ANNA LING PICK KIONG



Salutation
Professor

School/Centre
School of Health Sciences

Appointment
Dean, School of Health Sciences

Position
Professor

Email
anna_ling@imu.edu.my

Professional Network


Education

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PhD (Plant Biotechnology), 2004 UPM
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BSc (Hons) (Resource Biotechnology), 1999 UNIMAS

Memberships

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Royal Society of Biology, UK Fellow 2023 - 2024
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Malaysian Board of Technologist Professional Technologist 2021 - 2022
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Malaysian Board of Technologist Graduate Technologist 2018 - Present
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Malaysian Society for Molecular Biology and Biotechnology Member 2017 - Present
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International Association for Plant Biotechnology Member 2016 - 2022
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Society for the Advancement of Breeding Research in Asia and Oceania (SABRAO) Member 2012 - Present
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Malaysian Genetics Society Member 2011 - Present

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Research Funding
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The Effect of Laminarin on Microglia Dectin-1 in the Pathogenesis of Alzheimer’s Disease: An in silico Approach IMU Internal Research Grant | 01 Sep 2024 - 30 Jun 2025
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Enhancing DENV Vaccine Efficacy Through The Immunoinformatics Aided Design of Peptide Model with Cross-serotypically Conserved Epitopes IMU Internal Research Grant | 05 Aug 2024 - 08 Nov 2024
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Biochemical and transcriptomic profiling analysis of ML 125-2 and ML 82-2 rice mutant lines under reproductive stage drought stress IMU Internal Research Grant | 01 Jun 2024 - 31 Dec 2024
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Development and Commercialization of Climate-Resilient Rice Varieties to Increase National Yield Production Dana Penyelidikan Strategik MOSTI (SRF) | 01 Feb 2024 - 31 Jan 2027
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A systematic review on the anti-hyperglycaemic effect of Syzygium aromaticum based on in vitro and in vivo studies IMU Internal Research Grant | 01 Jun 2023 - 31 Dec 2023
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Elucidation of gene signature and pathway between gut microbiome dysbiosis and neurological diseases IMU Internal Research Grant | 01 Jun 2023 - 31 Dec 2023
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Computational approaches in Zika virus (ZIKV) vaccine candidates design IMU Internal Research Grant | 01 Jun 2023 - 31 Dec 2023
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Biochemical and transcriptomic profiling analysis of drought tolerant and early maturity related genes in four potential rice mutant lines IMU Internal Research Grant | 01 Jun 2023 - 31 Dec 2023
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Molecular target prediction for selected neuronal tumours Australian Government New Colombo Fund | 14 Dec 2022 - 10 Feb 2023
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Toxic effects of salsolinol in neuronal cells via mitophagy pathway IMU Internal Research Grant | 01 Dec 2022 - 31 Dec 2023
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Elucidation of gene signature and molecular pathway selected neurodegenerative diseases via data analytic approaches Biomedical Science | 01 Jun 2022 - 31 Dec 2022
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Elucidation of gene signatures and molecular pathway associated with iron-induced neurodegeneration via data analytic approach Medical Biotechnology | 01 Jun 2022 - 31 Dec 2022
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Elucidation of gene signature and molecular pathway of selected neuronal tumour via data analytic approaches Biomedical Science | 01 Jun 2022 - 31 Dec 2022
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Investigating the mechanism of action of madecassoside, orientin and iso-orientin against β- amyloid-induced ferroptosis in SH-SY5Y cells IMU | 01 Jun 2022 - 31 Dec 2022
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Analysis of putative gene signatures of ZIKV-infection on neurological diseases Australian Government New Colombo Fund | 06 Dec 2021 - 25 Feb 2022
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Identification of co-expressed hub genes and pathways in Zika and Dengue neuropathogenesis using data analytic approaches Australian Government New Colombo Fund | 06 Dec 2021 - 25 Feb 2022
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Prediction of age-related neurodegenerative diseases – data science approaches BMSc I/2021(09) | 01 May 2021 - 31 Oct 2021
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Studies to investigate mechanisms of anti-autophagic effects of orientin against beta amyloid-stimulated BV2 microglia cells IMU | 01 Jan 2021 - 01 Jul 2021
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Neuroprotective role of orientin on β-amyloid-induced cell death in SH-SY5Y neuronal cells via mTOR signalling pathway Bachelor in Medical Sciences (Hons) | 01 Jan 2021 - 31 Jul 2022
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The roles of orientin and madecassoside in regulating NFkB signaling pathway and apoptotic pathway in beta-amyloid induced BV2 microglial cells IMU | 06 Dec 2020 - 31 May 2021
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Investigating the mechanism of action of orientin and madecassoside against α-synuclein-induced cell death in SH-SY5Y human neuronal cells IMU | 01 Jul 2020 - 01 Dec 2020
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Anti-Neuroinflammatory Mechanism of Safinamide in Inhibiting Lipopolysaccharide-Induced Microglial Activation IMU | 01 Feb 2020 - 01 Jul 2021
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Investigating the mechanism of action of orientin against β-amyloid-induced cell death in BV2 microglial cells IMU | 01 Dec 2019 - 01 May 2020
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Role of orientin against β-amyloid-induced cell death in SH-SY5Y human neuronal cells IMU | 01 Oct 2019 - 01 Jun 2020
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Investigating the Effect of Orientin in THP1 and HepG2 Cells Infected by DENV2 IMU | 18 Dec 2018 - 19 Apr 2018
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Orientin Protects Neuronal Cell Lines From Hydrogen Peroxide Induced Oxidative Damage Via Up-Regulating P13k/Akt Survival And Nrf2/Keap1 Redox Signalling Pathways While DownRegulating Mapk/Erk Apoptosis Pathway FRGS | 01 Jul 2013 - 31 Dec 2015
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Investigation on the structure activity and mechanism of action of anti-inflammatory flavones FRGS | 01 May 2013 - 30 Apr 2016
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In Vitro Tissue culture of Sargassum special with enhanced biochemical properties through application of gamma irradiation FRGS | 01 Apr 2013 - 31 Dec 2016
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Production and characterisation of edible human rotavirus VP6 protein expressed in engineered Centella asiatica cells ERGS | 01 Oct 2012 - 31 Mar 2016
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Development of advanced and promising mutant lines derived from mutagenesis of Oryza sativa cv MR219 for drought tolerant, blast resistant and quality traits eScience | 01 Jan 2012 - 01 Jan 2014

