Asma Ismail
Salutation
Academician Professor Emerita Datuk Dr
School/Centre
School of Medicine
Department
Microbiology and Immunology
Appointment
Vice Chancellor and Chief Executive Officer
Position
Professor
Email
Education
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Doctor of the University (Honorary Degree) (Honorary), 2017
Keele University, England
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Doctor of Literature (Honorary Degree) (Literature), 2017
Kyoto University of Foreign Studies, Japan
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Doctorate of Science (Honorary) (Science), 2013
University of Glasgow, Scotland
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PhD (Cellular and Molecular Biology), 1986
Univ. of Nevada, Reno,USA
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M.A (Microbiology), 1983
Indiana University, Bloomington, USA
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B.Sc. (Distinction) (Biology), 1980
Univ. Of Nevada, Reno,USA
Publications
Research Articles
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TolC facilitates the intracellular survival and immunomodulation of salmonella typhi in human Host cells
VIRULENCE 2024
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Identification and analysis of immunoreactive proteins of Shigella flexneri in human sera and stool specimens
PEERJ 2024
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Implementation of the Medan City Outer Ring Area Development Acceleration Program (Study in Medan Marelan District)
INDONESIAN INTERDISCIPLINARY JOURNAL OF SHARIA ECONOMICS (IIJSE) 2023
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Deletion of Salmonella enterica serovar Typhi tolC reduces bacterial adhesion and invasion toward host cells
FRONTIERS IN MICROBIOLOGY 2023
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Performance of immunodiagnostic tests for typhoid fever: a systematic review and meta-analysis
PATHOGENS 2021
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Nucleic acid-based lateral flow biosensor for Salmonella Typhi and Salmonella Paratyphi: A detection in stool samples of suspected carriers
DIAGNOSTICS 2021
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Analysis of top management support and its impact towards successful of maintenance management task in manufacturing plant
TEST ENG MANAG 2020
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A road map for Malaysian Science
NATURE 2018
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How Malaysian science can improve lives as well as the economy
NATURE 2018
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Integration of molecular dynamics simulation and hotspot residues grafting for de novo scFv design against Salmonella Typhi TolC protein
JOURNAL OF MOLECULAR RECOGNITION 2018
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Delineation of B-cell Epitopes of Salmonella enterica serovar Typhi Hemolysin E: Potential antibody therapeutic target
SCIENTIFIC REPORTS 2017
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Salivary anti-50 kDa antibodies as a useful biomarker for diagnosis of typhoid fever
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH: JCDR 2017
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Outer membrane proteins analysis of Shigella sonnei and evaluation of their antigenicity in Shigella infected individuals
PLOS ONE 2017
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Crystal structure of an antigenic outer-membrane protein from Salmonella Typhi
FOUNDATIONS OF CRYSTALLOGRAPHY 2017
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Impact of membrane pore structure on protein detection sensitivity of affinity-based immunoassay
POLISH JOURNAL OF CHEMICAL TECHNOLOGY 2016
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Pulsed-field gel electrophoresis analysis of Salmonella enterica serovar Typhi isolates in the north-east region of Peninsular Malaysia between 2002 and 2009
J APPL LIFE SCI INT 2016
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Role of TolC in virulence of salmonella enterica serovar Typhi
J. PURE APPL. MICROBIOL 2016
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Optimization of polyvinylidene fluoride (PVDF) membrane fabrication for protein binding using statistical experimental design
JOURNAL OF IMMUNOASSAY AND IMMUNOCHEMISTRY 2016
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Evaluation of endothelial cell adhesion molecules and anti-C1q antibody in discriminating between active and non-active systemic lupus erythematosus
THE MALAYSIAN JOURNAL OF MEDICAL SCIENCES: MJMS 2016
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Application of streptavidin mass spectrometric immunoassay tips for immunoaffinity based antibody phage display panning
JOURNAL OF MICROBIOLOGICAL METHODS 2016
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Generation of a naïve human single chain variable fragment (scFv) library for the identification of monoclonal scFv against Salmonella Typhi Hemolysin E antigen
TOXICON 2016
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Molecular epidemiology of Cryptosporidium in HIV/AIDS patients in Malaysia.
