ANNA LING PICK KIONG



Salutation
Professor

School/Centre
School of Health Sciences

Department

Appointment
Dean, School of Health Sciences

Position
Professor


Professional Network


Education

a
PhD (Plant Biotechnology), 2004 UPM
a
BSc (Hons) (Resource Biotechnology), 1999 UNIMAS

Memberships

a
Royal Society of Biology, UK | International | Fellow
a
Malaysian Board of Technologist | National | Professional Technologist
a
Malaysian Board of Technologist | National | Graduate Technologist
a
Malaysian Society for Molecular Biology and Biotechnology | National | Member
a
International Association for Plant Biotechnology | International | Member
a
Society for the Advancement of Breeding Research in Asia and Oceania (SABRAO) | International | Member
a
Malaysian Genetics Society | National | Member

Research Funding
a
The Effect of Laminarin on Microglia Dectin-1 in the Pathogenesis of Alzheimer’s Disease: An in silico Approach IMU Internal Research Grant | 01 Sep 2024 - 30 Jun 2025
a
Enhancing DENV Vaccine Efficacy Through The Immunoinformatics Aided Design of Peptide Model with Cross-serotypically Conserved Epitopes IMU Internal Research Grant | 05 Aug 2024 - 08 Nov 2024
a
Biochemical and transcriptomic profiling analysis of ML 125-2 and ML 82-2 rice mutant lines under reproductive stage drought stress IMU Internal Research Grant | 01 Jun 2024 - 31 Dec 2024
a
Development and Commercialization of Climate-Resilient Rice Varieties to Increase National Yield Production Dana Penyelidikan Strategik MOSTI (SRF) | 01 Feb 2024 - 31 Jan 2027
a
A systematic review on the anti-hyperglycaemic effect of Syzygium aromaticum based on in vitro and in vivo studies IMU Internal Research Grant | 01 Jun 2023 - 31 Dec 2023
a
Elucidation of gene signature and pathway between gut microbiome dysbiosis and neurological diseases IMU Internal Research Grant | 01 Jun 2023 - 31 Dec 2023
a
Computational approaches in Zika virus (ZIKV) vaccine candidates design IMU Internal Research Grant | 01 Jun 2023 - 31 Dec 2023
a
Biochemical and transcriptomic profiling analysis of drought tolerant and early maturity related genes in four potential rice mutant lines IMU Internal Research Grant | 01 Jun 2023 - 31 Dec 2023
a
Molecular target prediction for selected neuronal tumours Australian Government New Colombo Fund | 14 Dec 2022 - 10 Feb 2023
a
Toxic effects of salsolinol in neuronal cells via mitophagy pathway IMU Internal Research Grant | 01 Dec 2022 - 31 Dec 2023
a
Elucidation of gene signature and molecular pathway selected neurodegenerative diseases via data analytic approaches Biomedical Science | 01 Jun 2022 - 31 Dec 2022
a
Elucidation of gene signatures and molecular pathway associated with iron-induced neurodegeneration via data analytic approach Medical Biotechnology | 01 Jun 2022 - 31 Dec 2022
a
Elucidation of gene signature and molecular pathway of selected neuronal tumour via data analytic approaches Biomedical Science | 01 Jun 2022 - 31 Dec 2022
a
Investigating the mechanism of action of madecassoside, orientin and iso-orientin against β- amyloid-induced ferroptosis in SH-SY5Y cells IMU | 01 Jun 2022 - 31 Dec 2022
a
Analysis of putative gene signatures of ZIKV-infection on neurological diseases Australian Government New Colombo Fund | 06 Dec 2021 - 25 Feb 2022
a
Identification of co-expressed hub genes and pathways in Zika and Dengue neuropathogenesis using data analytic approaches Australian Government New Colombo Fund | 06 Dec 2021 - 25 Feb 2022
a
Prediction of age-related neurodegenerative diseases – data science approaches BMSc I/2021(09) | 01 May 2021 - 31 Oct 2021
a
Studies to investigate mechanisms of anti-autophagic effects of orientin against beta amyloid-stimulated BV2 microglia cells IMU | 01 Jan 2021 - 01 Jul 2021
a
Neuroprotective role of orientin on β-amyloid-induced cell death in SH-SY5Y neuronal cells via mTOR signalling pathway Bachelor in Medical Sciences (Hons) | 01 Jan 2021 - 31 Jul 2022
a
The roles of orientin and madecassoside in regulating NFkB signaling pathway and apoptotic pathway in beta-amyloid induced BV2 microglial cells IMU | 06 Dec 2020 - 31 May 2021
a
Investigating the mechanism of action of orientin and madecassoside against α-synuclein-induced cell death in SH-SY5Y human neuronal cells IMU | 01 Jul 2020 - 01 Dec 2020
a
Anti-Neuroinflammatory Mechanism of Safinamide in Inhibiting Lipopolysaccharide-Induced Microglial Activation IMU | 01 Feb 2020 - 01 Jul 2021
a
Investigating the mechanism of action of orientin against β-amyloid-induced cell death in BV2 microglial cells IMU | 01 Dec 2019 - 01 May 2020
a
Role of orientin against β-amyloid-induced cell death in SH-SY5Y human neuronal cells IMU | 01 Oct 2019 - 01 Jun 2020
a
Investigating the Effect of Orientin in THP1 and HepG2 Cells Infected by DENV2 IMU | 18 Dec 2018 - 19 Apr 2018
a
Orientin Protects Neuronal Cell Lines From Hydrogen Peroxide Induced Oxidative Damage Via Up-Regulating P13k/Akt Survival And Nrf2/Keap1 Redox Signalling Pathways While DownRegulating Mapk/Erk Apoptosis Pathway FRGS | 01 Jul 2013 - 31 Dec 2015
a
Investigation on the structure activity and mechanism of action of anti-inflammatory flavones FRGS | 01 May 2013 - 30 Apr 2016
a
In Vitro Tissue culture of Sargassum special with enhanced biochemical properties through application of gamma irradiation FRGS | 01 Apr 2013 - 31 Dec 2016
a
Production and characterisation of edible human rotavirus VP6 protein expressed in engineered Centella asiatica cells ERGS | 01 Oct 2012 - 31 Mar 2016
a
Development of advanced and promising mutant lines derived from mutagenesis of Oryza sativa cv MR219 for drought tolerant, blast resistant and quality traits eScience | 01 Jan 2012 - 01 Jan 2014

