CHIN BEEK YOKE



Salutation
Professor

School/Centre
School of Health Sciences

Department
Applied Biomedical Science and Biotechnology

Appointment
Dean, Industrial Partnership ; Head, Centre For Cancer And Stem Cell Research

Position
Professor

Email
chinbeekyoke@imu.edu.my



Education

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PhD (Toxicological Sciences), 2001 Johns Hopkins University
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ScM (Physiology), 1995 Johns Hopkins University
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B.A. (Biological Sciences), 1987 Mount Holyoke College

Publications

Research Articles

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Carbon monoxide increases macrophage bacterial clearance through Toll-like receptor (TLR) 4 expression.(Source: Cell Mol Biol (Noisy-le-grand).) Full Citation: Cell Mol Biol … N/A | 2022
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HO-1: Antidote to inflammation and stress N/A | 2022
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Carbon Monoxide Suppresses Neointima Formation in Transplant Arteriosclerosis by Inhibiting Vascular Progenitor Cell Differentiation ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY | 2021
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Stimulation of pro-alpha (1)(I) collagen by TGF-beta (1) in mesangial cells: role of the p38 MAPK pathway (vol 280, pg F495, 2001) AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY | 2020
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Macrophages sense and kill bacteria through carbon monoxide–dependent inflammasome activation THE JOURNAL OF CLINICAL INVESTIGATION | 2014
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Carbon monoxide enhances early liver regeneration in mice after hepatectomy HEPATOLOGY | 2011
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Carbon monoxide induced PPARγ SUMOylation and UCP2 block inflammatory gene expression in macrophages PLOS ONE | 2011
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Intraoperative administration of inhaled carbon monoxide reduces delayed graft function in kidney allografts in Swine AMERICAN JOURNAL OF TRANSPLANTATION | 2010
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Nitric oxide–dependent bone marrow progenitor mobilization by carbon monoxide enhances endothelial repair after vascular injury CIRCULATION | 2010
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Cell surface biliverdin reductase mediates biliverdin-induced anti-inflammatory effects via phosphatidylinositol 3-kinase and Akt JOURNAL OF BIOLOGICAL CHEMISTRY | 2009
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Carbon monoxide is a poison… to microbes! CO as a bactericidal molecule CURRENT OPINION IN PHARMACOLOGY | 2009
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Heme oxygenase and carbon monoxide initiate homeostatic signaling JOURNAL OF MOLECULAR MEDICINE | 2008
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Inhale to survive, cycle or die? Carbon monoxide and cellular proliferation CELL CYCLE | 2008
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CARBON MONOXIDE PREVENTS REJECTION OF CARDIAC ALLOGRAFTS VIA ACTIVATION OF HIF1A;: 1455 TRANSPLANTATION | 2008
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INCLUDING TOXICOLOGICAL SCIENCES SCIENCES | 2007
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Carbon monoxide signals via inhibition of cytochrome c oxidase and generation of mitochondrial reactive oxygen species THE FASEB JOURNAL | 2007
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Inhaled carbon monoxide prevents graft-induced intimal hyperplasia in swine JOURNAL OF SURGICAL RESEARCH | 2007
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Toll‐like receptor 4 suppression leads to islet allograft survival THE FASEB JOURNAL | 2007
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Hypoxia-inducible factor 1α stabilization by carbon monoxide results in cytoprotective preconditioning PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES | 2007
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Restoring HOmeostasis: is heme oxygenase-1 ready for the clinic? TRENDS IN PHARMACOLOGICAL SCIENCES | 2007
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Carbon monoxide reverses established pulmonary hypertension THE JOURNAL OF EXPERIMENTAL MEDICINE | 2006
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CARBON MONOXIDE SUPPRESSES NEOINTIMA FORMATION IN TRANSPLANT ARTERIOSCLEROSIS BY INHIBITING DIFFERENTIATION OF VASCULAR PROGENITOR CELLS. TRANSPLANTATION | 2006
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Carbon monoxide orchestrates a protective response through PPARγ IMMUNITY | 2006
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Bilirubin can induce tolerance to islet allografts (vol 147, pg 762, 2006) ENDOCRINOLOGY | 2006
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Bilirubin can induce tolerance to islet allografts ENDOCRINOLOGY | 2006
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Carbon monoxide increases macrophage bacterial clearance through Toll-like receptor (TLR) 4 expression. CELLULAR AND MOLECULAR BIOLOGY (NOISY-LE-GRAND, FRANCE) | 2005
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Transcriptional regulation of the HO-1 gene in cultured macrophages exposed to model airborne particulate matter AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY | 2003
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Transcriptional regulation of the heme oxygenase 1 gene in cultured macrophages exposed to model airborne particulate matter AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY | 2002
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Stimulation of pro-α1 (I) collagen by TGF-β1 in mesangial cells: role of the p38 MAPK pathway AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY | 2001
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Achieving molecular selectivity in imaging using multiphoton Raman spectroscopy techniques TRAFFIC | 2001
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Mechanism of particulate matter-induced injury in cultured macrophages N/A | 2001
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AP-1 and STAT mediate hyperoxia-induced gene transcription of heme oxygenase-1 AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY | 2000
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Mitogen-activated protein kinase pathway mediates hyperoxia-induced apoptosis in cultured macrophage cells AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY | 1999
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Transforming growth factor β1 rescues serum deprivation-induced apoptosis via the mitogen-activated protein kinase (MAPK) pathway in macrophages JOURNAL OF BIOLOGICAL CHEMISTRY | 1999
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CELL BIOLOGY AND METABOLISM-Transforming growth factor b1 rescues serum deprivation-induced apoptosis via the mitogen-activated protein kinase (MAPK) pathway in macrophages JOURNAL OF BIOLOGICAL CHEMISTRY | 1999
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Protective effects of heme oxygenase-1 in acute lung injury CHEST | 1999
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Pulmonary apoptosis in aged and oxygen-tolerant rats exposed to hyperoxia AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY | 1998
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Mitogen Activating Protein Kinase (MAPK) mediates carbon particle-induced tumor necrosis factor-α expression FASEB JOURNAL | 1998
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Transcriptional activation of the HO-1 gene by lipopolysaccharide is mediated by 5′ distal enhancers: role of reactive oxygen intermediates and AP-1 AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY | 1998
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Induction of apoptosis by particulate matter: role of TNF-α and MAPK AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY | 1998
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Mechanism of hemoglobin-induced protection against endotoxemia in rats: a ferritin-independent pathway AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY | 1997
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Differential gene expression of antioxidant enzymes in macrophages exposed to carbon particles adsorbed with benzo-[a]-pyrene ACS DIVISION OF FUEL CHEMISTRY, PREPRINTS | 1997
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Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia JOURNAL OF BIOLOGICAL CHEMISTRY | 1997
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Hyaluronan fragments induce nitric-oxide synthase in murine macrophages through a nuclear factor κB-dependent mechanism JOURNAL OF BIOLOGICAL CHEMISTRY | 1997
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Mechanisms of IL-8 synthesis in human bronchial epithelial cells exposed to ozone N/A | 1995
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Culture of arterial chemoreceptor cells from adult cats in defined medium BRAIN RESEARCH | 1994