TROPICAL BIOMEDICINE 2015
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Crystal structure of an antigenic outer-membrane protein from Salmonella Typhi suggests a potential antigenic loop and an efflux mechanism
SCIENTIFIC REPORTS 2015
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Identification of carriers among individuals recruited in the typhoid registry in Malaysia using stool culture, polymerase chain reaction, and dot enzyme immunoassay as detection tools
ASIA PACIFIC JOURNAL OF PUBLIC HEALTH 2015
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Multi‐isotype antibody responses against the multimeric Salmonella Typhi recombinant hemolysin E antigen
MICROBIOLOGY AND IMMUNOLOGY 2015
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PCR-based Gene Synthesis, Cloning, Expression, Purification and Characterization of Bst DNA Polymerase in E. coli Cells
CURRENT SYNTHETIC AND SYSTEMS BIOLOGY 2015
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Influence of the physicochemical environment on membrane-protein binding: investigation using a fabricated PVDF membrane
JOURNAL OF POLYMER ENGINEERING 2015
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Genetic relationship and correspondence of Salmonella Typhi isolated from water samples in typhoid outbreak localities with food handlers and contact by using Pulsed Field Gel Electrophoresis (PFGE)
ASIAN PACIFIC JOURNAL OF TROPICAL DISEASE 2014
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Salmonella Typhi TolC protein: A molecular dynamics investigation
ASIAN PACIFIC JOURNAL OF TROPICAL DISEASE 2014
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In-house Loop Amplification (LAMP) method for the diagnosis of Salmonella Paratyphi A in low-resource settings
ASIAN PACIFIC JOURNAL OF TROPICAL DISEASE 2014
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Evaluation of In-house Loop Amplification (LAMP) method for the diagnosis of Salmonella Typhi based on StgB gene
ASIAN PACIFIC JOURNAL OF TROPICAL DISEASE 2014
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The evaluation of a multiplex PCR-DNA dipstick assay with culture method and EZ Typhi Carrier DNA assay to detect Salmonella Typhi in well water samples
ASIAN PACIFIC JOURNAL OF TROPICAL DISEASE 2014
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The identification and detection of a unique gene in Salmonella enterica subsp. enterica Weltevreden using PCR-based approach
ASIAN PACIFIC JOURNAL OF TROPICAL DISEASE 2014
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Establishment of an in‐House Loop‐Mediated Isothermal Amplification (LAMP) for a Rapid Detection of S almonella Typhi and S almonella Paratyphi A at Low‐Resource Settings
JOURNAL OF FOOD SAFETY 2014
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Asymmetric helicase-dependent amplification combined with lateral flow assay (HDA-LFA) for the detection of S. Paratyphi A
ASIAN PACIFIC JOURNAL OF TROPICAL DISEASE 2014
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Construction and characterization of a Salmonella enterica serovar Typhi tolC deletion mutant
ASIAN PACIFIC JOURNAL OF TROPICAL DISEASE 2014
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Assembly and stability of Salmonella enterica ser. Typhi TolC protein in POPE and DMPE
JOURNAL OF BIOLOGICAL PHYSICS 2014
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Overexpression, purification and validation of antigenic Salmonella enterica serovar Typhi proteins identified from LC-MS/MS
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY 2014
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Influence of polymer concentration on PVDF membrane fabrication for immunoassay analysis
JOURNAL OF APPLIED SCIENCES 2014
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Principles and application of antibody libraries for infectious diseases
BIOTECHNOLOGY LETTERS 2014
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Rapid detection of Salmonella Typhi by loop-mediated isothermal amplification (LAMP) method
BRAZILIAN JOURNAL OF MICROBIOLOGY 2014
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Epidemiological analysis of typhoid fever in Kelantan from a retrieved registry
MALAYSIAN JOURNAL OF MICROBIOLOGY 2013
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Synthesis of Polyvinylidene Fluoride (PVDF) Membrane for Protein Adsorption: Effect of Casting Thickness.