Publications

Research Articles

a
Neuroprotective effects of safinamide against autophagy in 6-hydroxydopamine-induced SH-SY5Y cell model of Parkinson’s disease JOURNAL OF APPLIED PHARMACEUTICAL SCIENCE | 2024
a
Evaluation and characterization of advanced rice mutant line of rice (Oryza sativa), MR219-4 and MR219-9 under drought condition N/A | 2023
a
Anti-neuroinflammatory mechanism of safinamide in inhibiting lipopolysaccharide-induced microglial activation. PHARMACEUTICAL SCIENCES ASIA | 2023
a
Mesenchymal stem cells as future treatment for cardiovascular regeneration and its challenges ANNALS OF TRANSLATIONAL MEDICINE | 2023
a
THE ROLES OF ANTIFIBROTIC THERAPIES IN POST-SARS-CoV-2 INFECTION MALAYSIAN JOURNAL OF BIOCHEMISTRY & MOLECULAR BIOLOGY | 2023
a
Plants as Edible Vaccine PLANTS AS BIOREACTORS FOR INDUSTRIAL MOLECULES | 2023
a
Anti-neuroinflammatory of Chloroform Extract of Panax ginseng Root Culture on Lipopolysaccharide-stimulated BV2 Microglia Cells REPORTS OF BIOCHEMISTRY & MOLECULAR BIOLOGY | 2022
a
ANTI-APOPTOTIC ACTIONS OF SAFINAMIDE IN 6-HYDROXYDOPAMINE-INDUCED CELL MODEL OF PARKINSON’S DISEASE MALAYSIAN JOURNAL OF BIOCHEMISTRY & MOLECULAR BIOLOGY | 2022
a
Role of orientin against beta-amyloid induced cell death in SH-SY5Y human neuronal cells MALAYSIAN JOURNAL OF BIOCHEMISTRY & MOLECULAR BIOLOGY | 2022
a
CRISPR/Cas9 in plant biotechnology: applications and challenges BIOTECHNOLOGIA. JOURNAL OF BIOTECHNOLOGY COMPUTATIONAL BIOLOGY AND BIONANOTECHNOLOGY | 2022
a
Applying stem cell therapy in intractable diseases: a narrative review of decades of progress and challenges STEM CELL INVESTIGATION | 2022
a
THE THE EFFECTS OF ORIENTIN ON THP-1 CELLS INFECTED BY DENV2 JOURNAL OF MICROBIOLOGY, BIOTECHNOLOGY AND FOOD SCIENCES | 2022
a
How Do Abnormalities in the Cerebrospinal Fluid Impact Neuropsychology with Progressing Age? CNS & NEUROLOGICAL DISORDERS DRUG TARGETS | 2022
a
An Overview of Herbal Medicines for Idiopathic Pulmonary Fibrosis PROCESSES | 2022
a
Bioinformatics approaches and applications in plant biotechnology JOURNAL OF GENETIC ENGINEERING AND BIOTECHNOLOGY | 2022
a
The Role of Monoamine Oxidase B Inhibitors in the Treatment of Parkinson’s Disease-An Update CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (FORMERLY CURRENT DRUG TARGETS-CNS & NEUROLOGICAL DISORDERS) | 2022
a
Current updates and research on plant-based vaccines for coronavirus disease 2019 Clinical and Experimental Vaccine Research | 2021
a
Immunotherapies for Parkinson's disease: Progression of Clinical Development. CNS & NEUROLOGICAL DISORDERS DRUG TARGETS | 2021
a
Gene introduction approaches in chloroplast transformation and its applications JOURNAL OF GENETIC ENGINEERING AND BIOTECHNOLOGY | 2021
a
Anticancer Properties of Strobilanthes crispus: A Review Processes | 2021
a
An overview of complementary and alternative medicine for alzheimer's and parkinson's disease MALAYSIAN JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2021
a
RESEARCH ARTICLE COVID-19 and its effects on neurological functions TROPICAL BIOMEDICINE | 2021
a
Gene introduction approaches in chloroplast transformation and its application JOURNAL OF GENETIC ENGINEERING AND BIOTECHNOLOGY | 2021
a
A mini review on neuroprotective effects of Syzygium cumini JOURNAL OF MEDICINE & BIOMEDICAL RESEARCH | 2021
a
COVID-19 and its effects on neurological functions TROPICAL BIOMEDICINE | 2021
a
Anti-neuroinflammatory responses in lipopolysaccharide-stimulated BV2 microglial cells upon treatment with methanol extract of Panax ginseng root. JOURNAL OF TRADITIONAL CHINESE MEDICINE | 2021
a
The Mechanism of Action of Salsolinol in Brain: Implications in Parkinson’s Disease CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (FORMERLY CURRENT DRUG TARGETS-CNS & NEUROLOGICAL DISORDERS) | 2020
a
Mechanisms of action of amyloid-beta and its precursor protein in neuronal cell death Metabolic brain disease | 2020
a
Focus: Plant-based Medicine and Pharmacology: Antidiabetic Potential of Syzygium sp.: An Overview Yale Journal of Biology and Medicine | 2020
a
Anticancer potential of Syzygium species: a review Plant Foods for Human Nutrition | 2019
a
Overview of the Pharmacological Activities of Aframomum melegueta. Pertanika Journal of Tropical Agricultural Science | 2019
a
