PHYU SYNN OO



Salutation
Dr

School/Centre
School of Medicine

Department
Pathology

Position
Senior Lecturer


Professional Network


Education

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PhD (Cell biology, Molecular biology), 2018 University of Miyazaki
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MMedSc (Pathology) (Pathology (Histopath, Haematopath, Chempath, Microbiology)), 2013 University of Medicine 1 Yangon
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MBBS (Medicine), 2005 University of Medicine 1 Yangon

Memberships

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MALAYSIAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY Ordinary Member 2023 - Present
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Japan Society of Clinical Molecular Morphology Member 2014 - 2019
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Japanese Association of Anatomists Member 2014 - 2019
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Japan Society of Histochemistry and Cytochemistry Member 2013 - Present
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Myanmar Society of Pathology Member 2013 - Present

Research Funding
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Comparison of the facility index with the examiners’ estimation of item difficulty and cognitive levels of questions within summative examinations in a preclinical medical curriculum IMU Internal Research Grant | 25 Apr 2024 - 31 Jan 2026
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ANTI-MICROBIAL EFFECTS OF QUEBRACHITOL: A SYSTEMATIC REVIEW IMU Internal Research Grant | 25 Mar 2024 - 31 Dec 2024
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Prognostic significance of dynamin-related protein 1 (Drp1) expression in cancers: A systematic review IMU Internal Research Grant | 01 Mar 2024 - 31 Jul 2024
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Study to elucidate the involvement of Drp1 signalling pathways in oestrogen-regulated mitochondrial dynamics in ER-positive breast cancer cell lines FRGS 2023 | 01 Oct 2023 - 30 Sep 2025
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Comparative study on the effects of two cooking processes on selected toxic heavy metal concentrations in selected varieties of commercially available fish and prawns consumed in Malaysia. IMU Internal Research Grant | 01 Jun 2023 - 31 Dec 2023
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Determination of the role of Dynamin-related protein 1 post-translational modification (phosphoDrp1) in ER-positive human breast cancer samples IMU Internal Research Grant | 10 Mar 2023 - 31 Dec 2024
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An Assessment of Tobacco-related Content and Health Warnings in Popular Malaysian films during 2014-2019 IMU BMedSc Program | 01 Jan 2023 - 31 Jul 2023
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Comparative study of carbohydrate (glycogen) preservation in formalin-fixed and alternative fixatives-fixed animal tissue sections IMU Biomedical Science Program | 20 Jun 2022 - 30 Sep 2022
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Efficacy of Neoadjuvant chemotherapy for locally invasive cervical cancer in pregnancy: An updated Systematic Review and Metanalysis IMU Staff grant | 12 Jan 2022 - 31 Mar 2022
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Comparison of formalin and formalin-alternative fixatives on tissue morphology, protein and nucleic acid preservation: A systematic review IMU | 14 Jun 2021 - 16 Oct 2021
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A systematic review of the association between diabetes mellitus and risk of gastrointestinal malignancies Bachelor of Pharmacy (Hons) | 01 Jun 2021 - 30 Nov 2021
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Combination of hormonal therapy and mitochondrial-targeted therapy as a novel strategy for breast cancer treatment IMU | 01 Mar 2021 - 31 Jul 2022
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Comparative study of Methyl Green Pyronin Y (MGPY) staining in formalin-fixed and alternative fixatives-fixed tissues in histological visualization of nucleic acid in mouse tissue sections IMU | 01 Jul 2020 - 01 Oct 2020
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Estrogen regulates mitochondrial morphology through Dynamin-related protein 1 (Drp1) and phosphorylated Drp1 in MCF7 cells 女性研究者支援加速化のための研究助成 | 01 Apr 2017 - 31 Mar 2018
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The role of miRNAs in estrogen-regulated mitochondrial morphology via human breast cancer A grant for research from Faculty of Medicine University of Miyazaki | 01 Apr 2016 - 31 Mar 2017
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高感度蛍光in situハイブリダイゼーション法によるmicroRNA発現解析 KAKENHI Grant-in-Aid for Scientific Research (C) | 01 Apr 2016 - 31 Mar 2018
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Mitochondria as therapeutic target in breast cancer stem cells A grant for research from Faculty of Medicine University of Miyazaki | 01 Apr 2014 - 31 Mar 2015
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Prevalence of Iron deficience anaemia in Pregnant women in Pyin-Ma-Na WHO | 01 Apr 2009 - 31 Mar 2011

