CHYE SOI MOI



Salutation
Associate Professor Dr

School/Centre
School of Health Sciences

Department
Applied Biomedical Science and Biotechnology

Position
Associate Professor




Education

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PhD (Immunodiagnostic of Angiostrongylus cantonenesis infection), 1998 Kaohsiung Medical University
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Degree (Medical Technology), 1988 Kaohsiung Medical University

Memberships

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Institute of Biomedical Science UK | International | Fellow
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MyBiomed | National | Member

Publications

Research Articles

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Biomedical science students’ perception of the use of role-play in learning stress and anger management skills Asia Pacific Scholar | 2024
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Prospecting bioactivity in Antarctic algae: A review of extracts, isolated compounds and their effects FITOTERAPIA | 2024
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Blood-based therapies to combat neurodegenerative diseases METABOLIC BRAIN DISEASE | 2024
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Association among lifestyle and risk factors with SARS-CoV-2 infection TUBERCULOSIS AND RESPIRATORY DISEASES | 2023
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Blood-Brain Barrier and Neurovascular Unit Dysfunction in Parkinson's Disease: From Clinical Insights to Pathogenic Mechanisms and Novel Therapeutic Approaches CNS & NEUROLOGICAL DISORDERS DRUG TARGETS | 2023
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Prevention of Parkinson's disease: from risk factors to early interventions. CNS & NEUROLOGICAL DISORDERS DRUG TARGETS | 2023
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Melatonin ameliorates high glucose-induced autophagy in Schwann cells INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2023
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Pteropine Orthoreovirus (PRV7S) does not Establish Persistent Infection in NP460 Cells but with Inflammatory Response Triggered BIOMEDICAL AND ENVIRONMENTAL SCIENCES | 2023
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Anti-neuroinflammatory mechanism of safinamide in inhibiting lipopolysaccharide-induced microglial activation. PHARMACEUTICAL SCIENCES ASIA | 2023
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THE ROLES OF ANTIFIBROTIC THERAPIES IN POST-SARS-CoV-2 INFECTION MALAYSIAN JOURNAL OF BIOCHEMISTRY & MOLECULAR BIOLOGY | 2023
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Unravelling the genetic links between Parkinson’s disease and lung cancer BIOLOGICAL CHEMISTRY | 2023
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Melatonin Induced Schwann Cell Proliferation and Dedifferentiation Through NF-ĸB, FAKDependent but Src-Independent Pathways REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2022
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ANTI-APOPTOTIC ACTIONS OF SAFINAMIDE IN 6-HYDROXYDOPAMINE-INDUCED CELL MODEL OF PARKINSON’S DISEASE MALAYSIAN JOURNAL OF BIOCHEMISTRY & MOLECULAR BIOLOGY | 2022
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How Do Abnormalities in the Cerebrospinal Fluid Impact Neuropsychology with Progressing Age? CNS & NEUROLOGICAL DISORDERS DRUG TARGETS | 2022
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Potential role of melatonin in prevention and treatment of lung cancer HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION | 2022
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Pteropine Orthoreovirus, PRV7S (Sikamat Virus) Demonstrates Oncolysis in Nasopharyngeal Carcinoma Cell Lines FRONTIERS IN BIOSCIENCE-LANDMARK | 2022
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An Overview of Herbal Medicines for Idiopathic Pulmonary Fibrosis PROCESSES | 2022
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The Role of Monoamine Oxidase B Inhibitors in the Treatment of Parkinson’s Disease-An Update CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (FORMERLY CURRENT DRUG TARGETS-CNS & NEUROLOGICAL DISORDERS) | 2022
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Melatonin Induces Autophagy via Reactive Oxygen Species-Mediated Endoplasmic Reticulum Stress Pathway in Colorectal Cancer Cells MOLECULES | 2021
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A mini review on neuroprotective effects of Syzygium cumini JOURNAL OF MEDICINE AND BIOMEDICAL RESEARCH | 2021
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Edible Bird’s Nest: Recent Updates and Industry Insights Based On Laboratory Findings FRONTIERS IN PHARMACOLOGY | 2021
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Potential role of melatonin in prevention and treatment of leukaemia HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION | 2021
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An overview of complementary and alternative medicine for alzheimer's and parkinson's disease MALAYSIAN JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2021
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Development of ATP13A2-deficient in vitro Model for PARK9 Parkinson’s Disease Current Signal Transduction Therapy | 2021