Physicochemical characteristics and nutritional compositions of MR219 mutant rice and their effects on glycaemic responses in BALB/c mice. International Food Research Journal | 2019
a
TARGETING AUTOPHAGY IN ALZHEIMER’S DISEASE: AN OVERVIEW MALAYSIAN JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2019
a
Siti Nor Safriena Muhamad, Anna Pick J APPL PHYCOL | 2019
a
Investigating anti-neuroinflammatory mechanism of orientin in lipopolysaccharide-induced BV2 microglia cells ASIA PACIFIC JOURNAL OF MOLECULAR BIOLOGY AND BIOTECHNOLOGY | 2019
a
Neuroprotective Mechanisms of Orientin against Hydrogen Peroxide-induced Oxidative Damage in SH-SY5Y Cells JOURNAL OF BIOCHEMISTRY, MICROBIOLOGY AND BIOTECHNOLOGY | 2018
a
Highlights of the issue 11, 2018 NEUROLOGICAL SCIENCES | 2018
a
A mini review on phytochemical constituents and pharmacological activities of Adenium obesum JOURNAL OF TROPICAL AGRICULTURAL SCIENCE | 2018
a
A PEG 4000-degrading and hexavalent molybdenum-reducing Pseudomonas putida strain Egypt-15 Journal of the National Science Foundation of Sri Lanka | 2018
a
A Mini Review on Phytochemical Constituents and Pharmacological Activities of Adenium obesum. Pertanika Journal of Tropical Agricultural Science | 2018
a
Therapeutic potential of combined viral transduction and CRISPR/Cas9 gene editing in treating neurodegenerative diseases Neurological Sciences | 2018
a
Effect of plant growth regulators on direct regeneration and callus induction from Sargassum polycystum C. Agardh Journal of Applied Phycology | 2018
a
Nanoparticles as carriers of phytochemicals: Recent applications against lung cancer INT. J. RES. BIOMED. BIOTECHNOL | 2018
a
Madecassoside activates anti‑neuroinflammatory mechanisms by inhibiting lipopolysaccharide‑induced microglial inflammation International journal of molecular medicine | 2018
a
Niosomes: a review of their structure, properties, methods of preparation, and medical applications Asian Biomedicine | 2018
a
Harnessing neuroplasticity: modern approaches and clinical future International Journal of Neuroscience | 2018
a
Biomarkers and therapeutic advances in glioblastoma multiforme ASIAPACIFIC JOURNAL OF CLINICAL ONCOLOGY | 2018
a
Anticancer mechanisms of Strobilanthes crispa Blume hexane extract on liver and breast cancer cell lines Oncology letters | 2017
a
The modified Gompertz model demonstrates a variable growth rate between two Centella asiatica phenotypes JOURNAL OF BIOCHEMISTRY, MICROBIOLOGY AND BIOTECHNOLOGY | 2017
a
Bioactivity of Mesona palustris (Black Cincau) as a nutraceutical agent J. ENG. SCI. RES | 2017
a
Neuroprotective roles of asiaticoside on hydrogen peroxide-induced toxicity in SH-SY5Y cells JOURNAL OF FUNDAMENTAL AND APPLIED SCIENCES | 2017
a
An Overview of Pharmacological Activities of Syzygium sp. CANCER | 2017
a
Addendum: Hussein et al. The modified Gompertz model demonstrates a variable growth rate between two Centella asiatica phenotypes. Journal of Biochemistry, Microbiology and Biotechnology, 2017, Vol 5, No 1, 18-20. JOURNAL OF BIOCHEMISTRY, MICROBIOLOGY AND BIOTECHNOLOGY | 2017
a
Investigating Prostaglandin E2 and Intracellular Oxidative Stress Levels in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages upon Treatment with Strobilanthes crispus INTERNATIONAL JOURNAL OF MEDICAL AND HEALTH SCIENCES | 2016
a
Niosome: a mini review on its structure, properties, methods of preparation and medical applications JOURNAL OF CHEMICAL AND PHARMACEUTICAL RESEARCH | 2016
a
Neurotoxic effect of salsolinol through oxidative stress induction and Nrf2-Keap1 signalling regulation JOURNAL OF CHEMICAL AND PHARMACEUTICAL RESEARCH, | 2016
a
Anti-inflammatory Effect of Strobilanthes crispus methanolic extract on Lipopolysaccharide-stimulated RAW 264.7 Macrophages JOURNAL OF MEDICAL AND BIOLOGICAL SCIENCES | 2016
a
Modelling the effect of picloram on the growth kinetics of cell suspension cultures of Ficus deltoidea L. JOURNAL OF BIOCHEMISTRY, MICROBIOLOGY AND BIOTECHNOLOGY | 2016
a
Medicinal properties of pitaya: a review SPATULA DD | 2016
a
Plant-Based Vaccines: Production and Challenges. JOURNAL OF BOTANY | 2016
a
A review on medicinal properties of orientin Advances in pharmacological sciences | 2016
a
Modelling the growth kinetics of callus cultures from the seedling of Jatropha curcas L. according to the modified gompertz model JOURNAL OF BIOCHEMISTRY, MICROBIOLOGY AND BIOTECHNOLOGY | 2016
a
