Selvam James Thavaraj



Salutation
Associate Professor Dr

School/Centre
School of Dentistry

Department
Clinical Oral Health Sciences

Position
Associate Professor


Professional Network


Education

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Fellow of the Royal College of Pathologists (Pathology), 2009 Royal College of Pathologists, United Kingdom
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Doctor of Philosophy (Oral Cancer), 2005 University of Bristol
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Fellowship in Dental Surgery (Dentistry), 1999 Royal College of Surgeons of England
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Bachelor of Dental Surgery (Dentistry), 1994 United Medical and Dental Schools, University of London

Publications

Research Articles

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Incidental Thyroid Tissue in Sentinel Nodes From Oral Squamous Cell Carcinoma THE LARYNGOSCOPE | 2024
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The evolving molecular characterisation, histological criteria and nomenclature of adenoid ameloblastoma as a World Health Organisation tumour type HISTOPATHOLOGY | 2024
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Developing and validating a multivariable prognostic-predictive classifier for treatment escalation of oropharyngeal squamous cell carcinoma: the PREDICTR-OPC study CLINICAL CANCER RESEARCH | 2024
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Computational pathology in cancer diagnosis, prognosis, and prediction–present day and prospects THE JOURNAL OF PATHOLOGY | 2023
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Intratumoral pan-ErbB targeted CAR-T for head and neck squamous cell carcinoma: interim analysis of the T4 immunotherapy study JOURNAL FOR IMMUNOTHERAPY OF CANCER | 2023
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Multiscale deep learning framework captures systemic immune features in lymph nodes predictive of triple negative breast cancer outcome in large‐scale studies THE JOURNAL OF PATHOLOGY | 2023
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Multifactorial estimation of clinical outcome in HPV-associated oropharyngeal squamous cell carcinoma via automated image analysis of routine diagnostic H&E slides and neural network modelling ORAL ONCOLOGY | 2023
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Interplay of adherens junctions and matrix proteolysis determines the invasive pattern and growth of squamous cell carcinoma ELIFE | 2023
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Clinical outcomes in relapsed oropharyngeal cancer after definitive (chemo) radiotherapy ORAL DISEASES | 2023
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Does BRAF mutation status and related clinicopathological factors affect the recurrence rate of ameloblastoma? A systematic review, meta‐analysis and metaregression JOURNAL OF ORAL PATHOLOGY & MEDICINE | 2023
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Abstract P5-01-01: Multiscale Deep Learning framework to capture systemic immune features in lymph nodes predictive of triple negative breast cancer outcome CANCER RESEARCH | 2023
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Fungal infection drives metabolic reprogramming in epithelial cells via aerobic glycolysis and an alternative TCA cycle shunt N/A | 2022
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Predicting progression-free survival after systemic therapy in advanced head and neck cancer: Bayesian regression and model development N/A | 2022
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High content image analysis in routine diagnostic histopathology predicts outcomes in HPV-associated oropharyngeal squamous cell carcinomas MEDRXIV | 2022
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A deep learning pipeline to capture the prognostic immune responses in lymph nodes of breast cancer patients CANCER RESEARCH | 2022
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Adenoid ameloblastoma harbors beta-catenin mutations MODERN PATHOLOGY | 2022
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Predicting progression-free survival after systemic therapy in advanced head and neck cancer: Bayesian regression and model development ELIFE | 2022
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Centralised pathology service for sentinel node biopsy in oral cavity cancer: The Southeast England Consortium experience JOURNAL OF ORAL PATHOLOGY & MEDICINE | 2022
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Human papillomavirus-associated combined neuroendocrine and squamous cell carcinoma of the sinonasal tract HEAD AND NECK PATHOLOGY | 2022
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Clinical outcomes, Kadish-INSICA staging and therapeutic targeting of somatostatin receptor 2 in olfactory neuroblastoma EUROPEAN JOURNAL OF CANCER | 2022
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Candida albicans enhances the progression of oral squamous cell carcinoma in vitro and in vivo MBIO | 2022
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TNM 8 staging is a better prognosticator than TNM 7 for patients with locally advanced oral cavity squamous cell carcinoma treated with surgery and post-operative radiotherapy RADIOTHERAPY AND ONCOLOGY | 2021
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Odell's clinical problem solving in dentistry (vol 230, pg 506, 2021) BRITISH DENTAL JOURNAL | 2021
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CLINICOPATHOLOGIC FEATURES OF HUMAN PAPILLOMAVIRUS–ASSOCIATED ORAL EPITHELIAL DYSPLASIA ORAL SURGERY, ORAL MEDICINE, ORAL PATHOLOGY AND ORAL RADIOLOGY | 2021
