TAN ENG LAI



Salutation
Professor

School/Centre
School of Pharmacy

Department
Life Sciences

Appointment
Dean, School Of Postgraduate Studies

Position
Professor

Email
englai_tan@imu.edu.my



Education

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PhD (Cancer cell biology), 2004 University of Malaya, Kuala Lumpur, Malaysia
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M. Biotechnology (Biotechnology), 1999 University of Malaya, Kuala Lumpur, Malaysia
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B.Sc (Biotechnology) (Biotechnology), 1996 Murdoch University, Perth, Western Australia

Memberships

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Malaysian Society for Molecular Biology and Biotechnology (MSMBB) | National | Member

Publications

Research Articles

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Periodontitis and lipopolysaccharides: How far have we understood? EXPLORATION OF IMMUNOLOGY | 2024
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Author Correction: Conditioned media of pancreatic cancer cells and pancreatic stellate cells induce myeloid-derived suppressor cells differentiation and lymphocytes suppression SCIENTIFIC REPORTS | 2023
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Effect of Sustained Systemic Administration of Ginger (Z officinale) Rhizome Extracts on Salivary Flow in Mice INTERNATIONAL DENTAL JOURNAL | 2022
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Conditioned media of pancreatic cancer cells and pancreatic stellate cells induce myeloid-derived suppressor cells differentiation and lymphocytes suppression SCIENTIFIC REPORTS | 2022
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3D Clumps/Extracellular Matrix Complexes of Periodontal Ligament Stem Cells Ameliorate the Attenuating Effects of LPS on Proliferation and Osteogenic Potential JOURNAL OF PERSONALIZED MEDICINE | 2021
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Establishing a technique for isolation and characterization of human periodontal ligament derived mesenchymal stem cells THE SAUDI DENTAL JOURNAL | 2020
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Self-reported perception of a Dedicated research semester in Pharmacy curriculum in enhancing research competencies The Asia Pacific Scholar | 2020
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Fucosterol exerts protection against amyloid β-induced neurotoxicity, reduces intracellular levels of amyloid β and enhances the mRNA expression of neuroglobin in amyloid β-induced SH-SY5Y cells INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2019
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The Roles of the Professoriate 53 in Response to the Evolving Nature of the University N/A | 2017
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Epiregulin (EPR) Reduces Epidermal Growth Factor (EGF) Receptor Expression In Oral Squamous Cell Carcinoma (OSCC) Cell Lines ORAL SURGERY, ORAL MEDICINE, ORAL PATHOLOGY AND ORAL RADIOLOGY | 2015
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In vitro differentiation of mesenchymal stem cells into mesangial cells when co‐cultured with injured mesangial cells CELL BIOLOGY INTERNATIONAL | 2014
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Elucidating the roles of miR-372 in cell proliferation and apoptosis of nasopharyngeal carcinoma TW01 cells EXPERIMENTAL ONCOLOGY | 2014
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Inhibitory potency of 8-methoxypsoralen on cytochrome P450 2A6 (CYP2A6) allelic variants CYP2A6* 15, CYP2A6* 16, CYP2A6* 21 and CYP2A6* 22: differential susceptibility due to different sequence locations of the mutations PLOS ONE | 2014
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The effect of epiregulin on epidermal growth factor receptor expression and proliferation of oral squamous cell carcinoma cell lines CANCER CELL INTERNATIONAL | 2014
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Bioactive molecules: current trends in discovery, synthesis, delivery and testing IEJSME | 2013
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The effect of cytokines on microRNA expression in TW01 nasopharyngeal carcinoma cells JOURNAL OF ADVANCES IN MEDICINE AND MEDICAL RESEARCH | 2013
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Effects of IL-6, IL-10 and TGF-β on the expression of survivin and apoptosis in nasopharyngeal carcinoma TW01 cells EXPERIMENTAL ONCOLOGY | 2012
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Interleukins, laminin and Epstein-Barr virus latent membrane protein 1 (EBV LMP1) promote metastatic phenotype in nasopharyngeal carcinoma BMC CANCER | 2010
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Functional characterization of cytochrome P450 2A6 allelic variants CYP2A6* 15, CYP2A6* 16, CYP2A6* 21, and CYP2A6* 22 DRUG METABOLISM AND DISPOSITION | 2010
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In vitro modulation of naturally occurring flavonoids on cytochrome P450 2A6 (CYP2A6) activity XENOBIOTICA | 2010
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Clarithromycin resistance and point mutations in the 23S rRNA gene in Helicobacter pylori isolates from Malaysia JOURNAL OF DIGESTIVE DISEASES | 2010
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Improved Accuracy for Diagnosis of Nasopharyngeal Carcinoma by the Combination of Recombinant EBV Proteins ZEBRA/IgA and LMP2A/IgG ELISA SELECTED ARTICLES FROM THE 7TH NATIONAL GENETICS CONGRESS 2007 | 2009
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Selected Articles from the 7th National Genetics Congress 2007 PERTANIKA JOURNAL OF TROPICAL AGRICULTURAL SCIENCE | 2009
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Pharmacogenomics in drug therapy and interaction: the role of cytochrome P450 INT E-JOURNAL SCI MED EDUC | 2008
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Biological properties of TW01 cells expressing latent membrane protein-1 gene of EBV-derived from nasopharyngeal carcinoma cells at different stages of malignancy EXPERIMENTAL ONCOLOGY | 2007
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Human leukocyte class 1 antigen alleles A2 and A11 are not associated with nasopharyngeal carcinoma in West Malaysia SINGAPORE MEDICAL JOURNAL | 2007
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Sequence Variations of the Latent Membrane Protein 1 of Epstein-Barr Virus Isolates from Cases of Malaysian Nasopharyngeal Carcinoma: A Preliminary Study MALAYSIAN JOURNAL OF SCIENCE | 2007
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Evaluation of plasma Epstein-Barr virus DNA load as a prognostic marker for nasopharyngeal carcinoma SINGAPORE MEDICAL JOURNAL | 2006
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Quantification of Epstein-Barr virus DNA load, interleukin-6, interleukin-10, transforming growth factor-β1 and stem cell factor in plasma of patients with nasopharyngeal carcinoma BMC CANCER | 2006
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BRCA1 Exon 11 Mutations in Breast Cancer in Malaysia MEDICAL JOURNAL OF MALAYSIA | 2004
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Epstein-Barr virus (EBV) subtypes and variants in malignant tissue from Malaysian patients JOURNAL OF CLINICAL AND EXPERIMENTAL HEMATOPATHOLOGY | 2003
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Analyses of Epstein‐Barr virus latent membrane protein‐1 in Malaysian nasopharyngeal carcinoma: High prevalence of 30‐bp deletion, Xho1 polymorphism and evidence of dual infections JOURNAL OF MEDICAL VIROLOGY | 2003
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Rapid determination of clarithromycin resistance in Malaysian Helicobacter pylori strains using molecular detection methods MEDICAL JOURNAL OF MALAYSIA | 2002