Characterization of a molybdenum-reducing bacterium with the ability to degrade phenol, isolated in soils from Egypt BIOTECHNOLOGIA. JOURNAL OF BIOTECHNOLOGY COMPUTATIONAL BIOLOGY AND BIONANOTECHNOLOGY | 2015
a
Isolation and characterization of a molybdenum-reducing, phenol-and catechol-degrading Pseudomonas putida strain amr-12 in soils from Egypt SCIENTIFIC STUDY AND RESEARCH-CHEMISTRY AND CHEMICAL ENGINEERING BIOTECHNOLOGY FOOD INDUSTRY | 2015
a
Cytotoxic and apoptogenic effects of Strobilanthes crispa Blume extracts on nasopharyngeal cancer cells Molecular medicine reports | 2015
a
Modelling the effect of 2-4, D on the growth kinetics of cell suspension cultures of Ficus deltoidea L JOURNAL OF BIOCHEMISTRY, MICROBIOLOGY AND BIOTECHNOLOGY | 2015
a
Strobilanthes crispus extract induces apoptosis through enhanced caspases activities in cervical cancer cells INTERNATIONAL CONFERENCE ON BIOLOGICAL, ENVIRONMENT AND FOOD ENGINEERING (BEFE-2014) AUGUST | 2014
a
An Investigation of Anti-Inflammatory Properties of Methanol Extract of Syzygium malaccense on Lipopolysaccharide-Stimulated Raw 264.7 Macrophages INTERNATIONAL CONFERENCE ON LATEST TRENDS IN FOOD, BIOLOGICAL & ECOLOGICAL SCIENCES PHUKET (THAILAND)(ICLTFBE(TM)14) | 2014
a
金钱榕提取物抑制 3T3-L1 脂肪细胞抗脂肪沉积研究 (英文) JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B (BIOMEDICINE & BIOTECHNOLOGY) | 2014
a
Inhibitory activities of methanol extracts of Andrographis paniculata and Ocimum sanctum against dengue-1 virus INTERNATIONAL CONFERENCE ON BIOLOGICAL ENVIRONMENTAL AND FOOD ENGINEERING: BALI, INDONESIA | 2014
a
Anti-adipogenic effects of extracts of Ficus deltoidea var. deltoidea and var. angustifolia on 3T3-L1 adipocytes JOURNAL OF ZHEJIANG UNIVERSITY SCIENCE B | 2014
a
Neuroprotective effects of orientin on hydrogen peroxide‑induced apoptosis in SH‑SY5Y cells Molecular medicine reports | 2014
a
Antioxidant and xanthine oxidase inhibitory activities of Swietenia macrophylla and Punica granatum INTERNATIONAL CONFERENCE ON BIOLOGICAL, ENVIRONMENT AND FOOD ENGINEERING (BEFE-2014), AUGUST | 2014
a
Neuroprotective effect of Strobilanthus crispus extracts on hydrogen peroxide-induced SH-SY5Y cells NEURO-DEGENERATIVE DISEASES | 2013
a
Isolation and Identification of Antioxidant Compounds in Methanolic Extract of Both Female and Male Plants of Ficus deltoidea MALAYSIAN JOURNAL OF CHEMISTRY | 2013
a
Neuroprotective effects of orientin on hydrogen peroxide-induced apoptosis in SH-SY5Y neuroblastoma cells NEURO-DEGENERATIVE DISEASES | 2013
a
Investigating neuroprotective effects of methanol extract of Ocimum sanctum on hydrogen peroxide-induced SH-SY5Y cells NEURO-DEGENERATIVE DISEASES | 2013
a
Cytotoxicity and mechanism of action of Strobilanthes crispus extracts on selected cancer cell lines N/A | 2013
a
Morphological and biochemical responses of Oryza sativa L.(cultivar MR219) to ion beam irradiation JOURNAL OF ZHEJIANG UNIVERSITY SCIENCE B | 2013
a
Comparative effects of plant growth regulators on leaf and stem explants of Labisia pumila var. alata JOURNAL OF ZHEJIANG UNIVERSITY SCIENCE B | 2013
a
Screening of anti-dengue activity in methanolic extracts of medicinal plants BMC complementary and alternative medicine | 2012
a
Adventitious roots induction of recalcitrant tropical woody plant, Eurycoma longifolia Romanian Biotechnological Letters | 2012
a
Morphological and biochemical responses of Eurycoma longifolia callus to gamma irradiation BIOREMEDIATION, BIODIVERSITY AND BIOAVAILABILITY | 2012
a
Cytotoxicity and mechanism of action of Stobilanthes crispus extracts on selected cancer cell lines SIRIRAJ MEDICAL JOURNAL | 2012
a
Anticancer properties of Strobilanthes crispus crude extract and cytotoxicity of its fraction on liver cancer (HepG2) cells SIRIRAJ MEDICAL JOURNAL | 2012
a
Effect of Strobilanthes crispus extracts on various cancer cell lines INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | 2011
a
Strategies in enhancing secondary metabolites production in plant cell cultures. 5 | 2011
a
Effect of Strobilanthes crispus extracts on various cancer cell lines N/A | 2011
a
Towards understanding of physiological changes in cell culture of recalcitrant woody plant, Eurycoma longifolia, in response to carbon and nitrogen sources JOURNAL OF MEDICINAL PLANTS RESEARCH | 2011
a
Strategies in enhancing secondary metabolites production in plant cell cultures MED AROMAT PLANT SCI BIOTECHNOL | 2011