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Endosomal‐lysosomal dysfunctions in Alzheimer’s disease: Pathogenesis and therapeutic interventions Metabolic Brain Disease | 2021
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Role of the gut microbiome in Alzheimer’s disease Reviews in the Neurosciences | 2021
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Anticancer Properties of Strobilanthes crispus: A Review PROCESSES | 2021
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Toxicity Effects of Chinese Herbal ‘Five-seeds’ Formulation on Human Kidney HEK-293 and Chang Liver Cells ASM Science Journal | 2021
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Immunotherapies for Parkinson's disease: Progression of Clinical Development. CNS & NEUROLOGICAL DISORDERS - DRUG TARGETS | 2021
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Mechanisms of action of amyloid-beta and its precursor protein in neuronal cell death Metabolic brain disease | 2020
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Pharmacological effects of melatonin as neuroprotectant in rodent model: a review on the current biological evidence Cellular and molecular neurobiology | 2020
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Lifestyle intervention to prevent Alzheimer’s disease Reviews in the Neurosciences | 2020
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Focus: Plant-based Medicine and Pharmacology: Antidiabetic Potential of Syzygium sp.: An Overview The Yale journal of biology and medicine | 2020
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Recent advances in tau-directed immunotherapy against Alzheimer’s disease: an overview of pre-clinical and clinical development Metabolic brain disease | 2020
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The mechanism of action of salsolinol in brain: implications in Parkinson’s disease CNS & NEUROLOGICAL DISORDERS - DRUG TARGETS | 2020
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Melatonin inhibits high glucose-induced ox-LDL/LDL expression and apoptosis in human umbilical endothelial cells Hormone Molecular Biology and Clinical Investigation | 2020
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Melatonin promotes Schwann cell dedifferentiation and proliferation through the Ras/Raf/ERK and MAPK pathways, and glial cell‑derived neurotrophic factor expression Experimental and Therapeutic Medicine | 2020
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Mechanisms of action of amyloid-beta and its precursor protein in neuronal cell death Metabolic Brain Disease | 2020
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Melatonin Induces Apoptosis and Inhibits the Proliferation of Cancer Cells via Reactive Oxygen Species-mediated MAPK and mTOR Pathways CLINICAL CANCER DRUGS | 2019
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Development of in vitro PARK 9 Parkinson’s disease model using carbonate apatite nanoparticles JOURNAL OF PARKINSON'S DISEASE | 2019
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TARGETING AUTOPHAGY IN ALZHEIMER’S DISEASE: AN OVERVIEW MALAYSIAN JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2019
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Anticancer Potential of Syzygium Species: a Review Plant Foods for Human Nutrition | 2019
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THE PRO-APOPTOTIC MECHANISMS OF MELATONIN IN CANCER Malaysian Journal of Biochemistry and Molecular Biology | 2019
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A new prospective on the role of melatonin in diabetes and its complications Hormone Molecular Biology and Clinical Investigation | 2019
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The roles of microRNA-331 family in cancers JOURNAL OF CANCER RESEARCH AND PRACTICE | 2019
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Neurotrophic properties and the de novo peptide sequencing of edible bird's nest extracts Food Bioscience | 2019
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Overview of the Pharmacological Activities of Aframomum melegueta. Pertanika Journal of Tropical Agricultural Science | 2019
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The potential therapeutic actions of melatonin in colorectal cancer Hormone Molecular Biology and Clinical Investigation | 2019
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Anticancer potential of Syzygium species: a review Plant Foods for Human Nutrition | 2019
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Melatonin prevents oxidative stress-induced mitochondrial dysfunction and apoptosis in high glucose-treated Schwann cells via upregulation of Bcl2, NF-κB, mTOR, Wnt signalling pathways Antioxidants | 2019
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Enantiomeric pairs of copper (II) polypyridyl-alanine complex salts: anticancer studies Transition Metal Chemistry | 2018
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A mini review on phytochemical constituents and pharmacological activities of Adenium obesum Journal of Tropical Agricultural Science | 2018