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An unusual clinico-radiological presentation of epithelioid haemangioma as an external ear mass OTOLARYNGOLOGY CASE REPORTS | 2021
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RUNIMC: An R-based package for imaging mass cytometry data analysis and pipeline validation BIORXIV | 2021
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British association of head and neck oncologists (BAHNO) standards 2020 JOURNAL OF ORAL PATHOLOGY AND MEDICINE | 2021
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Treating the N0 neck in early stage oral cancer: a pause for re-assessment? BRITISH JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY | 2021
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Serial step sections at narrow intervals with immunohistochemistry are required for accurate histological assessment of sentinel lymph node biopsy in oral squamous cell carcinoma HEAD & NECK | 2021
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EGFR overexpression increases radiotherapy response in HPV-positive head and neck cancer through inhibition of DNA damage repair and HPV E6 downregulation CANCER LETTERS | 2021
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Overview of oral potentially malignant disorders: from risk factors to specific therapies CANCERS | 2021
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Hypoxia-sensing CAR T cells provide safety and efficacy in treating solid tumors CELL REPORTS MEDICINE | 2021
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RNA in situ hybridization for human papillomavirus testing in oropharyngeal squamous cell carcinoma on a routine clinical diagnostic platform JOURNAL OF ORAL PATHOLOGY & MEDICINE | 2021
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Odell's Clinical Problem Solving in Dentistry E-Book: Odell's Clinical Problem Solving in Dentistry E-Book N/A | 2020
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A Lump in the Neck ODELL'S CLINICAL PROBLEM SOLVING IN DENTISTRY E-BOOK: ODELL'S CLINICAL PROBLEM SOLVING IN DENTISTRY E-BOOK | 2020
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Round and rhabdoid sinonasal tumours: pitfalls and confusions DIAGNOSTIC HISTOPATHOLOGY | 2020
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Development of sentinel lymph node biopsy technique in patients with salivary gland cancer using the IDEAL framework EUROPEAN JOURNAL OF SURGICAL ONCOLOGY | 2020
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Trans-oral robotic surgery for oropharyngeal cancer: implications for pathologists DIAGNOSTIC HISTOPATHOLOGY | 2020
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The impact of intensity‐modulated radiation treatment on dento‐alveolar microvasculature in pharyngeal cancer implant patients JOURNAL OF ORAL REHABILITATION | 2020
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Radical (chemo) radiotherapy in oropharyngeal squamous cell carcinoma: comparison of TNM 7th and 8th staging systems RADIOTHERAPY AND ONCOLOGY | 2020
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Candidalysin activates innate epithelial immune responses via epidermal growth factor receptor NATURE COMMUNICATIONS | 2019
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Homeostatic and tumourigenic activity of SOX2+ pituitary stem cells is controlled by the LATS/YAP/TAZ cascade ELIFE | 2019
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Clinical evaluation of tumour‐infiltrating lymphocytes as a prognostic factor in patients with human papillomavirus‐associated oropharyngeal squamous cell carcinoma HISTOPATHOLOGY | 2019
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Palatine tonsil SUVmax on FDG PET-CT as a discriminator between benign and malignant tonsils in patients with and without head and neck squamous cell carcinoma of unknown primary CLINICAL RADIOLOGY | 2019
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Coronectomy root retrievals: a review of 92 cases ORAL SURGERY, ORAL MEDICINE, ORAL PATHOLOGY AND ORAL RADIOLOGY | 2019
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A Review of 120 Coronectomy Root Retrievals JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY | 2019
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Cemento-Osseous dysplasia-related jaw necrosis− a case report and literature review DENTAL UPDATE | 2019
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Clinico-pathological features of oropharyngeal squamous cell carcinomas in Malaysia with reference to HPV infection. N/A | 2018
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Yap/Taz-TEAD activity links mechanical cues to cell progenitor behavior during hindbrain segmentation BIORXIV | 2018
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Clinico-pathological features of oropharyngeal squamous cell carcinomas in Malaysia with reference to HPV infection INFECTIOUS AGENTS AND CANCER | 2018
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Prognostic utility of HPV specific testing in addition to p16 immunohistochemistry in oropharyngeal squamous cell carcinoma ANNALS OF ONCOLOGY | 2018
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Annexin A1 regulates EGFR activity and alters EGFR-containing tumour-derived exosomes in head and neck cancers EUROPEAN JOURNAL OF CANCER | 2018
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Tumour compartment transcriptomics demonstrates the activation of inflammatory and odontogenic programmes in human adamantinomatous craniopharyngioma and identifies the MAPK/ERK pathway as a novel therapeutic target ACTA NEUROPATHOLOGICA | 2018