a
Production of Flavonoid compounds in cell cultures of Ficus deltoidea as influenced by medium composition INTERNATIONAL JOURNAL OF MEDICINAL AND AROMATIC PLANTS | 2011
a
Optimization of protoplast isolation protocols from callus of Eurycoma longifolia JOURNAL OF MEDICINAL PLANTS RESEARCH | 2010
a
Optimisation of protoplast isolation protocols using in vitro leaves of Dendrobium crumenatum (pigeon orchid) AFRICAN JOURNAL OF AGRICULTURAL RESEARCH | 2010
a
Morphological and physiological responses of Orthosiphon stamineus callus to gamma irradiation at different doses WORLD JOURNAL OF AGRICULTURAL SCIENCES | 2010
a
Callus induction of Ocimum sanctum and estimation of its total flavonoids content. ASIAN JOURNAL OF AGRICULTURAL SCIENCES | 2009
a
Effects of plant growth regulators on adventitious roots induction from different explants of Orthosiphon stamineus AM-EURASIAN J SUSTAIN AGRIC | 2009
a
Establishment of protoplast isolation protocols of Orthosiphon staminues AM-EURASIAN J SUSTAIN AGRIC | 2009
a
adventitious Root Production of Centella asiatica in response to plant growth regulators and sucrose concentration MEDICINAL AND AROMATIC PLANT SCIENCE AND BIOTECHNOLOGY | 2009
a
Adventitious rooting of Orthosiphon stamineus in response to sucrose concentrations and medium pH AM EURASIAN J SUST AGRIC | 2009
a
In vitro assessment of tolerance of Orthosiphon stamineus to induced water and salinity stress Asian Journal of Plant Sciences | 2009
a
Ion-beam technology for novel rice improvement N/A | 2009
a
Establishment and maintenance of growth parameters for cell suspension cultures of Ficus deltoidea PROCEEDINGS OF THE SEMINAR ON MEDICINAL AND AROMATIC PLANTS (MAPS 2008) | 2009
a
Effects of medium composition on the morphological and physiological changes of Oncidium Sharry Baby plantlets. AMERICAN-EURASIAN JOURNAL OF SUSTAINABLE AGRICULTURE | 2009
a
Induction and maintenance of callus from leaf explants of Mirabilis jalapa L MEDICINAL AND AROMATIC PLANT SCIENCE AND BIOTECHNOLOGY | 2009
a
Induction and multiplication of callus from endosperm of Cycas revoluta AFRICAN JOURNAL OF BIOTECHNOLOGY | 2008
a
Establishment and optimisation of growth parameters for cell suspension cultures of Ficus deltoidea AMERICAN-EURASIAN JOURNAL OF SUSTAINABLE AGRICULTURE | 2008
a
Physiological responses of Citrus sinensis to gamma irradiation WORLD APPL. SCI. J | 2008
a
Induction of somatic embryos from different explants of Citrus sinensis JOURNAL OF PLANT SCIENCES | 2008
a
Physiological responses of Orthosiphon stamineus plantlets to gamma irradiation AMERICAN-EURASIAN JOURNAL OF SUSTAINABLE AGRICULTURE | 2008
a
Callus induction from leaf explants of Ficus deltoidea Jack INT J AGRIC RES | 2007
a
Callus induction from leaf explants of Melaleuca alternifolia INT J AGRIC RES | 2007
a
A summary of reported chemical constituents and medicinal uses of Eurycoma longifolia. JOURNAL OF TROPICAL MEDICINAL PLANTS | 2007
a
A summary report on chemical constituents and medicinal uses of Centella asiatica. JOURNAL OF TROPICAL MEDICINAL PLANTS | 2007
a
Somatic embryogenesis: an alternative method for in vitro micropropagation N/A | 2006
a
Potential biochemical markers for somatic embryos of Eurycoma longifolia Jack Journal of Plant Biology | 2006
a
Adventitious shoots regeneration from root and stem explants of Eurycoma longifolia Jack-an important tropical medicinal plants INTERNATIONAL JOURNAL OF AGRICULTURE RESEARCH | 2006
a
of Eurycoma Iongifolia Jack J. PLANT BIOL | 2006
a
Effects of precursor supplementation on the production of triterpenes by Centella asiatica callus culture PAK J BIOL SCI | 2005
a
Multiple shoots formation of an important tropical medicinal plant, Eurycoma longifolia Jack Plant biotechnology | 2005
a
Micropropagation of Eurycoma longifolia Jack via formation of somatic embryogenesis Asian Journal of Plant Sciences | 2005
a
Micropropagation of Eurycoma longifolia Jack via formation of somatic embryogenesis. N/A | 2005
a
Triterpene production in Centella asiatica (L.) urban (pegaga) callus and cell suspension cultures N/A | 2004
a
Triterpenoids distribution in whole plant and callus cultures of Centella asiatica accessions INTERDISCIPLINARY APPROACHES IN NATURAL PRODUCTS RESEARCH: PROCEEDINGS OF THE 16TH NATIONAL SEMINAR ON NATURAL PRODUCTS | 2001

