KOH RHUN YIAN



Salutation
Dr

School/Centre
School of Health Sciences

Department
Applied Biomedical Science and Biotechnology

Appointment
Head of Division, Applied Biomedical Sciences and Biotechnology

Position
Senior Lecturer

Email
rhunyian_koh@imu.edu.my

Professional Network


Education

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PhD (Molecular Biology), 2010 Universiti Putra Malaysia
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Bachelor of Science (Biomedical Science), 2006 Universiti Putra Malaysia

Memberships

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Persatuan Sains Bioperubatan Malaysia Member 2022 - Present

Research Funding
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Fabrication, physicochemical properties, antibacterial evaluation, and in vitro healing assessment of curcumin, quercetin and metal organic framework-loaded scaffolds for bioactive wound dressings IMU Internal Research Grant | 15 Jul 2024 - 30 Jun 2026
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Fabrication, antibacterial activity and cytocompatibility of alginate-carboxymethyl cellulose hydrogel loaded with bioactive glass and alizarin for skin tissue regeneration IMU Internal Research Grant | 01 Jul 2024 - 30 Jun 2025
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Investigation of melatonin-induced necroptosis in cancer cells by targeting RIP/ RIP3/MLKL pathway IMU Internal Research Grant | 01 Jul 2024 - 31 Jan 2025
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Effects of Quebrachitol on Viability, Apoptosis and Reactive Oxygen Species Levels in High Glucose-Treated Schwann Cells IMU Internal Research Grant | 01 Jul 2024 - 31 Dec 2024
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Molecular mechanism of β-hydroxybutyrate-induced cytotoxicity and apoptosis in cancer cell line IMU Internal Research Grant | 01 Jul 2024 - 30 Jun 2025
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Transcriptomic analysis to study the effect of palm-derived nutrients on insulin-resistant cell lines. IMU Internal Research Grant | 10 Jun 2024 - 14 Sep 2024
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Biochemical and transcriptomic profiling analysis of ML 125-2 and ML 82-2 rice mutant lines under reproductive stage drought stress IMU Internal Research Grant | 01 Jun 2024 - 31 Dec 2024
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Effect of Microalgae Extracts on Ultraviolet (UV) Irradiation-Induced Damage in a Human Retinal Pigment Epithelium (RPE) Cell Line IMU Internal Research Grant | 01 Jun 2024 - 31 Dec 2024
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Anticancer effects of Gamma-Tocotrienol Against Breast Cancer: A systematic Review IMU Internal Research Grant | 01 Jun 2024 - 31 Dec 2024
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Anticancer effects of Spirulina: A systematic Review IMU Internal Research Grant | 01 Jun 2024 - 31 Dec 2024
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Targeting cytotoxic T lymphocytes resistant pancreatic cancer using cyclin-dependent kinase inhibitors IMU Internal Research Grant | 01 Jun 2024 - 31 Dec 2024
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ANTI-MICROBIAL EFFECTS OF QUEBRACHITOL: A SYSTEMATIC REVIEW IMU Internal Research Grant | 25 Mar 2024 - 31 Dec 2024
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Biomimetic quercetin-curcumin loaded 3D biopolymeric scaffolds for skin tissue regeneration and repair: Cytocompatibility, antibacterial and antioxidant studies IMU Internal Research Grant | 21 Mar 2024 - 31 Jan 2025
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Transcriptomic analysis to study the effect of palm-derived phytosterol on insulin-resistant cell lines IMU Internal Research Grant | 01 Mar 2024 - 31 Jul 2024
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Synthesis and Antibacterial Study of Aurein-conjugated Silver Nanoparticles IMU Internal Research Grant | 01 Dec 2023 - 30 Jun 2025
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Potential antidiabetic effects of palm-derived phytosterol in in-vitro insulin sensitive cell models. IMU Internal Research Grant | 01 Sep 2023 - 31 Aug 2025
