar 2010
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三核亜鉛錯体の自己集積による水溶性かご型超分子の分子認識機構 ホスト・ゲスト化学シンポジウム講演要旨集 第 6 回ホスト・ゲスト化学シンポジウム | 01 Jan 2010
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Design and Synthesis of An Extremely Stable Polycationic Trigonal Prism Based on the Self-Assembly of Linear Tetrakis((Zn2+–1,4,7,10-tetraazacyclododecane)Complex with Trithiocyanurate and Its Complexation with DNA 2nd International Symposium on Bioinorganic Chemistry of the New Era | 31 Jul 2009
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Formation of a Supramolecular Trigonal Prism by Self-Assembly of Linear Tetrakis(Zn2+–cyclen) with Trithiocyanurate in Aqueous Solution and Its Complexation with DNA (Cyclen = 1,4,7,10-tetraazacyclododecane) 14th International Conference on Biological Inorganic Chemistry (ICBIC14) | 25 Jul 2009
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Design, Synthesis, and Anti-Trypanosomal Activities of Dinuclear Zinc (II)-Macrocyclic Polyamine Complexes 129th Annual Meeting of The Pharmaceutical Society of Japan | 26 Mar 2009
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Molecular Recognition in Aqueous Solution Utilizing Supramolecular Complexes Formed by Self-Assembly of Multinuclear Zinc(II) Complexes and Polyanionic Compounds 3rd Tokyo University of Science International Collaboration Workshop (3rd TUS-ICW) | 15 Mar 2009
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Design and Synthesis, and Anti-Trypanosomal Activities of Dinuclear Zinc (II)-Macrocyclic Polyamine Complexes 2nd Indo-Japanese International Joint Symposium on Overcoming Intractable Infectious Diseases Prevalent in Asian Countries | 23 Dec 2008
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Design and Synthesis of New Chemical Entity (Stilbene) appended Macrocyclic Polyamine Metal Complexes 2nd MAKNA Scientific Gathering | 23 Jul 2008
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Molecular Recognition in Aqueous Solution by 3:1 Complexation of Bis(Zn2+-cyclen) Having a 2,2’-Bipyridyl Linker and Ruthenium The 48th Annual Meeting of the Pharmaceutical Society of Japan (Kanto Division) | 09 Oct 2004
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Design, Synthesis and Molecular Recognition by Multinuclear Supramolecular of a Bis(Zn2+-cyclen) Having a 2,2’-Bipyridyl Linker The 13th Symposium on Roles of Metals in Biological Reactions, Biology and Medicine | 05 Jun 2003
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Design and Synthesis of Multinuclear Supramolecular Complexes from Bis(Zn2+-cyclen) Dimer Having 2,2’-Bipyridyl Group as a Linker 123rd Annual Meeting of The Pharmaceutical Society of Japan | 28 Mar 2003
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Modification of DNA by the Platinum Complex of the Dimeric Zn2+ Complex Having a 2,2’- Bipyridyl Linker The 1st Asian Meeting of Bioinorganic Chemistry (ASBIC) | 14 Mar 2003
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New Supramolecular Trigonal Prisms from Linear Multinuclear Zn2+-cyclen Complexes and Trithiocyanurate in Aqueous Solution (Cyclen = 1,4,7,10-Tetraazacyclododecane) 122nd Annual Meeting of The Pharmaceutical Society of Japan | 29 Mar 2002
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Design, Synthesis of Macrocyclic Polyamine Zn2+ Complex Having Selectivity Recognition of DNA Minor Groove and its Biological Activities 122nd Annual Meeting of The Pharmaceutical Society of Japan | 29 Mar 2002
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Design and Synthesis of Macrocyclic Polyamine Zn2+ Complex Having Selectivity Recognition of DNA Minor Groove 15th Symposium on Biofunctional Chemistry | 01 Sep 2001
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Design and Synthesis of Macrocyclic Polyamine Zn2+ Complex Having Selectivity Recognition of DNA Minor Groove 121st Annual Meeting of The Pharmaceutical Society of Japan | 29 Mar 2001

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Patents

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Invention of Co-Delivery of Cholesterol Lowering Drugs and Nutraceuticals | 22 Mar 2022
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Invention of Co-Delivery of Cholesterol Lowering Drugs and Nutraceuticals | 29 Oct 2019
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Supramolecule Complex as Polyphosphates detector probe and its detection method, and polyphosphates second messenger signal transduction inhibitor | 08 Apr 2005


Supervisions
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Fong Kar Wai | Doctorate | 01 Jun 2021 Thesis: Novel Schiff-based Ruthenium Complexes of Polypyridyl Derivatives as Antibacterial Photosensitizers and Gold-TFBG-assisted Chemosensors Featuring Ruthenium Complexes for Quantitative Detection of SARS-CoV-2 Virus and Multi-drug Resistant Bacteria
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Ng Xiao Ying | Doctorate | 03 May 2021 Thesis: Membrane-targeting peptides enhancing uptake of antibacterial and anticancer ruthenium-based photosensitisers: feasibility and synergistic mechanism studies
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Liew Hui Shan (Vanessa) | Master (Research) | 06 May 2019 - 13 Oct 2021 Thesis: Novel gemcitabine – Re(I) tricarbonyl complexes combinations, conjugates and formulations with liquid crystalline nanoparticles for pancreatic cancer photodynamic therapy and bioimaging (IMU Pancreatic Cancer Challenge Grant)
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Mak Kit Kay | Doctorate | 02 Feb 2019 - 06 Jun 2023 Thesis: Integration of Artificial intelligence (AI) and Computer Aided Drug Discovery (CADD) techniques for the development of novel drug-like Keap1-Nrf2 inhibitors/direct Nrf2 activators
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Geetha a/p Maniam | Master (Research) | 01 Feb 2018 - 04 May 2020 Thesis: Preparation, Characterization and Anticancer Effects of Gemcitabine-Tocotrienols Entrapped Niosomes in Pancreatic Cancer