Other Publications

a
Neuroprotective Role of Orientin on β-amyloid-induced Cell Death in SH-SY5Y Neuronal Cells via mTOR Signaling Pathway IICBE Int’l Conference Program | 16 Nov 2023
a
THE ROLE OF MADECASSOSIDE IN REGULATING NF-B SIGNALING PATHWAY IN BETA-AMYLOID INDUCED BV2 MICROGLIAL CELLS ADPD 2023:International Conference on Alzheimer’s and Parkinson’s Diseases and related neurological disorders | 28 Mar 2023
a
ANTI-NEUROINFLAMMATORY RESPONSES IN LIPOPOLYSACCHARIDE-STIMULATED BV2 MICROGLIA CELLS UPON TREATMENT WITH MADECASSOSIDE 11th FENS Forum of Neurosciences | 07 Jul 2018
a
Anti-Neuroinflammatory Effect of Orientin in Lipopolysaccharide-Stimulated Bv2 Microglial Cells IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-PLANT | 01 Jan 2018
a
Neuroprotective Roles of Asiaticoside on Hydrogen Peroxide-induced Toxicity in SH-SY5Y Cells 4th International Conference on Agriculture, Biotechnology, Science and Engineering | 25 Aug 2017
a
Investigating Prostaglandin E2 and Intracellular Oxidative Stress Levels in Lipopolysaccharide-stimulated RAW 264.7 Macrophages upon Treatment with Strobilanthes crispus The 18th International Conference on Allergy, Asthma, Immunology and Rheumatology (ICAAIR 2016) | 02 May 2016
a
Investigating Prostaglandin E2 and Intracellular Oxidative Stress Levels in Lipopolysaccharide-stimulated RAW 264.7 Macrophages upon Treatment with Parkia speciosa International Conference on Latest Trends in Biotechnology and Biodiversity | 24 Aug 2015
a
ORIENTIN PROTECTS NEURONAL CELL LINE FROM HYDROGEN PEROXIDE INDUCED OXIDATIVE DAMAGE VIA UP-REGULATING NRF2/KEAP1 REDOX SIGNALLING PATHWAYS The 12th International Conference on Alzheimer’s & Parkinson’s Disease 2015 | 18 Mar 2015
a
ORIENTIN PROTECTS NEURONAL CELL LINE FROM HYDROGEN PEROXIDE INDUCED OXIDATIVE DAMAGE VIA UP-REGULATING PI3K/AKT SURVIVAL WHILE DOWN-REGULATING MAPK/ERK APOPTOSIS PATHWAY The 12th International Conference on Alzheimer’s & Parkinson’s Disease 2015 | 18 Mar 2015
a
Mechanism action of neuroprotective effects of methanol extract of Ocimum sanctum on hydrogen peroxide-induced SH-SY5Y cells in Nrf2/Keap1 signalling pathway regulation The 12th International Conference on Alzheimer’s & Parkinson’s Disease 2015 | 18 Mar 2015
a
Inhibitory activities of methanol extracts of Andrographis paniculata and Ocimum sanctum against dengue-1 virus International Conference on Biological, Environment and Food Engineering | 05 Aug 2014
a
NEUROPROTECTIVE EFFECTS OF ORIENTIN ON HYDROGEN PEROXIDE-INDUCED APOPTOSIS IN SH-SY5Y NEUROBLASTOMA CELLS The 11th International Conference on Alzheimer’s & Parkinson’s Disease 2013 | 06 Mar 2013
a
Neuroprotective effect of Strobilanthus crispus extracts on hydrogen peroxide-induced SH-SY5Y cells The 11th International Conference on Alzheimer’s & Parkinson’s Disease 2013 | 06 Mar 2013
a
Investigating neuroprotective effects of methanol extract of Ocimum sanctum on hydrogen peroxide-induced SH-SY5Y cells The 11th International Conference on Alzheimer’s & Parkinson’s Disease 2013 | 06 Mar 2013
a
ANTI-CANCER PROPERTIES OF STROBILANTHES CRISPUS CRUDE EXTRACT AND CYTOTOXICITY OF ITS FRACTIONS ON LIVER CANCER (HepG2) CELLS Molecular Medicine Conference (MMC) 2012 | 19 Dec 2012
a
Screening of anti-dengue activity in methanolic extracts of six medicinal plants The 16th World Congress on Advances in Oncology and 14th International Symposium on Molecular medicine | 06 Oct 2011

Books

a
2023 John Wiley & Sons Ltd (2023). Plants as Edible Vaccine
a
Springer Nature Singapore (2023). Plant Molecular Farming: Concept and Strategies
a
Nova Science Publisher Inc., New York (2019). CRISPR/Cas9: The Emergence and Applications of a Revolutionary Gene-Editing Tool.