JOURNAL OF APPLIED POLYMER SCIENCE 2013
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Epidemiologiocal analysis of typhoid fever in Kelantan from a retrived registry.
MALAYSIAN JOURNAL OF MEDICAL SCIENCES 2013
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Electrophoretic interactions between nitrocellulose membranes and proteins:
COLLOIDS AND SURFACES B:BIOINTERFACES 2013
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Rapid detection of Salmonella Typhi by loop-mediated isothermal amplification (LAMP method
BRAZILLIAN JOURNAL OF MICROBIOLOGY 2013
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Phage display antibodies for diagnostic applications.
BIOLOGICALS: JOURNAL OF THE INTERNATIONAL ASSOCIATION OF BIOLOGICAL STANDARDIZATION 2013
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Salmonella enterica serovar Typhi cutF is upregulated during environmental stress
THE JOURNAL OF GENERAL AND APPLIED MICROBIOLOGY 2013
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Cloning, expression, and purification of the hemolysin/cytolysin (HlyE antigen) from Salmonella enterica serovar Typhi: potential application for immunoassay development
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE 2013
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Phenotyping identification of candida albicans for the production of in house helicase for nucleic acid-based detections for fast diagnosis
RESEARCH JOURNAL OF PHARMACEUTICAL, BIOLOGICAL AND CHEMICAL SCIENCES 2013
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Synthesis of polyvinylidene fluoride (PVDF) membranes for protein binding: Effect of casting thickness
JOURNAL OF APPLIED POLYMER SCIENCE 2013
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Phage display antibodies for diagnostic applications
BIOLOGICALS 2013
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Electrophoretic interactions between nitrocellulose membranes and proteins: Biointerface analysis and protein adhesion properties
COLLOIDS AND SURFACES B: BIOINTERFACES 2013
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A pentaplex PCR assay for the detection and differentiation of Shigella species
BIOMED RESEARCH INTERNATIONAL 2013
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Temperature-regulated expression of outer membrane proteins in Shigella flexneri
GUT PATHOGENS 2013
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Corrigendum to “A 35kDa antigenic protein from Shigella flexneri: In silico structural and functional studies”[Biochem. Biophys. Res. Commun. 415 (2011) 229–234]
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2012
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Salmonella enterica serovar Typhi cutF is upregulated during environmental stress
THE JOURNAL OF GENERAL AND APPLIED MICROBIOLOGY 2012
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Ribotyping identification of Escherichia coli producing temperature-labile helicase
INTERNATIONAL JOURNAL OF INTEGRATIVE BIOLOGY, 2012
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Pulsed-field gel electrophoresis analysis of Salmonella enterica serovar Typhi isolates in the north-east region of peninsular Malaysia between 2002 and 2009
ASIAN PACIFIC JOURNAL OF TROPICAL DISEASES 4(3): 242 2012
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Isolation and Identification of Helicase from Escherichia coli for Biotechnology Processes
APCBEE PROCEDIA 2012
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Isolation and identification of Candida albicans to produce in house helicase for PCR
PROCEEDINGS OF THE ANNUAL INTERNATIONAL CONFERENCE, SYIAH KUALA UNIVERSITY-LIFE SCIENCES & ENGINEERING CHAPTER 2012
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Isolation and Identification of Helicase from Anoxybacillus sp for DNA amplification
APCBEE PROCEDIA 2012
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An in-house multiplex PCR for detection of S. typhi and S. paratyphi A: A comparison between detection method by agarose gel electrophoresis and lateral flow assay
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES 2012
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Investigating membrane morphology and quantity of immobilized protein for the development of lateral flow immunoassay
JOURNAL OF IMMUNOASSAY AND IMMUNOCHEMISTRY 2012
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Rapid multi sample DNA amplification using rotary-linear polymerase chain reaction device (PCRDisc)
BIOMICROFLUIDICS 2012
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Directed evolution of nucleotide-based libraries using lambda exonuclease
BIOTECHNIQUES 2012
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A preliminary study of comparative genomics of Salmonella Typhi isolates in Kelantan.
