THIAGARAJAN MADHESWARAN



Salutation
Dr

School/Centre
School of Pharmacy

Department
Pharmaceutical Technology

Appointment
Head Of Department, Pharmaceutical Technology

Position
Senior Lecturer

Email
thiagarajan@imu.edu.my

Professional Network


Education

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PhD (Pharmaceutical Sciences), 2014 Yeungnam University, South Korea
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Master of Pharmacy (Pharmaceutical Analysis), 2008 The Tamil Nadu Dr MGR Medical University, Chennai, India
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Bachelor of Pharmacy (Pharmaceutical Sciences), 2005 The Tamil Nadu Dr MGR Medical University, Chennai, India

Memberships

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International Pharmaceutical Federation (FIP) | International | FIP member
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The British Society for Nanomedicine | National | Nanomembership- Scientific
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Association of Pharmaceutical Teachers of India | National | Member
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Tamil Nadu Pharmacy Council, Chennai, India | National | Registered Pharmacist

Publications

Research Articles

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18-β-Glycyrrhetinic acid encapsulated PLGA nanoparticles attenuate lung cancer proliferation and migration JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY | 2024
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Coencapsulation of Gemcitabine and Thymoquinone in Citrem–Phosphatidylcholine Hexosome Nanocarriers Improves In Vitro Cellular Uptake in Breast Cancer Cells MOLECULAR PHARMACEUTICS | 2023
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Zerumbone-incorporated liquid crystalline nanoparticles inhibit proliferation and migration of non-small-cell lung cancer in vitro NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY | 2023
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Recent Advances in the Development of Liquid Crystalline Nanoparticles as Drug Delivery Systems PHARMACEUTICS | 2023
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Formulation Development of Gemcitabine and Thymoquinone Co-Loaded Soy Phosphatidylcholine and Citrem-Based Nonlamellar Lyotropic Liquid Crystalline Nanoassemblies and In Vitro Anti-Breast Cancer Activity N/A | 2023
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Acknowledgment to the Reviewers of Pharmaceutics in 2022 PHARMACEUTICS | 2023
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Strategies to improve the stability of amorphous solid dispersions in view of the hot melt extrusion (HME) method INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2023
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Unravelling the molecular mechanisms underlying chronic respiratory diseases for the development of novel therapeutics via in vitro experimental models EUROPEAN JOURNAL OF PHARMACOLOGY | 2022
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Acknowledgment to Reviewers of Polymers in 2021 N/A | 2022
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Acknowledgment to Reviewers of Pharmaceutics in 2021 N/A | 2022
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Acknowledgment to Reviewers of Polymers in 2021 POLYMERS | 2022
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Acknowledgment to Reviewers of Materials in 2021 MATERIALS | 2022
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Announcing the Winner of the Inaugural Nano Letters Seed Grant Program, Central America, South Asia, Africa Region NANO LETTERS | 2022
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Nanotheranostics for Treatment and Diagnosis of Infectious Diseases N/A | 2022
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Berberine-loaded liquid crystalline nanoparticles inhibit non-small cell lung cancer proliferation and migration in vitro ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH | 2022
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Acknowledgment to Reviewers of Pharmaceutics in 2021 PHARMACEUTICS | 2022
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Evaluation of the Cytotoxic Activity and Anti-Migratory Effect of Berberine–Phytantriol Liquid Crystalline Nanoparticle Formulation on Non-Small-Cell Lung Cancer In Vitro PHARMACEUTICS | 2022
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Recent advances in the development of multifunctional lipid-based nanoparticles for Co-Delivery, combination treatment strategies, and theranostics in breast and lung cancer JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY | 2022
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Novel Gemcitabine-Re (I) Bisquinolinyl Complex Combinations and Formulations with Liquid Crystalline Nanoparticles for Pancreatic Cancer Photodynamic Therapy FRONTIERS IN PHARMACOLOGY | 2022
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Exploring the role of antibiotics and steroids in managing respiratory diseases JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY | 2022
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A Perspective on Therapeutic Applications and Strategies to Mitigate Toxicity of Metallic Nanoparticles CURRENT PHARMACEUTICAL DESIGN | 2022
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Unravelling the Therapeutic Potential of Nano-Delivered Functional Foods in Chronic Respiratory Diseases NUTRIENTS | 2022