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Publications

Research Articles

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Neuroprotective effects of safinamide against autophagy in 6-hydroxydopamine-induced SH-SY5Y cell model of Parkinson’s disease JOURNAL OF APPLIED PHARMACEUTICAL SCIENCE 2024
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THE ROLES OF ANTIFIBROTIC THERAPIES IN POST-SARS-CoV-2 INFECTION MALAYSIAN JOURNAL OF BIOCHEMISTRY & MOLECULAR BIOLOGY 2023
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Plants as Edible Vaccine PLANTS AS BIOREACTORS FOR INDUSTRIAL MOLECULES 2023
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Mesenchymal stem cells as future treatment for cardiovascular regeneration and its challenges ANNALS OF TRANSLATIONAL MEDICINE 2023
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Anti-neuroinflammatory mechanism of safinamide in inhibiting lipopolysaccharide-induced microglial activation. PHARMACEUTICAL SCIENCES ASIA 2023
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Anti-neuroinflammatory of Chloroform Extract of Panax ginseng Root Culture on Lipopolysaccharide-stimulated BV2 Microglia Cells REPORTS OF BIOCHEMISTRY & MOLECULAR BIOLOGY 2022
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Role of orientin against beta-amyloid induced cell death in SH-SY5Y human neuronal cells MALAYSIAN JOURNAL OF BIOCHEMISTRY & MOLECULAR BIOLOGY 2022
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Applying stem cell therapy in intractable diseases: a narrative review of decades of progress and challenges STEM CELL INVESTIGATION 2022
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CRISPR/Cas9 in plant biotechnology: applications and challenges BIOTECHNOLOGIA. JOURNAL OF BIOTECHNOLOGY COMPUTATIONAL BIOLOGY AND BIONANOTECHNOLOGY 2022
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ANTI-APOPTOTIC ACTIONS OF SAFINAMIDE IN 6-HYDROXYDOPAMINE-INDUCED CELL MODEL OF PARKINSON’S DISEASE MALAYSIAN JOURNAL OF BIOCHEMISTRY & MOLECULAR BIOLOGY 2022
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THE THE EFFECTS OF ORIENTIN ON THP-1 CELLS INFECTED BY DENV2 JOURNAL OF MICROBIOLOGY, BIOTECHNOLOGY AND FOOD SCIENCES 2022
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How Do Abnormalities in the Cerebrospinal Fluid Impact Neuropsychology with Progressing Age? CNS & NEUROLOGICAL DISORDERS DRUG TARGETS 2022
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An Overview of Herbal Medicines for Idiopathic Pulmonary Fibrosis PROCESSES 2022
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Bioinformatics approaches and applications in plant biotechnology JOURNAL OF GENETIC ENGINEERING AND BIOTECHNOLOGY 2022
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The Role of Monoamine Oxidase B Inhibitors in the Treatment of Parkinson’s Disease-An Update CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (FORMERLY CURRENT DRUG TARGETS-CNS & NEUROLOGICAL DISORDERS) 2022
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Current updates and research on plant-based vaccines for coronavirus disease 2019 Clinical and Experimental Vaccine Research 2021
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Immunotherapies for Parkinson's disease: Progression of Clinical Development. CNS & NEUROLOGICAL DISORDERS DRUG TARGETS 2021
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Gene introduction approaches in chloroplast transformation and its applications JOURNAL OF GENETIC ENGINEERING AND BIOTECHNOLOGY 2021
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Anticancer Properties of Strobilanthes crispus: A Review Processes 2021
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An overview of complementary and alternative medicine for alzheimer's and parkinson's disease MALAYSIAN JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY 2021
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RESEARCH ARTICLE COVID-19 and its effects on neurological functions TROPICAL BIOMEDICINE 2021
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Gene introduction approaches in chloroplast transformation and its application JOURNAL OF GENETIC ENGINEERING AND BIOTECHNOLOGY 2021
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COVID-19 and its effects on neurological functions TROPICAL BIOMEDICINE 2021
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Anti-neuroinflammatory responses in lipopolysaccharide-stimulated BV2 microglial cells upon treatment with methanol extract of Panax ginseng root. JOURNAL OF TRADITIONAL CHINESE MEDICINE 2021
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A mini review on neuroprotective effects of Syzygium cumini JOURNAL OF MEDICINE & BIOMEDICAL RESEARCH 2021
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The Mechanism of Action of Salsolinol in Brain: Implications in Parkinson’s Disease CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (FORMERLY CURRENT DRUG TARGETS-CNS & NEUROLOGICAL DISORDERS) 2020
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Focus: Plant-based Medicine and Pharmacology: Antidiabetic Potential of Syzygium sp.: An Overview Yale Journal of Biology and Medicine 2020
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Mechanisms of action of amyloid-beta and its precursor protein in neuronal cell death Metabolic brain disease 2020
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Siti Nor Safriena Muhamad, Anna Pick J APPL PHYCOL 2019
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Investigating anti-neuroinflammatory mechanism of orientin in lipopolysaccharide-induced BV2 microglia cells ASIA PACIFIC JOURNAL OF MOLECULAR BIOLOGY AND BIOTECHNOLOGY 2019