MALAYSIAN JOURNAL OF PUBLIC HEALTH MEDICINE. 2011
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A 35 kDa antigenic protein from Shigella flexneri: in silico structural and functional studies
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2011
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Genetic diversity of Salmonella enteric serovar Typhi in Kelantan
MALAYSIAN JOURNAL OF PUBLIC HEALTH MEDICINE GENETIC DIVERSITY OF SALMONELLA ENTERIC SEROVAR TYPHI IN KELANTAN. 2011
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Early detection of cases and carriers of Typhoid and other food borne diseases
MALAYSIAN JOURNAL OF PUBLIC HEALTH MEDICINE. 2011
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Morphology and polymorph study of a polyvinylidene fluoride (PVDF) membrane for protein binding: Effect of the dissolving temperature
DESALINATION 2011
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Structural and functional studies of a 50 kDa antigenic protein from Salmonella enterica serovar Typhi
JOURNAL OF MOLECULAR GRAPHICS AND MODELLING 2011
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Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms and typhoid susceptibility in Asian Malay population in Malaysia
MICROBES AND INFECTION 2011
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Identification of appropriate sample and culture method for isolation of new thermophilic bacteria from hot spring
AFRICAN JOURNAL OF MICROBIOLOGY RESEARCH VO.5 (3) 2011
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Demonstration of an outer membrane protein that is antigenically specific for Acinetobacter baumannii
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE 2011
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How common is intestinal parasitism in HIV-infected patients in Malaysia?
TROPICAL BIOMEDICINE 2011
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Hindered diffusion in lateral flow nitrocellulose membrane: Experimental and modeling studies
JOURNAL OF MEMBRANE SCIENCE 2010
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Amplification of SPPS150 and Salmonella typhi DNA with a high throughput oscillating flow polymerase chain reaction device
BIOMICROFLUIDICS 2010
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Serum neopterin is elevated in patients infected with Shigella
GUT PATHOGENS 2010
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An improve dot enzyme immunoassay for serodiagnosis of melioidosis
INT JOURNAL INFECT. DISEASES 2010
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Development of Lateral Flow Immunoassay via Membranes Morphologies and Quantity of Immobilised Protein
JOURNAL OF CHROMATOGRAPHY B 2010
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Sustainable Urban Transport Research Centre, Department of Civil and Structural Engineering, Faculty of Engineering and Built Environment, Universiti Kebangsaan Malaysia, Selangor, Malaysia
JOURNAL OF APPLIED SCIENCES 2010
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Thermal analysis of an oscillating flow polymerase
JOURNAL OF HEAT TRANSFER 2009
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Optimization of Membrane Formulation and Process Variables via Crossed-Design Concept in Design of Experimental (DOE)
SEPARATION SCIENCE AND TECHNOLOGY 2009
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Development of lateral flow membranes for immunoassay separation
DESALINATION AND WATER TREATMENT, 2009
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Morphological and thermal-mechanical stretching properties on polymeric lateral flow nitrocellulose membrane
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH 2009
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Hand decontamination practices and the appropriate use of gloves in two adult intensive care units in Malaysia
THE JOURNAL OF INFECTION IN DEVELOPING COUNTRIES 2009
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Toll-like receptors and cytokines in immune responses to persistent mycobacterial and Salmonella infections
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY 2009
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Ventilator-associated nosocomial pneumonia in intensive care units in Malaysia
THE JOURNAL OF INFECTION IN DEVELOPING COUNTRIES 2009
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Optimization of membrane performance by thermal-mechanical stretching process using responses surface methodology (RSM)
SEPARATION AND PURIFICATION TECHNOLOGY 2009
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Analysis of lolB gene sequence and its use in the development of a PCR assay for the detection of Vibrio cholerae
JOURNAL OF MICROBIOLOGICAL METHODS 2008
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Enzyme-linked amperometric electrochemical genosensor assay for the detection of PCR amplicons on a streptavidin-treated screen-printed carbon electrode
ANALYTICAL CHEMISTRY 2008
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Synthesis and characterization of polymeric nitrocellulose membranes: Influence of additives and pore formers on the membrane morphology
JOURNAL OF APPLIED POLYMER SCIENCE 2008
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Baseline assessment of intensive care-acquired nosocomial infection surveillancein three adult intensive care units in Malaysia
THE JOURNAL OF INFECTION IN DEVELOPING COUNTRIES 2008
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Amplification of ST50 gene using dry-reagent–based polymerase chain reaction for the detection of Salmonella typhi
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE 2007
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Baseline assessment of intensive care-acquired nososcomial infection surveillance in three adult intensive care units in Malaysia
JOURNAL INFECT DEVELOPING COUNTRIES 2007
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Value creation in the Knowledge Economy: A Malaysian Experience in Diagnostics.