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Intraoperative sentinel node imaging versus SPECT/CT in oral cancer–A blinded comparison EUROPEAN JOURNAL OF SURGICAL ONCOLOGY | 2018
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Developing and validating a multivariable predictive biomarker for treatment selection for oropharyngeal squamous cell carcinoma: The PREDICTR-OPC study. JOURNAL OF CLINICAL ONCOLOGY | 2017
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ATR gene mutations in HPV negative oropharyngeal cancer. N/A | 2017
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MAPK pathway activation in the embryonic pituitary results in stem cell compartment expansion, differentiation defects and provides insights into the pathogenesis of papillary craniopharyngioma DEVELOPMENT | 2017
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Brown Tumours: A Case of a Non-Healing Tooth Socket EC DENTAL SCIENCE | 2017
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An overview of autosomal dominant tumour syndromes with prominent features in the oral and maxillofacial region HEAD AND NECK PATHOLOGY | 2017
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Transoral laser microsurgery versus radiation therapy in the management of T1 and T2 laryngeal glottic carcinoma: which modality is cost‐effective within the UK? CLINICAL OTOLARYNGOLOGY | 2017
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Outcomes of intensity‐modulated radiotherapy as primary treatment for oropharyngeal squamous cell carcinoma–a European singleinstitution analysis CLINICAL OTOLARYNGOLOGY | 2017
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MAPK pathway control of stem cell proliferation and differentiation in the embryonic pituitary provides insights into the pathogenesis of papillary craniopharyngioma DEVELOPMENT | 2017
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Candidalysin is a fungal peptide toxin critical for mucosal infection NATURE | 2016
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Head and neck sarcomas: clinical and histopathological presentation, treatment modalities, and outcomes THE JOURNAL OF LARYNGOLOGY & OTOLOGY | 2016
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18 F-FDG PET/CT to assess response and guide risk-stratified follow-up after chemoradiotherapy for oropharyngeal squamous cell carcinoma EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING | 2016
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Human papillomavirus-associated neoplasms of the sinonasal tract and nasopharynx SEMINARS IN DIAGNOSTIC PATHOLOGY | 2016
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Changes in epidermal growth factor receptor gene copy number during oral carcinogenesis CANCER EPIDEMIOLOGY, BIOMARKERS & PREVENTION | 2016
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Quantification of lymph nodes in the central compartment of the neck: a cadaveric study EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY | 2016
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Sentinel node biopsy for primary salivary gland tumours; feasibility study of a new technique BRITISH JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY | 2016
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Down‐regulation of LPA receptor 5 contributes to aberrant LPA signalling in EBV‐associated nasopharyngeal carcinoma THE JOURNAL OF PATHOLOGY | 2015
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Biphenotypic human papillomavirus-associated head and neck squamous cell carcinoma: a report of two cases DIAGNOSTIC PATHOLOGY | 2015
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Human papillomavirus testing in diagnostic head and neck histopathology DIAGNOSTIC HISTOPATHOLOGY | 2015
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Down-regulation of LPA receptor 5 contributes to aberrant LPA signalling in EBV-associated nasopharyngeal carcinoma. N/A | 2015
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Multicentric human papillomavirus–associated head and neck squamous cell carcinoma HEAD & NECK | 2015
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Dermatophytes activate skin keratinocytes via mitogen-activated protein kinase signaling and induce immune responses INFECTION AND IMMUNITY | 2015
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Activated WNT signaling in postnatal SOX2-positive dental stem cells can drive odontoma formation SCIENTIFIC REPORTS | 2015
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Adenoid ameloblastoma: clinicopathologic description of five cases and systematic review of the current knowledge ORAL SURGERY, ORAL MEDICINE, ORAL PATHOLOGY AND ORAL RADIOLOGY | 2015
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Histological evaluation of mandibular third molar roots retrieved after coronectomy BRITISH JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY | 2014
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Bortezomib sensitises TRAIL-resistant HPV-positive head and neck cancer cells to TRAIL through a caspase-dependent, E6-independent mechanism CELL DEATH & DISEASE | 2014
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Patients with HPV-related tonsil squamous cell carcinoma rarely harbour oncogenic HPV infection at other pharyngeal sites ORAL ONCOLOGY | 2014
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Human papillomavirus testing in head and neck squamous cell carcinoma: best practice for diagnosis HISTOPATHOLOGY: METHODS AND PROTOCOLS | 2014
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Psychosocial implications BRITISH DENTAL JOURNAL | 2014