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Phytantriol-Based Berberine-Loaded Liquid Crystalline Nanoparticles Attenuate Inflammation and Oxidative Stress in Lipopolysaccharide-Induced RAW264. 7 Macrophages NANOMATERIALS | 2022
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Bacterial cancer therapy: A turning point for new paradigms FEATURE DRUG DISCOVERY TODAY | 2022
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Autoantibodies and autoimmune disorders in SARS-CoV-2 infection: pathogenicity and immune regulation ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH | 2022
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Versatility of liquid crystalline nanoparticles in inflammatory lung diseases Nanomedicine | 2021
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Anti‐inflammatory and anticancer activities of Naringenin‐loaded liquid crystalline nanoparticles in vitro Journal of food biochemistry | 2021
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Celastrol-loaded liquid crystalline nanoparticles as an anti-inflammatory intervention for the treatment of asthma International Journal of Polymeric Materials and Polymeric Biomaterials | 2021
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Middle East Respiratory Syndrome (MERS) Virus—Pathophysiological Axis and the Current Treatment Strategies AAPS PharmSciTech | 2021
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Rutin loaded liquid crystalline nanoparticles inhibit non-small cell lung cancer proliferation and migration in vitro Life sciences | 2021
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Effect of Propolis Nanoparticles against Enterococcus faecalis Biofilm in the Root Canal Molecules | 2021
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Biomimetic bacterial and viral-based nanovesicles for drug delivery, theranostics, and vaccine applications Drug Discovery Today | 2021
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Acknowledgment to Reviewers of Pharmaceuticals in 2020 Pharmaceuticals | 2021
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Acknowledgment to Reviewers of Pharmaceutics in 2020 N/A | 2021
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Acknowledgment to Reviewers of Pharmaceutics in 2020 PHARMACEUTICS | 2021
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Human serum albumin as multifunctional nanocarrier for cancer therapy Journal of Pharmaceutical Sciences | 2021
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Combating Intracellular Pathogens with Nanohybrid-Facilitated Antibiotic Delivery International Journal of Nanomedicine | 2020
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Curcumin-loaded niosomes downregulate mRNA expression of pro-inflammatory markers involved in asthma: an in vitro study Nanomedicine | 2020
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Green synthesis and antibacterial potential of Artemisia vulgaris extract in silver nanoparticles against wound bacteria JURNAL ILMIAH FARMASI | 2020
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Perspectives and advancements in the design of nanomaterials for targeted cancer theranostics Chemico-biological interactions | 2020
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Recent Emergence of Rhenium (I) Tricarbonyl Complexes as Photosensitisers for Cancer Therapy Molecules | 2020
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Encapsulation of berberine into liquid crystalline nanoparticles to enhance its solubility and anticancer activity in MCF7 human breast cancer cells Journal of Drug Delivery Science and Technology | 2020
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Hand sanitizers: a review on formulation aspects, adverse effects, and regulations International journal of environmental research and public health | 2020
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Immunological axis of berberine in managing inflammation underlying chronic respiratory inflammatory diseases Chemico-biological interactions | 2020
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Effect of surface charge of nanohybrids on the intracellular bacterial killing efficiency N/A | 2020
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Molecular and immunological mechanisms underlying the various pharmacological properties of the potent bioflavonoid, rutin ENDOCRINE, METABOLIC & IMMUNE DISORDERS-DRUG TARGETS (FORMERLY CURRENT DRUG TARGETS-IMMUNE, ENDOCRINE & METABOLIC DISORDERS) | 2020
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Acknowledgement to Reviewers of Pharmaceutics in 2019 PHARMACEUTICS | 2020
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Acknowledgement to Reviewers of Pharmaceutics in 2019 Pharmaceutics | 2020
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Applications of nanocarriers as drug delivery vehicles for active phytoconstituents Current pharmaceutical design | 2020
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Labeling and tracking cells with gold nanoparticles Drug discovery today | 2020
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Molecular mechanisms of action of naringenin in chronic airway diseases European journal of pharmacology | 2020
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Preparation, characterisation and biological applications of Rutin loaded liquid crystalline nanoparticles in targeting airway diseases SYDNEY NEW HORIZONS-2019 | 2019
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Preparation, characterization and in-vitro efficacy of quercetin loaded liquid crystalline nanoparticles for the treatment of asthma Journal of Drug Delivery Science and Technology | 2019