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A Mini Review on Phytochemical Constituents and Pharmacological Activities of Adenium obesum. Pertanika Journal of Tropical Agricultural Science | 2018
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Single-chain Fv antibodies for targeting neurodegenerative diseases CNS & NEUROLOGICAL DISORDERS - DRUG TARGETS | 2018
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Medicinal properties of Clinacanthus nutans: A review Tropical Journal of Pharmaceutical Research | 2018
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Tau proteins and tauopathies in Alzheimer’s disease Cellular and molecular neurobiology | 2018
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Edible bird’s nest improves motor behavior and protects dopaminergic neuron against oxidative and nitrosative stress in Parkinson’s disease mouse model OURNAL OF FUNCTIONAL FOODS | 2018
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Niosomes: a review of their structure, properties, methods of preparation, and medical applications Asian Biomedicine | 2018
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THE ROLES OF MELATONIN IN PARKINSON’S DISEASE: AN OVERVIEW JOURNAL OF CELLULAR AND MOLECULAR PHYSIOLOGY | 2017
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Clinacanthus nutans hexane extracts induce apoptosis through a caspase-dependent pathway in human cancer cell lines Asian Pacific Journal of Cancer Prevention | 2017
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A mini review on medicinal effects of edible bird’s nest LETTERS IN HEALTH AND BIOLOGICAL SCIENCES | 2017
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Letters In Health and Biological Sciences LETT. HEALTH BIOL. SCI | 2017
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An Overview of Pharmacological Activities of Syzygium sp. SF PHARMA J | 2017
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Star-branched Folate-conjugated PLLA-PEG Block Copolymers as Nanocarriers for Targeted Delivery of Doxorubicin MALAYSIA POLYMER INTERNATIONAL CONFERENCE | 2017
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Anticancer mechanisms of Strobilanthes crispa Blume hexane extract on liver and breast cancer cell lines Oncology Letters | 2017
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para‐Phenylenediamine induces apoptosis through activation of reactive oxygen species‐mediated mitochondrial pathway, and inhibition of the NF‐κB, m TOR, and W nt pathways in human urothelial cells Environmental toxicology | 2017
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Structural characterization, ROS-inductive and proteasome inhibitory properties of ternary and binary copper (II) complexes of N2-and N2O2-ligands Inorganica Chimica Acta | 2016
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Para-phenylenediamine containing hair dye: An overview of mutagenicity, carcinogenicity and toxicity JOURNAL OF ENVIRONMENTAL & ANALYTICAL TOXICOLOGY | 2016
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Neurotoxic effect of salsolinol through oxidative stress induction and Nrf2-Keap1 signalling regulation OURNAL OF CHEMICAL AND PHARMACEUTICAL RESEARCH | 2016
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MiRNA-331-5p expression level is altered in neuronal cell under elevated oxidative stress Frontiers in Cellular Neuroscience | 2016
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Melatonin protects against hyperglycemia-induced Schwann cells apoptosis through MTOR and Wnt signaling pathways CONFERENCE ABSTRACT: 14 TH MEETING OF THE ASIAN-PACIFIC SOCIETY FOR NEUROCHEMISTRY. DOI: 10.3389/CONF. FNCEL | 2016
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Ternary and binary copper (II) complexes: Synthesis, characterization, ROS-inductive, proteasome inhibitory, and anticancer properties Journal of Coordination Chemistry | 2016
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Cytotoxic and apoptogenic effects of Strobilanthes crispa Blume extracts on nasopharyngeal cancer cells Molecular Medicine Reports | 2015
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Strobilanthes crispus extract induces apoptosis through enhanced caspases activities in cervical cancer cells INTERNATIONAL CONFERENCE ON BIOLOGICAL, ENVIRONMENT AND FOOD ENGINEERING (BEFE-2014) AUGUST | 2014
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Inhibitory activities of methanol extracts of Andrographis paniculata and Ocimum sanctum against dengue-1 virus INTERNATIONAL CONFERENCE ON BIOLOGICAL ENVIRONMENTAL AND FOOD ENGINEERING: BALI, INDONESIA | 2014
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金钱榕提取物抑制 3T3-L1 脂肪细胞抗脂肪沉积研究 (英文) JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B (BIOMEDICINE & BIOTECHNOLOGY) | 2014
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4‐chloro‐1, 2‐phenylenediamine Induces Apoptosis in Mardin–Darby canine kidney cells via activation of caspases Environmental Toxicology | 2014
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para-Phenylenediamine-induces apoptosis via a pathway dependent on PTK-Ras-Raf-JNK activation but independent of the PI3K/Akt pathway in NRK-52E cells Molecular Medicine Reports | 2014