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Investigation of melatonin induced pyroptosis in cancer cells by targeting the PKM2/caspase-8/caspase-3/GSDME pathway IMU Internal Research Grant | 01 Jul 2023 - 31 Jan 2024
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A systematic review on the toxicity of salsolinol and its metabolites IMU Internal Research Grant | 01 Jun 2023 - 31 Dec 2023
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A systematic review on the anti-hyperglycaemic effect of Syzygium aromaticum based on in vitro and in vivo studies IMU Internal Research Grant | 01 Jun 2023 - 31 Dec 2023
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Biochemical and transcriptomic profiling analysis of drought tolerant and early maturity related genes in four potential rice mutant lines IMU Internal Research Grant | 01 Jun 2023 - 31 Dec 2023
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Effects of DJ-1 Knockdown in Non-small Cell Lung Cancer IMU Internal Research Grant | 01 Jun 2023 - 31 Dec 2023
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Photoprotective Potential of Mycosporine-Like Amino Acids (MAAs) and Bioactive Compounds from Antarctic Microalgae on Human Keratinocytes IMU Internal Research Grant | 01 Mar 2023 - 28 Feb 2026
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Quality Assurance in Molecular Diagnostic Laboratory: A Systematic Review IMU Internal Research Grant | 01 Jan 2023 - 31 Oct 2023
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Toxic effects of salsolinol in neuronal cells via mitophagy pathway IMU Internal Research Grant | 01 Dec 2022 - 31 Dec 2023
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Students’ perception of role-plays in teaching stress and anger management skills IMU Internal Research Grant | 01 Oct 2022 - 31 May 2023
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Delineating protein kinase pathways mediating immune resistance in pancreatic cancer FRGS | 01 Sep 2022 - 31 Aug 2025
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Investigation of melatonin induced autophagy in Hep G2, A549, HT-29 and Jurkat cells via SIRT1/FoxO3a pathway Bachelor of Science (Hons) in Biomedical Science | 01 Jul 2021 - 31 Jan 2022
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Elucidating the oncolytic effect of Pteropine orthoreovirus in killing Nasopharyngeal Carcinoma cell lines through apoptosis pathway Master in MHS | 01 Jul 2021 - 01 Mar 2022
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Comparative anticancer study of ternary [M(phen)(edda)] complexes (M(II) = Cu, Zn) towards melanoma cell lines with different expression of EZH1/EZH2 B Pharm Final Year Project Fund | 14 Jun 2021 - 18 Sep 2021
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Cytotoxicity of bio-based surfactants derived from palm oil derivatives Bachelor of Science (Hons) in Biomedical Science | 01 Jun 2021 - 30 Nov 2021
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Docking, synthesis and anticancer studies of amides of polyunsaturated fatty acids (PUFA) and nucleosides as inhibitors of epigenetic modifier PRC2/EZH2 BMedSc | 01 Jan 2021 - 30 Apr 2021
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Biocompatibility of bio-based surfactants for improved latex film properties with the bioburden testing Lembaga Getah Malaysia | 01 Jan 2021 - 01 Mar 2021
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Studies to investigate mechanisms of anti-autophagic effects of orientin against beta amyloid-stimulated BV2 microglia cells IMU | 01 Jan 2021 - 01 Jul 2021
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Neuroprotective role of orientin on β-amyloid-induced cell death in SH-SY5Y neuronal cells via mTOR signalling pathway Bachelor in Medical Sciences (Hons) | 01 Jan 2021 - 31 Jul 2022
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The roles of orientin and madecassoside in regulating NFkB signaling pathway and apoptotic pathway in beta-amyloid induced BV2 microglial cells IMU | 06 Dec 2020 - 31 May 2021