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Overview of the Pharmacological Activities of Aframomum melegueta. Pertanika Journal of Tropical Agricultural Science 2019
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TARGETING AUTOPHAGY IN ALZHEIMER’S DISEASE: AN OVERVIEW MALAYSIAN JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY 2019
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Anticancer potential of Syzygium species: a review Plant Foods for Human Nutrition 2019
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Physicochemical characteristics and nutritional compositions of MR219 mutant rice and their effects on glycaemic responses in BALB/c mice. International Food Research Journal 2019
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Neuroprotective Mechanisms of Orientin against Hydrogen Peroxide-induced Oxidative Damage in SH-SY5Y Cells JOURNAL OF BIOCHEMISTRY, MICROBIOLOGY AND BIOTECHNOLOGY 2018
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Highlights of the issue 11, 2018 NEUROLOGICAL SCIENCES 2018
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A mini review on phytochemical constituents and pharmacological activities of Adenium obesum JOURNAL OF TROPICAL AGRICULTURAL SCIENCE 2018
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A Mini Review on Phytochemical Constituents and Pharmacological Activities of Adenium obesum. Pertanika Journal of Tropical Agricultural Science 2018
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A PEG 4000-degrading and hexavalent molybdenum-reducing Pseudomonas putida strain Egypt-15 Journal of the National Science Foundation of Sri Lanka 2018
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Effect of plant growth regulators on direct regeneration and callus induction from Sargassum polycystum C. Agardh Journal of Applied Phycology 2018
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Nanoparticles as carriers of phytochemicals: Recent applications against lung cancer INT. J. RES. BIOMED. BIOTECHNOL 2018
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Madecassoside activates anti‑neuroinflammatory mechanisms by inhibiting lipopolysaccharide‑induced microglial inflammation International journal of molecular medicine 2018
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Niosomes: a review of their structure, properties, methods of preparation, and medical applications Asian Biomedicine 2018
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Harnessing neuroplasticity: modern approaches and clinical future International Journal of Neuroscience 2018
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Biomarkers and therapeutic advances in glioblastoma multiforme ASIAPACIFIC JOURNAL OF CLINICAL ONCOLOGY 2018
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Therapeutic potential of combined viral transduction and CRISPR/Cas9 gene editing in treating neurodegenerative diseases Neurological Sciences 2018
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Anticancer mechanisms of Strobilanthes crispa Blume hexane extract on liver and breast cancer cell lines Oncology letters 2017
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The modified Gompertz model demonstrates a variable growth rate between two Centella asiatica phenotypes JOURNAL OF BIOCHEMISTRY, MICROBIOLOGY AND BIOTECHNOLOGY 2017
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Bioactivity of Mesona palustris (Black Cincau) as a nutraceutical agent J. ENG. SCI. RES 2017
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Neuroprotective roles of asiaticoside on hydrogen peroxide-induced toxicity in SH-SY5Y cells JOURNAL OF FUNDAMENTAL AND APPLIED SCIENCES 2017
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An Overview of Pharmacological Activities of Syzygium sp. CANCER 2017
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Addendum: Hussein et al. The modified Gompertz model demonstrates a variable growth rate between two Centella asiatica phenotypes. Journal of Biochemistry, Microbiology and Biotechnology, 2017, Vol 5, No 1, 18-20. JOURNAL OF BIOCHEMISTRY, MICROBIOLOGY AND BIOTECHNOLOGY 2017
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Investigating Prostaglandin E2 and Intracellular Oxidative Stress Levels in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages upon Treatment with Strobilanthes crispus INTERNATIONAL JOURNAL OF MEDICAL AND HEALTH SCIENCES 2016
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Anti-inflammatory Effect of Strobilanthes crispus methanolic extract on Lipopolysaccharide-stimulated RAW 264.7 Macrophages JOURNAL OF MEDICAL AND BIOLOGICAL SCIENCES 2016
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Niosome: a mini review on its structure, properties, methods of preparation and medical applications JOURNAL OF CHEMICAL AND PHARMACEUTICAL RESEARCH 2016
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Neurotoxic effect of salsolinol through oxidative stress induction and Nrf2-Keap1 signalling regulation JOURNAL OF CHEMICAL AND PHARMACEUTICAL RESEARCH, 2016
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Modelling the effect of picloram on the growth kinetics of cell suspension cultures of Ficus deltoidea L. JOURNAL OF BIOCHEMISTRY, MICROBIOLOGY AND BIOTECHNOLOGY 2016
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Medicinal properties of pitaya: a review SPATULA DD 2016
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Plant-Based Vaccines: Production and Challenges. JOURNAL OF BOTANY 2016