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Anti-adipogenic effects of extracts of Ficus deltoidea var. deltoidea and var. angustifolia on 3T3-L1 adipocytes JOURNAL OF ZHEJIANG UNIVERSITY SCIENCE B | 2014
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Apoptosis induced by para‐phenylenediamine involves formation of ROS and activation of p38 and JNK in chang liver cells Environmental Toxicology | 2014
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Neuroprotective effects of orientin on hydrogen peroxide‑induced apoptosis in SH‑SY5Y cells Molecular medicine reports | 2014
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Edible bird’s nest ameliorates oxidative stress-induced apoptosis in SH-SY5Y human neuroblastoma cells BMC complementary and alternative medicine | 2014
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Cytotoxicity and mechanism of action of Strobilanthes crispus extracts on selected cancer cell lines N/A | 2013
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Screening of anti-dengue activity in methanolic extracts of medicinal plants BMC complementary and alternative medicine | 2012
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[Zn (phen)(O, N, O)(H 2 O)] and [Zn (phen)(O, N)(H 2 O)] with O, N, O is 2, 6-dipicolinate and N, O is l-threoninate: synthesis, characterization, and biomedical properties EUROPEAN JOURNAL OF BIOCHEMISTRY | 2012
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Genotoxicity of dicrotophos, an organophosphorous pesticide, assessed with different assays in vitro Environmental Toxicology | 2012
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Fenthion and terbufos induce DNA damage, the expression of tumor‐related genes, and apoptosis in HEPG2 cells ENVIRONMENTAL AND MOLECULAR MOLECULAR MUTAGENESIS | 2011
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para-Phenylenediamine-induced autophagy in human uroepithelial cell line mediated mutant p53 and activation of ERK signaling pathway Toxicology in Vitro | 2011
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Effect of Strobilanthes crispus extracts on various cancer cell lines INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | 2011
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Involvement of PI3K/Akt-modulated expression of Bcl-2 and Bax in para-phenylenediamine induce apoptosis in NRK52E cells INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | 2011
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Para-phenylenediamine induced DNA damage and apoptosis through oxidative stress and enhanced caspase-8 and-9 activities in Mardin–Darby canine kidney cells Toxicology in Vitro | 2010
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Single strand DNA breaks in human lymphocytes exposed to para-phenylenediamine and its derivatives Bulletin of Environmental Contamination and Toxicology | 2008
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Sevoflurane-induced oxidative stress and cellular injury in human peripheral polymorphonuclear neutrophils Food and chemical toxicology | 2006
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p-Phenylenediamine induces p53-mediated apoptosis in Mardin–Darby canine kidney cells Toxicology in Vitro | 2006
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Mass spectrometric data characteristics of commonly abused amphetamines with sequential derivatization at two active sites Forensic Science International | 2006
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Characteristics of Commonly Abused Amphetamines with Sequential DerivatiAation at Two Active Sites FORENSIC SCIENCE INTERNATIONAL | 2006
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Seroprevalence of melioidosis in diabetic patients in Taiwan. JOURNAL OF MICROBIOLOGY, IMMUNOLOGY, AND INFECTION | 2005
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Mass Spectrometric Data of Commonly Abused Amphetamines and Their Derivatives - Cross Contribution of Ion Intensity between the Analytes and Their Isotopically Labeled Analogs FORENSIC SCIENCE REVIEW | 2005
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Immuno-PCR for detection of antigen to Angiostrongylus cantonensis circulating fifth-stage worms Clinical Chemistry | 2004
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The infectivity and antigenicity of Toxocara canis eggs can be retained after long-term preservation Pathogens and Global Health | 2004
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Recombinant truncated flagellin of Burkholderia pseudomallei as a molecular probe for diagnosis of melioidosis CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY | 2003
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Immunodiagnosis of human eosinophilic meningitis using an antigen of Angiostrongylus cantonensis L5 with molecular weight 204 kD Acta Tropica | 2000
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Detection of circulating antigen by monoclonal antibodies for immunodiagnosis of angiostrongyliasis The American journal of tropical medicine and hygiene | 1997
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Detection of antibodies to surface antigens of Angiostrongylus cantonensis by ELISA Pathogens and Global Health | 1995