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Activation of the GLI transcription factor by canonical hedgehog signaling and non-canonical pathways in colorectal cancer. IMU | 01 Aug 2020 - 01 Dec 2020
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Investigating the mechanism of action of orientin and madecassoside against α-synuclein-induced cell death in SH-SY5Y human neuronal cells IMU | 01 Jul 2020 - 01 Dec 2020
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Investigation of melatonin induced autophagy in Hep G2, A549, HT-29 and Jurkat cells via PERK/CHOP/Bcl-2/Beclin-1 pathways Bmed Sci | 01 Jul 2020 - 31 Dec 2020
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Molecular mechanism of melatonin-induced modulation autophagy induced by high glucose in Schwann cells Bmed Sci | 01 Jul 2020 - 30 Jun 2021
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Investigation of the Anticancer Effects of Alpha Synuclein in Lung Cancer IMU | 01 Jun 2020 - 01 May 2022
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Anti-Neuroinflammatory Mechanism of Safinamide in Inhibiting Lipopolysaccharide-Induced Microglial Activation IMU | 01 Feb 2020 - 01 Jul 2021
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Molecular mechanism of novel anti-phospho-tau serine 396/404 single chain variable fragment (scFv) antibody on the reversal of Tau pathology in Alzheimer’s disease FRGS | 01 Jan 2020 - 01 Jun 2020
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Gene expression profiling of Wharton`s Jelly Mesenchymal Stem Cells (WJ-MSCs) cultured in various media conditions IMU | 01 Dec 2019 - 01 May 2020
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Investigating the mechanism of action of orientin against β-amyloid-induced cell death in BV2 microglial cells IMU | 01 Dec 2019 - 01 May 2020
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Role of orientin against β-amyloid-induced cell death in SH-SY5Y human neuronal cells IMU | 01 Oct 2019 - 01 Jun 2020
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Anti Apoptotic Actions of Safinamide in 6OHDA_Induced Cell Model of Parkinson's Disease IMU | 01 Jul 2019 - 01 Jun 2020
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Effect of novel metal complexes as α-synuclein inhibitors in Parkinson’s disease in vitro model IMU | 01 Jul 2019 - 01 Dec 2019
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Molecular mechanism of melatonin induces Schwann cell proliferation and dedifferentiation in nerve regeneration IMU | 01 Jul 2019 - 01 Jun 2020
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Investigation of Melatonin Ameliorated Autophagy in CNE1, HT29 and Jurkat Cells via Endoplasmic Reticulum Stress-and Mitochondrial Stress-Dependent Pathways IMU | 01 Jul 2019 - 01 Jan 2020
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Biocompability of bio-based surfactants for improved film properties Malaysian Rubber Board (LGM) | 18 Oct 2018 - 18 Sep 2018
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Neuroprotective effect of safinamide against autoplay ion 6-hydroxydopamine induced cell model of Parkinson's disease IMU | 18 Oct 2018 - 19 Sep 2019
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Roles of Receptor Interacting Protein Kinase 1 in beta-Amyloid deposition mediated through autophagy in Alzheimer's disease IMU | 18 Aug 2018 - 18 Dec 2018
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Effects of amyloid precursor protein overexpression on NF-κB, Rho-GTPase and pro-apoptosis Bcl-2 pathways in neuronal cells IMU | 18 Jul 2018 - 18 Dec 2018
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Induction of intracellular cell death in breast cancer cells by silencing MUC1, RAD51 and PAR1 using carbonite apatite nanoparticles Internal Grant | 12 Jul 2018 - 12 Sep 2018
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Investigation of melanin induces anticancer effects in CNE1, HT29 and Jurkat cells via autophagy pathway IMU | 01 Jul 2018 - 01 Jan 2019
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Investigation on Neurotoxic Effect of Salsolinol in NE-4C Neural Stem Cells through RAS/RAF/ERK, P13K, NFκB and Wnt Signaling Pathways IMU | 01 Jul 2018 - 01 Dec 2018

