HO KET LI



Salutation
Dr

School/Centre
School of Pharmacy

Department
Life Sciences

Appointment
Head of Department, Life Sciences

Position
Senior Lecturer




Education

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PhD (Biotherapeutics), 2011 Universiti Putra Malaysia
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Bachelor of Science (Biotechnology), 2007 Universiti Putra Malaysia

Research Funding
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Effect of Geldanamycin in reducing the lymphocyte suppression ability of metastatic pancreatic cancer cells IMU Internal Research Grant | 02 Sep 2024 - 31 Jan 2025
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DIFFERENTIAL GENE EXPRESSION IN DIFFERENT STAGES OF ALZHEIMER DISEASE IMU Internal Research Grant | 01 Jun 2024 - 31 Oct 2024
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Membrane proteome profiling on primary pancreatic ductal adenocarcinoma (PDAC) cell lines IMU Internal Research Grant | 01 Jan 2024 - 31 Oct 2024
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Development, characterization, and in vitro evaluation of topical cream containing essential oil of Vernonia amygdalina leaves to enhance its anti-inflammatory property IMU Internal Research Grant | 21 Sep 2023 - 31 Jan 2024
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Assessing the Efficacy of Genistein in Decreasing the Expression of Complement Component 3 (C3) and TGFβ-induced Proteins in SW1990 and PSC Cell Lines IMU Internal Research Grant | 04 Sep 2023 - 31 Aug 2024
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Membrane proteome profiling on metastatic pancreatic ductal adenocarcinoma (PDAC) cell lines IMU Internal Research Grant | 01 Sep 2023 - 30 Jun 2024
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Identify and verify differentially expressed proteins in SW1990, PANC10.05 and PSC cell lines IMU Internal Research Grant | 03 Jul 2023 - 31 Oct 2023
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Synthesis of Carbon-based Nanomaterials for Targeted AsPC1, PANC10.05, SW1990, and BxPC3 Pancreatic Adenocarcinoma Epithelial Cell Line IMU Internal Research Grant | 01 Jun 2023 - 31 Oct 2023
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Unraveling mechanism of anti-tumor and immunomodulatory activity of silver nanoparticles from flavonoid-rich-Strobilanthes crispus leaves against breast cancer in vivo. FRGS | 01 Oct 2021 - 30 Sep 2024
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Data Integration and Identification of Differentially Expressed Genes in Primary Pancreatic Ductal Adenocarcinoma (PDAC), Metastatic PDAC and Stromal Cells IMU internal grant | 02 Aug 2021 - 02 Aug 2022
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The Influence of Conditioned Media (from Panceatic Stellate Cells) on the Proliferation of Pancreatic Cancer Cell Lines (AsPC1, PANC10.05, SW1990 and BxPC3) Bachelor of Pharmacy (Hons) | 05 Jul 2021 - 30 Nov 2021
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Student perceptions and experience of a continuous interactive quiz using Telegram application Bachelor of Dental Surgery | 01 May 2021 - 30 Sep 2021
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Differential Gene expression of Primary and Metastatic PDAC Leading to the Difference in Immunomodulation: Data Integration MMM | 01 Mar 2021 - 30 Sep 2021
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Differential Gene expression of Primary and Metastatic PDAC Leading to the Difference in Immuno-modulation: Data Integration MSc in Molecular Medicine | 01 Mar 2021 - 30 Sep 2021
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A systematic review of the efficacy of Chinese medicine combined with conventional drug treatment in rheumatoid arthritis IMU Chinese Medicine | 01 Feb 2021 - 30 Jun 2021
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Comparing the Proteomic Profiles of Myeloid Derived Suppressor Cells (MDSCs) Induced by the Conditioned Media of Metastatic Pancreatic Ductal Adenocarcinoma Cells (PDACs), Pancreatic Stellate Cells (PSCs) and Their Co-Culture MMM | 01 Aug 2020 - 31 Dec 2021
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The Influence of Conditioned Media (from metastatic PDAC and/or PSC) on Myeloid Derived Suppressor Cells (MDSCs) Proliferation MMM | 01 Aug 2020 - 31 Dec 2021
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Synthesis of Vitamin E Based-Reduced Graphene Oxide Nanosheets for Anti-Cancer Drug Delivery System IMU | 01 Jul 2020 - 01 Sep 2020
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The influence of conditioned media (from PDAC and/or PSC co-cultures) on T helper 1 cells, T helper 2 cells, CD8+ T cells and Treg cells apoptosis IMU | 01 Jul 2020 - 01 Nov 2020
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Evaluation of the secretome signature of combinatory nanomedicine calcium carbonate-loaded polygonum minus extract with 5-fluorouracil-sulforaphane-thymoquinone on human primary SW480 and metastatic SW620 colon cancer cells Geran University Putra Malaysia 2020 | 18 Jun 2020 - 17 Jun 2022
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Influence of IsaA gene disruption on staphylococcal phenotypic characters, genes and protein expression profiles IMU | 01 Aug 2019 - 01 Jul 2021
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The influence of conditioned media (from PDAC and/or PSC co-cultures) and MDSC (differentiation induced by PDAC and/or PSC co-cultures) on B lymphocytes proliferation IMU | 01 Jul 2019 - 01 Nov 2019
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Comparing the secretome profiles of PDAC, PSC and their co-culture International Medical University (Bpharm) | 01 Jul 2019 - 31 Dec 2019
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The influence of pancreatic ductal adenocarcinoma (PDA) cells and pancreatic stellate cells (PSC) on myeloid derived suppressor cells (MDSC) immunosuppressive properties FRGS | 01 Jan 2019 - 01 Jan 2023
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The role of pancreatic ductal adenocarcinoma (PDA) cells and pancreatic stellate cells (PSC) co-culture in promoting the differentiation of myeloid derived suppressor cells (MDSC) International Medical University (Bpharm) | 01 Jul 2018 - 31 Oct 2018
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The role of pancreatic ductal adenocarcinoma (PDA) cells and pancreatic stellate cells (PSC) in promoting the differentiation of myeloid derived suppressor cells (MDSC) international Medical University (Master in Molecular Medicine) | 01 Jan 2018 - 01 Jan 2019
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Exploring students’ perception on the barriers and drivers of flipped classroom in a big classroom setting International Medical University | 01 Dec 2017 - 01 Jan 2019
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Investigation Panax ginseng ability to potentiate/synergise/antagonize the inhibitory effects of hedyotis diffusa on colorectal cancer cell growth, cell migration and colony formation international Medical University (Bpharm | 01 Jul 2016 - 31 Oct 2016
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Functional characterization of REG1A gene in colorectal cancer cells international Medical University (Bpharm) | 01 Jul 2015 - 31 Oct 2015
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Cytotoxic and cytostatic effects of phenoxodiol on C6, HepG2, Cne1 and HT-29 cancer cell lines international Medical University (Master in Molecular Medicine) | 01 Sep 2014 - 28 Feb 2015
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In vitro evaluation of antioxidative and selective cytotoxic properties of 9 basic traditional chinese medicine decoctions International Medical University (Bpharm) | 01 Jul 2013 - 01 Nov 2013

