GAN SOOK YEE



Salutation
Associate Professor Dr

School/Centre
School of Pharmacy

Department
Life Sciences

Appointment
Associate Dean, Academic

Position
Associate Professor

Email
sookyee_gan@imu.edu.my



Education

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PhD (Molecular Biology), 2005 University of Malaya
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Master (Master of Philosophy), 2001 University of Malaya
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Bachelor (Bachelor of Science (Biotechnology)), 1995 University Pertanian Malaysia

Publications

Research Articles

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Pharmacy students’ and supervisors’ perceptions of the effectiveness of assessment rubrics for undergraduate research performance review PHARMACY EDUCATION | 2023
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Lipopolysaccharide (LPS) stimulation of Pancreatic Ductal Adenocarcinoma (PDAC) and macrophages activates the NLRP3 inflammasome that influences the levels of pro-inflammatory cytokines in a co-culture model CANCER BIOLOGY & THERAPY | 2023
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The Crosstalk between Pancreatic Ductal Adenocarcinoma (PDAC) and Macrophages in Tumour Microenvironments, and Its Effects on Inflammasome Activation and Pro-Inflammatory Cytokine Levels N/A | 2022
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Genes associated with amyloid-beta-induced inflammasome-mediated neuronal death identified using functional gene trap mutagenesis approach The international journal of biochemistry & cell biology | 2021
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Piper sarmentosum Roxb. Attenuates Beta Amyloid (Aβ)-Induced Neurotoxicity Via the Inhibition of Amyloidogenesis and Tau Hyperphosphorylation in SH-SY5Y Cells Current Alzheimer Research | 2021
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Recent progress in genetically modified microalgae for enhanced carbon dioxide sequestration Biomass and Bioenergy | 2021
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Catalpol ameliorates insulin sensitivity and mitochondrial respiration in skeletal muscle of type-2 diabetic mice through insulin signaling pathway and AMPK/SIRT1/PGC-1α/PPAR-γ activation Biomolecules | 2020
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Self-reported perception of a Dedicated research semester in Pharmacy curriculum in enhancing research competencies The Asia Pacific Scholar | 2020
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Functional Gene Trap Mutagenesis Screen for Genes and Molecular Mechanisms Underlying Amyloid-β-induced Inflammasome-mediated Neuronal Death N/A | 2020
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The role of neuronal NLRP1 inflammasome in Alzheimer’s disease: bringing neurons into the neuroinflammation game Molecular neurobiology | 2019
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The NLRP3 inflammasome is involved in the neuroprotective mechanism of neural stem cells against microglia-mediated toxicity in SH-SY5Y cells via the attenuation of tau hyperphosphorylation and amyloidogenesis Neurotoxicology | 2019
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Fucosterol exerts protection against amyloid β-induced neurotoxicity, reduces intracellular levels of amyloid β and enhances the mRNA expression of neuroglobin in amyloid β-induced SH-SY5Y cells International journal of biological macromolecules | 2019
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Green algal molecular responses to temperature stress Acta physiologiae plantarum | 2019
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Piper sarmentosum Roxb. root extracts confer neuroprotection by attenuating beta amyloid-induced pro-inflammatory cytokines released from microglial cells Current Alzheimer Research | 2019
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Piper sarmentosum Roxb. confers neuroprotection on beta-amyloid (Aβ)-induced microglia-mediated neuroinflammation and attenuates tau hyperphosphorylation in SH-SY5Y cells Journal of ethnopharmacology | 2018
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Effect of elevated temperature on the physiological responses of marine Chlorella strains from different latitudes Journal of Applied Phycology | 2018
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In vitro neuroprotective effects of naringenin nanoemulsion against β-amyloid toxicity through the regulation of amyloidogenesis and tau phosphorylation International journal of biological macromolecules | 2018
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Fucosterol inhibits the cholinesterase activities and reduces the release of pro-inflammatory mediators in lipopolysaccharide and amyloid-induced microglial cells Journal of applied phycology | 2018
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Gene expression profile of marine Chlorella strains from different latitudes: stress and recovery under elevated temperatures Journal of Applied Phycology | 2018
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Agrobacterium-mediated gene delivery and transient expression in the red macroalga Chondrus crispus Botanica Marina | 2018
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Random mutagenesis and precise gene editing technologies: applications in algal crop improvement and functional genomics European Journal of Phycology | 2017
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MicroRNAs serving as potential biomarkers and therapeutic targets in nasopharyngeal carcinoma: A critical review Critical reviews in oncology/hematology | 2016
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Comparison of visual observation and emission intensity of resazurin for antimicrobial properties of hexane, dichloromethane, methanol and water extracts from a brown alga, Turbinaria ornata COGENT BIOLOGY | 2016
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Antioxidative, anticholinesterase and anti-neuroinflammatory properties of Malaysian brown and green seaweeds INTERNATIONAL JOURNAL OF INDUSTRIAL AND MANUFACTURING ENGINEERING | 2015
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Elucidating the roles of miR-372 in cell proliferation and apoptosis of nasopharyngeal carcinoma TW01 cells Experimental oncology | 2014
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The effect of cytokines on microRNA expression in TW01 nasopharyngeal carcinoma cells JOURNAL OF ADVANCES IN MEDICINE AND MEDICAL RESEARCH | 2013
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Effects of IL-6, IL-10 and TGF-β on the expression of survivin and apoptosis in nasopharyngeal carcinoma TW01 cells Experimental oncology | 2012
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Interleukins, laminin and Epstein-Barr virus latent membrane protein 1 (EBV LMP1) promote metastatic phenotype in nasopharyngeal carcinoma BMC cancer | 2010
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PHYLOGENY OFCHLORELLASTRAINS ISOLATED FROM DIFFERENT LATITUDES FROM THE NORTH TO THE SOUTH POLE: 304 Phycologia | 2009
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GENETIC TRANSFORMATION OFCHLORELLA VULGARIS: 95 Phycologia | 2009
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Seaweed diversity in Malaysia STATUS OF BIOLOGICAL DIVERSITY IN MALAYSIA AND THREAT ASSESSMENT OF PLANT SPECIES IN MALAYSIA. FOREST RESEARCH INSTITUTE MALAYSIA | 2007
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Identification of random amplified polymorphic DNA (RAPD) marker for differentiating male from female and sporophytic thalli of Gracilaria changii (Rhodophyta) Journal of Applied Phycology | 2007
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Crop improvement in seaweed cultivation ADVANCES IN SEAWEED CULTIVATION AND UTILISATION IN ASIA. UNIVERSITY OF MALAYA MARITIME RESEARCH CENTER PUBLICATION | 2006
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Development of a Genetic Transformation System for Gracila Changii (Rhodophphyta) N/A | 2005
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Morphological and molecular characterisation and differentiation of Sargassum baccularia and S. polycystum (Phaeophyta) Journal of applied phycology | 2004
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Development of a transformation system for Gracilaria changii (Gracilariales, Rhodophyta), a Malaysian red alga via microparticle bombardment The 4 th Annual Seminar of National Science Fellowship | 2004
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Transient expression of lacZ in particle bombarded Gracilaria changii (Gracilariales, Rhodophyta) Journal of Applied Phycology | 2003
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Molecular taxonomic studies of Gracilaria changii from various locations using the random amplified polymorphic DNA (RAPD) technique/Gan Sook Yee. N/A | 1999