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A review on medicinal properties of orientin Advances in pharmacological sciences 2016
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Modelling the growth kinetics of callus cultures from the seedling of Jatropha curcas L. according to the modified gompertz model JOURNAL OF BIOCHEMISTRY, MICROBIOLOGY AND BIOTECHNOLOGY 2016
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Characterization of a molybdenum-reducing bacterium with the ability to degrade phenol, isolated in soils from Egypt BIOTECHNOLOGIA. JOURNAL OF BIOTECHNOLOGY COMPUTATIONAL BIOLOGY AND BIONANOTECHNOLOGY 2015
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Isolation and characterization of a molybdenum-reducing, phenol-and catechol-degrading Pseudomonas putida strain amr-12 in soils from Egypt SCIENTIFIC STUDY AND RESEARCH-CHEMISTRY AND CHEMICAL ENGINEERING BIOTECHNOLOGY FOOD INDUSTRY 2015
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Cytotoxic and apoptogenic effects of Strobilanthes crispa Blume extracts on nasopharyngeal cancer cells Molecular medicine reports 2015
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Modelling the effect of 2-4, D on the growth kinetics of cell suspension cultures of Ficus deltoidea L JOURNAL OF BIOCHEMISTRY, MICROBIOLOGY AND BIOTECHNOLOGY 2015
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Strobilanthes crispus extract induces apoptosis through enhanced caspases activities in cervical cancer cells INTERNATIONAL CONFERENCE ON BIOLOGICAL, ENVIRONMENT AND FOOD ENGINEERING (BEFE-2014) AUGUST 2014
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金钱榕提取物抑制 3T3-L1 脂肪细胞抗脂肪沉积研究 (英文) JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B (BIOMEDICINE & BIOTECHNOLOGY) 2014
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An Investigation of Anti-Inflammatory Properties of Methanol Extract of Syzygium malaccense on Lipopolysaccharide-Stimulated Raw 264.7 Macrophages INTERNATIONAL CONFERENCE ON LATEST TRENDS IN FOOD, BIOLOGICAL & ECOLOGICAL SCIENCES PHUKET (THAILAND)(ICLTFBE(TM)14) 2014
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Inhibitory activities of methanol extracts of Andrographis paniculata and Ocimum sanctum against dengue-1 virus INTERNATIONAL CONFERENCE ON BIOLOGICAL ENVIRONMENTAL AND FOOD ENGINEERING: BALI, INDONESIA 2014
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Antioxidant and xanthine oxidase inhibitory activities of Swietenia macrophylla and Punica granatum INTERNATIONAL CONFERENCE ON BIOLOGICAL, ENVIRONMENT AND FOOD ENGINEERING (BEFE-2014), AUGUST 2014
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Anti-adipogenic effects of extracts of Ficus deltoidea var. deltoidea and var. angustifolia on 3T3-L1 adipocytes JOURNAL OF ZHEJIANG UNIVERSITY SCIENCE B 2014
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Neuroprotective effects of orientin on hydrogen peroxide‑induced apoptosis in SH‑SY5Y cells Molecular medicine reports 2014
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Comparative effects of plant growth regulators on leaf and stem explants of Labisia pumila var. alata JOURNAL OF ZHEJIANG UNIVERSITY SCIENCE B 2013
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Morphological and biochemical responses of Oryza sativa L.(cultivar MR219) to ion beam irradiation JOURNAL OF ZHEJIANG UNIVERSITY SCIENCE B 2013
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Investigating neuroprotective effects of methanol extract of Ocimum sanctum on hydrogen peroxide-induced SH-SY5Y cells NEURO-DEGENERATIVE DISEASES 2013
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Neuroprotective effect of Strobilanthus crispus extracts on hydrogen peroxide-induced SH-SY5Y cells NEURO-DEGENERATIVE DISEASES 2013
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Neuroprotective effects of orientin on hydrogen peroxide-induced apoptosis in SH-SY5Y neuroblastoma cells NEURO-DEGENERATIVE DISEASES 2013
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Isolation and Identification of Antioxidant Compounds in Methanolic Extract of Both Female and Male Plants of Ficus deltoidea MALAYSIAN JOURNAL OF CHEMISTRY 2013
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Screening of anti-dengue activity in methanolic extracts of medicinal plants BMC complementary and alternative medicine 2012
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Adventitious roots induction of recalcitrant tropical woody plant, Eurycoma longifolia Romanian Biotechnological Letters 2012
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Morphological and biochemical responses of Eurycoma longifolia callus to gamma irradiation BIOREMEDIATION, BIODIVERSITY AND BIOAVAILABILITY 2012
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Cytotoxicity and mechanism of action of Stobilanthes crispus extracts on selected cancer cell lines SIRIRAJ MEDICAL JOURNAL 2012
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Anticancer properties of Strobilanthes crispus crude extract and cytotoxicity of its fraction on liver cancer (HepG2) cells SIRIRAJ MEDICAL JOURNAL 2012
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Strategies in enhancing secondary metabolites production in plant cell cultures. 5 2011
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Effect of Strobilanthes crispus extracts on various cancer cell lines INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 2011
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Towards understanding of physiological changes in cell culture of recalcitrant woody plant, Eurycoma longifolia, in response to carbon and nitrogen sources JOURNAL OF MEDICINAL PLANTS RESEARCH 2011