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Other Publications

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Toll-like receptor 4 suppression leads to islet allograft survival following transplantation. AMERICAN JOURNAL OF TRANSPLANTATION | 01 Jan 2007
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Induction of tumor necrosis factor alpha (TNF alpha) signaling genes in alveolar macrophages (M phi) after exposure to ultrafine particles (UFP). TOXICOLOGICAL SCIENCES | 01 Jan 2003
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Microarray evaluation of global gene regulation by tumor necrosis factor alpha MOLECULAR BIOLOGY OF THE CELL | 01 Jan 2001
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The application of nonlinear Raman spectroscopy to provide molecular specificity in 3-D biological imaging Technical Digest. Summaries of papers presented at the Conference on Lasers and Electro-Optics. Postconference Technical Digest (IEEE Cat. No. 01CH37170) | 01 Jan 2001
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Application of coherent antistokes Raman scattering (CARS) to imaging mammalian cells: a means for gaining molecular selectivity in multiphoton imaging Multiphoton Microscopy in the Biomedical Sciences | 01 Jan 2001
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Macrophages generate H202 after exposure to carbon particles plus benzo [a] pyrene. FASEB JOURNAL | 01 Jan 2000
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Regulation of particulate matter (PM)-induced secretion of chemokines in macrophages by the mitogen activated protein kinase (MAPK) pathway. American Journal of Respiratory and Critical Care Medicine | 01 Jan 1999
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Differential activation of Bcl-2 related proteins and Fas ligand death pathways in hyperoxia-induced apoptosis in macrophages. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | 01 Jan 1999
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Induction of caspases and bcl-2 related proteins in particulate matter (PM)-induced apoptosis matter cultured macrophages. American Journal of Respiratory and Critical Care Medicine | 01 Jan 1999
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The mitogen activated protein kinases (MAPK) pathway mediates heme oxygenase-1 (HO-1) gene transcription in macrophages exposed to particulate matter (PM). American Journal of Respiratory and Critical Care Medicine | 01 Jan 1999
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Activation of extracellular signal-regulated kinase 1 (ERK1) and activator protein-1 (AP-1) by transforming growth factor-beta 1 in mesangial cells is dependent on TGF-beta type II receptor. FASEB JOURNAL | 01 Jan 1998
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Differential gene expression of antioxidant enzymes in macrophages exposed to carbon particles adsorbed with benzo-[a]-pyrene. Abstracts of Papers of the American Chemical Society | 01 Jan 1997
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Transforming growth factor beta 1 (TGF-beta 1) rescues serum deprivation-induced apoptosis via the mitogen-activated protein kinases (MAPK) pathway in macrophages. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 01 Jan 1997
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Differential gene expression of antioxidant enzymes (AOE) in a murine alveolar macrophage cell line in response to carbon black adsorbed with benzo-[a]-pyrene. FASEB JOURNAL | 01 Jan 1997
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OZONE EXPOSURE STIMULATES NUCLEAR FACTOR-KAPPA-BETA (NF-KAPPA-B) AND INTERLEUKIN-8 (IL-8) EXPRESSION IN 16HBE14O-CELLS FASEB JOURNAL | 01 Jan 1995
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IDENTIFICATION OF FUNCTIONING CULTURED CAROTID-BODY TYPE-I CELLS FROM ADULT CAT FASEB JOURNAL | 01 Jan 1993
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IMMUNOCYTOCHEMICAL CHARACTERIZATION OF THE JUNCTION BETWEEN BOVINE PULMONARY MICROVASCULAR ENDOTHELIAL-CELLS FASEB JOURNAL | 01 Jan 1991