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Other Publications

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Epstein barr virus latent membrane protein 1: genotypic and antigenic differences in relation to nasopharyngeal carcinoma JOURNAL OF CLINICAL VIROLOGY | 01 Jan 2003
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Low prevalence of primary clarithromycin resistance in Malaysian H. pylori strains using molecular detection methods GASTROENTEROLOGY | 01 Jan 2002

Books

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Springer, Tokyo (2015). Institute for Research, Development and Innovation (IRDI) of the International Medical University (IMU), Malaysia


Supervisions
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Spoorthi Ravi Banavar | Doctorate | 05 Sep 2016 Thesis: Development and validation of clumps of mesenchymal stem cells (C-MSCs) in scaffold free bone regeneration and tissue engineering.
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Chong Yuen Ping | Master (Research) | 01 Jan 2018 Thesis: The Role of Pancreatic Ductal Adenocarcinoma (PDA) Cells and Pancreatic Stellate Cells (PSC) in Promoting the Differentiation of Myeloid Derived Suppressor Cells (MDSC)
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Cheng Jia jie | Undergraduate | 01 Jul 2020 - 01 Nov 2020 Thesis: Diagnostic and Prognostic DNA Methylation Markers in NPC: A Critical Review
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Brandon Ko Wei Kwong | Undergraduate | 01 Jul 2020 - 30 Nov 2021 Thesis: An assessment of the efficacy of immunotherapy as compared to the standard treatment for NPC: A critical review
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Tang Wei Kid | Undergraduate | 01 Jul 2020 - 01 Nov 2021 Thesis: Pros and cons of corticosteroid use in Covid-10 patients
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Lim Weg Kit | Undergraduate | 01 Jul 2020 - 01 Nov 2021 Thesis: THE EFFECT OF ASTAXANTHIN ON THE BIOLOGICAL FUNCTIONS OF NPC CELLS AND EXPRESSION OF SOX2 GENE
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Ong Chun Wei | Undergraduate | 01 Jul 2020 - 01 Nov 2021 Thesis: The use of traditional Chinese medicine for NPC patients undergoing concomittant chemoraiotherapy
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Wong Shen Hau | Undergraduate | 01 Jul 2020 - 01 Nov 2021 Thesis: Curcumin as potential complementary medicine in cancer combination therapy: A critical review
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Tsen Min Tze | Doctorate | 01 Jan 2013 - 30 Nov 2018 Thesis: Isolation and Functional Characterisation of Cancer Stem Cells from Nasopharyngeal Carcinoma (NPC)
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Wong Li Zhe | Master (Mixed Mode) | 01 May 2014 - 31 Oct 2015 Thesis: FUCOSTEROL FROM PADINA AUSTRALIS PROTECTS SH-SY5Y CELLS AGAINST AMYLOID-INDUCED NEUROTOXICITY BY ENHANCING THE EXPRESSION OF NEUROGLOBIN

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