ASM SCIENCE JOURNAL, 2007
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Development in Rapid diagnostics: Impact on quality of Health care.
MALAYSIAN JOURNAL OF PUBLIC HEALTH MEDICINE. 2007
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Preparation and Characterization of Various Membrane Morphologies for Lateral Flow Immunoassay Development
JOURNAL OF APPLIED MEMBRANE SCIENCE AND TECHNOLOGY, 2007
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Development of A Dot Enzyme Immunoassay (EIA) for the Acute Detection of Nosocomial Infections Due to Acinetobacter Baumanii,
THE MALAYSIAN JOURNAL OF MEDICAL SCIENCES, 2006
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A Sensitive and Specific Enzyme-Linked Immunosorbent Assay (Elisa) for Detection of Specific IGM Antibody in Typhoid Fever
THE MALAYSIAN JOURNAL OF MEDICAL SCIENCES 2005
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Molecular approach to identify possible typhoid carriers among food handlers in Kota Bharu Kelantan.
MALAYSIAN JOURNAL OF MEDICAL SCIENCES. 2005
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Molecular screening of Shigella dysenteriae carrier status among healthy food handlers in Kota Bharu, Kelantan
MALAYSIAN JOURNAL OF MEDICAL SCIENCES. 2005
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Molecular investigation on Campylobacter jejuni carrier state to among food handlers in Kota Bharu, Kelantan
THE MALAYSIAN JOURNAL OF MEDICAL SCIENCES. 2005
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Plenary Lectures and Symposia
THE MALAYSIAN JOURNAL OF MEDICAL SCIENCES: MJMS 2004
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Research at Universiti Sains Malaysia: biotechnology
RESEARCH AT UNIVERSITI SAINS MALAYSIA 2004
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RELATIONSHIP BETWEEN HELICOBACTER PYLORI ICEA ALLELES AND GASTRODUODENAL DISEASES IN MALAYSIA
MEDICAL JOURNAL OF MALAYSIA 2002
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Demonstration of specific heat shock proteins in the outer membrane of Salmonella paratyphi A.
MALAYSIAN JOURNAL OF MEDICAL SCIENCES 2001
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A PCR method targeted to a novel non-virulent gene for identification of Vibrio cholerae
MALAYSIAN JOURNAL OF MEDICAL SCIENCES, 2001
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New advances in the diagnosis of typhoid and detection of typhoid carriers
THE MALAYSIAN JOURNAL OF MEDICAL SCIENCES: MJMS 2000
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Abstracts of the 5th National Conference On Medical Sciences 4th–5th May 1999 Held at the School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia.
THE MALAYSIAN JOURNAL OF MEDICAL SCIENCES: MJMS 2000
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Antimicrobial effects of Psidium guajava extract as one mechanism of its antidiarrhoeal action
THE MALAYSIAN JOURNAL OF MEDICAL SCIENCES: MJMS 1999
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Rapid and reliable serological diagnosis of enteric fever: comparative sensitivity and specificity of Typhidot and Typhidot-M tests in febrile Malaysian children
ACTA TROPICA 1999
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5th National Conference on Medical Sciences
THE MALAYSIAN JOURNAL OF MEDICAL SCIENCES: MJMS 1999
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Susceptibility pattern of Streptococcus pneumoniae among pre-school children in Kota Bharu, Malaysia
JOURNAL OF TROPICAL PEDIATRICS 1998
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Comparative sensitivity and specificity of typhidot and typhidot-M tests in the diagnosis of enteric fever in Malaysian children
MEDICAL JOURNAL OF INDONESIA 1998
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Recent advances in the rapid serodiagnosis of Typhoid fever
MEDICAL JOURNAL OF INDONESIA, 1998
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A new challenge in R&D: Commercialization.