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Therapeutic potential of Artemisia vulgaris: An insight into underlying immunological mechanisms Journal of Environmental Pathology, Toxicology and Oncology | 2019
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Current potential and challenges in the advances of liquid crystalline nanoparticles as drug delivery systems Drug discovery today | 2019
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Molecular modulators of celastrol as the keystones for its diverse pharmacological activities Biomedicine & Pharmacotherapy | 2019
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Formulation and characterization of glibenclamide and quercetin-loaded chitosan nanogels targeting skin permeation Therapeutic delivery | 2019
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Immunological axis of curcumin-loaded vesicular drug delivery systems Future medicinal chemistry | 2018
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Nanogels linked with chitosan: a perspective Minerva medica | 2018
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Assessing the potential of liposomes loaded with curcumin as a therapeutic intervention in asthma COLLOIDS AND SURFACE B: BIOINTERFACES | 2018
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Dosage Form Design Considerations: Volume I N/A | 2018
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Three-dimensional (3-D) printing technology exploited for the fabrication of drug delivery systems Current pharmaceutical design | 2018
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Dosage Form Design Parameters: Volume II N/A | 2018
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Lipid based nanocarriers system for topical delivery of photosensitizers Drug discovery today | 2017
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In vitro and in vivo skin distribution of 5α-reductase inhibitors loaded into liquid crystalline nanoparticles Journal of pharmaceutical sciences | 2017
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Emerging potential of stimulus-responsive nanosized anticancer drug delivery systems for systemic applications Archives of Pharmacal Research | 2017
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Protective and curative effects of polyphenolic extracts from Ichnocarpus frutescense leaves on experimental hepatotoxicity by carbon tretrachloride and tamoxifen Annals of hepatology | 2016
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In vitro and in vivo evaluation of skin permeation and distribution of 5alpha-reductase inhibitors using chitosan-coated liquid crystalline nanoparticles N/A | 2016
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Enhanced skin permeation of 5α-reductase inhibitors entrapped into surface-modified liquid crystalline nanoparticles Archives of pharmacal research | 2015
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Entrapment of curcumin into monoolein-based liquid crystalline nanoparticle dispersion for enhancement of stability and anticancer activity International journal of nanomedicine | 2014
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Enhanced topical delivery of finasteride using glyceryl monooleate-based liquid crystalline nanoparticles stabilized by cremophor surfactants Aaps Pharmscitech | 2014
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Enhanced Topical Delivery of Finasteride Using Glycerjl Monooleate-Based Liquid Crystalline Nanoparticles Stailized by Cremophor Surfactants -'^OEOE--**OE ----...' | 2014
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Design and in vitro evaluation of finasteride-loaded liquid crystalline nanoparticles for topical delivery Aaps Pharmscitech | 2013
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Effect of saturated fatty acids on tacrolimus-loaded liquid crystalline nanoparticles Journal of Drug Delivery Science and Technology | 2013
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3-Caffeoyl, 4-dihydrocaffeoylquinic acid from Salicornia herbacea attenuates high glucose-induced hepatic lipogenesis in human HepG2 cells through activation of the liver kinase B1 and silent information regulator T1/AMPK-dependent path -'^OEOE--**OE ----...' | 2013
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Preparation, characterization, and release study of tacrolimus-loaded liquid crystalline nanoparticles Journal of dispersion science and technology | 2013
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In vitro release and skin permeation of tacrolimus from monoolein-based liquid crystalline nanoparticles Journal of drug delivery science and technology | 2012
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Pharmacognostical Studies of Zanthoxylum tetraspermum Wignt and Arn Research Journal of Pharmacy and Technology | 2010
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High-performance liquid chromatography method for the quantification of pantoprazole in rat plasma INTERNATIONAL JOURNAL OF CHEMTECH RESEARCH | 2010
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Bioequivalence study and bioanalytical method development of Levofloxacin tablets in albino rat plasma using RP-HPLC method ARCHIVES OF APPLIED SCIENCE RESEARCH | 2010
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RP-HPLC method development and validation for the simultaneous estimation of ofloxacin and tinidazole in tablets INT. J. PHARMTECH RES | 2009
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Anti-carcinoma Activity of Polyphenolic Extract of Ichnocarpus frutescens Planta Medica | 2009