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Publications

Research Articles

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Biomedical science students’ perception of the use of role-play in learning stress and anger management skills Asia Pacific Scholar 2024
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Polymeric surfactants synthesised from palm-based oleic acid as potential biocompatible agents in natural rubber latex compounding JOURNAL OF RUBBER RESEARCH 2024
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Blood-based therapies to combat neurodegenerative diseases METABOLIC BRAIN DISEASE 2024
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Neuroprotective effects of safinamide against autophagy in 6-hydroxydopamine-induced SH-SY5Y cell model of Parkinson’s disease JOURNAL OF APPLIED PHARMACEUTICAL SCIENCE 2024
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Neurotoxicity of nanoplastics: A review F1000RESEARCH 2024
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Focus: Chronic Disease: Natural Bioactive Compounds from Macroalgae and Microalgae for the Treatment of Alzheimer’s Disease: A Review THE YALE JOURNAL OF BIOLOGY AND MEDICINE 2024
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Cancer Antibody Engineering: Comparison of Mammalian, Yeast, Bacterial, Plants, Cell-free and Hybridoma Expression Systems CURRENT PHARMACEUTICAL BIOTECHNOLOGY 2024
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Virus-like Particles-Based Vaccine to Combat Neurodegenerative Diseases CURRENT PHARMACEUTICAL BIOTECHNOLOGY 2024
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Prospecting bioactivity in Antarctic algae: A review of extracts, isolated compounds and their effects FITOTERAPIA 2024
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Prevention of Parkinson's disease: from risk factors to early interventions. CNS & NEUROLOGICAL DISORDERS DRUG TARGETS 2023
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THE ROLES OF ANTIFIBROTIC THERAPIES IN POST-SARS-CoV-2 INFECTION MALAYSIAN JOURNAL OF BIOCHEMISTRY & MOLECULAR BIOLOGY 2023
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How Do Abnormalities in the Cerebrospinal Fluid Impact Neuropsychology with Progressing Age? CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (FORMERLY CURRENT DRUG TARGETS-CNS & NEUROLOGICAL DISORDERS) 2023
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Melatonin ameliorates high glucose-induced autophagy in Schwann cells INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY 2023
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Anti-neuroinflammatory mechanism of safinamide in inhibiting lipopolysaccharide-induced microglial activation. PHARMACEUTICAL SCIENCES ASIA 2023
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Blood-brain Barrier and Neurovascular Unit Dysfunction in Parkinson's Disease: From Clinical Insights to Pathogenic Mechanisms and Novel Therapeutic Approaches CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (FORMERLY CURRENT DRUG TARGETS-CNS & NEUROLOGICAL DISORDERS) 2023
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Association among lifestyle and risk factors with SARS-CoV-2 infection TUBERCULOSIS AND RESPIRATORY DISEASES 2023
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The Role of Monoamine Oxidase B Inhibitors in the Treatment of Parkinson’s Disease-An Update CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (FORMERLY CURRENT DRUG TARGETS-CNS & NEUROLOGICAL DISORDERS) 2023
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Unravelling the genetic links between Parkinson’s disease and lung cancer BIOLOGICAL CHEMISTRY 2023
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ANTI-APOPTOTIC ACTIONS OF SAFINAMIDE IN 6-HYDROXYDOPAMINE-INDUCED CELL MODEL OF PARKINSON’S DISEASE MALAYSIAN JOURNAL OF BIOCHEMISTRY & MOLECULAR BIOLOGY 2022
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Anti-neuroinflammatory of Chloroform Extract of Panax ginseng Root Culture on Lipopolysaccharide-stimulated BV2 Microglia Cells REPORTS OF BIOCHEMISTRY & MOLECULAR BIOLOGY 2022
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Roles of receptor‐interacting protein kinase 1 in SH‐SY5Y cells with beta amyloid‐induced neurotoxicity JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 2022
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Melatonin induced schwann cell proliferation and dedifferentiation through NF-ĸB, FAK-dependent but src-independent pathways REPORTS OF BIOCHEMISTRY & MOLECULAR BIOLOGY 2022
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An Overview of Herbal Medicines for Idiopathic Pulmonary Fibrosis PROCESSES 2022
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Potential role of melatonin in prevention and treatment of lung cancer HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION 2022
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Pteropine Orthoreovirus, PRV7S (Sikamat virus) demonstrates Oncolysis in nasopharyngeal carcinoma cell lines FRONTIERS IN BIOSCIENCE-LANDMARK 2022
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Anti-neuroinflammatory responses in lipopolysaccharide-stimulated BV2 microglial cells upon treatment with methanol extract of Panax ginseng root. JOURNAL OF TRADITIONAL CHINESE MEDICINE= CHUNG I TSA CHIH YING WEN PAN 2021
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A mini review on neuroprotective effects of Syzygium cumini JOURNAL OF MEDICINE AND BIOMEDICAL RESEARCH 2021