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Production of Flavonoid compounds in cell cultures of Ficus deltoidea as influenced by medium composition INTERNATIONAL JOURNAL OF MEDICINAL AND AROMATIC PLANTS 2011
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Strategies in enhancing secondary metabolites production in plant cell cultures MED AROMAT PLANT SCI BIOTECHNOL 2011
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Optimization of protoplast isolation protocols from callus of Eurycoma longifolia JOURNAL OF MEDICINAL PLANTS RESEARCH 2010
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Optimisation of protoplast isolation protocols using in vitro leaves of Dendrobium crumenatum (pigeon orchid) AFRICAN JOURNAL OF AGRICULTURAL RESEARCH 2010
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Morphological and physiological responses of Orthosiphon stamineus callus to gamma irradiation at different doses WORLD JOURNAL OF AGRICULTURAL SCIENCES 2010
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Adventitious rooting of Orthosiphon stamineus in response to sucrose concentrations and medium pH AM EURASIAN J SUST AGRIC 2009
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Effects of medium composition on the morphological and physiological changes of Oncidium Sharry Baby plantlets. AMERICAN-EURASIAN JOURNAL OF SUSTAINABLE AGRICULTURE 2009
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Establishment and maintenance of growth parameters for cell suspension cultures of Ficus deltoidea PROCEEDINGS OF THE SEMINAR ON MEDICINAL AND AROMATIC PLANTS (MAPS 2008) 2009
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In vitro assessment of tolerance of Orthosiphon stamineus to induced water and salinity stress Asian Journal of Plant Sciences 2009
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Establishment of protoplast isolation protocols of Orthosiphon staminues AM-EURASIAN J SUSTAIN AGRIC 2009
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adventitious Root Production of Centella asiatica in response to plant growth regulators and sucrose concentration MEDICINAL AND AROMATIC PLANT SCIENCE AND BIOTECHNOLOGY 2009
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Induction and maintenance of callus from leaf explants of Mirabilis jalapa L MEDICINAL AND AROMATIC PLANT SCIENCE AND BIOTECHNOLOGY 2009
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Effects of plant growth regulators on adventitious roots induction from different explants of Orthosiphon stamineus AM-EURASIAN J SUSTAIN AGRIC 2009
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Callus induction of Ocimum sanctum and estimation of its total flavonoids content. ASIAN JOURNAL OF AGRICULTURAL SCIENCES 2009
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Induction and multiplication of callus from endosperm of Cycas revoluta AFRICAN JOURNAL OF BIOTECHNOLOGY 2008
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Establishment and optimisation of growth parameters for cell suspension cultures of Ficus deltoidea AMERICAN-EURASIAN JOURNAL OF SUSTAINABLE AGRICULTURE 2008
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Physiological responses of Orthosiphon stamineus plantlets to gamma irradiation AMERICAN-EURASIAN JOURNAL OF SUSTAINABLE AGRICULTURE 2008
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Induction of somatic embryos from different explants of Citrus sinensis JOURNAL OF PLANT SCIENCES 2008
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Physiological responses of Citrus sinensis to gamma irradiation WORLD APPL. SCI. J 2008
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Callus induction from leaf explants of Ficus deltoidea Jack INT J AGRIC RES 2007
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Callus induction from leaf explants of Melaleuca alternifolia INT J AGRIC RES 2007
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A summary of reported chemical constituents and medicinal uses of Eurycoma longifolia. JOURNAL OF TROPICAL MEDICINAL PLANTS 2007
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A summary report on chemical constituents and medicinal uses of Centella asiatica. JOURNAL OF TROPICAL MEDICINAL PLANTS 2007
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Potential biochemical markers for somatic embryos of Eurycoma longifolia Jack Journal of Plant Biology 2006
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Adventitious shoots regeneration from root and stem explants of Eurycoma longifolia Jack-an important tropical medicinal plants INTERNATIONAL JOURNAL OF AGRICULTURE RESEARCH 2006
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of Eurycoma Iongifolia Jack J. PLANT BIOL 2006
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Effects of precursor supplementation on the production of triterpenes by Centella asiatica callus culture PAK J BIOL SCI 2005
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Multiple shoots formation of an important tropical medicinal plant, Eurycoma longifolia Jack Plant biotechnology 2005
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Micropropagation of Eurycoma longifolia Jack via formation of somatic embryogenesis Asian Journal of Plant Sciences 2005
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Triterpenoids distribution in whole plant and callus cultures of Centella asiatica accessions INTERDISCIPLINARY APPROACHES IN NATURAL PRODUCTS RESEARCH: PROCEEDINGS OF THE 16TH NATIONAL SEMINAR ON NATURAL PRODUCTS 2001