Supervisions
a
KAVIISH A/L VIJAYAKUMAR | Master (Mixed Mode) | 01 Sep 2024 Thesis: The Effect of Laminarin on Microglia Dectin-1 in the Pathogenesis of Alzheimer’s Disease: An in silico Approach
a
NORSARAH BINTI MOHAMAD NAZUIR, KIRAN ADAM A/L S.MAHADEV | Undergraduate | 05 Aug 2024 - 08 Nov 2024 Thesis: Enhancing DENV Vaccine Efficacy Through The Immunoinformatics Aided Design of Peptide Model with Cross-serotypically Conserved Epitopes
a
Ong Jia Xian, Eu Jun Hong | Undergraduate | 01 Jun 2024 - 31 Dec 2024 Thesis: Biochemical and transcriptomic profiling analysis of ML 125-2 and ML 82-2 rice mutant lines under reproductive stage drought stress
a
Emily Wong, Earon Lee | Undergraduate | 01 Jun 2023 - 31 Dec 2023 Thesis: Computational approaches in Zika virus (ZIKV) vaccine candidates design
a
Yip Tuck Mun, Low Jun Ying | Undergraduate | 01 Jun 2023 - 31 Dec 2023 Thesis: Biochemical and transcriptomic profiling analysis of drought tolerant and early maturity related genes in four potential rice mutant lines
a
Kogulakannan Alagappan | Undergraduate | 01 Jun 2023 - 31 Dec 2023 Thesis: A systematic review on the anti-diabetic effect of Sygyzium aromaticum
a
Freddy Ling, Ho Chee Ying, Law Yao Yang, REMAANAND A/L RAWI@JAGEN | Undergraduate | 01 Jun 2023 - 31 Dec 2023 Thesis: Elucidation of gene signature and pathway between gut microbiome dysbiosis and neurological diseases
a
Karishma Thevathasan, Jacqueline Joyce Pan, Shifa Dhannani, Methasit Klungpremchij, Melissa Priscilla, Gabriella Munoz, | Undergraduate | 14 Dec 2022 - 10 Feb 2023 Thesis: Identification of co-expressed hub genes and pathways in Zika and Dengue neuropathogenesis using data analytic approaches
a
MADHUMITA ANBAZHAGAN | Master (Mixed Mode) | 01 Jul 2022 - 31 Mar 2023 Thesis: THE MECHANISM OF ACTION OF SALSOLINOL IN BV2-MICROGLIAL CELLS VIA INFLAMMATORY PATHWAYS
a
Niwasini a/p Krishna Kumar; Soo Yen Ee; Tan Yu Shan | Undergraduate | 01 Jan 2022 - 01 Jan 2022 Thesis: Investigating the mechanism of action of madecassoside, orientin and iso-orientin against β-amyloid-induced ferroptosis in SH-SY5Y cells
a
Gan Yee Chian | Undergraduate | 01 Jan 2022 - 01 Jan 2022 Thesis: Elucidation of gene signatures and molecular pathway associated with iron-induced neurodegeneration via data analytic approach
a
Aeisha Isobel Gibson, HEW RHU JHENN, Sara Muhamed-Saleh, Sharumathy A/P Kannan | Undergraduate | 01 Jan 2022 - 01 Jan 2022 Thesis: Gene Signature or Pathway Prediction of selected neurodegenerative diseases or neuronal cancer using data analytic approaches
a
Oo Ju Nn | Master (Mixed Mode) | 01 Jan 2021 - 01 Jan 2022 Thesis: Apoptotic effects of salsolinol on BV2 microglial cells
a
Chen Wai Hong | Undergraduate | 01 Jan 2021 - 01 Jan 2022 Thesis: ANTI-NEUROINFLAMMATORY EFFECT OF SAFINAMIDE IN LIPOPOLYSACCHARIDE-STIMULATED BV-2 MICROGLIA
a
Chi Hung Khon, mark.hong, Nhi Vu, Divyesh Naidu, Cathy Cam, Kiannie Elijah | Undergraduate | 01 Jan 2021 - 01 Jan 2022 Thesis: Identification of co-expressed hub genes and pathways in Zika and Dengue neuropathogenesis using data analytic approaches
a
Dionne So, Emma Chapman, George Banis, Christopher Jin, Molly Wright, Francis Zhang | Undergraduate | 01 Jan 2021 - 01 Jan 2022 Thesis: Analysis of putative genes of Zika-infection on neurological diseases
a
LAVITRAA SURARIKNE A/L MANIARASU | Undergraduate | 01 Jan 2021 - 01 Jan 2022 Thesis: Neuroprotective role of orientin on β-amyloid-induced cell death in SH-SY5Y neuronal cells via mTOR signalling pathway
a
Chee Chun Onn, Seow Ke Sin, Tan Yung Cheng | Undergraduate | 01 Jan 2021 - 01 Jan 2022 Thesis: A computational study to elucidate anti-amyloid potential of iso-orientin on beta amyloid stimulated SHSY5Y cells
a
Brianna, Priesha A/P Manindran | Undergraduate | 01 Jan 2021 - 01 Jan 2021 Thesis: Prediction of age-related neurodegenerative diseases – data science approaches
a
Amina Ismail Hussein | Master (Mixed Mode) | 01 Jan 2021 - 01 Jan 2022 Thesis: In silico characterisation and in vitro validation of orientin on secretases activities
a
Jashann Ashwyn | Undergraduate | 01 Jan 2020 - 01 Jan 2021 Thesis: Anti-Neuroinflammatory Mechanism of Safinamide in Inhibiting Lipopolysaccharide-Induced Microglial Activation
a