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Physiochemical and In-Vitro Cytotoxicity Properties of Biocompatible Palm Fatty Acid-Based Polyesters SAINS MALAYS 2021
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ANTIMICROBIAL AGENTS AND ANTI-ADHESION MATERIALS FOR MEDICAL AND SURGICAL GLOVES RUBBER CHEMISTRY AND TECHNOLOGY 2021
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An overview of complementary and alternative medicine for alzheimer's and parkinson's disease MALAYSIAN JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY 2021
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Evaluation of biocompatible palm-based polymeric surfactants for potential natural rubber latex stabilisation applications JOURNAL OF RUBBER RESEARCH 2021
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Development of ATP13A2-deficient In vitro Model for PARK9 Parkinson’s Disease CURRENT SIGNAL TRANSDUCTION THERAPY 2021
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Endosomal‐lysosomal dysfunctions in Alzheimer’s disease: Pathogenesis and therapeutic interventions METABOLIC BRAIN DISEASE 2021
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Potential role of melatonin in prevention and treatment of leukaemia HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION 2021
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Effects of Amyloid Precursor Protein Overexpression on NF-κB, Rho-GTPase and Pro-Apoptosis Bcl-2 Pathways in Neuronal Cells REPORTS OF BIOCHEMISTRY & MOLECULAR BIOLOGY 2021
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Anticancer Properties of Strobilanthes crispus: A Review PROCESSES 2021
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Immunotherapies for Parkinson’s disease: progression of clinical development CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (FORMERLY CURRENT DRUG TARGETS-CNS & NEUROLOGICAL DISORDERS) 2021
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Role of the gut microbiome in Alzheimer’s disease REVIEWS IN THE NEUROSCIENCES 2021
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Edible bird’s nest: recent updates and industry insights based on laboratory findings FRONTIERS IN PHARMACOLOGY 2021
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Melatonin induces autophagy via reactive oxygen species-mediated endoplasmic reticulum stress pathway in colorectal cancer cells MOLECULES 2021
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Melatonin induces apoptosis and inhibits the proliferation of cancer cells via reactive oxygen species-mediated MAPK and mTOR pathways CLINICAL CANCER DRUGS 2020
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The mechanism of action of salsolinol in brain: implications in Parkinson’s disease CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (FORMERLY CURRENT DRUG TARGETS-CNS & NEUROLOGICAL DISORDERS) 2020
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Melatonin inhibits high glucose-induced ox-LDL/LDL expression and apoptosis in human umbilical endothelial cells HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION 2020
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Melatonin promotes Schwann cell dedifferentiation and proliferation through the Ras/Raf/ERK and MAPK pathways, and glial cell‑derived neurotrophic factor expression EXPERIMENTAL AND THERAPEUTIC MEDICINE 2020
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Recent advances in tau-directed immunotherapy against Alzheimer’s disease: an overview of pre-clinical and clinical development METABOLIC BRAIN DISEASE 2020
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Synthesis, characterization, and anti‐cancer activity of new chalcone derivatives containing naphthalene and fluorine moieties DRUG DEVELOPMENT RESEARCH 2020
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Pharmacological effects of melatonin as neuroprotectant in rodent model: a review on the current biological evidence CELLULAR AND MOLECULAR NEUROBIOLOGY 2020
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Focus: plant-based medicine and pharmacology: Antidiabetic potential of Syzygium sp.: An overview THE YALE JOURNAL OF BIOLOGY AND MEDICINE 2020
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Mechanisms of action of amyloid-beta and its precursor protein in neuronal cell death METABOLIC BRAIN DISEASE 2020
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TARGETING AUTOPHAGY IN ALZHEIMER’S DISEASE: AN OVERVIEW MALAYSIAN JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY 2019
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Development of in vitro PARK 9 Parkinson’s disease model using carbonate apatite nanoparticles JOURNAL OF PARKINSON'S DISEASE 2019
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The pro-apoptotic mechanisms of melatonin in cancer MALAYSIAN JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY 2019
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The roles of microRNA-331 Family in Cancers JOURNAL OF CANCER RESEARCH AND PRACTICE 2019
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Overview of the Pharmacological Activities of Aframomum melegueta. PERTANIKA JOURNAL OF TROPICAL AGRICULTURAL SCIENCE 2019
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Wound healing property of curcuminoids as a microcapsule-incorporated cream PHARMACEUTICS 2019
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Receptor-interacting protein kinase 1 (RIPK1) as a potential therapeutic target: an overview of its possible role in the pathogenesis of Alzheimer's disease CURRENT ALZHEIMER RESEARCH 2019