Publications

Research Articles

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Chinese Medicine External Therapy Combined with Conventional Drug Treatment for Rheumatoid Arthritis: A Systematic Review and Meta-analysis. INTERNATIONAL E-JOURNAL OF SCIENCE, MEDICINE & EDUCATION | 2024
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Polygonum minus: A Tropical Medicinal Herb with Vast Applications in Food, Agricultural, and Medicinal Fields FOOD BIOSCIENCE | 2024
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The Paradoxical Role of Immune Response in Cancer Microenvironment N/A | 2024
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Pharmacy students’ and supervisors’ perceptions of the effectiveness of assessment rubrics for undergraduate research performance review PHARMACY EDUCATION | 2023
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Author Correction: Conditioned media of pancreatic cancer cells and pancreatic stellate cells induce myeloid-derived suppressor cells differentiation and lymphocytes suppression SCIENTIFIC REPORTS | 2023
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Yuen Ping Chong, Evelyn Priya Peter, Feon Jia Ming Lee, Chu Mun Chan, Shereen Chai, Lorni Poh Chou Ling, Eng Lai Tan, Sook Han Ng, Atsushi Masamune, Siti Aisyah Abd Ghafar SCIENTIFIC REPORTS | 2023
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Impact of IsaA Gene Disruption: Decreasing Staphylococcal Biofilm and Alteration of Transcriptomic and Proteomic Profiles MICROORGANISMS | 2022
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Conditioned media of pancreatic cancer cells and pancreatic stellate cells induce myeloid-derived suppressor cells differentiation and lymphocytes suppression SCIENTIFIC REPORTS | 2022
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Perceptions, behaviours, barriers, and needs of flipped classroom learning: opinions of first-year pharmacy students PHARMACY EDUCATION | 2021
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Formulation and characterisation of 1-ethyl-3-methylimidazolium acetate-in-oil microemulsions as the potential vehicle for drug delivery across the skin barrier JOURNAL OF MOLECULAR LIQUIDS | 2019
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The evaluation of students’ written reflection on the learning of general chemistry lab experiment MOJES: MALAYSIAN ONLINE JOURNAL OF EDUCATIONAL SCIENCES | 2018
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Antiproliferative, antimigratory, and anticlonogenic effects of Hedyotis diffusa, Panax ginseng, and their combination on colorectal cancer cell lines JOURNAL OF HERBS, SPICES & MEDICINAL PLANTS | 2018
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Hedyotis diffusa and Panax ginseng combination: Better anticancer properties? Appl FOOD SCI. J | 2018
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Anti-proliferative activity and preliminary phytochemical screening of Ipomoea quamoclit leaf extracts RES J MED PLANT | 2015
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Vanillin differentially affects azoxymethane-injected rat colon carcinogenesis and gene expression JOURNAL OF MEDICINAL FOOD | 2012
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Cytotoxic effects of commercial wheatgrass and fiber towards human acute promyelocytic leukemia cells [Hl60] N/A | 2011
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Cytotoxic effects of commercial wheatgrass and fiber towards human acute promyelocytic leukemia cells (HL60). PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2011
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Toxicology study of vanillin on rats via oral and intra-peritoneal administration FOOD AND CHEMICAL TOXICOLOGY | 2011
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Apoptosis and cell cycle arrest of human colorectal cancer cell line HT-29 induced by vanillin CANCER EPIDEMIOLOGY | 2009