Kirthikah A/P Kadiresen, Gan Wen Cong , Yip Jia Qi, Chow Shiu Sheng | Undergraduate | 01 Jan 2020 - 01 Jan 2021 Thesis: The roles of orientin and madecassoside in regulating NFkB signaling pathway and apoptotic pathway in beta-amyloid induced BV2 microglial cells
a
Alexandra Cottle, Edwin Phamanivanh, and Jacqueline Holliday | Undergraduate | 01 Jan 2020 - 01 Jan 2021 Thesis: Strategies, Issues, and Potentials of Plant-based Therapeutics
a
Dhanya Lakshmi Vicknaraj | Undergraduate | 01 Jan 2020 - 01 Jan 2021 Thesis: Mechanisms of anti-autophagic effects of orientin against beta amyloid-stimulated BV2 microglia cells
a
Dhanshree, Estrella Ting Lou Lou | Undergraduate | 01 Jan 2019 - 01 Jan 2020 Thesis: Investigating the mechanism of action of orientin against β-amyloid-induced cell death in BV2 microglial cells
a
Nor Sabrina binti Shek Daud | Undergraduate | 01 Jan 2019 - 01 Jan 2020 Thesis: Role of orientin against β-amyloid-induced cell death in SH-SY5Y human neuronal cells
a
Jong Ting, Lee Tze Shin, Ong Teng Khai, Tiong Kong Kah | Undergraduate | 01 Jan 2019 - 01 Jan 2020 Thesis: Investigating the mechanism of action of orientin and madecassoside against α-synuclein-induced cell death in SH-SY5Y human neuronal cells
a
Cheah Chee Hoe, Koay Chien Yi, Teo You Zheng | Undergraduate | 01 Jan 2018 - 01 Jan 2018 Thesis: Investigating Anti-Neuroinflammatory Responses in Lipopolysaccharide-Stimulated BV2 Microglia Cells upon Treatment with Panax ginseng Root Culture
a
Low Hwei Jean, Nurnabihahtulhanani binti Mohd Said, Claire Chong Khai Li | Undergraduate | 01 Jan 2018 - 01 Jan 2018 Thesis: Phytochemical screening and characterisation of compounds in Syzygium aqueum extracts
a
Chong Yoke Yeng, Stefanie Shee Mei En, Wong Sze Wei | Undergraduate | 01 Jan 2018 - 01 Jan 2018 Thesis: Cytotoxic and Apoptogenic Effects of Syzygium aqueum Stem Extracts on Breast, Liver and Nasopharyngeal Carcinoma Cell Lines
a
Bernadette Tune Xin Jie, Stephanie Loo Jyet Quan | Undergraduate | 01 Jan 2018 - 01 Jan 2019 Thesis: Investigating the effect of orientin in THP1 and HepG2 cells infected by DENV2
a
Syed Ali bin Abdul Rahman Alhadad, Joshua Kuruvilla | Undergraduate | 01 Jan 2018 - 01 Jan 2018 Thesis: Investigating the autophagic mechanisms of orientin and madecassoside in lipopolysaccharide-stimulated BV2 microglia cells
a
Vikram Rao a/l Vasanth Rao | Master (Mixed Mode) | 01 Jan 2018 - 01 Jan 2019 Thesis: Investigating the effect of Orientin (flavone) and Madecassoside (triterpenoid) on Saffold virus infection in SH-SY5Y (neuroblastoma) and BV2 (microglial) cells
a
Andrew Octavian Sasmita, Gan Pei Hong | Undergraduate | 01 Jan 2017 - 01 Jan 2017 Thesis: Investigating anti-neuroinflammatory mechanism of Orientin and Madecassoisde in lipopolysaccharide-stimulated BV2 microglia cells
a
Lam Kit Ying | Master (Research) | 01 Jan 2014 - 01 Jan 2017 Thesis: Orientin Protects Neuronal Cell Lines From Hydrogen Peroxide Induced Oxidative Damage Via Up-Regulating P13k/Akt Survival And Nrf2/Keap1 Redox Signalling Pathways While Down-Regulating Mapk/Erk Apoptosis Pathway
a
Siti Nor Safriena binti Muhamad | Master (Research) | 01 Jan 2014 - 01 Jan 2017 Thesis: Effect of Plant Growth Regulators on Direct Regeneration and Callus Induction from Sargassum polycystum
a
Wong Ying Pei | Doctorate | 01 Jan 2013 - 01 Jan 2020 Thesis: Expression of edible human rotavirus VP6-subunits in Agrobacterium-mediated transformed Centella asiatica cells
a
Asma Ilyani binti Kadar | Master (Research) | 01 Jan 2012 - 01 Jan 2016 Thesis: Improvement of rice grain quality through mutation breeding
a
Sharinah Ideris | Master (Research) | 01 Jan 2012 - 01 Jan 2014 Thesis: Chemical constituents from the roots of Gonoithalamus macrophyllus with antimalarial activity
a
Norkamilah Mohamed @ Abdullah | Master (Research) | 01 Jan 2012 - 01 Jan 2014 Thesis: Chemical constituents from the non-polar fraction of Goniothalamus macrophyllus
a
Lim Zi Xiong | Master (Research) | 01 Jan 2009 - 01 Jan 2011 Thesis: Establishment of Eurycoma longifolia (Tongkat Ali) root culture for the production of pharmaceutically important lead compounds
a
Lee Pui Sinn | Master (Research) | 01 Jan 2008 - 01 Jan 2010 Thesis: Micropropagation of Ficus deltoidea through direct and indirect regeneration
a
Ong Siew Ling | Master (Research) | 01 Jan 2008 - 01 Jan 2010 Thesis: Production of flavonoids in cell cultures of Ficus deltoidea