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The potential therapeutic actions of melatonin in colorectal cancer HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION 2019
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A new prospective on the role of melatonin in diabetes and its complications HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION 2019
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Omics-based biomarkers in the diagnosis of diabetes JOURNAL OF BASIC AND CLINICAL PHYSIOLOGY AND PHARMACOLOGY 2019
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Anticancer potential of Syzygium species: a review PLANT FOODS FOR HUMAN NUTRITION 2019
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Melatonin prevents oxidative stress-induced mitochondrial dysfunction and apoptosis in high glucose-treated schwann cells via upregulation of Bcl2, NF-κB, mTOR, Wnt signalling pathways ANTIOXIDANTS 2019
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Neurotrophic properties and the de novo peptide sequencing of edible bird's nest extracts FOOD BIOSCIENCE 2019
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Neuroprotective mechanisms of orientin against hydrogen peroxide-induced oxidative damage in SH-SY5Y cells JOURNAL OF BIOCHEMISTRY, MICROBIOLOGY AND BIOTECHNOLOGY 2018
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A mini review on phytochemical constituents and pharmacological activities of Adenium obesum JOURNAL OF TROPICAL AGRICULTURAL SCIENCE 2018
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A Mini Review on Phytochemical Constituents and Pharmacological Activities of Adenium obesum. PERTANIKA JOURNAL OF TROPICAL AGRICULTURAL SCIENCE 2018
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Medicinal properties of Clinacanthus nutans: A review TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH 2018
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Single-chain Fv antibodies for targeting neurodegenerative diseases CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (FORMERLY CURRENT DRUG TARGETS-CNS & NEUROLOGICAL DISORDERS) 2018
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Edible bird’s nest improves motor behavior and protects dopaminergic neuron against oxidative and nitrosative stress in Parkinson’s disease mouse model JOURNAL OF FUNCTIONAL FOODS 2018
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Madecassoside activates anti‑neuroinflammatory mechanisms by inhibiting lipopolysaccharide‑induced microglial inflammation INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 2018
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Tau proteins and tauopathies in Alzheimer’s disease CELLULAR AND MOLECULAR NEUROBIOLOGY 2018
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Neuroprotective roles of asiaticoside on hydrogen peroxide-induced toxicity in SH-SY5Y cells JOURNAL OF FUNDAMENTAL AND APPLIED SCIENCES 2017
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An Overview of Pharmacological Activities of Syzygium sp. CANCER 2017
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In vitro study of modulatory effects of extracts of Strobilanthes crispus on human cDNA-expressed cytochrome P450 2A6 (CYP2A6) DRUG METABOLISM AND PHARMACOKINETICS 2017
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Functional roles of receptor interacting protein kinase 1 in Alzheimer's disease JOURNAL OF MEDICAL DISCOVERY 2017
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Letters In Health and Biological Sciences LETT. HEALTH BIOL. SCI 2017
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The roles of melatonin in Parkinson’s disease: An overview AM. J. PHYSIOL.-LUNG C 2017
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Clinacanthus nutans hexane extracts induce apoptosis through a caspase-dependent pathway in human cancer cell lines ASIAN PACIFIC JOURNAL OF CANCER PREVENTION: APJCP 2017
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Physicochemical and antimicrobial properties of natural rubber latex films in the presence of vegetable oil microemulsions JOURNAL OF APPLIED POLYMER SCIENCE 2017
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Anticancer mechanisms of Strobilanthes crispa Blume hexane extract on liver and breast cancer cell lines ONCOLOGY LETTERS 2017
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A mini review on medicinal effects of edible bird’s nest LETTERS IN HEALTH AND BIOLOGICAL SCIENCES 2017
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para‐Phenylenediamine induces apoptosis through activation of reactive oxygen species‐mediated mitochondrial pathway, and inhibition of the NF‐κB, m TOR, and W nt pathways in human urothelial cells ENVIRONMENTAL TOXICOLOGY 2017
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Repurposing pentoxifylline for the treatment of fibrosis: an overview ADVANCES IN THERAPY 2017
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Niosomes: a review of their structure, properties, methods of preparation, and medical applications ASIAN BIOMED 2017
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Anti-inflammatory Effect of Strobilanthes crispus methanolic extract on Lipopolysaccharide-stimulated RAW 264.7 Macrophages J. BIOMED. SCI 2016
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Melatonin protects against hyperglycemia-induced Schwann cells apoptosis through MTOR and Wnt signaling pathways CONFERENCE ABSTRACT: 14 TH MEETING OF THE ASIAN-PACIFIC SOCIETY FOR NEUROCHEMISTRY. DOI: 10.3389/CONF. FNCEL 2016