Publications

Research Articles

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Natural fixatives alternative to formalin in histopathology: A systematic review. THE MEDICAL JOURNAL OF MALAYSIA 2023
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Changes in e-cigarette use, cigarette smoking, and dual use among the youth (13-15 years) in 10 countries (2013-2019)-analyses of Global Youth Tobacco Surveys (GYTS) NICOTINE AND TOBACCO RESEARCH 2023
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Tobacco Imagery in the 50 most popular Malaysian movies released during 2015–2019 NICOTINE AND TOBACCO RESEARCH 2023
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The HDAC inhibitor, SAHA, combined with cisplatin synergistically induces apoptosis in alpha-fetoprotein-producing hepatoid adenocarcinoma cells ACTA HISTOCHEMICA ET CYTOCHEMICA 2019
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The HDAC inhibitor, SAHA, prevents colonic inflammation by suppressing pro-inflammatory cytokines and chemokines in DSS-induced colitis Acta histochemica et cytochemica 2018
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Estrogen regulates mitochondrial morphology through phosphorylation of dynamin-related protein 1 in MCF7 human breast cancer cells Acta histochemica et cytochemica 2018
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Estrogen accelerates cell proliferation through estrogen receptor α during rat liver regeneration after partial hepatectomy Acta histochemica et cytochemica 2017
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The role of estrogen receptors in intestinal homeostasis and disease RECEPTOR CLIN. INVESTIG 2016
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Ontogenetic changes in the expression of estrogen receptor β in mouse duodenal epithelium Clinics and research in hepatology and gastroenterology 2015
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Oral cancer in Myanmar: A preliminary survey based on hospital‐based cancer registries Journal of oral pathology & medicine 2011
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Immunohistochemical study of human papillomavirus infection in squamous cell carcinoma of oral cavity. MYANMAR HEALTH SCIENCES RESEARCH JOURNAL 2010

Other Publications

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A comparative study of nucleic acid and glycogen preservation in formalin-fixed and alternative fixative-fixed tissue sections FAOPS 2023 | 01 Nov 2023
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Common Urologic disease and disorder Urinary Health Webinar 2023 | 14 Jan 2023
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The Potential uses of Natural Substances as a Replacement to Formalin fixatives Center for Complementary and Alternative Medicine research day 2022 | 15 Jun 2022
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Khandsari sugar: a promising alternative fixative to formalin in histochemical staining. International Undergraduate Medical Research Conference 2021 | 02 Nov 2021
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Update in Breast Cancer Monthly CME, Myanmar Medical Council (Taunggyi) | 12 Jun 2019
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Clinical utility of immature platelet fraction Mindray BC-6200 Product lunch | 15 Dec 2018
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A role of estrogen and estrogen receptor α in mitochondrial morphology through phosphorylation of Dynamin-related protein 1 in human breast cancer cells 59th Annual meeting of Japan Society of Histochemistry and Cytochemistry | 29 Sep 2018
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Estrogen accelerates phosphorylation of Dynamin-related protein 1 (Drp1) through estrogen receptor α in MCF7 58th Japan Society of Histochemistry and Cytochemistry | 01 Sep 2017
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Estrogen regulates mitochondrial morphology through dynamin-related protein 1 (Drp1) and phosphorylated Drp1 in MCF7 cells 122nd Annual meeting of the Japanese Association of Anatomists | 01 Mar 2017
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Role of estrogen on mitochondrial dynamics through Drp1 and pDrp1 in human breast cancer cell line 3rd Myanmar-Japan Joint symposium | 02 Dec 2016
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Role of estrogen on mitochondrial dynamin-related protein 1 (Drp1) in MCF7 human breast cancer cell line 72nd The Japanese Association of Anatomists, Kyushu branch meeting | 01 Oct 2016
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Estrogen regulates mitochondrial morphology through mitochondrial elongation factor 1 (MIEF1) in human breast cancer cells 2nd Myanmar-Japan Joint symposium | 04 Dec 2015
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Mitochondrial elongation factor 1 (MIEF1) regulates mitochondrial morphology through estrogen in MCF7 47th annual meeting of Japanese Society for Clinical Molecular Morphology | 01 Sep 2015
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Effects of estrogen on mitochondrial elongation through MIEF1 in human breast cancer cell line Joint meeting of the 120th Annual Meeting of The Japanese Association of Anatomists and the 92nd Annual Meeting of The Physiological Society of Japan | 01 Mar 2015
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Mitochondria localization and morphology may be regulated by mitochondrial elongation factor 1 (MIEF1) through estrogen in MCF7 70th The Japanese Association of Anatomists Kyushu branch meeting | 01 Oct 2014
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The possible role of MIEF1 in mitochondrial elongation by estrogen in MCF7 46th annual meeting of Japanese Society for Clinical Molecular Morphology | 01 Oct 2014