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Human Papillomavirus-associated oropharyngeal cancer: an observational study of diagnosis, prevalence and prognosis in a UK population BMC CANCER | 2013
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Oncogenic human papillomavirus-associated nasopharyngeal carcinoma: an observational study of correlation with ethnicity, histological subtype and outcome in a UK population INFECTIOUS AGENTS AND CANCER | 2013
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Human papillomavirus-associated adenocarcinoma of the palatine tonsil. HUMAN PATHOLOGY | 2013
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Standards and datasets for reporting cancers N/A | 2013
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Detection of Oncogenic Human Papillomavirus in Nasopharyngeal Carcinoma 202ND SUMMER SCIENTIFIC MEETING OF THE PATHOLOGICAL SOCIETY OF GREAT BRITAIN AND IRELAND | 2012
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Murine model of concurrent oral and vaginal Candida albicans colonisation HOST-FUNGUS INTERACTIONS: METHODS AND PROTOCOLS | 2012
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Glycosylation of Candida albicans cell wall proteins is critical for induction of innate immune responses and apoptosis of epithelial cells PLOS ONE | 2012
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Human papillomavirus detection in dysplastic and malignant oral verrucous lesions JOURNAL OF CLINICAL PATHOLOGY | 2012
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Carcinoma cuniculatum arising in the tongue HEAD AND NECK PATHOLOGY | 2012
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HPV specific testing: a requirement for oropharyngeal squamous cell carcinoma patients HEAD AND NECK PATHOLOGY | 2012
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Evaluation of human papillomavirus testing for squamous cell carcinoma of the tonsil in clinical practice JOURNAL OF CLINICAL PATHOLOGY | 2011
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Candida albicans yeast and hyphae are discriminated by MAPK signaling in vaginal epithelial cells PLOS ONE | 2011
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A biphasic innate immune MAPK response discriminates between the yeast and hyphal forms of Candida albicans in epithelial cells CELL HOST & MICROBE | 2010
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Permacol in augmentation rhinoplasty. CLINICAL OTOLARYNGOLOGY: OFFICIAL JOURNAL OF ENT-UK; OFFICIAL JOURNAL OF NETHERLANDS SOCIETY FOR OTO-RHINO-LARYNGOLOGY & CERVICO-FACIAL SURGERY | 2010
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Is head and neck cancer infectious? Human papilloma virus in oral and pharyngeal cancer FACULTY DENTAL JOURNAL | 2010
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MAPK, MKP1 and c-Fos Discriminate Candida albicans Yeast from Hyphae in Epithelial Cells CELL HOST & MICROBE | 2010
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Osseointegrated implants: a potential route of entry for squamous cell carcinoma of the mandible BRITISH JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY | 2008
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Murine model of concurrent oral and vaginal Candida albicans colonization to study epithelial host–pathogen interactions MICROBES AND INFECTION | 2007
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Over‐expression of TGF‐β1 in Smad4‐deficient human oral carcinoma cells causes tumour regression in vivo by mechanisms that sensitize cells to apoptosis THE JOURNAL OF PATHOLOGY: A JOURNAL OF THE PATHOLOGICAL SOCIETY OF GREAT BRITAIN AND IRELAND | 2005
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Mechanisms of transforming growth factor beta-induced tumour suppression in Smad4-deficient human malignant keratinocytes N/A | 2005
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Caspase‐3 expression is reduced, in the absence of cleavage, in terminally differentiated normal oral epithelium but is increased in oral squamous cell carcinomas and correlates with tumour stage THE JOURNAL OF PATHOLOGY: A JOURNAL OF THE PATHOLOGICAL SOCIETY OF GREAT BRITAIN AND IRELAND | 2004

Other Publications

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Human papillomavirus in carcinomas of the sinonasal tract EUROGIN 2018-From control to elimination of HPV induced cancers | 01 Jan 2018
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Impact of human papilloma virus status on the response of head and neck carcinomas cell lines to novel therapeutic agents EUROPEAN JOURNAL OF CANCER | 01 Jan 2016
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Analysis of signalling pathways that mediate TGF-beta 1-regulated apoptosis in malignant oral keratinocytes JOURNAL OF ORAL PATHOLOGY & MEDICINE | 01 Jan 2006
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Caspase-3 expression is increased in lip and oral squamous cell carcinomas and positively correlates with more advanced tumour stage JOURNAL OF PATHOLOGY | 01 Jan 2003
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Over-expression of TGF-beta 1 in human oral carcinoma cells causes tumour regression in vivo independently of Smad4 by inducing apoptosis without altering cell proliferation. JOURNAL OF PATHOLOGY | 01 Jan 2003
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Butyrate induces terminal differentiation and apoptosis in cell lines derived from oral squamous cell carcinomas BRITISH JOURNAL OF CANCER | 01 Jan 2001

Books

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Elsevier (2020). Precursor lesions for squamous carcinoma of the upper aerodigestive tract