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Updates on Hepatic Stellate Cell Involvement in Liver Fibrosis JOURNAL OF MEDICAL DISCOVERY 2016
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MiRNA-331-5p expression level is altered in neuronal cell under elevated oxidative stress CONFERENCE ABSTRACT: 14 TH MEETING OF THE ASIAN-PACIFIC SOCIETY FOR NEUROCHEMISTRY. DOI: 10.3389/CONF. FNCEL 2016
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Neurotoxic effect of salsolinol through oxidative stress induction and Nrf2-Keap1 signalling regulation JOURNAL OF CHEMICAL AND PHARMACEUTICAL RESEARCH 2016
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A review on medicinal properties of orientin ADVANCES IN PHARMACOLOGICAL AND PHARMACEUTICAL SCIENCES 2016
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In vitro study of modulatory effects of extracts of Strobilanthes Crispus on human cDNA-expressed cytochrome P450 2A6 (CYP2A6) and CYP3A4 THE ALL RESULTS JOURNALS: BIOL 2016
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Para-phenylenediamine containing hair dye: An overview of mutagenicity, carcinogenicity and toxicity JOURNAL OF ENVIRONMENTAL & ANALYTICAL TOXICOLOGY 2016
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Medicinal properties of pitaya: a review SPATULA DD 2016
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Plant-based vaccines: production and challenges. JOURNAL OF BOTANY 2016
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Investigating prostaglandin E2 and intracellular oxidative stress levels in lipopolysaccharide-stimulated RAW 264.7 macrophages upon treatment with Strobilanthes crispus INTERNATIONAL JOURNAL OF MEDICAL AND HEALTH SCIENCES 2016
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Inhibition of transforming growth factor-β via the activin receptor-like kinase-5 inhibitor attenuates pulmonary fibrosis MOLECULAR MEDICINE REPORTS 2015
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Antioxidant activity of the sea bird nest (Eucheuma cottonii) and its radical scavenging effect on human keratinocytes JOURNAL OF MEDICAL AND BIOENGINEERING 2015
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Cytotoxic and apoptogenic effects of Strobilanthes crispa Blume extracts on nasopharyngeal cancer cells MOLECULAR MEDICINE REPORTS 2015
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5-Methoxytryptamine reacts with natural food flavour to produce 6-methoxy tetrahydro-β-carbolines: In vitro investigation of their antioxidant and cytotoxicity properties FOOD CHEMISTRY 2015
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Antioxidant and xanthine oxidase inhibitory activities of Swietenia macrophylla and Punica granatum INTERNATIONAL CONFERENCE ON BIOLOGICAL, ENVIRONMENT AND FOOD ENGINEERING (BEFE-2014), AUGUST 2014
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Metabolites from Actinomyces strain H6552 extract inhibit transforming growth factor-mediated pulmonary fibrosis TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH 2014
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An Investigation of Anti-Inflammatory Properties of Methanol Extract of Syzygium malaccense on Lipopolysaccharide-Stimulated Raw 264.7 Macrophages INTERNATIONAL CONFERENCE ON LATEST TRENDS IN FOOD, BIOLOGICAL & ECOLOGICAL SCIENCES PHUKET (THAILAND)(ICLTFBE(TM)14) 2014
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Formulation and evaluation of topical pentoxifylline-hydroxypropyl methylcellulose gels for wound healing application INT J PHARM PHARM SCI 2014
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Strobilanthes crispus extract induces apoptosis through enhanced caspases activities in cervical cancer cells INTERNATIONAL CONFERENCE ON BIOLOGICAL, ENVIRONMENT AND FOOD ENGINEERING (BEFE-2014) AUGUST 2014
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Neuroprotective effects of orientin on hydrogen peroxide‑induced apoptosis in SH‑SY5Y cells MOLECULAR MEDICINE REPORTS 2014
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Anti-adipogenic effects of extracts of Ficus deltoidea var. deltoidea and var. angustifolia on 3T3-L1 adipocytes JOURNAL OF ZHEJIANG UNIVERSITY SCIENCE B 2014
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Inhibitory activities of methanol extracts of Andrographis paniculata and Ocimum sanctum against dengue-1 virus INTERNATIONAL CONFERENCE ON BIOLOGICAL ENVIRONMENTAL AND FOOD ENGINEERING: BALI, INDONESIA 2014
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Apoptosis induced by para‐phenylenediamine involves formation of ROS and activation of p38 and JNK in chang liver cells ENVIRONMENTAL TOXICOLOGY 2014
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Edible bird’s nest ameliorates oxidative stress-induced apoptosis in SH-SY5Y human neuroblastoma cells BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE 2014
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金钱榕提取物抑制 3T3-L1 脂肪细胞抗脂肪沉积研究 (英文) JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B (BIOMEDICINE & BIOTECHNOLOGY) 2014
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Isolation and identification of antioxidant compounds in methanolic extract of both female and male plants of Ficus deltoidea MALAYS J CHEM 2013
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Screening of anti-dengue activity in methanolic extracts of medicinal plants BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE 2012