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Books

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American Thoracic Society (2010). Carbon Monoxide Enhances The Bactericidal Activity Of Macrophages Infected With Enterococci Faecalis
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American Thoracic Society (2010). Carbon Monoxide Enhances The Bactericidal Activity Of Macrophages Infected With Enterococci Faecalis
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Springer, Berlin, Heidelberg (1997). Epithelial Functionas a Focus of Ozone-Allergen Interaction
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Springer, Boston, MA (1994). Culturing carotid body cells of adult cats


Supervisions
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LEE KHAI SHIEN | Undergraduate | 06 Apr 2020 - 05 Oct 2020 Thesis: IDENTIFICATION OF POTENTIAL NOVEL COMPOUNDS THAT MAY ENHANCE ANTICANCER EFFECT OF POTENTIAL IKKα INHIBITORS
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Laurena Wong Gui Jin | Undergraduate | 06 Apr 2020 - 05 Oct 2020 Thesis: IDENTIFICATION OF INHIBITORY KAPPA B KINASES α (IKKα) INHIBITORS THAT HAVE AN ENHANCED INHIBITION ON THE NON-CANONICAL NF-κB PATHWAY IN PROSTATE CANCER
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VANESSA SEE VERN YEE | Undergraduate | 06 Apr 2020 - 05 Oct 2020 Thesis: DISCOVERY OF POTENTIAL IKKα INHIBITORS VIA IN VITRO CHEMICAL LIBRARY SCREENING AND ITS COMBINATION EFFECT WITH 5-FLUOROURACIL IN TREATING PANCREATIC CANCER
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Ramona Khanum | Doctorate | 04 Jan 2016 - 03 Jun 2019 Thesis: Targeting Clinically Relevant Biofilms of Staphylococcus epidermidis with lactoferrin and carbon monoxide
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Katie Long | Undergraduate | 01 Dec 2022 - 15 Feb 2023 Thesis: The Paradoxical use of Carbon Monoxide (CO) as a protective molecule against environmental pollutants: using a toxicant to reduce the negative effect of heavy metal toxicity.
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Asil Asaaka | Undergraduate | 01 Dec 2022 - 15 Feb 2023 Thesis: The Paradoxical use of Carbon Monoxide (CO) as a protective molecule against environmental pollutants: using a toxicant to reduce the negative effect of heavy metal toxicity.
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Gan Ming Yi | Undergraduate | 26 Nov 2018 - 11 May 2020 Thesis: Pentacyclic triterpenoids as antibiofilm agents against methicillin-resistant and biofilm-forming Staphylococcus aureus (MRSA).
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Yee Zong Yang | Doctorate | 07 Feb 2022 - 07 Feb 2025 Thesis: Functional roles of IKKα in pancreatic ductal adenocarcinoma (PDAC)

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