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Other Publications

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Neuroprotective Role of Orientin on β-amyloid-induced Cell Death in SH-SY5Y Neuronal Cells via mTOR Signaling Pathway IICBE Int’l Conference Program | 16 Nov 2023
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THE ROLE OF MADECASSOSIDE IN REGULATING NF-B SIGNALING PATHWAY IN BETA-AMYLOID INDUCED BV2 MICROGLIAL CELLS ADPD 2023:International Conference on Alzheimer’s and Parkinson’s Diseases and related neurological disorders | 28 Mar 2023
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ANTI-NEUROINFLAMMATORY RESPONSES IN LIPOPOLYSACCHARIDE-STIMULATED BV2 MICROGLIA CELLS UPON TREATMENT WITH MADECASSOSIDE 11th FENS Forum of Neurosciences | 07 Jul 2018
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Anti-Neuroinflammatory Effect of Orientin in Lipopolysaccharide-Stimulated Bv2 Microglial Cells IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-PLANT | 01 Jan 2018
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Neuroprotective Roles of Asiaticoside on Hydrogen Peroxide-induced Toxicity in SH-SY5Y Cells 4th International Conference on Agriculture, Biotechnology, Science and Engineering | 25 Aug 2017
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Investigating Prostaglandin E2 and Intracellular Oxidative Stress Levels in Lipopolysaccharide-stimulated RAW 264.7 Macrophages upon Treatment with Strobilanthes crispus The 18th International Conference on Allergy, Asthma, Immunology and Rheumatology (ICAAIR 2016) | 02 May 2016
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Investigating Prostaglandin E2 and Intracellular Oxidative Stress Levels in Lipopolysaccharide-stimulated RAW 264.7 Macrophages upon Treatment with Parkia speciosa International Conference on Latest Trends in Biotechnology and Biodiversity | 24 Aug 2015
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ORIENTIN PROTECTS NEURONAL CELL LINE FROM HYDROGEN PEROXIDE INDUCED OXIDATIVE DAMAGE VIA UP-REGULATING NRF2/KEAP1 REDOX SIGNALLING PATHWAYS The 12th International Conference on Alzheimer’s & Parkinson’s Disease 2015 | 18 Mar 2015
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ORIENTIN PROTECTS NEURONAL CELL LINE FROM HYDROGEN PEROXIDE INDUCED OXIDATIVE DAMAGE VIA UP-REGULATING PI3K/AKT SURVIVAL WHILE DOWN-REGULATING MAPK/ERK APOPTOSIS PATHWAY The 12th International Conference on Alzheimer’s & Parkinson’s Disease 2015 | 18 Mar 2015
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Mechanism action of neuroprotective effects of methanol extract of Ocimum sanctum on hydrogen peroxide-induced SH-SY5Y cells in Nrf2/Keap1 signalling pathway regulation The 12th International Conference on Alzheimer’s & Parkinson’s Disease 2015 | 18 Mar 2015
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Inhibitory activities of methanol extracts of Andrographis paniculata and Ocimum sanctum against dengue-1 virus International Conference on Biological, Environment and Food Engineering | 05 Aug 2014
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NEUROPROTECTIVE EFFECTS OF ORIENTIN ON HYDROGEN PEROXIDE-INDUCED APOPTOSIS IN SH-SY5Y NEUROBLASTOMA CELLS The 11th International Conference on Alzheimer’s & Parkinson’s Disease 2013 | 06 Mar 2013
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Neuroprotective effect of Strobilanthus crispus extracts on hydrogen peroxide-induced SH-SY5Y cells The 11th International Conference on Alzheimer’s & Parkinson’s Disease 2013 | 06 Mar 2013
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Investigating neuroprotective effects of methanol extract of Ocimum sanctum on hydrogen peroxide-induced SH-SY5Y cells The 11th International Conference on Alzheimer’s & Parkinson’s Disease 2013 | 06 Mar 2013
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ANTI-CANCER PROPERTIES OF STROBILANTHES CRISPUS CRUDE EXTRACT AND CYTOTOXICITY OF ITS FRACTIONS ON LIVER CANCER (HepG2) CELLS Molecular Medicine Conference (MMC) 2012 | 19 Dec 2012
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Screening of anti-dengue activity in methanolic extracts of six medicinal plants The 16th World Congress on Advances in Oncology and 14th International Symposium on Molecular medicine | 06 Oct 2011

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Books

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2023 John Wiley & Sons Ltd (2023). Plants as Edible Vaccine
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Springer Nature Singapore (2023). Plant Molecular Farming: Concept and Strategies
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Nova Science Publisher Inc., New York (2019). CRISPR/Cas9: The Emergence and Applications of a Revolutionary Gene-Editing Tool.