Other Publications

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Students’ preference and suggestion towards passive learning and active learning (flipped classroom) IMEC | 14 Aug 2015
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Anti-cancer property of vanillin on HT-29 colorectal cancer cell line and its toxic effect on animal model Pertandingan Penyelidikan, Rekacipta dan Inovasi UPM 2010 | 19 Mar 2010


Supervisions
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Hafisat Titiliope Oladapo | Master (Coursework) | 02 Sep 2024 Thesis: Effect of Geldanamycin in reducing the lymphocyte suppression ability of metastatic pancreatic cancer cells
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Sun Yi Jo | Master (Mixed Mode) | 04 Sep 2023 Thesis: Assessing the Efficacy of Genistein in Decreasing the Expression of Complement Component 3 (C3) and TGFβ-induced Proteins in SW1990 and PSC Cell Lines
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Leong Khai Sheng, Oh Xin YIn, Ooi Hong Seng | Undergraduate | 03 Jul 2023 - 31 Oct 2023 Thesis: Identify and verify differentially expressed proteins in SW1990, PANC10.05 and PSC cell lines
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Cathrine Wong Chuen Rui | Master (Mixed Mode) | 02 Aug 2021 Thesis: Data Integration and Identification of Differentially Expressed Genes in Primary Pancreatic Ductal Adenocarcinoma (PDAC), Metastatic PDAC and Stromal Cells
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Ala Ezeldin Merghani Eltahi | Master (Mixed Mode) | 01 Mar 2021 Thesis: Differential Gene expression of Primary and Metastatic PDAC Leading to the Difference in Immunomodulation: Data Integration
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Suriani Binti Samsudin | Master (Mixed Mode) | 01 Aug 2020 Thesis: The Influence of Conditioned Media (from metastatic PDAC and/or PSC) on Myeloid Derived Suppressor Cells (MDSCs) Proliferation
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Yeo Quin-Yie | Master (Mixed Mode) | 01 Aug 2020 Thesis: Comparing the Proteomic Profiles of Primary Pancreatic Ductal Adenocarcinoma Cells (PDACs), Pancreatic Stellate Cells (PSCs) and Their Co-Culture
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S. Kashmita A/P Sudra Pandi | Master (Mixed Mode) | 01 Aug 2020 Thesis: Comparing the Proteomic Profiles of Metastatic Pancreatic Ductal Adenocarcinoma Cells (PDACs), Pancreatic Stellate Cells (PSCs) and Their Co-Culture
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Dina Athariah Bahrani | Master (Mixed Mode) | 01 Aug 2020 Thesis: The Influence of Conditioned Media (from primary PDAC and/or PSC) on Myeloid Derived Suppressor Cells (MDSCs) Proliferation
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Evelyn Priya A/P Peter | Master (Mixed Mode) | 01 Sep 2019 - 04 Jan 2021 Thesis: The influence of conditioned media (from PDAC and/or PSC co-cultures) and MDSC (differentiation induced by PDAC and/or PSC co-cultures) on B lymphocytes proliferation
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Ma Pei Yee | Master (Mixed Mode) | 01 Jun 2019 Thesis: Influence of IsaAgene Disruption On Staphylococcal Phenotypic Characters, Genes and Protein Expression Profiles.
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Chong Yuen Ping | Master (Research) | 01 Jan 2019 Thesis: The Influence of Pancreatic Ductal Adenocarcinoma (PDA) Cells and Pancreatic Stellate Cells (PSC) on Myeloid Derived Suppressor Cells (MDSC) Differentiation and Immunosuppressive Properties
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Dave Ling | Master (Mixed Mode) | 01 Jan 2018 - 01 Jan 2019 Thesis: The role of pancreatic ductal adenocarcinoma (PDA) cells and pancreatic stellate cells (PSC) in promoting the differentiation of myeloid derived suppressor cells (MDSC)
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Ten Yi Yang | Master (Mixed Mode) | 01 Jan 2014 - 01 Jan 2015 Thesis: Cytotoxic and cytostatic effects of phenoxodiol on C6, HepG2, Cne1 and HT-29 cancer cell lines