Supervisions
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Doris Evelyn Jong Yah Hui | Master (Mixed Mode) | 25 Mar 2024 - 31 Mar 2024 Thesis: ANTI-MICROBIAL EFFECTS OF QUEBRACHITOL: A SYSTEMATIC REVIEW
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NURAMIRA SYAZREEN BINTI SUHAIMI | Doctorate | 04 Mar 2024 Thesis: Oestrogenic regulation in mitochondrial dynamics in breast cancer carcinogenesis: Study on PI3KAKT and MAPK signalling cascades pathway
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Fathimath Sumeyha | Master (Mixed Mode) | 01 Mar 2024 - 31 Jul 2024 Thesis: Prognostic significance of dynamin-related protein 1 (Drp1) expression in cancers: A systematic review
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JOACHIM TAN WEI HONG | Undergraduate | 01 Jun 2023 - 30 Nov 2023 Thesis: THE COMPARATIVE STUDY ON THE EFFECTS OF TWO COOKING PROCESSES ON SELECTED TOXIC HEAVY METAL CONCENTRATIONS IN VANNAMEI PRAWNS CONSUMED IN MALAYSIA
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NIK RAIMY DANIAL BIN NIK HISHAMUDDIN | Undergraduate | 01 Jun 2023 - 30 Nov 2023 Thesis: Comparative study on the effects of two cooking processes on selected toxic heavy metal concentrations in selected varieties of commercially available fish and prawns consumed in Malaysia.
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Jason Yap Jia Cheng | Undergraduate | 01 Jun 2023 - 31 Dec 2023 Thesis: Comparative study on the effects of two cooking processes on selected toxic heavy metal concentrations in selected varieties of commercially available fish and prawns consumed in Malaysia.
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Leong Wen Kang | Undergraduate | 10 Mar 2023 - 31 Dec 2024 Thesis: Determination of the role of Dynamin-related protein 1 post-translational modification (phosphoDrp1) in ER-positive human breast cancer samples
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Tay Jean Loong Billy | Undergraduate | 01 Jan 2023 - 31 Jul 2023 Thesis: An Assessment of Tobacco-related Content and Health Warnings in Popular Malaysian films during 2015 - 2019
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MARCEL CHONG MING HIN | Undergraduate | 20 Jun 2022 - 30 Sep 2022 Thesis: COMPARATIVE STUDY OF CARBOHYDRATE PRESERVATION IN FORMALIN-FIXED AND ZINC BASED FIXATIVE-FIXED MOUSE TISSUE SECTIONS
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Ilhaam Muneer Babar | Undergraduate | 20 Jun 2022 - 30 Sep 2022 Thesis: Comparative Study of Carbohydrate Preservation in Formalin-fixed and Khandsari-fixed Tissue Sections
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ILISHA MURTHY | Undergraduate | 20 Jun 2022 - 30 Sep 2022 Thesis: Comparative study of connective tissue and carbohydrate preservation in Formalin-fixed and Zinc Formalin fixed tissues in mouse tissue sections
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Maria Ashan | Undergraduate | 10 Jan 2022 Thesis: Combination of hormonal therapy and mitochondrial-targeted therapy as a novel strategy for breast cancer treatment
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Adrinna Yee Weng Lum | Undergraduate | 14 Jun 2021 - 15 Oct 2021 Thesis: Comparison of formalin and formalin-alternative fixatives on tissue morphology, protein and nucleic acid preservation: A systematic review
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Valerie Chee Chia Xian | Undergraduate | 14 Jun 2021 - 15 Oct 2021 Thesis: Comparison of formalin and formalin-alternative fixatives on tissue morphology, protein and nucleic acid preservation: A systematic review
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Lim Wei-Jet | Undergraduate | 14 Jun 2021 - 15 Oct 2021 Thesis: Comparison of formalin and formalin-alternative fixatives on tissue morphology, protein and nucleic acid preservation: A systematic review
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CHAN KAI XIN | Undergraduate | 01 Jun 2021 Thesis: A systematic review of the association between diabetes mellitus and risk of gastrointestinal malignancies
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Lee Ching Wann | Undergraduate | 01 Mar 2021 - 29 Oct 2021 Thesis: A SYSTEMATIC REVIEW ON THE ASSOCIATION BETWEEN DIABETES MELLITUS AND RISK OF HEPATOCELLULAR CARCINOMA
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LIAU CHEE SIANG | Undergraduate | 01 Mar 2021 - 29 Oct 2021 Thesis: DIABETES MELLITUS AND RISK OF UPPER GASTROINTESTINAL MALIGNANCIES: A SYSTEMATIC REVIEW
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RYAN LAY PEE CHIUN | Undergraduate | 01 Mar 2021 - 29 Oct 2021 Thesis: A SYSTEMATIC REVIEW OF THE ASSOCIATION BETWEEN DIABETES MELLITUS AND RISK OF LOWER GASTROINTESTINAL MALIGNANCIES
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Cheoh Jia Shen | Undergraduate | 06 Jul 2020 - 07 Nov 2020 Thesis: Comparative study of Methyl Green Pyronin Y (MGPY) staining in formalin-fixed and alternative fixatives-fixed tissues in histological visualization of nucleic acid in mouse tissue sections
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Cindy Yeoh Shin Ly | Undergraduate | 06 Jul 2020 - 07 Nov 2020 Thesis: Comparative study of Methyl Green Pyronin Y (MGPY) staining in formalin-fixed and alternative fixatives-fixed tissues in histological visualization of nucleic acid in mouse tissue sections
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Wee Hong Zhuang | Undergraduate | 06 Jul 2020 - 07 Nov 2020 Thesis: Comparative study of Methyl Green Pyronin Y (MGPY) staining in formalin-fixed and alternative fixatives-fixed tissues in histological visualization of nucleic acid in mouse tissue sections