Supervisions
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KAVIISH A/L VIJAYAKUMAR | Master (Mixed Mode) | 01 Sep 2024 Thesis: The Effect of Laminarin on Microglia Dectin-1 in the Pathogenesis of Alzheimer’s Disease: An in silico Approach
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NORSARAH BINTI MOHAMAD NAZUIR, KIRAN ADAM A/L S.MAHADEV | Undergraduate | 05 Aug 2024 - 08 Nov 2024 Thesis: Enhancing DENV Vaccine Efficacy Through The Immunoinformatics Aided Design of Peptide Model with Cross-serotypically Conserved Epitopes
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Ong Jia Xian, Eu Jun Hong | Undergraduate | 01 Jun 2024 - 31 Dec 2024 Thesis: Biochemical and transcriptomic profiling analysis of ML 125-2 and ML 82-2 rice mutant lines under reproductive stage drought stress
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Emily Wong, Earon Lee | Undergraduate | 01 Jun 2023 - 31 Dec 2023 Thesis: Computational approaches in Zika virus (ZIKV) vaccine candidates design
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Yip Tuck Mun, Low Jun Ying | Undergraduate | 01 Jun 2023 - 31 Dec 2023 Thesis: Biochemical and transcriptomic profiling analysis of drought tolerant and early maturity related genes in four potential rice mutant lines
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Kogulakannan Alagappan | Undergraduate | 01 Jun 2023 - 31 Dec 2023 Thesis: A systematic review on the anti-diabetic effect of Sygyzium aromaticum
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Freddy Ling, Ho Chee Ying, Law Yao Yang, REMAANAND A/L RAWI@JAGEN | Undergraduate | 01 Jun 2023 - 31 Dec 2023 Thesis: Elucidation of gene signature and pathway between gut microbiome dysbiosis and neurological diseases
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Karishma Thevathasan, Jacqueline Joyce Pan, Shifa Dhannani, Methasit Klungpremchij, Melissa Priscilla, Gabriella Munoz, | Undergraduate | 14 Dec 2022 - 10 Feb 2023 Thesis: Identification of co-expressed hub genes and pathways in Zika and Dengue neuropathogenesis using data analytic approaches
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MADHUMITA ANBAZHAGAN | Master (Mixed Mode) | 01 Jul 2022 - 31 Mar 2023 Thesis: THE MECHANISM OF ACTION OF SALSOLINOL IN BV2-MICROGLIAL CELLS VIA INFLAMMATORY PATHWAYS
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Niwasini a/p Krishna Kumar; Soo Yen Ee; Tan Yu Shan | Undergraduate | 01 Jan 2022 - 01 Jan 2022 Thesis: Investigating the mechanism of action of madecassoside, orientin and iso-orientin against β-amyloid-induced ferroptosis in SH-SY5Y cells
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Gan Yee Chian | Undergraduate | 01 Jan 2022 - 01 Jan 2022 Thesis: Elucidation of gene signatures and molecular pathway associated with iron-induced neurodegeneration via data analytic approach
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Aeisha Isobel Gibson, HEW RHU JHENN, Sara Muhamed-Saleh, Sharumathy A/P Kannan | Undergraduate | 01 Jan 2022 - 01 Jan 2022 Thesis: Gene Signature or Pathway Prediction of selected neurodegenerative diseases or neuronal cancer using data analytic approaches
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Oo Ju Nn | Master (Mixed Mode) | 01 Jan 2021 - 01 Jan 2022 Thesis: Apoptotic effects of salsolinol on BV2 microglial cells
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Chen Wai Hong | Undergraduate | 01 Jan 2021 - 01 Jan 2022 Thesis: ANTI-NEUROINFLAMMATORY EFFECT OF SAFINAMIDE IN LIPOPOLYSACCHARIDE-STIMULATED BV-2 MICROGLIA
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Chi Hung Khon, mark.hong, Nhi Vu, Divyesh Naidu, Cathy Cam, Kiannie Elijah | Undergraduate | 01 Jan 2021 - 01 Jan 2022 Thesis: Identification of co-expressed hub genes and pathways in Zika and Dengue neuropathogenesis using data analytic approaches
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Dionne So, Emma Chapman, George Banis, Christopher Jin, Molly Wright, Francis Zhang | Undergraduate | 01 Jan 2021 - 01 Jan 2022 Thesis: Analysis of putative genes of Zika-infection on neurological diseases
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LAVITRAA SURARIKNE A/L MANIARASU | Undergraduate | 01 Jan 2021 - 01 Jan 2022 Thesis: Neuroprotective role of orientin on β-amyloid-induced cell death in SH-SY5Y neuronal cells via mTOR signalling pathway
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Chee Chun Onn, Seow Ke Sin, Tan Yung Cheng | Undergraduate | 01 Jan 2021 - 01 Jan 2022 Thesis: A computational study to elucidate anti-amyloid potential of iso-orientin on beta amyloid stimulated SHSY5Y cells
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Brianna, Priesha A/P Manindran | Undergraduate | 01 Jan 2021 - 01 Jan 2021 Thesis: Prediction of age-related neurodegenerative diseases – data science approaches
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Amina Ismail Hussein | Master (Mixed Mode) | 01 Jan 2021 - 01 Jan 2022 Thesis: In silico characterisation and in vitro validation of orientin on secretases activities
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Jashann Ashwyn | Undergraduate | 01 Jan 2020 - 01 Jan 2021 Thesis: Anti-Neuroinflammatory Mechanism of Safinamide in Inhibiting Lipopolysaccharide-Induced Microglial Activation