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Other Publications

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Liquid Crystalline Nanoparticle Systems to Enhance the Delivery Of Anticancer Drugs National Level Seminar on "Innovation in Pharmaceuticals: Revolutionizing Global Wellness Through Public Health Advancement" | 10 Jan 2024
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Liquid Crystalline Nanoparticle Systems to Enhance the Delivery Of Anticancer Drugs The International Conference on Integration of Innovation, Research And Pharmaceutical Education, KTN-APSE CON-2023 | 21 Dec 2023
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“Development of abemaciclib-loaded solid lipid nanoparticles using quality-by-design approach and evaluation of its anticancer activity in MDA-MB-231 and T47D breast cancer cells 81st FIP World Congress of Pharmacy and Pharmaceutical Sciences | 24 Sep 2023
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Risk assessments of material attributes and process parameters 9th International Postgraduate Conference on Pharmaceutical Sciences (iPoPS) 2022 Workshop 4: Applying 'Quality by Design’ (QbD) in Pharmaceutical Dosage Form Development, IMU | 23 Jun 2022
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Cubosomes and Hexosomes: Smart lipid nanocarriers for drug delivery applications Webinar Series 1, College of Pharmaceutical Sciences, Government Medical College, Kozhikode | 07 Aug 2020
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Current application and future utility of self-assembled liquid crystalline nanoparticles as drug delivery carrier 27th International Virtual Learning Series, Arulmigu Kalasalingam College of Pharmacy, India | 30 Jun 2020
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Current Trends in Topical and Transdermal Drug Delivery International Webinar Series 4, Virtual event, Nandha College of Pharmacy, India | 15 Jun 2020
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Current Trends in Topical and Transdermal Drug Delivery Trends in Drug Delivery Systems : Post COVID 19 Scenario, Virtual event, GITAM University, Hyderabad | 29 May 2020
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Cubosomes and Hexosomes: from Production and Characterisation to Clinical Translation” WORKSHOP ON MICRO-/NANOPARTICLES FABRICATION AND CHARACTERISATION, IMU | 30 Sep 2019
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Current Application and Future Utility of Self-Assembled Liquid Crystalline Nanoparticles as Drug Delivery Carrier India-UK Second International Conference on Advanced Nanomaterials for Energy, Environment and Healthcare Applications (ANEH-2019) | 04 Feb 2019
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Granulation preparation Workshop on Granulation Technology From Bench to Market, IMU | 09 Oct 2017

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Books

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Academic Press (2023). Artificial intelligence (AI) in drug product designing, development, and manufacturing
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Academic Press (2022). Stimuli-responsive nanomaterials in infectious diseases
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Academic Press (2019). Nanoemulsions as effective carriers for the treatment of lung cancer
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Academic Press (2018). Drug–excipient interaction and incompatibilities
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Academic Press (2018). Drug Complexation: Implications in Drug Solubilization and Oral Bioavailability Enhancement

Medias

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The Current issue of “The view from here” is concerned with Cancer and Drug Delivery Drug Discovery Today, Elsevier | 27 Aug 2020
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Best Poster Award for IMU Dentistry Student at Congress in Bangkok International Medical University | 18 Aug 2020


Supervisions
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MS BONNIE CHIN | Master (Coursework) | 14 May 2021 - 31 Jan 2022 Thesis: Development of abemaciclib-loaded solid lipid nanoparticles using quality-by-design approach and evaluation of its anticancer activity in MCF7 breast cancer cells
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Mr Eddy Yii Chung Ann | Master (Coursework) | 30 Jul 2020 - 30 Sep 2021 Thesis: Quality-by-design approach on the development of dasatinib-loaded liquid crystalline nanoparticles using novel lipids to enhance the solubility and its anticancer activity in human PC3 prostate cancer cell line
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Ms Liew Hui Shan | Master (Research) | 24 Oct 2019 - 30 Nov 2020 Thesis: Novel gemcitabine - Re(1) Tricarbonyl complexes combinations, conjugates and formulations with liquid crystalline nanoparticles for pancreatic cancer photodynamic therapy and bioimaging
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Ms Leong Hui Wen | Master (Coursework) | 26 Mar 2021 - 28 Feb 2022 Thesis: Development of a physiological-based pharmacokinetic model to predict bendamustine exposure in paediatric population
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Ms Dvya Delilaa Clarence | Master (Coursework) | 18 May 2021 - 31 Jan 2022 Thesis: Assessing the potential of nano-delivery systems containing Zerumbone in targeting inflammation
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Nisanthei Gunasegaran | Master (Coursework) | 20 Dec 2022 Thesis: Quality by Design approach to optimise spray drying process in the development of nano-tocotrienol dry powder

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