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Other Publications

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Salsolinol-mediated toxicity and mechanism of action of safinamide in Parkinson’s disease International Conference on Sustainable Materials and Innovative Techniques” (ICSMIT'22) | 18 Mar 2022
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Anti-Neuroinflammatory Effect of Orientin in Lipopolysaccharide-Stimulated Bv2 Microglial Cells IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-PLANT | 01 Jan 2018
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Screening of anti-dengue activity in methanolic extracts of six medicinal plants INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | 01 Jan 2011
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Involvement of PI3K/Akt-modulated expression of Bcl-2 and Bax in para-phenylenediamine induce apoptosis in NRK52E cells INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | 01 Jan 2011
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Attenuation of liver myofibroblast activation by a small-molecule TGF-beta receptor I inhibitor INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | 01 Jan 2011
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PHARMACOLOGIC INHIBITION OF ACTIVIN RECEPTOR-LIKE KINASES-5 BY SB 431542 ATTENUATES BLEOMYCIN-INDUCED PULMONARY FIBROSIS RESPIROLOGY | 01 Jan 2010

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Supervisions
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Doris Evelyn Jong Yah Hui | Master (Coursework) | 01 Mar 2024 - 30 Sep 2024 Thesis: ANTI-MICROBIAL EFFECTS OF QUEBRACHITOL: A SYSTEMATIC REVIEW
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Chia Kiat Fatt | Doctorate | 01 Mar 2023 - 28 Feb 2026 Thesis: Photoprotective Potential of Mycosporine-Like Amino Acids (MAAs) and Bioactive Compounds from Antarctic Microalgae on Human Keratinocytes
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LOW HWEI JEAN | Master (Coursework) | 01 Mar 2023 - 31 Mar 2024 Thesis: Quality Assurance in Molecular Diagnostic Laboratory: A Systematic Review
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Ngai Zi Ni | Doctorate | 01 Jan 2023 - 31 Dec 2025 Thesis: Delineating protein kinase pathways mediating immune resistance in pancreatic cancer
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Madhumita A/P Anbazhagan | Master (Mixed Mode) | 01 Sep 2022 - 31 Mar 2023 Thesis: Neurotoxic mechanism of salsolinol in BV2 microglial cells via Nrf/Keap pathway
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Oo Ju Nn | Master (Mixed Mode) | 01 Mar 2022 - 30 Sep 2022 Thesis: APOPTOTIC EFFECTS OF SALSOLINOL ON BV2 MICROGLIAL CELLS
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Leong Yong Qi | Doctorate | 01 Jun 2020 - 31 Dec 2023 Thesis: Investigation of the Anticancer Effects of Alpha Synuclein in Lung Cancer

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