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Kirthikah A/P Kadiresen, Gan Wen Cong , Yip Jia Qi, Chow Shiu Sheng | Undergraduate | 01 Jan 2020 - 01 Jan 2021 Thesis: The roles of orientin and madecassoside in regulating NFkB signaling pathway and apoptotic pathway in beta-amyloid induced BV2 microglial cells
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Alexandra Cottle, Edwin Phamanivanh, and Jacqueline Holliday | Undergraduate | 01 Jan 2020 - 01 Jan 2021 Thesis: Strategies, Issues, and Potentials of Plant-based Therapeutics
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Dhanya Lakshmi Vicknaraj | Undergraduate | 01 Jan 2020 - 01 Jan 2021 Thesis: Mechanisms of anti-autophagic effects of orientin against beta amyloid-stimulated BV2 microglia cells
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Dhanshree, Estrella Ting Lou Lou | Undergraduate | 01 Jan 2019 - 01 Jan 2020 Thesis: Investigating the mechanism of action of orientin against β-amyloid-induced cell death in BV2 microglial cells
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Nor Sabrina binti Shek Daud | Undergraduate | 01 Jan 2019 - 01 Jan 2020 Thesis: Role of orientin against β-amyloid-induced cell death in SH-SY5Y human neuronal cells
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Jong Ting, Lee Tze Shin, Ong Teng Khai, Tiong Kong Kah | Undergraduate | 01 Jan 2019 - 01 Jan 2020 Thesis: Investigating the mechanism of action of orientin and madecassoside against α-synuclein-induced cell death in SH-SY5Y human neuronal cells
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Cheah Chee Hoe, Koay Chien Yi, Teo You Zheng | Undergraduate | 01 Jan 2018 - 01 Jan 2018 Thesis: Investigating Anti-Neuroinflammatory Responses in Lipopolysaccharide-Stimulated BV2 Microglia Cells upon Treatment with Panax ginseng Root Culture
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Low Hwei Jean, Nurnabihahtulhanani binti Mohd Said, Claire Chong Khai Li | Undergraduate | 01 Jan 2018 - 01 Jan 2018 Thesis: Phytochemical screening and characterisation of compounds in Syzygium aqueum extracts
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Chong Yoke Yeng, Stefanie Shee Mei En, Wong Sze Wei | Undergraduate | 01 Jan 2018 - 01 Jan 2018 Thesis: Cytotoxic and Apoptogenic Effects of Syzygium aqueum Stem Extracts on Breast, Liver and Nasopharyngeal Carcinoma Cell Lines
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Bernadette Tune Xin Jie, Stephanie Loo Jyet Quan | Undergraduate | 01 Jan 2018 - 01 Jan 2019 Thesis: Investigating the effect of orientin in THP1 and HepG2 cells infected by DENV2
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Syed Ali bin Abdul Rahman Alhadad, Joshua Kuruvilla | Undergraduate | 01 Jan 2018 - 01 Jan 2018 Thesis: Investigating the autophagic mechanisms of orientin and madecassoside in lipopolysaccharide-stimulated BV2 microglia cells
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Vikram Rao a/l Vasanth Rao | Master (Mixed Mode) | 01 Jan 2018 - 01 Jan 2019 Thesis: Investigating the effect of Orientin (flavone) and Madecassoside (triterpenoid) on Saffold virus infection in SH-SY5Y (neuroblastoma) and BV2 (microglial) cells
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Andrew Octavian Sasmita, Gan Pei Hong | Undergraduate | 01 Jan 2017 - 01 Jan 2017 Thesis: Investigating anti-neuroinflammatory mechanism of Orientin and Madecassoisde in lipopolysaccharide-stimulated BV2 microglia cells
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Lam Kit Ying | Master (Research) | 01 Jan 2014 - 01 Jan 2017 Thesis: Orientin Protects Neuronal Cell Lines From Hydrogen Peroxide Induced Oxidative Damage Via Up-Regulating P13k/Akt Survival And Nrf2/Keap1 Redox Signalling Pathways While Down-Regulating Mapk/Erk Apoptosis Pathway
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Siti Nor Safriena binti Muhamad | Master (Research) | 01 Jan 2014 - 01 Jan 2017 Thesis: Effect of Plant Growth Regulators on Direct Regeneration and Callus Induction from Sargassum polycystum
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Wong Ying Pei | Doctorate | 01 Jan 2013 - 01 Jan 2020 Thesis: Expression of edible human rotavirus VP6-subunits in Agrobacterium-mediated transformed Centella asiatica cells
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Asma Ilyani binti Kadar | Master (Research) | 01 Jan 2012 - 01 Jan 2016 Thesis: Improvement of rice grain quality through mutation breeding
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Sharinah Ideris | Master (Research) | 01 Jan 2012 - 01 Jan 2014 Thesis: Chemical constituents from the roots of Gonoithalamus macrophyllus with antimalarial activity
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Norkamilah Mohamed @ Abdullah | Master (Research) | 01 Jan 2012 - 01 Jan 2014 Thesis: Chemical constituents from the non-polar fraction of Goniothalamus macrophyllus
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Lim Zi Xiong | Master (Research) | 01 Jan 2009 - 01 Jan 2011 Thesis: Establishment of Eurycoma longifolia (Tongkat Ali) root culture for the production of pharmaceutically important lead compounds
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Lee Pui Sinn | Master (Research) | 01 Jan 2008 - 01 Jan 2010 Thesis: Micropropagation of Ficus deltoidea through direct and indirect regeneration
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Ong Siew Ling | Master (Research) | 01 Jan 2008 - 01 Jan 2010 Thesis: Production of flavonoids in cell cultures of Ficus deltoidea

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