MALAYSIAN J. MED. SCIENCES. 1997
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Longevity of antibody responses to a Salmonella typhi-specific outer membrane protein: interpretation of a dot enzyme immunosorbent assay in an area of high typhoid fever endemicity.
THE AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE 1997
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Retrospective review of dot enzyme immunoassay test for typhoid fever in an endemic area
SOUTHEAST ASIAN JOURNAL OF TROPICAL MEDICINE AND PUBLIC HEALTH 1995
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Rapid serodiagnosis of typhoid fever by dot enzyme immunoassay in an endemic area
CLINICAL INFECTIOUS DISEASES 1994
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Recent developments in the diagnosis of typhoid fever
PROCEEDINGS 4TH WESTERN PACIFIC CONGRESS ON CHEMOTHERAPY AND INFECTIOUS DISEASES. SUPPLEMENT TO JAMA SOUTHEAST ASIA 1994
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Development of a dot enzyme immunosorbent assay (EIA) for the rapid diagnosis of the typhoid fever
PANG T, KOH CL, PUTHUCHEARY SD. TYPHOID FEVER. STRATEGIES FOR THE 1992
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Clinical Field Trials on the Dot Enzyme lmmunosorbent Assay (EIA) for the Diagnosis of Typhoid Fever Ong, KH Department of Medical Microbiology & Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, 16150 Kota Bharu
TYPHOID FEVER: STRATEGIES FOR THE 90'S-SELECTED PAPERS FROM FIRST ASIA-PACIFIC SYMPOSIUM ON TYPHOID FEVER 1992
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Dot enzyme immunosorbent assay for the serodiagnosis of typhoid fever
SOUTHEAST ASIAN J TROP MED PUBLIC HEALTH 1991
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Demonstration of an antigenic protein specific for Salmonellatyphi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 1991
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Influence of iron-deprivation and fever temperatures on the in vitro susceptibility of Salmonella typhi to antibiotics used in the treatment of typhoid.
TROPICAL BIOMEDICINE 1991
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Effect of temperature on growth and siderophore production by Salmonella typhi.
TROPICAL BIOMEDICINE 1990
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Siderophore production by Salmonella typhi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 1988
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An update on diarrhoeal diseases in Malaysia.
THE SOUTHEAST ASIAN JOURNAL OF TROPICAL MEDICINE AND PUBLIC HEALTH 1988
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Utilization of siderophores by Candida albicans
MYCOPATHOLOGIA 1986
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Effect of elevated temperatures and low levels of trace metals on the growth and phenotypic development of Candida albicans
MYCOPATHOLOGIA 1986
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Siderophore production by the pathogenic yeast, Candida albicans
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 1985
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Effect of temperature on siderophore production by Candidaalbicans
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 1985
Other Publications
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The Molecular Dynamics Simulation of a Multi-domain Outer Membrane Protein A (OmpA) from Shigella flexneri in POPE Lipid Bilayer
Chemistry for a Clean and Healthy Planet | 01 Jan 2019
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Tentative Identification and Location of a Putative Ferri-siderophore receptor in Candida albicans.
Abstracts of the Annual Meeting of the American Society for Microbiology | 01 Jan 1988
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Effects of elevated temperature and cations on the growth phenotypic development and siderophore production of Candida albicans
Abstracts of the Annual Meeting of the American Society for Microbiology | 01 Jan 1985
Books
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Engineers Australia (2010). PCRDisc: Low Cost Molecular Diagnostics Using Microfluidics Platform
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Pan Stanford Publishing (2007). Design and Fabrication of a Chip Based DNA PCR System.
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(2004). Medical biotechnology research
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(2002). New Diagnostic tests, current status and usefulness. In WHO Guidelines for diagnosis, treatment, prevention and Epidemic Preparedness of typhoid fever