Other Publications

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Lab results, values and interpretation Pep-up your day talk 2022 | 25 Sep 2022
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Melatonin promotes Schwann cell dedifferentiation and proliferation through Ras/Raf/ERK pathway and glial cell-derived neurotrophic factor expression 14th International Conference on Alzheimer's and Parkinson's Diseases | 26 Mar 2019
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MELATONIN PROTECTS AGAINST HIGH GLUCOSE-INDUCED SCHWANN CELLS DYSFUNCTION: INVOLVEMENTS OF UPREGULATION OF BCL2 AND DOWNREGULATION OF ROS/ERK/NF-KB SIGNALING PATHWAYS 2nd ITCN and 2017 AMTNS | 21 May 2017
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APOPTOTIC EFFECTS OF SALSOLINOL ON NE4C NEURAL STEM CELLS THROUGH MAPK SIGNALING PATHWAY The 13th International Conference on Alzheimer's & Parkinson's diseases | 29 Mar 2017
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Screening of anti-dengue activity in methanolic extracts of six medicinal plants INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | 01 Jan 2011


Supervisions
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Ng Pei Ying | Doctorate | 01 Jan 2019 - 31 Aug 2022 Thesis: Molecular mechanism of novel anti-phospho-tau serine 396/404 single-chain variable fragment (scFv) antibodies on the reversal of Tau pathology in Alzheimer disease
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Low Hwei Jean | Master (Coursework) | 01 Aug 2022 - 31 Jul 2023 Thesis: Quality Assurance in Molecular Diagnostic Laboratory: A Systematic Review
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1) Mervyn Lim Chen Xi; 2) Luis Lim Wei Cheng; 3) Lim Ee Hue; 4) Choo Yinn Haury; | Undergraduate | 01 Jul 2022 - 31 Dec 2022 Thesis: Investigation of melatonin induced apoptotic cell death in cancer cells via a mitophagy-mediated autophagy pathway
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PHOR YU JIA | Undergraduate | 02 Jan 2023 - 31 Dec 2023 Thesis: Molecular mechanism of lactoferrin-induced cytotoxicity and apoptosis in cancer cell lines
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Tiong Yee Lian | Doctorate | 01 Sep 2012 - 31 Aug 2019 Thesis: Molecular mechanism involving in combination of melatonin with insulin therapy on diabetes and its complications
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Reena A/P Kasi | Master (Research) | 01 Sep 2011 - 31 Jul 2015 Thesis: phenylenediamine induces G2/M arrest and apoptosis via activating ERK-p53 apoptotic pathway and inhibiting PTK-Ras-Raf-JNK survival pathway in NRK52E cells
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BRENDA LIM WEN KENG ;KELVIN NG YEE CHEN;SIA WEI TONG | Undergraduate | 01 Jul 2024 - 31 Jan 2025 Thesis: Investigation of melatonin induced necroptosis in cancer cells by targeting RIP/ RIP3/MLKL pathway
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Esther Chong Yu Mae | Undergraduate | 01 Jul 2024 - 30 Jun 2025 Thesis: Molecular mechanism of β-hydroxybutyrate-induced cytotoxicity and apoptosis in cancer cell line