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Other Publications

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Effect of catalpol on liver glucose homeostasis in high fat diet/low dose streptozotocin-induced type 2 diabetes mellitus BRITISH JOURNAL OF PHARMACOLOGY | 01 Jan 2019

Books

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Springer, Cham (2016). Genetic and metabolic engineering of microalgae


Supervisions
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Yap Kah Heng | Doctorate | 01 Aug 2021 Thesis: Antidiabetic activities of catalpol on high-fat-diet/streptozotocin induced Type-2 diabetes mice by improving insulin sensitivity and mitochondrial function
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Jeremy Yap Kean Yi | Master (Research) | 01 Aug 2016 - 31 Jul 2020 Thesis: A microarray-coupled gene trap mutagenesis approach for the identification of NLRP1 inflammasome activation targets mediating beta amyloid (Aβ)-induced neuronal pyroptosis
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Lee Ting Wei | Master (Research) | 01 Jan 2010 - 01 Jan 2012 Thesis: Expression profiling of microRNA in nasopharyngeal carcinoma in response to interleukins and transforming growth factor: Towards unraveling the roles of microRNA in invasion and metastasis.
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Siti Aisya Bt Saud Gany | Master (Research) | 01 Jan 2012 - 01 Jan 2014 Thesis: Antioxidant and anti-neuroinflammatory properties of Padina, a genus of brown algae in the order of Dictyotales
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Tan Swee Ching | Master (Research) | 01 Jan 2012 - 01 Jan 2015 Thesis: Cholinesterase Inhibitory andneuroprotective properties of Sargassum, a genus of brownalgae in the order of Fucales.
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Ms Sangeetha Krishnansamy | Master (Coursework) | 24 Aug 2016 - 28 Feb 2017 Thesis: The regulation of inflammasome activation in BV 2 microglia cells by neuronal stem cells (NSCs)
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Cindy Wong | Master (Coursework) | 01 Mar 2017 - 01 Mar 2018 Thesis: Neuroprotective effect of neuronal stem cells (NSCs) on SHSY5Y cells via the regulation of inflammasome-mediated inflammation in BV2 microglia cells.
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Bahram Barati | Doctorate | 01 Jan 2019 - 30 Jul 2021 Thesis: The Effect of Elevated Temperature on Growth, Photosynthetic Performance, Biochemical Composition and Expression Pattern of Heat Induced Genes
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Anusha Ramessur | Doctorate | 06 Jul 2010 - 29 Jun 2013 Thesis: Genetic Transformation of Chondrus
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MR SAKTI JAIGANEISH A/L E. VENNARAJAN | Master (Research) | 29 Mar 2022 Thesis: Roles of salivary microRNAs as potential non-invasive biomarkers in assessing effectiveness of combined therapy with gliclazide and metformin regimen among obese Type 2 diabetes mellitus (T2DM) patients
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Mr Ng Jia Hao | Master (Research) | 30 Nov 2021 Thesis: The functional role of MIRO1 in NLRP1 inflammasome-mediated neuronal cell death
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MS NUR NAJIHAH BINTI SALAHUDDIN | Master (Coursework) | 25 Nov 2021 Thesis: “Synthesis, characterisation, antioxidant and alpha-glucosidase inhibitory activities of pectin-phenolic acid conjugate”
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Ms Agnes Gwenhure | Master (Coursework) | 26 Mar 2021 - 30 Sep 2021 Thesis: Mechanistic studies on the neuroprotective effect of beta-sitosterol during beta amyloid-induced microglia-mediated neuro-inflammation
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Ng Kar Wei | Undergraduate | 06 Jun 2021 - 06 Jun 2022 Thesis: In vitro antioxidative, anti-cholinesterase, and anti-α-amylase effects of gelatinphenolic acid conjugates

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